Show notes
Measure Brain Toxins For Multiple Recovery SolutionsAn expert is someone who has succeeded in making decisions and judgements simpler through knowing what to pay attention to and what to ignore.~ Edward deBonoWilliam Shaw, Ph.D., is board certified in the fields of clinical chemistry and toxicology by the American Board of Clinical Chemistry - with a profound interest in brain toxins. Before he founded The Great Plains Laboratory, Inc. in Lenexa, KS, Dr. Shaw worked for the Centers for Disease Control and Prevention (CDC), Children's Mercy Hospital, the University of Missouri at Kansas City School of Medicine, and Smith Kline Laboratories.I've followed his work for many years, use Great Plains Laboratory for biomedical testing every day in my practice, and am exceedingly pleased to share these moments with his profound experience for our CBJ listeners. Recently Dr. Shaw added GPL-TOX to measure brain toxins to Great Plains Labs armamentarium of essential mind tools. This CBJ Special 1-hour review will help listeners understand this possible next step for treatment failure globally.Ed Note: See Dr. Shaw's Bonus Notes below ↓ with many brain toxin reference topics for further review on this essential measurement tool.It's important to note that he is the author of two outstanding contributions to the evolution for the treatment of Autism, Biological Treatments for Autism and PDD, originally published in 1998, and Autism: Beyond the Basics, published in 2009. He is also a frequent speaker at conferences worldwide, a global authority with broad experience with the value of laboratory data and molecular insights regarding imbalanced brain functions.On a more personal note, Dr. Shaw is the stepfather of a child with autism and has helped thousands of patients and medical practitioners to successfully improve the lives of people with autism spectrum disorders, ADHD/Executive Function, Alzheimer's disease, arthritis, bipolar disorder, chronic fatigue, depression, fibromyalgia, immune deficiencies, multiple sclerosis, OCD, Parkinson's disease, seizure disorders, tic disorders, Tourette's syndrome, and other serious conditions.In this interview, we discuss useful details regarding the evolution and immediate value of measurements for brain toxins about many of these conditions.Dr. Shaw's Insightful Brain Toxin Details Here - CBJ/125GPL-TOX fulfills my lifetime wish to make toxin testing available for the public [spp-timestamp time="4:49"]90% of the people don't know specific toxin exposure and could spend $20,000 searching [spp-timestamp time="6:00"]GPL-TOX tests for 172 different chemicals at about $200 [spp-timestamp time="6:42"]What high values on GPL-TOX testing mean medically [spp-timestamp time="7:49"]My first clinical case awareness on the relevance of brain toxins [spp-timestamp time="10:11"]Carbon Monoxide can cause kleptomania and death [spp-timestamp time="12:50"]One of the easiest things to remember about toxins [spp-timestamp time="13:22"]Humans are the most vulnerable to brain toxins and psych problems [spp-timestamp time="14:14"]Most common way they cause brain deterioration is through mitochondria [spp-timestamp time="15:52"]If you're waiting for the government to monitor toxins you might as well wait for the tooth fairy [spp-timestamp time="20:20"]The public must know: toxins cause a wide variety of mind/medical problems [spp-timestamp time="22:01"]Details for treatment and detox [spp-timestamp time="29:58"]Three treatments including sauna notes from 9-11 [spp-timestamp time="33:07"]Clinical observations regarding GPL-TOX for autism [spp-timestamp time="38:40"]Note on my recent article on glyphosate/GMO [see download below↓] [spp-timestamp time="39:40"]Glyphosate, clostridia and HPHPA values on OATS testing- increase dopamine neurotransmitters [spp-timestamp