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AJT Highlights — Science & Medicine
AJT Highlights

Host Roslyn Mannon, MD, discusses the latest issues of the American Journal of Transplantation, summarizing Editors’ Picks by highlighting the key messages, broader impact, and take-home points of each article. The views are her own and do not necessarily reflect those of the journal or the societies that support it.

Copyright: © Copyright 2019 All rights reserved.

Latest Episodes:

The impact and implications of the kidney allocation system (KAS 250) over kidney allocation in the United States Jan 08, 2024

Show notes

The podcast discusses the impact and implications the kidney allocation system (KAS 250) has had over kidney allocation in the United States, focusing on the effect on operational challenges, cold ischemic times, delayed graft function, and organ discard rates.

Guest speakers include Joel Adler (Dell Medical School, University of Texas in Austin) and John Friedewald (Northwestern Memorial Hospital).

AJT January 2024 Editors’ Picks Jan 01, 2024

Show notes

Host Roz is joined by AJT Editorial Board Member Michael Mengel, MD (University of Alberta) and AJT Editorial Fellow Kazem Fallahzadeh, MD (Emory University).

[2:43] Recurrent atypical antiglomerular basement membrane nephritis in the kidney transplant

[14:26] Pretransplantation coronavirus disease 2019 vaccination requirements: A matched case-control study of factors associated with waitlist inactivation

(Editorial) Coronavirus disease 2019 vaccine mandates and the Owl of Minerva

[21:45] Incomplete tissue product tracing during an investigation of a tissue-derived tuberculosis outbreak

[29:48] Risk for graft loss in pediatric and young adult kidney transplant recipients due to recurrent IgA nephropathy

[37:07] De novo membranous nephropathy in a pig-to-baboon kidney xenograft: A new xenograft glomerulopathy

AJT Decmber 2023 Editors’ Picks Dec 05, 2023

Show notes

Host Roz is joined by AJT Editorial Board Member Emily Blumberg, MD (University of Pennsylvania) and AJT Editorial Fellow Dempsey Hughes, MD (Northwestern Medicine).

[03:03] Predicting post–liver transplant outcomes in patients with acute-on-chronic liver failure using Expert-Augmented Machine Learning

[10:34] Clinical features, treatment, and outcomes of mpox in solid organ transplant recipients: A multicenter case series and literature review

[14:05] First case of rapidly fatal mpox from secondary (household) transmission in a kidney transplant recipient

[15:28] A joint program of antimicrobial stewardship and hospital-acquired infection control to reduce healthcare-associated infections after kidney transplantation: The Hipomenes study

[22:55] A rational approach to guide cost-effective de novo donor-specific antibody surveillance with tacrolimus immunosuppression

[30:04] (Editorial) Personalizing kidney transplant donor-specific antibody surveillance: The devil is in the details

[33:20] Donor antigen-specific regulatory T cell administration to recipients of live donor kidneys: A ONE Study consortium pilot trial

Kidney Utilization and Organ Procurement Organization Performance Nov 09, 2023

Show notes

In this specialty podcast, Arielle Cimeno, hosts Raymond Lynch and Amit Mathur to discuss recent trends and new initiatives to assess kidney utilization and organ procurement organization performance.

AJT November 2023 Editors’ Picks Nov 03, 2023

Show notes

Host Roz is joined by Ramsey Hachem, MD (Washington University School of Medicine in Saint Louis) and AJT Editorial Fellow Helen Tsai, MD (Montefiore Medical Center)

[03:30] Disseminated vaccine-induced varicella infection in a kidney transplant recipient

[06:50] Safety and Immunogenicity of the Live-Attenuated Varicella Vaccine in Pediatric Solid Organ Transplant Recipients: A Systematic Review and Meta-Analysis

[10:34] (Editorial) Balancing the live virus vaccine scales: protection vs risk

[14:22] Outcomes after flow cytometry crossmatch-positive lung transplants managed with perioperative desensitization

[19:25] Lung transplantation despite preformed donor-specific anti-HLA antibodies: 9-year single-center experience

[23:00] (Editorial) What is a Clinically Significant Donor-Specific Antibody Before Lung Transplantation?

