Journal of Clinical Oncology (JCO) Podcast

Latest Episodes:

The Rich Get Richer: Another Efficacious Option for Refractory Hairy Cell Leukemia Feb 21, 2012

Show notes

This podcast reports on a phase I/II trial investigating novel anti-CD22, moxetumomab pasudotox, in the treatment of patients with refractory hairy cell leukemia, which demonstrated responses in the majority of patients at all dose levels.

Rethinking Our Use of CSFs in the Adjuvant Treatment of Women Who Have Estrogen Receptor Positive Cancers Feb 06, 2012

Show notes

When dose dense treatment was first described we were greatly enthusiastic for all women with breast cancer. As the experience has matured we now realize that the benefit is confined to women with ER negative cancers. We think it is time to question our use of CSFs and dose dense treatment in ER+ women based on 2 large trials and a conclusive meta-analysis.

Recurrence and Survival Results of the GOG Lap2 Trial Confirm Safety of the Laparoscopic Approach to Surgical Staging and Treatment for Uterine Cancer Jan 30, 2012

Show notes

This podcast summarizes and discusses the outcome results of the GOG Lap2 trial which shows safety and clinical benefits of laparoscopy as compared to laparotomy for surgical staging and treatment of uterine cancer.

"Anything You Can't Do, I Can't Do Either": Transplantation for High Risk AML Jan 30, 2012

Show notes

This is a commentary on a report from the EBMT demonstrating a higher relapse rate after allogeneic transplantation in AML patients with FLT3 ITD mutations.

Safety and Efficacy of Sequential Adjuvant AI Therapy in ER Positive Breast Cancer Jan 19, 2012

Show notes

Long-term follow-up of efficacy and toxicity outcomes from the IES study of adjuvant aromatase inhibitor therapy in postmenopausal estrogen receptor positive breast cancer

The Role of Ovarian Suppression for Fertility Preservation in Women Receiving Adjuvant Breast Cancer Chemotherapy Jan 09, 2012

Show notes

This podcast discusses the findings from the manuscript by Munster et al. regarding the use of ovarian suppression for fertility preservation in young women receiving adjuvant chemotherapy in the context of the current literature and future directions.

Using BCR-ABL Transcript Levels After 3 Months of Therapy on Imatinib is the Best Way to Predict Long-Term Outcome for Patients with CML Treated with Imatinib Jan 09, 2012

Show notes

The study by Marin et al is another milestone in our understanding how to manage CML patients on tyrosine kinase inhibitors.

The Importance of Tumor Biopsies for Analysis of Mechanisms of Response and Resistance in Prostate Cancer Dec 19, 2011

Show notes

This podcast will summarize the results of Efstathious et al and discuss possible mechanisms of resistance to castration based therapies in prostate cancer.

Targeting the Angiopoietin-Tie2 Axis: A Promising Alternative Antiangiogenic Strategy for Epithelial Ovarian Cancer Dec 19, 2011

Show notes

Targeting the Angiopoietin-Tie2 axis is a promising alternative antiangiogenic strategy for the treatment of ovarian cancer that exhibits non-overlapping toxicities with inhibitors of the VEGF signaling pathway.

Interim PET Scans in Diffuse Large B-Cell Lymphoma - More Than Another Biomarker? Dec 12, 2011

Show notes

This podcast reviews data from a recent publication on the use of "early" interim PET scanning in diffuse large B-cell lymphoma and comments on the clinical utility of this imaging technique in the current management of patients with this disease.