time="44:51"]--------------Brain Toxin Download: For Dr. Shaw's Reference PDF - Explains GPL Test ResultsThe Importance of Testing for Glyphosate: The World’s Most Widely Used HerbicideDownload Here--------------Websites, References & Solutions For Brain Toxinshttp://gpl4u.com - MemorableGreat Plains Page for GPL-TOX - brain toxins references & additional insightsTo Order A GPL-TOX Test At Great Plains Laboratory - [Not an affiliate]GPL Professional Training/WorkshopsBiological Treatments for Autism and PDD- Shaw - Highly recommended - Global Amazon LinkAutism: Beyond the Basics - Shaw - Global Amazon LinkThe Toxin Solution - Pizzorno - Global Amazon LinkReferenced Notes: Sauna Process and Supplements for DetoxTrump's Legacy - Pesticides and Children's Brains NYTimes ReportEarlier Essential CBJ Interviews Referencing Brain ToxinsCBJ/037 Dr. Chris Martenson – Neurotoxins & World EconomicsCBJ/103 Dr. Joseph Pizzorno - Author of The Toxin Solution CBJ/134 Dr. Stephanie Seneff - Glyphosate Autism & CancerCBJ/140 Dr. Kurt Woeller - The Importance of Biomedical Testing in Autism-----------Dr. William Shaw Discusses the Dangers of Glyphosate with Author and Investigative Journalist Carey Gillam from The Great Plains Laboratory on Vimeo.--------Brain Toxins - References | Bonus From Dr. ShawReferences on GlyphosateBradberry SM, Proudfoot AT, Vale JA. Glyphosate poisoning. Toxicol Rev. 2004;23(3):159-67.Mesnage R et al. Major pesticides are more toxic to human cells than their declared active principles. Biomed Res Int. 2014: 179691Samsel A, Seneff S. Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance. Interdiscip Toxicol. 2013;6:159-184.Samsel A, Seneff S. Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies. Surg Neurol Int. 2015; 6: 45.Krüger M, Schledorn P, Schrödl W, Hoppe HW, Lutz W, Shehata AA. Detection of Glyphosate Residues in Animals and Humans. J Environ Anal Toxicol. 2014. 4:2 http://dx.doi.org/10.4172/2161- 0525.1000210Barbosa ER, Leiros da Costa MD, Bacheschi LA, Scaff M, Leite CC. Parkinsonism after glycine-derivative exposure. Mov Disord. 2001. 16: 565-568.Mesnage R, Defarge N, Spiroux de Vendômois J, Séralini GE. Potential toxic effects of glyphosate and its commercial formulations below regulatory limits. Food Chem Toxicol. 2015 Oct;84:133-53.Guyton KZ, Loomis D, Grosse Y et al. Carcinogenicity of tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate. Lancet Oncol. 2015 May;16(5):490-1Shehata AA, Schrödl W, Aldin AA, Hafez HM, Krüger M. The effect of glyphosate on potential pathogens and beneficial members of poultry microbiota in vitro. Curr Microbiol. 2013 Apr;66(4):350-8.Jayasumana C, Gunatilake S, Siribaddana S. Simultaneous exposure to multiple heavy metals and glyphosate may contribute to Sri Lankan agricultural nephropathy. BMC Nephrology 2015;16:103. doi 10.1186/s12882-015-0109-2Jayasumana C, Gunatilake S, Senanayake P. Glyphosate, hard water and nephrotoxic metals: Are they the culprits behind the epidemic of chronic kidney disease of unknown etiology in Sri Lanka? Int. J. Environ. Res. Public Health 2014;11:2125-2147.Clair E et al. Effects of Roundup® and glyphosate on three food microorganisms: Geotrichum candidum, Lactococcus lactis subsp. cremoris and Lactobacillus delbrueckii subsp. bulgaricus. Curr Microbiol. 2012;64: 486-491.DeWolf WE Jr. Inactivation of dopamine beta-hydroxylase by p-cresol: isolation and characterization of covalently modified active site peptides. Biochemistry. 1988;27: 9093-9101.Swanson NL, Leu A, Abrahamson J, and Wallet B. Genetically engineered crops, glyphosate and the deterioration of health in the United States of America. Journal of Organic Systems. 2014; 9(2):6- 37.Environmental Protection Agency. Pesticides Industry Sales & Usage. 