The Human Upgrade: Biohacking for Longevity & Performance

Latest Episodes:

Infections & Cancer, Finasteride Side Effects, Blueberry Benefits, Vitamin D & Fertility, and CoQ10 : 1552 Oct 09, 2026

Show notes

Infections Were Linked to About 1 in 8 Cancer Cases Worldwide

A new global analysis estimates that infections were responsible for roughly 2.3 million new cancer cases in 2024, about 12% of all cancers worldwide. H. pylori and HPV were the largest contributors, followed by hepatitis B, Epstein-Barr virus, and hepatitis C. Host Dave Asprey explores how persistent infections can contribute to cancer through chronic inflammation, DNA damage, altered immune surveillance, and other biological pathways. He explains why this does not mean cancer is contagious or that infection inevitably leads to cancer, but argues that identifying, preventing, and treating infections such as H. pylori, hepatitis B, and hepatitis C can be an overlooked part of a long-term prevention strategy.

Sources:

-IARC: Global Burden of Cancer Attributable to Infections in 2024

-PubMed: Global Burden of Cancer Attributable to Infections in 2024

~~~~

What We Really Know About Persistent Finasteride Side Effects

Finasteride reduces the conversion of testosterone into DHT by inhibiting 5-alpha reductase, but that enzyme also participates in pathways involved in neuroactive steroids. Some former users report persistent sexual, cognitive, mood, and physical symptoms after stopping the drug, a collection of symptoms commonly called post-finasteride syndrome. Small studies have reported differences in neurosteroids, gene expression, androgen signaling, and peripheral nerve function among symptomatic former users, but these studies cannot establish that finasteride caused those changes or determine how common persistent symptoms are. Host Dave Asprey examines the evidence between the two extremes, neither dismissing persistent symptoms nor assuming that finasteride permanently damages everyone who takes it. European regulators have also recognized suicidal ideation as a possible adverse effect of oral finasteride, although its frequency remains unknown.

Sources:

-EMA: Finasteride and Dutasteride Safety Review

-PubMed: Neuroactive Steroids After Finasteride Discontinuation

PubMed: Neuroactive Steroids and Features in Post-Finasteride Patients

PubMed: Differential Gene Expression in Post-Finasteride Syndrome

~~~

One Cup of Blueberries a Day Improved Measures of Vascular Function

In a six-month randomized controlled trial involving 115 adults with metabolic syndrome, consuming the equivalent of one cup of blueberries per day improved endothelial function and a measure of arterial stiffness, while a half-cup dose did not produce the same effects. Host Dave Asprey explains why describing blueberries simply as “antioxidants” misses much of their biology. Anthocyanins and other polyphenols can interact with gut microbes and influence vascular, inflammatory, and nitric oxide-related signaling. He also examines a small smoothie experiment showing that the polyphenol oxidase found in bananas sharply reduced the circulating metabolites of certain flavan-3-ols, while emphasizing that the experiment did not prove bananas erase the benefits of blueberries.

Sources:

-American Journal of Clinical Nutrition: Blueberries and Cardiometabolic Function

-Food & Function: Polyphenol Oxidase and Flavan-3-ol Bioavailability

~~~

Vitamin D Matters to Male Reproductive Biology, But It Is Not a Fertility Treatment

Vitamin D receptors are present throughout the male reproductive system, and vitamin D signaling may influence processes involved in sperm motility and fertilization. Observational research has linked low vitamin D with poorer sperm motility, but clinical outcomes are less straightforward. In a randomized trial of 330 vitamin D-insufficient infertile men, supplementation raised vitamin D levels but did not improve overall semen parameters. Researchers observed potentially interesting signals involving spontaneous pregnancy and live birth among a subgroup of men with low sperm counts, but those findings require confirmation. Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense while arguing that male fertility needs to be evaluated as a larger system involving metabolic health, sleep, heat exposure, medications, hormones, micronutrients, toxins, oxidative stress, and semen testing.

Sources:

-PubMed: Vitamin D Supplementation, Semen Quality and Live Birth Rate

