Journal of Clinical Oncology (JCO) Podcast

Latest Episodes:

Is Early Initiation of Adjuvant Chemotherapy for Breast Cancer Better? Feb 10, 2014

Show notes

Early commencement of adjuvant chemotherapy is unlikely to be relevant for the majority of patients but unnecessary delay may be unwise for patients in whom the effect of adjuvant chemotherapy is expected to be significant.

Single Agent Rituximab Active in Nodular Lymphocyte Predominant Hodgkin Lymphoma Feb 10, 2014

Show notes

This podcast describes the recent experience of single agent rituximab as management for newly diagnosed and relapsed nodular lymphocyte predominant Hodgkin lymphoma. The podcast includes a summary of the trial and discussion of the implications of the findings that rituximab has activity in both the upfront and relapsed setting.

Adjuvant Treatment for Gastric Cancer: The Story Continues to Evolve Feb 10, 2014

Show notes

The mature results of a randomized comparison of S-1 versus observation in Japanese patients who have undergone a D2 resection for gastric cancer continue to show a significant survival benefit supporting the use of post-operative chemotherapy.

Benefits of Modified Craniospinal Radiation Therapy for Children Treated for Medulloblastoma: Preserving Long-Term Neurocognitive Function Feb 10, 2014

Show notes

Children treated for medulloblastoma using reduced dose craniospinal radiation with local tumor bed boost have improved neurocognitive outcomes compared with conventional therapy, pointing to an opportunity for prevention of severe late effects by treatment modification.

Breast MRI As It Is, In Contrast To How We Wish It To Be Jan 06, 2014

Show notes

The meta-analysis by Houssami and colleagues notes no recurrence benefit of breast MRI, and adds to a growing body of data demonstrating that the use of breast MRI in the non-high risk preoperative setting provides little benefit when used routinely.

New Adoptive T Cell Therapy Has EBV-Positive Lymphomas on the Run Dec 16, 2013

Show notes

Reflections on a new report describing the successful therapy of lymphomas using adoptively transferred T cells targeting EBV latent membrane proteins.

Adjuvant High-Dose Interferon: New Evidence Regarding Treatment Duration and Survival Impact in Melanoma Dec 16, 2013

Show notes

This podcast provides observations and commentary on the study by Payne and colleagues entitled 'Phase II Pilot Study of Intravenous High Dose Interferon with or without Maintenance Treatment in Melanoma at High Risk of Recurrence.'

Some like It Even Hotter: Escalating Radioimmunotherapy in Follicular Lymphoma? Dec 02, 2013

Show notes

An increased-dosage radioimmunotherapy for upfront treatment of follicular lymphoma achieves excellent results, raising questions on the best choice of treatment in this disease.

Increasing Cytarabine Dose in AML Induction Improves Outcomes in Younger Patients Dec 02, 2013

Show notes

This podcast describes the recent experience of high dose cytarabine induction in patients with acute myeloid leukemia (AML), as reported in the EORTCGIMEMA AML-12 trial. The podcast includes a summary of the trial and discussion of the implications of the finding that high dose cytarabine induction improves outcomes in younger patients with AML.

The Value of Preoperative MRI in Predicting Outcome in Patients with Rectal Cancer Nov 25, 2013

Show notes

MRI done prior to surgery can be useful in determining the long-term outcomes after surgical resection in patients with rectal cancer.

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