Journal of Clinical Oncology (JCO) Podcast

Latest Episodes:

Routine Second Pathology Review for Node-Negative Breast Cancer: What is Learned and What is the Effect on Patient Care? May 07, 2012

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This Podcast reviews the design and results of the present study by Kennecke et al. and provides perspective regarding the clinical significance of these findings.

Pre-Operative Metformin in Early-Stage Breast Cancer May 07, 2012

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This podcast reviews the rationale behind evaluation of metformin as a potential anti-cancer agent in breast cancer and describes the findings of a recent window of opportunity trial looking at the impact of metformin upon proliferative indices in women with early breast cancer.

Fulvestrant and Anastrozole in Combination: FACT or Fiction? Apr 30, 2012

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This podcast reviews the results of the FACT trial in the context of other ongoing and proposed studies of endocrine therapy combinations.

A New Day Dawning for Hodgkin Lymphoma? Apr 30, 2012

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This podcast describes a phase 2 trial brentuximab vedotin in patients with Hodgkin lymphoma that has recurred after autologous hematopoietic stem cell transplantation. The podcast discusses the rationale for the trial, response to therapy, and associated toxicities. Future application of brentuximab vedotin to CD30+ malignancies is considered as well.

The German CAO/ARO/AIO-94 Randomized Phase III Trial After a Median Follow Up of 11 Years: Implications of Long Term Follow Up Apr 23, 2012

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In this study, the implications of long term follow up of the German Rectal Study on clinical practice and future trial design will be discussed.

Carboplatin-Gemcitabine-Bevacizumab: Expanding Treatment Options for Recurrent Platinum Sensitive Epithelial Ovarian Cancer Apr 23, 2012

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Carboplatin-Gemcitabine-Bevacizumab represents an additional regimen to consider for management of recurrent platinum sensitive epithelial ovarian cancer, although it raises several questions regarding the role of bevacizumab in this disease setting.

The Use of Adjuvant Therapy in Elderly Patients with Resected Non-Small Cell Lung Cancer (NSCLC) Apr 23, 2012

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This podcast discusses adjuvant therapy in elderly NSCLC patients.

Management and Prevention of Pain Related to Treatment or Disease Apr 16, 2012

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The podcast highlights recent JCO articles that underscore the need for improved assessment and management of cancer and treatment-related symptoms.

1 + 1 = 3. Combined Use of Anti-HER2 Agents in the Neoadjuvant Setting Apr 09, 2012

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The CHER-LOB trial is one of several that has demonstrated that adding lapatinib to trastuzumab and chemotherapy improves on the rates of complete pathological response among women receiving neoadjuvant therapy for HER2 positive breast cancer. Because the relationship between pCR and long-term outcomes remains ambiguous, this regimen is not recommended for ordinary use. However, these findings are a powerful support to the hypothesis that dual-modality anti-HER2 therapy is a potent combination.

Management of Low Stage Ovarian Clear Cell Carcinoma Apr 09, 2012

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A reflection on the problems clinicians face when making a decision on how best to advise patients regarding management of early clear cell carcinoma of the ovary.