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AJT Highlights — Science & Medicine
AJT Highlights

Host Roslyn Mannon, MD, discusses the latest issues of the American Journal of Transplantation, summarizing Editors’ Picks by highlighting the key messages, broader impact, and take-home points of each article. The views are her own and do not necessarily reflect those of the journal or the societies that support it.

Copyright: © Copyright 2019 All rights reserved.

Latest Episodes:

AJT September 2024 Editors’ Picks Sep 03, 2024

Show notes

Hosts Roz and Josh are joined by Alissar El Chediak, MD to discuss the key articles of the September issue of the American Journal of Transplantation.

Alissar El Chediak, MD is a transplant nephrologist at UT Southwestern

[02:55] – Liver Machine Perfusion Technology: Expanding the Donor Pool to Improve Access to Liver Transplantation

[08:01] – Editorial: Machine perfusion and liver transplant center behavior: Answers or more questions?

[11:01] - Obesity, Organ Failure, and Transplantation: A Review of the Role of Metabolic and Bariatric Surgery in Transplant Candidates and Recipients.

[18:48] – Virus Specific T Cell Therapy to Treat Refractory Viral infections in Solid Organ Transplant Recipients

[25:08] - Third-party virus-specific T cells for the treatment of double-stranded DNA viral reactivation and posttransplant lymphoproliferative disease after solid organ transplant

[28:48] – Editorial: Virus-specific T-cell efficacy after solid organ transplantation: more questions than answers

[34:05] - Successful BK virus–specific T cell therapy in a kidney transplant recipient with progressive multifocal leukoencephalopathy

[37:50] - The prevalence of postacute sequelae of coronavirus disease 2019 in solid organ transplant recipients: Evaluation of risk in the National COVID Cohort Collaborative

AJT August 2024 Editors' Picks Aug 08, 2024

Show notes

Description: Hosts Roz and Josh are joined by Maria Alejandra Mendoza, MD to discuss the key articles of the August issue of American Journal of Transplantation.

[01:57] Impact of deceased organ donor marijuana use on donor culture positivity and solid organ transplant recipient outcomes https://doi.org/10.1016/j.ajt.2024.02.022

[13:11] China Issued Rules on Human Organ Donation and Transplantation https://doi.org/10.1016/j.ajt.2024.04.002

[21:10] Advancing Mouse Models for Transplantation Research https://doi.org/10.1016/j.ajt.2024.01.006

[30:05] Differential induction of donor-reactive Foxp3+ Treg via blockade of CD154 vs. CD40 https://doi.org/10.1016/j.ajt.2024.03.033

[40:27] Total Robotic Liver Transplant: The Final Frontier of Minimally Invasive Surgery https://doi.org/10.1016/j.ajt.2024.03.030

AJT July 2024 Editors' Picks Jul 16, 2024

Show notes

Hosts Roz and Josh are joined by Mack Morris, MD to discuss the key articles of the July issue of American Journal of Transplantation.

[03:33] Biliary complications after adult-to-adult living-donor liver transplantation: An international multicenter study of 3633 cases https://doi.org/10.1016/j.ajt.2024.02.023

[13:07] The impact of time to death in donors after circulatory death on recipient outcome in simultaneous pancreas-kidney transplantation https://doi.org/10.1016/j.ajt.2024.02.008

[24:30] Should advanced perfusion be the standard of care for donation after circulatory death liver transplant? https://doi.org/10.1016/j.ajt.2024.03.021

[32:20] Immunosuppression Withdrawal in Living-donor Renal Transplant Recipients Following Induction with Anti-thymocyte Globulin and Rituximab: Results of a Prospective Clinical Trial https://doi.org/10.1016/j.ajt.2024.03.007

[40:30] Spatial multiomics of arterial regions from cardiac allograft vasculopathy rejected grafts reveal novel insights into the pathogenesis of chronic antibody-mediated rejection https://doi.org/10.1016/j.ajt.2024.01.004

Analytical Approaches to Policy Evaluation in Transplantation Jun 18, 2024

Show notes

In this specialty podcast, AJT Fellow and host David Cron is joined by Jesse Schold and Joel Adler to provide an overview policy evaluation in transplantation, including analytical approaches, pitfalls, and best practices.

References

Stewart et al. “Does anyone really know what (the kidney median waiting) time is?”

Noreen et al. “Augmenting the United States transplant registry with external mortality data: A moving target ripe for further improvement”

Shifman et al. “Association of state Medicaid expansion policies with pediatric liver transplant outcomes”

AJT June 2024 Editors' Picks Jun 11, 2024

Show notes

Host Roz is joined by AJT Associate Editor Orla Morrissey, MD (Monash University) and AJT Editorial Fellow Elena-Bianca Barbir, MD (Mayo Clinic-Rochester).

