Biohacking Beauty: The Anti-Aging Skincare Podcast

Latest Episodes:

The TRUTH About Botox They Don't Want You To Know Mar 12, 2025

Show notes

Welcome back to Biohacking Beauty! In this episode, we tackle the controversial topic of Botox and explore effective alternatives for those seeking more natural approaches to youthful skin. Young Goose co-founder Anastasia Khodzhaeva opens up about her personal experience with Botox treatments and why they didn't work for her, while we discuss the science behind various alternatives.

Rather than demonizing Botox, we examine both sides of this polarizing beauty topic, offering insights for those who use Botox and those looking for different options. From peptides and cellular repair compounds to professional treatments and at-home techniques, we break down what actually works when you're seeking youthful skin without neurotoxins.

Anastasia shares her journey through postpartum skin changes and how she found effective alternatives that worked for her unique situation. We also discuss how Young Goose formulations support skin regeneration at the cellular level, offering a different approach to common signs of aging. If you’ve ever wondered if Botox is for you, this is an episode you don’t want to miss.

We Also Discuss:

(04:31) Defining what we mean by "Botox alternatives"

(06:45) Anastasia's personal journey with Botox and TMJ

(19:01) How Botox works and potential side effects

(25:17) The debate around Botox as a "preventative" treatment

(32:11) Neuropeptides and how they differ from Botox

(36:31) NAD precursors and cellular repair mechanisms

(45:20) The role of autophagy in skin rejuvenation

(45:47) Red light therapy benefits and limitations

(51:03) Facial taping, massage, and professional treatments

(56:54) Finding a balanced approach that works for you

Learn more about:

Young Goose

Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/
Instagram: @young_goose_skincare

The Silent Killer Inside Your Cells (And How to Fight Back) Mar 07, 2025

Show notes

Hey everyone, welcome back to Biohacking Beauty! Today, we’re exploring one of the most fundamental mechanisms of aging—telomeres. These nucleotide sequences at the ends of our chromosomes act as protective caps, preserving DNA integrity during cell division. However, each time a cell replicates, telomeres shorten, eventually leading to cellular senescence, dysfunction, or apoptosis.

In this solo episode, I’m breaking down the molecular mechanisms behind telomere shortening, how factors like oxidative stress, inflammation, and metabolic dysfunction accelerate the process, and, most importantly, what we can do to slow or even reverse this decline.

We’ll dive into the latest research on NAD metabolism, autophagy, telomerase activation, and epigenetic regulation, as well as practical interventions like targeted supplementation, lifestyle modifications, and advanced skincare strategies that support telomere stability.

If you’re serious about cellular longevity, DNA repair, and optimizing your skin health at the deepest level, this episode is a must-listen.

Let’s get into it!

I Also Discuss:

(01:33 - 02:15) What Are Telomeres and Why Do They Matter?

(03:42 - 04:19) The Hidden Danger of Cellular Aging

(08:48 - 09:12) Can You Actually Reverse Telomere Shortening?

(12:45 - 13:27) Why Your Skin Shows Signs of Aging First

(10:41 - 11:12) The Best Supplements to Protect Your DNA

Learn More About

Young Goose

Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/
Instagram: @young_goose_skincare

Dr. Stephanie Venn-Watson: The Essential Fat That Reverses Aging—Why No One’s Talking About It? Mar 05, 2025

Show notes

Today, we’re diving into a discovery that could reshape how we think about aging—C15, a newly identified essential fatty acid that plays a crucial role in cellular resilience, inflammation control, and longevity.

For decades, we’ve been told to avoid saturated fats, but what if that advice led to widespread nutritional deficiencies? Dr. Stephanie Venn-Watson, a veterinary epidemiologist and co-founder of Fatty15, uncovered C15’s role in strengthening cell membranes, reducing oxidative stress, and even influencing epigenetic aging—all from studying long-lived Navy dolphins.

In this episode, we break down how C15 protects against cellular fragility, fights ferroptosis (a newly identified form of cell death), and why it’s critical for maintaining healthy skin and metabolic function. We’ll also explore why modern diets have nearly eliminated this nutrient—and what that means for your long-term health.

Dr. Venn-Watson’s research spans over 100 peer-reviewed studies, leading to the first essential fatty acid discovery in nearly a century. Her work is redefining how we approach nutrition, longevity, and skin health at the molecular level.

