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AJT Highlights — Science & Medicine
AJT Highlights

Host Roslyn Mannon, MD, discusses the latest issues of the American Journal of Transplantation, summarizing Editors’ Picks by highlighting the key messages, broader impact, and take-home points of each article. The views are her own and do not necessarily reflect those of the journal or the societies that support it.

Copyright: © Copyright 2019 All rights reserved.

Latest Episodes:

AJT February 2026 Editors’ Picks Feb 02, 2026

Show notes

Description: Hosts Roz and Dr. Sanchez-Fueyo are joined by Juan Pablo Huidobro to discuss the key articles of the February issue of the American Journal of Transplantation.

Juan Pablo Huidobro is an Assistant Professor in Nephrology at Pontifical Catholic University of Chile

[02:52] Evolving landscape of thrombotic microangiopathy in kidney transplant recipients in the post–C5 inhibitor era

[13:22] Erythropoietin prolongs graft survival in mice by counteracting trained immunity

[22:06] A new principle to attenuate ischemia reperfusion injury in kidney transplantation

[33:14] Sustained allogeneic kidney graft operational tolerance despite discontinued conventional immunosuppression after CD19-CAR-T-cell therapy for relapsed/refractory post-transplantation lymphoproliferative disorder

[40:15] Bloodstream Infection Subtypes and Characteristics Comparing Solid Organ Transplant and Non-Transplant Populations

AJT January 2026 Editors’ Picks Jan 01, 2026

Show notes

AJT January 2026 Editors’ Picks

Description: Hosts Roz and Dr. Sanchez-Fueyo are joined by Dr. Al-Faraaz Kassam to discuss the key articles of the January issue of the American Journal of Transplantation.

Al-Faraaz Kassam is an Assistant Professor in Transplant Surgery at Johns Hopkins University

[03:45] Evaluation of kidney procurement biopsy and machine perfusion on allograft outcomes: A retrospective cohort study of the OPTN database

[11:23] Improving the histologic detection of donor-specific antibody-negative antibody-mediated rejection in kidney transplants

[23:01] Exosome-primed T cell immunity is facilitated by complement activation

[32:26] Landscape of subclinical rejection in a large international cohort of pediatric kidney transplant (kTx) recipients

[42:19] Donor Heart Preservation at 10°C After Thoracoabdominal Normothermic Regional Perfusion Lowers Rates of Severe Primary Graft Dysfunction and Improves Recipient Transplant Outcomes

AJT December 2025 Editors’ Picks Dec 01, 2025

Show notes

AJT December 2025 Editors’ Picks

Description: Hosts Roz and Dr. Sanchez-Fueyo are joined by Hannah Bahakel to discuss the key articles of the December issue of the American Journal of Transplantation.

Hannah Bahakel is a Clinical Immunodeficiency fellow at Cincinnati Children’s Hospital Medical Center

[03:34] Higher vs standard mean arterial pressure target in the immediate postoperative period of liver transplantation to prevent acute kidney injury: A randomized clinical trial (LIVER-PAM)

[13:51] Donor-derived cell-free DNA significantly improves rejection yield in kidney transplant biopsies

[26:27] Tolerogenic lung allograft microenvironment suppresses pathogenic tissue remodeling following respiratory virus infection in mice

[37:11] Therapeutic needs in solid organ transplant recipients: The American Society of Transplantation patient survey

[48:19] Impact of kidney function on 200 days of antiviral prophylaxis for cytomegalovirus disease in cytomegalovirus-seronegative recipients of cytomegalovirus-seropositive donor kidneys: Post hoc analysis of a randomized, phase 3 trial of letermovir vs valganciclovir prophylaxis

AJT November 2025 Editors’ Picks Nov 01, 2025

Show notes

Description: Hosts Roz and Dr. Sanchez-Fueyo are joined by Christie Rampersad to discuss the key articles of the November issue of the American Journal of Transplantation.

Christie Rampersad is clinical associate, in the Division of Nephrology at the University of Toronto in the Ajmera Transplant Centre

[03:45] The early impacts of an attempt to standardize kidney procurement biopsy practices

[13:40] The current state of simultaneous heart-liver transplantation in the United States

[20:11] Engaging patients in organ transplant listing meetings: A survey study

[37:32] Single-cell transcriptional landscape of liver transplant rejection reveals tissue persistence of clonally expanded, treatment-resistant T cells

[45:32] Infectious disease surveillance and management in clinical xenotransplantation: Experience with the first human porcine kidney transplant

AJT October 2025 Editors’ Picks Sep 26, 2025

Show notes

AJT October 2025 Editors’ Picks

Description: Hosts Roz and Dr. Sanchez-Fueyo are joined by Dr. Christina Haugen to discuss the key articles of the October issue of the American Journal of Transplantation.

Dr. Christina Haugen is an Assistant Professor of Surgery at the University of Cincinnati.