2006 and 2007 Market Estimates. Available at https://www.epa.gov/sites/production/files/2015-10/documents/market_ estimates2007.pdf. Accessed July 15, 2015.Shehata AA et al. The effect of glyphosate on potential pathogens and beneficial members of poultry microbiota in vitro. Curr. Microbiol. 2013;66: 350-358.Larsen K et al. Effects of sublethal exposure to a glyphosate-based herbicide formulation on metabolic activities of different xenobiotic-metabolizing enzymes in rats. Int J Toxicol. 2014;33: 307-318.References on PhthalatesSilva MJ, et al. Improved quantitative detection of 11 urinary phthalate metabolites in humans using liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 789:393-404, 2003.Silva MJ, et al. Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000. Environ Health Perspect 112:331-338, 2004.Silva MJ, et al. Analysis of human urine for fifteen phthalate metabolites using automated solid-phase extraction. J Chromatogr B Analyt Technol Biomed Life Sci 805:161-167, 2004.Adibi JJ, et al. Prenatal exposures to phthalates among women in New York City and Krakow, Poland. Environ Health Perspect. 111:1719-22, 2003.Ritter, EJ, et al. Teratogenicity of di(2-ethylhexyl)phthalate, 2-ethylhexanol, 2-ethylhexanoic acid, and valproic acid, and potentiation by caffeine. Teratology 35 (1):41-6, 1987Ormond, G, et al. Endocrine disruptors in the workplace, hair spray, folate supplementation, and risk of hypospadias: Case-control study. Environ Health Perspect 117(2): 303–307, 2009.References on OrganophosphatesEskenazi B, et al. Organophosphate Pesticide Exposure and Neurodevelopment in Young Mexican-American Children. Environ Health Perspect 115:792–798 (2007).Eskenazi B, et al. Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population. Environ Health Perspect112:1116–1124, 2004.Windham, GC, et al. Autism spectrum disorders in relation to the distribution of hazardous air pollutants in the San Francisco Bay area. Environ. Health Perspect., 114:1438-1444, 2006.Laslo-Baker D, et al. Child neurodevelopmental outcome and maternal occupational exposure to solvents. Arch Pediatr Adolesc Med 158:956–961, 2004.Windham GC, Osorio AM, et al. Female reproductive toxicology. In: Occupational and Environmental Medicine (LaDou J, ed). 3rd ed. Norwalk, CT: Appleton and Lange, Inc, 397–413, 2004.Roberts, EM, et al. Maternal Residence Near Agricultural Pesticide Applications and Autism Spectrum Disorders among Children in the California Central Valley. .Environ Health Perspect 115:1482–1489, 2007.D'Amelio M, et al. Paraoxonase gene variants are associated with autism in North America, but not in Italy: possible regional specificity in gene-environment interactions. Mol Psychiatry 10(11):1006–1016, 2005.Sergiu P, et al. High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism. Life Sciences 78 (2006) 2244-2248.McCully, et al. KS Chemical pathology of homocysteine. II. Carcinogenesis and homocysteine thiolactone metabolism Annals of Clinical and Laboratory Science, 24: 27-59,1994.Boris, M, et al. Association of MTHFR Gene Variants with Autism. Journal of American Physicians and Surgeons 9:106-108, 2004.Brown, TP, et al. Pesticides and Parkinson's disease – is there a link? Environmental Health Perspect 114(2): 156–164, 2006.References for Other Toxic ChemicalsAnderson ME, Kirkland KH, Guidotti TL, Rose C. (2006). A Case Study of tire crumb use on playgrounds: risk analysis and communication when major clinical knowledge gaps exist. Environ Health Perspect. 114: 1-3.Brown DR. (2007) "Artificial Turf". Environment & Human Health, Inc.Perera FP, Chang HW, Tang D, Roen EL, Herbstman J, Margolis A, Huang TJ, Miller RL, Wang S, and Rauh V. (2014) Early-life exposure to polycyclic aromatic hydrocarbons and ADHD behavior problems. PLos One. 9: e111670.Zhang JJ, Han IK, Zhang L, and Crain W. (2008). Hazardous chemicals in synthetic turf materials and their bioaccessibility in digestive fluids. J Expo Sci Environ Epidemiol. 