[3:16] The respiratory syncytial virus vaccines are here: Implications for solid organ transplantation

[19:14] Association between cytomegalovirus viremia and long-term outcomes in lung transplant recipients

[35:40] Genetic versus self-reported African ancestry of the recipient and neighborhood predictors of kidney transplantation outcomes in 2 multiethnic urban cohorts

[EDITORIAL] Untangling genetic and environmental risks in kidney transplant outcomes: The interplay of self-identified race, genetic ancestry, monogenic risk alleles, and socioeconomic factors

[45:15] Low-affinity CD8+ T cells provide interclonal help to high-affinity CD8+ T cells to augment alloimmunity

[53:44] Outcomes in solid organ transplant recipients with a pretransplant diagnosis of melanoma

The impact of the 2018 change in heart allocation and what the heart community can learn from experiences with continuous distribution of lung May 10, 2024

Show notes

In this AJT specialty podcast, Luise Holzhauser, hosts Shelley Hall and Marie Budev to discuss the impact of the 2018 change in heart allocation and what the heart community can learn from experiences with continuous distribution of lung.

AJT May 2024 Editors' Picks May 01, 2024

Show notes

Host Roz is joined by AJT Executive Guest Editor Nadim Mahmud, MD, MPH (University of Pennsylvania) and AJT Editorial Fellow Tina Marinelli, MBBS, MPH&TM, FRACP (Royal Prince Alfred Hospital).

[03:10] Semidirected Living Donors in Israel: Sociodemographic Profile, Religiosity, and Social Tolerance [11:54] TCRseq Reveals Selected Donor-reactive CD8+ T cell Clones Resist Anti-Thymocyte Globulin Depletion after Kidney Transplantation [18:47] Natural killer cell functional genetics and donor-specific antibody-triggered microvascular inflammation [26:36] Surgical site infections after kidney transplantation are independently associated with graft loss [38:26] Introduction to Virtual Special Issue, Insights into ACLF: From Pathogenesis to Interventions [39:21] Immunopathogenesis of acute on chronic liver failure [43:43] Geographic disparities in access to liver transplant for advanced cirrhosis: Time to ring the alarm!

AJT April 2024 Editors' Picks Apr 01, 2024

Show notes

Host Roz is joined by AJT Editor-in-Chief Emeritus Allan Kirk, MD, PhD, (Duke University) and AJT Editorial Fellow Laura Binari, MD (Vanderbilt University).

[2:34] Abdominal computed tomography measurements of body composition and waitlist mortality in kidney transplant candidates

[14:09] A2/A2B to B deceased donor kidney transplantation in the Kidney Allocation System era

[24:01] Xenotransplantation Papers

[25:07] Xenotransplantation experiments in brain-dead human subjects–A critical appraisal

[28:11] The decedent model: A new paradigm for de-risking high stakes clinical trials like xenotransplantation

[32:45] Exploring the single-cell immune landscape of kidney allograft inflammation using imaging mass cytometry

AJT March 2024 Editors' Picks Mar 04, 2024

Show notes

Host Roz is joined by AJT Editorial Board Member Alexandre Loupy, MD, PhD (Necker Hospital) and AJT Editorial Fellow Thiago J Borges, PhD (Massachusetts General Hospital).

[2:39] Transplanting old organs promotes senescence in young recipients

[11:33] The Banff 2022 Kidney Meeting Report: Reappraisal of microvascular inflammation and the role of biopsy-based transcript diagnostics

[15:45] The Banff 2022 Kidney Meeting Work Plan: Data-driven refinement of the Banff Classification for renal allografts

(Editorial) [18:12] The Banff process—Reloaded: A joint initiative from the Banff Foundation for Allograft Pathology and the American Journal of Transplantation

[20:25] Antiobesity pharmacotherapy to facilitate living kidney donation

[27:04] Ambient air pollution is associated with graft failure/death in pediatric liver transplant recipients

AJT February 2024 Editors' Picks Feb 01, 2024

Show notes

Host Roz is joined by AJT Editorial Board Member John Greenland, MD, PhD (University of California, San Francisco) and AJT Editorial Fellow David Cron, MD, MS (Massachusetts General Hospital).

[2:53] Pure laparoscopic donor hepatectomy: Experience of 556 cases at Seoul National University Hospital

[11:26] Smoking exposure-induced bronchus-associated lymphoid tissue in donor lungs does not prevent tolerance induction after transplantation & Aging exacerbates murine lung ischemia-reperfusion injury by excessive inflammation and impaired tissue repair response

[20:28] Augmenting the Unites States transplant registry with external mortality data: A moving target ripe for further improvement

(Editorial) How hard are the hard outcomes reported in national transplant registries?

[32:25] Maintaining the permanence principle of death during normothermic regional perfusion in controlled donation after the circulatory determination of death: Results of a prospective clinical study

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