[03:28] Renal resistance trajectories during hypothermic machine perfusion in kidneys donated after circulatory death: Associations with donor characteristics and posttransplant outcomes—An analysis of COMPARE trial data

[10:26] Donor-specific mesenchymal stem cell infusion in human and nonhuman primate kidney transplantation

[19:21] Potential targeting of urokinase-type plasminogen activator receptor–formyl peptide receptor signaling to prevent recurrence in posttransplant primary podocytopathies

[30:20] The relationship between cessation of brain and systemic circulation after withdrawal of life-sustaining measures

[36:03] Pretransplant natural antibody levels identify a subset of deceased donor kidney transplant recipients that benefit from infliximab induction

AJT September 2025 Editors’ Picks Sep 02, 2025

Show notes

Hosts Roz and Dr. Sanchez-Fueyo discuss the key articles of the September issue of the American Journal of Transplantation.

[03:30] Blunted cardiac reserve as a marker of cirrhotic cardiomyopathy—Cardiac outcomes following liver transplantation and comparison to the existing guidelines

[14:18] Back-table intra-arterial administration of C1 esterase inhibitor to deceased donor kidney allografts improves posttransplant allograft function: Results of a randomized double-blind placebo-controlled clinical trial

[25:55] Donor-derived cell-free DNA is associated with the degree of immunosuppression in lung transplantation

[36:24] A two-threshold algorithm using donor-derived cell-free DNA fraction and quantity to detect acute rejection after heart transplantation

[45:00] Cell therapy with human Interleukin 10–producing ILC2s enhances islet function and inhibits allograft rejection

Kidney transplantation for undocumented immigrants in the United States: challenges and Ethical considerations Aug 01, 2025

Show notes

In this Specialty Podcast, Dr. Dami Ko is joined by Dr. Katherine Rizzolo, and Dr. Leonela Villegas to discuss kidney transplantation for undocumented immigrants in the United States, particularly the challenges they face and ethical considerations.

Dr. Dami Ko is an assistant professor at Northeastern University, specializing in post-transplant care and quality of life.

Dr. Katherine Rizzolo is a nephrologist in Boston, MA.

Dr. Leonela Villegas is a Pediatric Nephrologist at Hartford, CT

References:

Long-term impact of immigration status on outcomes in pediatric kidney transplant recipients.

Successful pathways to liver transplant for undocumented immigrants.

Undocumented immigrants: A glaring inequity in transplant.

AJT August 2025 Editors’ Picks Aug 01, 2025

Show notes

Hosts Roz and Alberto are joined by new Editorial Fellow Dr. Sofia Bin to discuss the key articles of the August issue of the American Journal of Transplantation.

Dr. Sofia Bin is an assistant professor of medical and surgical sciences at the University of Bologna.

[02:46] Gut microbiome alterations precede graft rejection in kidney transplantation patients

[10:31] Molecular diagnosis of kidney allograft rejection based on the Banff Human Organ Transplant gene panel: a multicenter international study

Editorial: Graft biopsy reimagined: Integrating morphology and molecular maps

[22:20] Does a changing donor pool explain the recent rise in the United States kidney nonuse rate?

[32:45] A scintigraphic look at the dead donor rule in donation after the circulatory determination of death with the use of normothermic regional perfusion: A single-center interventional trial

Editorial: Normothermic regional perfusion in donation after circulatory determination of death—Confirming the absence of brain reperfusion

[37:03] Global variation in living donor liver transplantation practices impacts donor and recipient short-term outcomes: initial insights from the International LDLT Registry

AJT July 2025 Editors’ Picks Jul 02, 2025

Show notes

Hosts Roz and Alberto discuss the key articles of the July issue of the American Journal of Transplantation.

[03:48] Liver transplantation for hepatitis D virus/hepatitis B virus coinfection in Italy: an intention-to-treat analysis of long-term outcomes

[13:42] 10 degree C static storage of porcine donation after circulatory death livers improves biliary viability and mitigates ischemia-reperfusion injury

[22:20] Fewer medullary pyramids in the living kidney donor are associated with graft failure in the recipient

[33:35] Microvascular inflammation in kidney allografts: New directions for patient management

MOMOT (Mouse Models in Transplant) articles:

Can mouse kidney transplant models inform mechanisms of injury and acceptance in clinical kidney transplantation?

Best practices in islet transplantation in mice

AJT June 2025 Editors’ Picks Jun 03, 2025

Show notes

Host Roz is joined by new co-host Alberto Sanchez-Fueyo, MD, PhD to discuss the key articles of the June issue of the American Journal of Transplantation.

Dr. Sanchez-Fueyo is a Professor of Hepatology, and the Academic Director of the Institute of Liver Studies, King's College, London.

[02:51] Recipient toll-like receptor 4 determines the outcome of ischemia-reperfusion injury in steatotic liver transplantation in mice

[10:47] Association between everolimus combination therapy and cancer risk after liver transplantation: A nationwide population-based quasi-cohort study

[21:35] Balancing equity and human leukocyte antigen matching in deceased-donor kidney allocation with eplet mismatch

Editorial: Equitable allocation through human leukocyte antigen eplet matching: A promising strategy with several challenges

[32:51] Impact of the lung allocation system score modification by blood type on US lung transplant candidates

Editorial: From flawed to fairer: Reducing blood type bias in lung transplant allocation

Recommended article: The economic value of a transplant nephrologist: The case for improving compensation models

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