18: 600-607.Legler, J., Fletcher T., Govarts E., Porta M., Blumberg B., Heindel JJ., Transande L. (2015) Obesity, diabetes, and associated costs of exposure to endocrine-disrupting chemicals in the European Union. J Clin Endocrinol Metab. 100: 1278-88.Chopra V., Harley K., Lahiff M., and Eskenazi B. (2014) Association between phthalates and attention deficit disorder and learning disability in US children, 6-15 years. Enviorn Res. 128: 64-9Moretto A. and Colosio C. (2011). Biochemical and toxicological evidence of neurological effects of pesticides: the example of Parkinson's disease. Neurotoxicology. 32: 383-91.Elwan MA., Richardson JR., Guillot TS., Caudle MW., and Miller GW. (2006) Pyrethroid pesticide-induced alterations in dopamine transporter function. Toxiocol Appl Pharmacol. 211: 199-97.Steventon GB., Waring RH., and Williams AC. (1990) Pesticide toxicity and motor neuron disease. J Neurol Neurosurg Psychiatry. 53: 621-622.Lowenstein J. (2014) Agent Orange and Heart Disease: Is there a connection? FASEB J. 28: 1531-1533.Goldner WS., Sandler DP., Yu F., Shostrom V., Hoppin JA., KamelF., LeVanTD. (2013) Hypothyroidism and pesticide use among male private pesticide applicators in the agricultural health study. J Occup Environ Med. 55: 1171-1178.Kim JS., Lim HS., Cho SI., Cheong HK., and Lim MK. (2003) The impact of Agent Orange exposure among Korean Vietnam veterans. Ind Health. 41: 149-157.Heck JE., Park AS., Qiu J., Cockburn M., and Ritz B. (2014) Risk of leukemia in relation to exposure to ambient air toxins in pregnancy and early childhood. Int J Hyg Environ Health. 217: 662-668.References for Mitochondrial DisordersPoling JS, Frye RE, Zimmerman AW, et al. Developmental regression 1. and mitochondrial dysfunction in a child with autism. J Child Neurol 2006;21(2):170-172.Poling JS. Father: Child's case shifts autism debate. The Atlanta Journal-2. Constitution. April 11, 2008.Oliveira G, Diogo L, Oliveira CR, et al. Mitochondrial dysfunction in 3. autism spectrum disorders: A population-based study. Dev Med Child Neurol 2005; 49 (10):726-733. Nissenkorn A, Zeharia A, Lev D, et al. Multiple presentation of 4. mitochondrial disorders. Arch Dis Child 1999;81:209–214.Not Your Mother's Mitochondrial Disease. Myths & Facts About 5. Mitochondrial Cytopathies By Sumit Parikh, M.D. & Bruce H. Cohen, M.D. Cleveland Clinic website electronic brochure. http://my.clevelandclinic.org/disorders/Mitochondrial_Disease/hic_Myths_and_Facts_About_Mitochondrial_Diseases.aspx.Weissman JR, et al. Mitochondrial Disease in Autism Spectrum Disorder 6. Patients: A Cohort Analysis. PLoS ONE 3(11): e3815. doi:10.1371/journal.pone.0003815, 2008.Gibson KM, Elpeleg ON, Jakobs C, Costeff H, Kelley RI. Multiple 7. syndromes of 3-methylglutaconic aciduria. Pediatr Neurol. 1993 Mar-Apr;9(2):120-3.Rossignol DA, Bradstreet JJ. Evidence of Mitochondrial Dysfunction in 8. Autism and Implications for Treatment Am J of Biochem Biotech 4(2): 208-217, 2008.Filiano JJ, Goldenthal MJ, Rhodes CH, Marin-Garcia J. Mitochondrial 9. dysfunction in patients with hypotonia, epilepsy, autism, and developmental delay: HEADD syndrome. J Child Neurol., 17:435-439, 2002.Pons R, Andreu AL, Checcarelli N, et al. Mitochondrial DNA 10. abnormalities and autistic spectrum disorders. J. Pediatr., 144:81-85.Serajee FJ, Zhang H, Huq AH. Prevalence of common mitochondrial 11. point mutations in autism. Neuropediatrics, 37 (Suppl 1):S127, 2006.Weissman JR, Kelley RI, Bauman ML, Cohen BH, Murray KF, et al. 12. (2008) Mitochondrial Disease in Autism Spectrum Disorder Patients: A Cohort Analysis. PLoS ONE 3(11): e3815. doi:10.1371/journal.pone.0003815.González L, et al. Endoscopic, histologic, and immunologic characteristics of the digestive mucosa in autis…
Full show notes at the publisher 
Our TOPPODCAST Picks 
Stay Connected