~~~

CoQ10 Shows Why a Great Mechanism Does Not Guarantee a Great Treatment

CoQ10 plays a central role in mitochondrial energy production and electron transport, making it an appealing candidate for diseases involving mitochondrial dysfunction, oxidative stress, and neuronal energy failure. Early biological reasoning and smaller studies looked promising, but larger clinical trials have repeatedly failed to show the expected neurological benefits. A randomized trial of 600 people with early Parkinson’s disease found no evidence that high-dose CoQ10 slowed disease progression, while a large Huntington’s disease trial was stopped early for futility. A Phase II ALS trial also found insufficient evidence to justify moving to a larger Phase III study. Host Dave Asprey uses CoQ10 as a broader lesson in biohacking: a supplement can have a legitimate biological function while still failing to improve the clinical outcome you care about.

Sources:

-PubMed: High-Dose CoQ10 in Early Parkinson Disease

-Neurology: CoQ10 in Huntington Disease

-PubMed: Phase II CoQ10 Trial in ALS

~~~

This episode is designed for biohackers, longevity enthusiasts, men thinking about hair loss or fertility, and anyone trying to distinguish a compelling biological mechanism from a proven intervention. Host Dave Asprey examines how chronic infections contribute to cancer risk, what the evidence really says about persistent finasteride symptoms, why blueberries may influence vascular health through polyphenol signaling, where vitamin D fits into male fertility, and why CoQ10 is a powerful example of promising biology failing to translate into clinical outcomes. The larger lesson is simple: understand the mechanism, look for meaningful human outcomes, measure your own biology, and avoid confusing a plausible explanation with proof that an intervention works.

Keywords: infection cancer risk, cancer causing infections, H pylori cancer, HPV cancer, Epstein Barr virus cancer, chronic infection cancer, finasteride side effects, post finasteride syndrome, finasteride neurosteroids, allopregnanolone finasteride, DHT hair loss, blueberries cardiovascular health, blueberries endothelial function, blueberry polyphenols, anthocyanins gut microbiome, banana smoothie polyphenols, polyphenol oxidase, vitamin D male fertility, vitamin D sperm quality, male infertility, CoQ10 mitochondria, CoQ10 Parkinson’s disease, CoQ10 neurodegeneration, mitochondrial health, biohacking research roundup

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• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/

• Upgrade Labs: https://upgradelabs.com

Timestamps:

00:00 — Intro

00:45 — Infections From 2024

02:15 — Finasteride Concerns

04:38 — Blueberries and Bananas

06:40 — Vitamin D and Fertility

08:18 — CoQ10 Trial Failures

09:47 — Takeaway

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How to Unlock Psychic Abilities to Know When You’ll Die : 1551 Oct 08, 2026

Show notes

Get a free digital and audiobook copy of Angelic Attendants at https://askjulieryan.com/request-ebook/

Psychic Abilities, Medical Intuition, Energy Healing, Remote Viewing & What Happens When We Die with Julie Ryan

Host Dave Asprey sits down with Julie Ryan, psychic, medical intuitive, inventor, author, entrepreneur, and host of the Ask Julie Ryan podcast, to explore intuition, consciousness, energetic healing, remote viewing, communication with spirits, past lives, dreams, and what Julie says happens as people approach death.

Julie Ryan is a psychic and medical intuitive who says she can sense medical conditions, facilitate energetic healings, communicate with spirits, scan animals, access past lives, and tell how close someone may be to death. She is also an inventor, author, radio host, podcaster, and serial entrepreneur who has founded nine companies across five industries. Her surgical device inventions are sold globally, and unlike many people working in the intuitive space, Julie says her psychic and medical intuitive abilities were learned.

Her book Angelic Attendants: What Really Happens As We Transition From This Life Into The Next explores what she describes as the process of dying, including the presence of angels, deceased family members, friends, pets, and other experiences that may occur near the end of life.

Julie explains how she went from building companies and inventing surgical devices to learning psychic and medical intuitive skills she now teaches to others. She describes how she believes people can remotely sense information about the body, distinguish intuition from ordinary thoughts, and develop abilities that often get ignored or shut down as people grow older.

Dave and Julie explore what it means to “scan” someone from a distance, how Julie says she perceives injuries and illness inside the body, and why she sees intuition as another form of information processing rather than something reserved for a small group of gifted people. Julie also explains why visual, auditory, and kinesthetic learners may experience intuitive information differently.

They also discuss energetic healing, emotional trauma, brainwave patterns, spiritual experiences during surgery, communication with deceased loved ones, and the role dreams may play in receiving intuitive information. Dave shares his own experiences with intuition, altered brain states, grief, and the peaceful death of his mother.