We Also Discuss:

(00:01) Discovery of C15 Fatty Acid Benefits

(08:37) Importance of C15 Fatty Acid

(19:09) C15 Fatty Acid Impact on Health

(36:11) Uncovering the Role of C15

(45:10) The Case for C15 Fatty Acid

(53:48) Optimal Absorption of C15 Fatty Acid

Learn more about:

Young Goose

Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/
Instagram: @young_goose_skincare

Stephanie and Fatty15

Website: https://fatty15.com/

Instagram: https://www.instagram.com/fatty15/

LinkedIn: https://www.linkedin.com/in/stephanievennwatson/

Stop Wasting Money! THIS Is Real Anti-Aging… Feb 28, 2025

Show notes

For years, skincare has been about quick fixes, hydration, plumping, and surface-level treatments that make your skin look better but don’t actually reverse aging. But what if the future of skincare wasn’t about temporary effects, but about reprogramming your skin at the cellular level?

In this episode of Biohacking Beauty, I take a deep dive into longevity skincare and the science behind true skin rejuvenation. We’re going beyond the outdated skincare model and breaking down the Skin Longevity Matrix, a biohacking approach designed to restore youthful function from within.

I cover why NAD+ is the "molecule of life" and a critical driver of skin repair, helping cells recover from oxidative stress and damage. We’ll explore how spermidine activates autophagy, the body’s natural detox system, to clear out aging cells and renew skin from the inside out.

I’ll also explain the essential role of copper peptides in collagen remodeling and why they’re key for structural skin regeneration. Plus, we’ll dive into the problem with traditional vitamin C and why advanced forms like MAP and THDA provide superior antioxidant protection without causing oxidative stress. Finally, I’ll break down how eliminating senescent “zombie cells” can dramatically slow down aging and prevent chronic inflammation in the skin.

This is the next frontier of skincare—science-backed, longevity-focused, and designed to make your skin act younger, not just look younger.

If you’re ready to upgrade your skincare routine with the latest breakthroughs in anti-aging science, this episode is for you!

I Also Discuss:

(00:02) Biohacking Beauty

(05:18) Why NAD+ Is the Foundation of Youthful Skin

(12:56) How Spermidine Supercharges Skin Detox & Renewal

(19:09) Revitalizing Skin With Key Skincare Molecules

(27:41) The Truth About Vitamin C in Skincare

(32:23) How to Eliminate Senescent “Zombie” Cells for Younger Skin

Learn More About

Young Goose

Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/
Instagram: @young_goose_skincare

Nick Engerer: Your Skincare Routine Won’t Fix THIS Aging Problem Feb 26, 2025

Show notes

Today, we’re diving into something that goes way beyond skincare, how your skin is actually a powerful window into your overall health and longevity. Most people think of aging as just wrinkles and fine lines, but the reality is that what’s happening on the surface is a direct reflection of what’s going on at the cellular level.

To explore this, I’m joined by Nick Engerer, a longevity scientist and the founder of A Longer Life, where he helps people take a data-driven, strategic approach to optimizing health and aging. Nick’s work is all about cutting through the noise, moving beyond trends and hype to focus on what actually works when it comes to extending healthspan and improving quality of life.

In this episode, we get into why your skin and hair are some of the most revealing biomarkers of aging, how UV exposure accelerates biological aging in ways most people don’t realize, and what you can do to slow that process down. We also tackle one of the biggest challenges in wellness today, decision fatigue. With endless options for supplements, treatments, and interventions, how do you know what’s actually worth your time and money?

Nick’s background is unique, he started as a solar radiation scientist before pivoting into longevity science, bringing a data-driven approach to proactive health. Through A Longer Life, he’s building a framework to help people apply longevity strategies in a practical, sustainable way.

If you want to learn how to take control of your skin health, optimize your longevity, and navigate the overwhelming world of wellness with confidence, this episode is for you.

We Also Discuss:

(00:00) The Essence of Biohacking

(14:36) Investing in Longevity and Skincare

(22:16) The Science of Skincare and Aging

(31:45) Reproductive Signals and Longevity Strategy

(45:03) Navigating Wellness and Longevity Overwhelm

(54:21) Optimizing Evening Routine for Wellness

(01:00:12) Exploring New Mindset Course

Learn more about:

Young Goose

Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/
Instagram: @young_goose_skincare

Nick Engerer

The Hidden Science of Skin Aging (And How to Reverse It) Feb 21, 2025

Show notes

For years, skincare has focused on surface-level solutions, moisturizers, retinol, collagen creams… but what if we told you that true skin rejuvenation starts at the cellular level? Traditional skincare is designed to mask aging, but new research in longevity science reveals that the root causes of aging go much deeper.

