Journal of Clinical Oncology (JCO) Podcast

Latest Episodes:

Outcome in Systemic Anaplastic Large Cell Lymphoma: Beyond ALK Oct 08, 2012

Show notes

The prognostic importance of ALK-protein expression was established over a decade ago. More recent studies emphasize that age is also an important driving force and in patients

Should Gemtuzumab Ozogamicin Be Re-added to the Therapeutic Armamentarium for Acute Myeloid Leukemia? Sep 17, 2012

Show notes

Although gemtuzumab ozogamicin has been withdrawn from the marketplace, three randomized trials prompt review of that decision.

Immunohistochemical Double Hit Score in Diffuse Large B-Cell Lymphoma: The Potential to Screen All Tumors for High-Risk Biology Sep 04, 2012

Show notes

This podcast summarizes and places in clinical context two studies describing straightforward immunohistochemical methods to risk-stratify diffuse large B-cell lymphoma.

In a Sea of Data the Water is Still Murky: Meta-Analysis of Cognition in Breast Cancer Aug 27, 2012

Show notes

Cognitive impairment occurs in a subset of breast cancer survivors after chemotherapy but the incidence remains unknown.

KRAS G13D Mutations in Metastatic Colorectal Cancer: Are They Different From Codon 12? Aug 24, 2012

Show notes

This podcast discusses the manuscript by Tejpar et al in which patients whose colorectal tumors harbor a specific KRAS mutation, G13D, appear to have benefit in two clinical trials with regard to tumor response and progression-free survival with cetuximab treatment.

Taxane Induced Peripheral Neuropathy: A Continued Challenge but Not a Biomarker of Treatment Efficacy Aug 10, 2012

Show notes

Although historically toxicity was often thought to be a biomarker of efficacy, often it appears to be a marker of dose intensity and individual susceptibility as is the case in this retrospective study of taxane induced peripheral neuropathy and breast cancer outcome.

Is This Nomogram Ready To Roll? Jun 25, 2012

Show notes

In this podcast, Dr. Hudis reviews the use of a novel nomogram to predict the benefits of postoperative adjuvant radiation therapy for older women with early stage breast cancer. This discussion highlights the information from prospective randomized trials, their limitations, and the potential for a nomogram to guide clinicians facing patients who might not have qualified for the earlier studies.

Adjuvant Chemotherapy in Older Patients with Stage III Colon Cancer Jun 04, 2012

Show notes

As oncologists treat an increasing number of older patients with colon cancer, and as treatment options improve for older patients, oncologists should work with geriatricians to make the best treatment decisions.

The Combination of Bortezomib, Thalidomide, and Dexamethasone in Relapsed Multiple Myeloma May 14, 2012

Show notes

This podcast will provide a critical evaluation of the combination of bortezomib, thalidomide, and dexamethasone in relapsed multiple myeloma

Personalized Therapy for Breast Cancer: Is It Really Happening? May 09, 2012

Show notes

This Podcast reviews and comments on the use of the National Comprehensive Cancer Network (NCCN) Breast Cancer Outcome Database to demonstrate the actual rollout of the use of gene expression profile (GEP) testing for women with hormone receptor positive, node negative breast cancer and the accompanying changes in breast cancer chemotherapy utilization