This episode is essential listening for anyone interested in psychic abilities, intuition, consciousness, energy healing, remote viewing, medical intuition, dreams, the afterlife, grief, near-death awareness, spirituality, neuroscience, and the possibility that human perception may extend beyond what most people are trained to notice.

You’ll Learn:

How Julie says psychic and medical intuitive abilities can be learned and trained
How she remotely “scans” the body and interprets information about illness, injury, and healing
How to tell the difference between intuition and ordinary thoughts or emotions
What Julie says happens spiritually during surgery, dreams, and communication with deceased loved ones
How her 12 phases of transition may indicate when someone is approaching death
Why Dave believes intuition and science can overlap, especially in observation, discovery, and consciousness research

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Julie Ryan, psychic abilities, psychic powers, medical intuitive, medical intuition, intuition, intuitive abilities, energy healing, energetic healing, remote viewing, consciousness, spirituality, afterlife, what happens when you die, death and dying, near death, spirit communication, communicating with spirits, deceased loved ones, past lives, psychic training, intuitive training, spiritual healing, dreams, vivid dreams, grief, angels, guardian angels, consciousness research, neuroscience, brainwaves, psychic brain, spiritual experiences, emotional healing, energy medicine, mind body connection, holistic healing, biohacking, human potential, Dave Asprey, The Human Upgrade

Resources:

• Get A Free Digital And Audiobook Copy Of Angelic Attendants At https://askjulieryan.com/request-ebook/

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/davetube

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

Thank you to our sponsors!

- Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh

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- Calroy | Learn more about Selentra HP and get your exclusive discount at calroy.com/dave

Timestamps:

00:00 — Trailer

01:00 — Psychic Powers

03:52 — Scanning Through Spirit

07:02 — First Intuitive Knowing

14:10 — Fairies and Elementals

17:29 — No Evil Spirits

23:11 — Medical Intuition

32:00 — The Energy Field Membrane

37:43 — Spirits in the Operating Room

46:17 — Dreams, Mold, and Lyme

54:04 — What Happens as We Die

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How to Live Healthier Without Obsessing Over Health : 1550 Oct 06, 2026

Show notes

Grab 20% off KORA Organics with code HUMAN20 at https://koraorganics.pxf.io/9VdD0E.

Clean Living, Stress Reduction, Sleep, Skincare & Simple Wellness Habits with Miranda Kerr

Host Dave Asprey sits down with Miranda Kerr, founder of KORA Organics, entrepreneur, model, and longtime wellness advocate, to explore clean living, stress, sleep, skincare, meditation, parenting, and why her approach to health has become simpler over time.

Miranda shares how her mother’s cancer diagnosis when she was 16 changed the way her family looked at everyday ingredients and helped spark her lifelong interest in organic living, holistic health, and reducing unnecessary exposures. That experience later became a driving force behind KORA Organics and her focus on certified organic skincare.

They explore the habits Miranda now prioritizes after years of experimenting with wellness, including morning sunlight, quality food, meditation, sleep, breathwork, strong relationships, and time with family. She also explains how she manages stress while raising four children and running an international company.

Dave and Miranda discuss raising healthy kids without making health feel restrictive, navigating different health values within a family, and why acceptance matters when you cannot control another person’s choices.

The episode also covers clean beauty, plant-based retinol alternatives, non-nano zinc sunscreen, essential oils, rose quartz, intention, and the philosophy behind KORA Organics. Miranda also explains why constantly chasing new wellness tools eventually pushed her back toward a smaller set of foundational habits that consistently make her feel better.

This episode is essential listening for anyone interested in clean living, stress reduction, meditation, sleep, healthy parenting, skincare, organic beauty, biohacking, and building a wellness routine that supports your life rather than taking it over.

You’ll Learn:

Why Miranda’s mother’s health scare changed the way she thought about food, skincare, and everyday ingredients
Why her wellness routine has become simpler instead of more complicated over time
The foundational habits Miranda prioritizes for energy, stress, sleep, and overall health
How meditation, breathwork, morning sunlight, and evening light management fit into her daily routine
How she teaches her children about healthy food without creating fear or restriction
Why acceptance matters when your partner does not share the same health priorities
How Miranda approaches clean beauty, organic skincare, retinol alternatives, and non-nano mineral sunscreen
Why KORA Organics incorporates rose quartz, positive words, essential oils, and intention into its products