[25:38] Deceased Donor Kidneys from Higher Distressed Communities are Significantly Less Likely to be Utilized for Transplantation

[35:11] (Editorial) Understanding the mechanisms and implications of the association between community distress and organ non-utilization

[37:18] Sex as a Biological Variable: Mechanistic Insights and Clinical Relevance in Solid Organ Transplantation

AJT October 2023 Editors’ Picks Oct 03, 2023

Show notes

Host Roz is joined by AJT Editorial Fellow Salil Kumar, MD (incoming Assistant Professor at MD Anderson Medical Center)

[2:24] Importance of social vulnerability on long-term outcomes after heart transplantation

[12:51] Microbiota-dependent and -independent effects of obesity on transplant rejection and hyperglycemia

[21:26] Memory T follicular helper cells drive donor-specific antibodies independent of memory B cells and primary germinal center and alloantibody formation

[28:52] Validation of a prediction system for risk of kidney allograft failure in pediatric kidney transplant recipients: An international observational study

[36:44] Qualifying a novel clinical trial endpoint (iBOX) predictive of long-term kidney transplant outcomes

AJT September 2023 Editors’ Picks Aug 31, 2023

Show notes

Host Roz is joined by AJT Editorial Board Member Kenneth Newell, MD, PhD (Emory University) and AJT Editorial Fellow Kyle Jackson, MD, PhD (Emory University)

[2:45] Identifying and understanding variation in population-based access to liver transplantation in the United States

[12:44] Intra-graft B cell differentiation during the development of tolerance to kidney allografts is associated with a regulatory B cell signature revealed by single cell transcriptomics

[18:21] Single-cell RNA sequencing reveals peripheral blood mononuclear immune cell landscape associated with operational tolerance in a kidney transplant recipient

[22:20] Impact of allele-specific anti-HLA class I antibodies on organ allocation

[28:12] Autoantibodies against DNA-topoisomerase I promote renal allograft rejection by increasing alloreactive T cell responses

Ethical Issues Related to Informed Consent and Informed Authorization for Xenotransplantation Aug 15, 2023

Show notes

In this specialty podcast, Carrie Thiessen, MD, PhD (University of Wisconsin-Madison) hosts Robert Montgomery, MD, PhD, (NYU Langone) and Muhammad Mohiuddin, MBBS, (University of Maryland) to discuss ethical issues related to informed authorization and informed consent for decedent kidney and human cardiac xenotransplants.

AJT August 2023 Editors’ Picks Aug 10, 2023

Show notes

Host Roz is joined by AJT Editorial Board Member Sanjay Kulkarni, MD, (Yale School of Medicine) and AJT Editorial Fellow Luise Holzhauser, MD (University of Pennsylvania)

[2:40] In a real-life setting, risk factors, Coronary artery calcium score and coronary stenosis at Computed Tomography Angiography are associated with MACE and all-cause mortality among kidney transplant candidates

[16:00] The minimum weight and age of kidney donors: En bloc kidney transplantation from preterm neonatal donors weighing less than 1.2kg to adult recipients

[24:35] Increased volume of organ offers and decreased efficiency of kidney placement under circle-based kidney allocation

[31:07] Recipient Race Modifies the Association between Obesity and Long-term Graft Outcomes After Kidney Transplantation

International efforts to eliminate gender disparities in allocation of liver transplants: MELD 3.0 & Gender-Equity Model for Liver Allocation (GEMA) Jul 17, 2023

Show notes

In this AJT specialty podcast, Aly Strauss, hosts Allison Kwong and Manuel Rodriguez-Peralvarez to discuss MELD 3.0, Gender-Equity Model for Liver Allocation (GEMA), and international efforts to eliminate gender disparities in allocation of liver transplants.

Bernards et al. AJT: https://pubmed.ncbi.nlm.nih.gov/35871752/

Kim et al. Meld 3.0: https://pubmed.ncbi.nlm.nih.gov/34481845/

Meld 3.0 calculator: https://medcalculators.stanford.edu/meld

Rodriguez-Peralvarez et al. GEMA: https://pubmed.ncbi.nlm.nih.gov/36528041/

GEMA calculator: http://gema-transplant.com/

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