Journal of Clinical Oncology (JCO) Podcast

Latest Episodes:

Long Term Cardiac Safety Data from the HERA Adjuvant Trastuzumab Trial Jun 09, 2014

Show notes

This podcast discusses the report of cardiac monitoring data from the HERA trial, places the findings in context with data from other trials, and considers how the report relates to clinical practice.

Breast Needle Core Biopsy: The Impact Surgeons and Geography Have on Utilization and the Impact on Patient Care Jun 09, 2014

Show notes

This is a review of breast needle biopsy for the diagnosis of breast cancer and how surgeons and geography affect utilization and the resultant impact on quality of care.

Identifying High-Risk Myeloma Jun 02, 2014

Show notes

FISH genetics, LDH and beta 2-microglobulin can identify a group of newly diagnosed myeloma patients with a two-year survival of only 52% in spite of bortezomib-based therapy.

Attempting to Avoid Chemotherapy in CLL with Lenalidomide and Rituximab May 27, 2014

Show notes

The current study, reporting on the upfront use of lenalidomide and rituximab in CLL, suggests high response rates and excellent tolerability in younger as well as older patients, albeit with a modest median progression-free survival.

Breast Cancer Chemotherapy Effects on Brain Activation During Multitasking and Relation to Cognitive Complaints May 27, 2014

Show notes

This podcast summarizes the findings of a recent longitudinal functional MRI study examining the effects of breast cancer chemotherapy on multitasking-related brain activation and its relationship to cognitive complaints, and discusses implications and future directions.

Delayed Diagnostic Lumbar Puncture to Optimize Central-Nervous-System-Directed Therapy in Childhood Acute Lymphoblastic Leukemia May 12, 2014

Show notes

This podcast discusses the measures to optimize central-nervous-system-directed therapy in children with acute lymphoblastic leukemia.

Capecitabine Versus Continuous Infusion 5-FU for Rectal Cancer Neoadjuvant Chemoradiation: Equivalent Effectiveness Raises Real-World Questions About Efficacy, Adherence and Economic Implications May 05, 2014

Show notes

This trial supports the use of neoadjuvant capecitabine monotherapy as a potentially more convenient radiosensitizer that does not sacrifice surgical and pathologic outcomes in rectal cancer. However, further study is needed.

Evolving Treatment Paradigms for Primary Mediastinal Diffuse Large B-Cell Lymphoma May 05, 2014

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This podcast reviews the current role of PET and radiotherapy in PMBL.

Response Assessment in Hodgkin Lymphoma: Size Matters! May 05, 2014

Show notes

This podcast concerns the potential complimentary role played by PET and CT in the assessment of response in patients with Hodgkin lymphoma.

Second Tumors in PTEN Mutation-Positive Patients: Are They Recurrences or New Primaries? Apr 28, 2014

Show notes

Among more than 2,000 patients with an invasive cancer, more than 5% had a mutation in PTEN and almost half of these patients had a second malignancy. This observation has implications for patients with breast, endometrial and thyroid cancer, and those with known PTEN mutations.