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AJT Highlights — Science & Medicine
AJT Highlights

Host Roslyn Mannon, MD, discusses the latest issues of the American Journal of Transplantation, summarizing Editors’ Picks by highlighting the key messages, broader impact, and take-home points of each article. The views are her own and do not necessarily reflect those of the journal or the societies that support it.

Copyright: © Copyright 2019 All rights reserved.

Latest Episodes:

Overcoming Barriers: Revitalizing Pancreas Transplantation in the U.S. May 29, 2025

Show notes

In this specialty podcast, Dr. Alissar El Chediak is joined by Dr. Jon Odorico and Dr. Ron Parsons to discuss the current state of pancreas transplantation, identify barriers and strategies for referral and candidate selection, and discuss solutions to address the decline in procedures.

Alissar El Chediak, MD is a transplant nephrologist at UT Southwestern Medical Center.

Jon Odorico, MD is a transplant surgeon at the University of Wisconsin.

Ron Parsons, MD is a transplant surgeon at the University of Pennsylvania.

References:

Generating strategies for a national comeback in pancreas transplantation: A Delphi survey and US conference report

Bird Flu and Transplant Patients: Emerging Risks and Clinical Insights May 28, 2025

Show notes

In this Specialty Podcast, Dr. Alejandra Mendoza is joined by Dr. Cameron Wolfe, infectious diseases specialist at Duke University, to discuss the growing concern of avian influenza (H5N1) in transplant recipients. Together, they explore the latest epidemiologic developments, potential risks to immunocompromised patients, and key considerations for clinicians managing solid organ and stem cell transplant recipients in the face of this evolving threat.

Dr. Alejandra Mendoza is a transplant infectious diseases physician at the University of Utah. Dr. Cameron Wolfe is a professor of medicine in the division of infectious diseases at Duke University.

References:

Clinician Update on Human Cases of H5N1 and Influenza A Virus Surveillance (COCA Calls)

AJT May 2025 Editors’ Picks May 01, 2025

Show notes

Host Roz is joined by Timucin Taner, MD, PhD and Dami Ko, PhD to discuss the key articles of the May issue of the American Journal of Transplantation.

Dr. Timucin Taner is a professor of surgery at Mayo Clinic, Rochester, MN. Dr. Dami Ko is an assistant professor at the School of Nursing at Northeastern University.

[02:51] Development and validation of the Neuro-Score: a specific scale to detect and monitor cognitive impairment in kidney or liver transplant recipients

Editorial: Cognitive impairment after liver and kidney transplant: An easy way to check

[14:16] Randomized trial investigating the utility of a liver tissue transcriptional biomarker in identifying adult liver transplant recipients not requiring maintenance immunosuppression

[20:46] Donor-specific immune senescence as a candidate biomarker of operational tolerance following liver transplantation in adults: Results of a prospective, multicenter cohort study

Editorial: Acquired immune tolerance 2.0

[29:10] Major histocompatibility complex and peptide specificity underpin CD8+ T cell direct alloresponse

Editorial: Direct and indirect allorecognition—not so different after all?

AJT April 2025 Editors’ Picks Apr 11, 2025

Show notes

Host Roz is joined by Rene Bermea, MD and Gonzalo Sapisochin, MD, PhD to discuss the key articles of the April issue of the American Journal of Transplantation.

Dr. Rene Bermea is an instructor at Harvard Medical School, and a transplant pulmonologist and intensivist. Dr. Gonzalo Sapisochin is an associate professor of surgery, abdominal transplant and surgical oncology at the University of Toronto, Canada.

[04:31] Generalizability of kidney transplant data in electronic health records — The Epic Cosmos database vs the Scientific Registry of Transplant Recipients

Editorial: Finding actionable information in the universe of data

[14:17] High-dimensional profiling of immune responses to kidney transplant reveals heterogeneous T helper 1 and B cell effectors associated with rejection

Editorial: Multimodal profiling of transplant rejection: Discerning the forest from the trees

[23:02] The ability of an electronic nose to distinguish between complications in lung transplant recipients

[34:58] The Rochester Protocol for living donor liver transplantation of unresectable colorectal liver metastasis: A 5-year report on selection, approval, and outcomes

AJT March 2025 Editors' Picks Mar 01, 2025

Show notes

Host Roz is joined by Ross Doyle, PhD to discuss the key articles of the March issue of American Journal of Transplantation.

Dr. Ross Doyle is a consultant nephrologist at Mater Hospital in Dublin, Ireland.

(Mentioned) A blood-based PT-LIFE (Pediatric Liver Transplantation-LIver Fibrosis Evaluation) biomarker panel for noninvasive evaluation of pediatric liver fibrosis after liver transplantation: A prospective derivation and validation study

Editorial: Are we closer to abandoning protocol graft biopsies after pediatric liver transplantation?

(Mentioned) Deceased donor urinary Dickkopf-3 associates with future allograft function following kidney transplantation

[04:08] Cure models, survival probabilities, and solid organ transplantation for patients with colorectal cancer

Editorial: When is it safe to transplant after cancer–adding data to the decision

[11:05] Navigating challenges in recipient selection for end-chain kidneys

[18:00] Severe ischemia-reperfusion injury induces epigenetic inactivation of LHX1 in kidney progenitor cells after kidney transplantation

[28:31] The differential impact of early graft dysfunction in kidney donation after brain death and after circulatory death: Insights from the Dutch National Transplant Registry

AJT February 2025 Editors' Picks Feb 01, 2025

Show notes

Hosts Roz and Josh are joined by Dr. Adam Stewart to discuss the key articles of the February issue of the American Journal of Transplantation.