How constantly experimenting with wellness tools can become counterproductive
Why sunlight, sleep, food, relationships, and stress management remain the foundation even after years of exploring wellness

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Miranda Kerr, KORA Organics, clean living, clean beauty, wellness, healthy living, holistic health, skincare, organic skincare, certified organic skincare, healthy skin, anti-aging skincare, skin health, non-nano zinc sunscreen, mineral sunscreen, retinol alternative, bakuchi oil, meditation, TM meditation, breathwork, stress reduction, stress management, sleep, circadian rhythm, morning sunlight, blue light, grounding, healthy parenting, raising healthy kids, nutrition, toxins, environmental toxins, ingredient safety, essential oils, rose quartz, mindset, intention, biohacking, healthy aging, wellness routine, simple wellness, holistic wellness

Resources:

• Grab 20% Off KORA Organics with code HUMAN20 at https://koraorganics.pxf.io/9VdD0E

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/davetube

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

Thank you to our sponsors!

- KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off

- Neuronic | Go to www.neuronic.online Code DAVE for $100 off

- Puori | Use code DAVE at puori.com/DAVE to get 32% off your first Puori CP1 Pure Collagen order when you start a subscription. You save more than $26.

- LMNT | Right now, grab any LMNT drink mix and they'll throw in a free sample pack. Go to drinklmnt.com/dave to get yours.

Timestamps:

00:00 — Trailer

00:51 — Miranda’s Health Awakening

06:21 — Mind, Body & Crystals

13:12 — Roots of Positive Thinking

17:04 — The McDonald's Birthday Hack

22:36 — Acceptance in Relationships

28:34 — Intention Behind the Products

32:28 — Proving Organic Skincare Works

36:56 — Stress & Morning Rituals

42:09 — Back to Basics

48:17 — Health Without Public Pressure

51:06 — Closing Thoughts

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It's Boring, But It Slashed ALL My Visceral Fat In My 50s : 1549 Oct 04, 2026

Show notes

Try TrueDark glasses: https://truedark.com

Try Danger Coffee: https://dangercoffee.com/discount/davetube

Try Suppgrade Labs: https://shopsuppgradelabs.com/

I'm in the best shape of my life, and it has nothing to do with working harder. In this video, I break down the 5 unconventional hacks that helped me lose over 100 pounds, kill brain fog, and feel two decades younger, starting with something as simple as what I put in my morning coffee. If you're tired of doing everything 'right' and still feeling old, this one's for you.

You'll Learn:

How putting grass-fed butter and MCT oil in your coffee can unlock steady energy and effortless fat loss
Why eating more saturated fat, not less, supports your brain, hormones, and metabolism
How the "calories in, calories out" myth keeps you stuck and why food quality matters far more than quantity
Which "healthy" foods like spinach, oats, and beans are packed with anti-nutrients that cause inflammation and block nutrient absorption
How intermittent fasting flips your body from sugar-burning to fat-burning mode and triggers cellular repair
Why dialing in your nutrition beats grinding in the gym and how over-exercising can actually stall fat loss and speed up aging

Timestamps:

00:00 — The 300-Pound Millionaire

01:26 — Discovery in Tibet

03:05 — Eat More Saturated Fat

04:38 — The Low-Fat Scam

07:01 — Quality Over Quantity

09:20 — Hidden Plant Toxins

12:04 — Watch the Fructose

13:08 — Skip Breakfast

16:38 — Diet Beats the Gym

Thank you to our sponsors!

- Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh

-EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.

-iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE

Connect with Dave Asprey!

Website: https://daveasprey.com

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Dave Asprey’s BEYOND Conference: https://beyondconference.com/

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Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

Join my Substack: https://substack.daveasprey.com

Upgrade Labs: https://upgradelabs.com

40 Years of Zen: https://40yearsofzen.com

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Vagus Nerve Memory, Cat Cancer Genes, Inherited Intelligence, Mulberry Microbes, and Vitamin D : 1548 Oct 02, 2026

Show notes

Vagus Nerve Stimulation Improves Cognitive Scores in a Small Trial

In a 24-week trial involving people with mild cognitive impairment, participants assigned to electrical stimulation at vagus-innervated parts of the ear improved by an average of 3.2 points on a general cognitive test, compared with 0.3 points in a sham-stimulation group. Host Dave Asprey explores the proposed connection between the vagus nerve and the locus coeruleus, a brainstem region involved in attention and learning. He explains why an improved test score is intriguing but does not show that vagus nerve stimulation prevents Alzheimer’s disease—or that a consumer device will reproduce the study’s results.pubmed.ncbi.nlm.nih+1

Sources:

https://pubmed.ncbi.nlm.nih.gov/36150665/

https://pmc.ncbi.nlm.nih.gov/articles/PMC13214873/

https://theconversation.com/vagus-nerve-stimulation-shows-promise-as-a-way-to-counter-alzheimers-disease-and-age-related-memory-loss-269465