In this episode of Biohacking Beauty, I break down the real drivers of skin aging, from mitochondrial dysfunction and NAD decline to epigenetic shifts, senescent cells, and impaired autophagy. I also discuss why most anti-aging products don’t actually reverse aging, and how cutting-edge biohacking ingredients like NAD+, spermidine, copper peptides, and advanced vitamin C are changing the game.

This is the future of skincare, moving beyond temporary fixes and truly reprogramming skin cells for longevity.

If you’ve ever wondered why your skin isn’t responding to traditional skincare, or how you can actually slow down and even reverse the aging process, this episode is for you!

I Also Discuss:

(00:01) The Science of Ageless Skin

(04:54) Your Mitochondria Are Aging Your Face

(12:21) Can You Actually Reverse Skin Aging?

(17:21) The Truth About Skincare Lies

Learn More About

Young Goose

Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/
Instagram: @young_goose_skincare

Hannah Went: Your Skincare Routine Won’t Fix THIS Aging Problem Feb 19, 2025

Show notes

Welcome back to Biohacking Beauty! Today, we’re diving into the cutting-edge science of biological vs. chronological aging and how epigenetic testing is revolutionizing the way we understand skin longevity. Aging isn’t just about the number of birthdays you’ve had—it’s about how your cells are aging at the molecular level. And now, thanks to advancements in epigenetics and AI-driven diagnostics, we can measure and even influence that process.

In this episode, I sit down with Hannah Went, an expert in biological age testing and the Director of Operations at TruDiagnostic, a leading epigenetics company. We explore how biological aging manifests in the skin, why epigenetic markers are more predictive of health than genetics, and how personalized interventions can actually slow or even reverse aging at the cellular level.

Hannah also shares groundbreaking research on how lifestyle choices, like diet, sleep, and even skincare, can alter gene expression and influence the rate at which we age. Plus, we discuss how advanced testing methods can provide real-time feedback on how well anti-aging interventions are actually working. If you’ve ever wanted to take a data-driven approach to longevity, this episode is packed with insights you won’t want to miss.

Hannah Went is the Director of Operations at TruDiagnostic, a company at the forefront of biological age testing and longevity research. With a background in epigenetics and functional medicine, she’s dedicated to helping individuals track and optimize their health using cutting-edge diagnostic tools.

We Also Discuss:

(00:01) Epigenetics and Biological Age Testing

(13:47) Aging and Skin Link Exploration

(26:13) Genetic Influence on Phenotype and Aging

(31:37) Aging, Skin Health, and Lifestyle Factors

(44:43) At-Home Genetic Testing Support

Learn more about:

Young Goose

Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/
Instagram: @young_goose_skincare

Hannah Went

Website: everythingepigenetics.com
Instagram: @everythingepigenetics

This is Why Sunscreen Alone Won’t Save Your Skin Feb 14, 2025

Show notes

Have you ever wondered why traditional sunscreens aren’t enough to protect your skin from all forms of light damage? In this episode of Biohacking Beauty, I’m sitting down with Jamie McGuire to break down the truth about blue light exposure, SPF, and effective melasma protocols.

We dive into why hyperpigmentation often worsens with artificial light exposure, the importance of full-spectrum protection, and how Young Goose’s innovative formulas address common skin concerns like melasma, sensitivity, and inflammation. Plus, we tackle the "clean beauty" debate—are some ingredients being unfairly criticized?

Jamie McGuire is a skincare expert with over 15 years of experience in personalized skincare protocols. Her holistic approach focuses on helping clients achieve long-term skin health through science-backed recommendations and innovative biohacking products.

Whether you’re dealing with melasma or looking for smarter protection against blue light, this episode offers valuable insights and real solutions to refine your routine for radiant, resilient skin.