[00:02:38] A competing risks model to estimate the risk of graft failure and patient death after kidney transplantation using continuous donor-recipient age combinations

[00:09:00] Donor-derived bartonellosis in solid organ transplant recipients from unhoused donors in Alberta

[00:16:54] Contemporary prevalence and practice patterns of out-of-sequence kidney allocation

Editorial: Out-of-sequence allocation: a necessary innovation or a new inequity in transplantation?

Editorial: Ethical implications of prioritizing utility at all costs: The rise of out-of-sequence transplants

[00:28:18] Association of nonstandardized model for end-stage liver disease score exceptions with waitlist mortality in adult liver transplant candidates

AJT January 2025 Editors’ Picks Jan 02, 2025

Show notes

Hosts Roz and Josh are joined by Sergio Acuna, MD to discuss the key articles of the January issue of American Journal of Transplantation.

Dr. Sergio Acuna is a clinical instructor in abdominal transplant surgery at the University of Alabama at Birmingham

[03:21] The dangerous precedent of censoring scientific dissemination

[08:45] Long-term ex situ normothermic machine perfusion allows regeneration of human livers with severe bile duct injury

Editorial: Time will tell: Employing long-term normothermic machine perfusion to gain new insight into bile duct regeneration

[14:00] Probable antibody-mediated rejection in kidney transplantation is a rare and challenging phenotype to define: Findings from a single-center study

[19:54] The relationship of microvascular inflammation with antibody-mediated rejection in kidney transplantation

Editorial: Exploring microvascular inflammation and the spectrum of antibody-mediated rejection

[25:56] Long-term persistence of seroprotection against measles following measles-mumps-rubella vaccination administered before and after pediatric liver transplantation

[31:26] Detection of viral RNA and DNA and immune response following administration of live attenuated measles and varicella vaccines in children with chronic liver disease

AJT December 2024 Editors’ Picks Dec 03, 2024

Show notes

Hosts Roz and Josh are joined by Abraham Matar, MD to discuss the key articles of the December issue of American Journal of Transplantation.

Dr. Abraham ‘Abe’ Matar is a Transplant Surgery Fellow at the University of Minnesota

[02:15] Economic Evaluation of Weight Loss and Transplantation Strategies for Kidney Transplant Candidates with Obesity

Editorial: Selecting Weight Loss Strategies for Kidney Transplant Candidacy: Weighty decisions

[11:44] Electrostimulation suppresses allograft rejection via promoting lymphatic regulatory T cell migration mediated by lymphotoxin (LT)-LTb receptor signaling

[18:57] Ischemia Reperfusion Responses in Human Lung Transplants at the Single Cell Resolution

[28:36] The suggestion of mitigating disparity in the liver transplantation field among ABO blood type

AJT November 2024 Editors’ Picks Nov 01, 2024

Show notes

Description: Hosts Roz and Josh are joined by Sharon Weeks Groh, MD to discuss the key articles of the November issue of American Journal of Transplantation.

Dr. Sharon Weeks Groh is a transplant surgeon at Walter Reed

[02:08] Robotic living donor hepatectomy is associated with superior outcomes for both the donor and the recipient compared to laparoscopic or open - A single center prospective registry study of 3,448 cases

[09:34] Public Attitudes to Xenotransplantation: A National Survey in the United States

[18:09] Non-clinical and clinical characterization of MAU868, a novel human-derived monoclonal neutralizing antibody targeting BK polyomavirus VP1

[25:52] Establishing targets for goal-directed anesthesia in renal transplantation: a cohort analysis of high-saliency surgical time-courses.

Editorial: Intraoperative blood pressure management during kidney transplantation: grafts under pressure.

[36:53] Why partial heart transplantation could be regulated as organ transplantation

AJT October 2024 Editors’ Picks Oct 01, 2024

Show notes

Hosts Roz and Josh are joined by Frances Lee, MD to discuss the key articles of the October issue of American Journal of Transplantation.

[00:02:31] Pre-transplant Use of Immune Checkpoint Inhibitors for Hepatocellular Carcinoma: A Multicenter, Retrospective Cohort Study

Editorial: Integrating immune check inhibitors in liver transplantation for hepatocellular carcinoma: The right time and the right patient

[00:11:46] Association of Procurement Technique with Organ Yield and Cost Following Donation After Circulatory Death

Editorial: Dawn Has Arrived, Illuminating Thrilling Opportunities and Fresh Challenges in a New Era of U.S. Transplantation

[00:24:53] Common Definitions and Variables are Needed for the United States to Join the Conversation on Acute on Chronic Liver Failure

[00:33:15] Enhanced role of multipair donor swaps in response to size incompatibility: The first two 5-way and the first 6-way liver paired exchanges

[00:40:15] Comparing the prognostic performance of iBOX and biopsy-proven acute rejection for long-term kidney graft survival

[00:48:22] Incomplete reporting of clinically significant acute rejection episodes in the National Kidney Transplant Registry

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