We Also Discuss:

46:04 - 49:10 – The Reality of "Clean Beauty": Understanding Controversial Ingredients

49:11 - 50:39 – Melasma and Hyperpigmentation: Understanding the Triggers

50:40 - 54:30 – Melasma Protocol Breakdown: Step-by-Step Routine

54:31 - 57:07 – The Power of BioShield SPF 40: Protection Beyond UV Rays

57:08 - 01:00:13 – Why Retinol Sensitivity Happens (and How Bioretinol Prevents It)

01:00:14 - 01:02:23 – Red Light Therapy Synergy with Green Tea Phyto Serum

Learn More About

Jamie McGuire

Instagram: @jamieanneaesthetics
Website: www.jamieanne.co/

Young Goose

Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/
Instagram: @young_goose_skincare

Dr. Scott Sherr: Stress & Light on Your Skin Are Aging Your Entire Body Feb 12, 2025

Show notes

Most people don’t think about their skin until they have to. The reality is, by the time we notice fine lines, dullness, or inflammation, deeper processes have already been at play for years. But what if your skin isn’t just reflecting aging? What if it’s reflecting your overall health, stress levels, and even brain function?

In this episode of Biohacking Beauty, I sit down with Dr. Scott Sherr to uncover the fascinating connection between your skin and brain, a relationship most people don’t even realize exists. This conversation originally took place on The Smarter Not Harder Podcast, where Scott and I explored the skin-brain axis and how your skin is more than just a barrier, it’s an active communicator with your nervous system, influencing everything from inflammation to stress resilience and even cognitive function.

We also tackle some of the biggest misconceptions in skincare, like why hydration doesn’t actually come from the outside, how sun exposure impacts your skin at a cellular level, and the surprising ways senescent cells in your skin accelerate whole-body aging. Plus, we break down the latest science on hormones, collagen production, and microbiome health, and how all of these factors impact how your skin ages.

Dr. Scott Sherr is the host of the Smarter Not Harder Podcast and a physician specializing in health optimization, hyperbaric therapy, and longevity medicine. As the founder of Integrative HBOT and a leading expert in performance medicine, he helps individuals leverage cutting-edge science to enhance vitality, slow aging, and optimize brain and body function.

If you want to know how to extend your skin’s youthfulness beyond just skincare products, this is an episode you won’t want to miss!

We Also Discuss:

(00:00) Skin-Brain Axis

(12:43) Skin Aging and Evolution

(27:15) Skin Microbiome and Postbiotics

(35:39) Hormones, Skin Aging, and Repair

(49:16) Living Smarter, Not Harder

(56:07) Sunscreen and Skin Protection

(01:01:36) Vitamin C and Spermidine in Skincare

(01:10:16) Skin Health and Spermidine Benefits

(01:16:43) Biohacking Beauty Podcast and Skincare

Learn more about:

Young Goose

Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/
Instagram: @young_goose_skincare

Scott Sherr

Website: https://home-sf.co/
Instagram: https://www.instagram.com/drscottsherr/
Youtube: Smarter not Harder Podcast

This is Why Bio-Retinol Is the Future of Vitamin A Feb 07, 2025

Show notes

Have you ever wondered why some skincare products seem to work wonders for some people, while others see little to no results? In this episode of Biohacking Beauty, I’m sitting down with Jamie McGuire, a skincare consultant with over 15 years of experience, to break down the truth behind personalized skincare and why a one-size-fits-all approach just doesn’t cut it.

We dive into the difference between traditional retinol and bio-retinol, the science of vitamin A delivery systems, and how the right formulations can repair your skin without triggering irritation. Plus, we tackle the “clean beauty” debate—are some ingredients unfairly villainized? We share tips on balancing safe skincare choices with products that actually move the needle for your long-term skin health.

Jamie McGuire is a seasoned skincare expert and founder of a wellness platform that prioritizes personalized regimens and holistic approaches to beauty. Her mission is to help clients navigate an overwhelming skincare landscape with science-backed recommendations that support radiant, resilient skin.

Whether you’re a skincare minimalist or a product enthusiast, this episode will give you the tools to refine your routine and reach your goals.

We Also Discuss:

24:00 - 28:25- Why Bio-Retinol Stands Out: Gentle Yet Powerful Skin Renewal

28:26 - 31:27 - How Bio-Retinol Mimics Your Body’s Natural Vitamin A Process

31:28 - 35:52 - The Debate on Clean Beauty: Are ‘Toxins’ in Skincare Really Harmful?

35:53 - 41:20 - Breaking Down Ingredients: What You Should Really Avoid

41:21 - 46:03 - Pick Your Poison: Finding Balance in Your Skincare Choices

Learn More About

Jamie McGuire

Instagram: @jamieanneaesthetics
Website: www.jamieanne.co/

Young Goose

Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/
Instagram: @young_goose_skincare

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