~~~

Nearly 500 Cat Tumors Reveal Cancer Genes Shared With Humans

Researchers analyzed 493 matched tumor and normal-tissue samples across 13 types of cancer in domestic cats. They found alterations in genes familiar to human cancer researchers, including TP53, and tested whether a mutation called FBXW7 might predict drug sensitivity in lab-grown models of feline mammary tumors. Host Dave Asprey examines why naturally occurring cancers in pets could help scientists investigate treatments across species, while making clear that a promising response in six laboratory tumor models is not a proven treatment for cats or people.pmc.ncbi.nlm.nih

Sources:

https://pmc.ncbi.nlm.nih.gov/articles/PMC7618901/

https://pubmed.ncbi.nlm.nih.gov/41712721/

https://www.sciencedaily.com/releases/2026/09/260924231826.htm

~~~

Twin-Family Study Challenges a Simple Explanation for Inherited Intelligence

Why do parents and children often score similarly on tests of cognitive ability? Researchers using Germany’s TwinLife data found that genetic transmission explained more of that resemblance than the particular shared-home-environment pathway their model tested. Host Dave Asprey unpacks the distinction between why relatives resemble one another and whether a child’s environment matters. The study does not show that parenting, education, or other experiences have no effect on cognition.pub.uni-bielefeld+1

Sources:

https://pub.uni-bielefeld.de/record/2993432

https://www.psypost.org/genetics-not-shared-environments-drives-parent-child-similarities-in-cognitive-ability/

~~~

Mulberry Compounds May Change Gut Bacteria and Metabolism

A review of mulberry research highlights how leaves, fruit, and differently processed extracts contain distinct mixtures of compounds that gut microbes may use. In mouse experiments, a fraction combining mulberry polyphenols and polysaccharides produced more favorable microbiome and metabolic changes than either fraction alone; transferring microbes from treated mice passed along some of those effects. Host Dave Asprey explores the idea that a plant extract’s preparation may matter as much as its name—and why the findings do not yet establish a microbiome benefit from mulberry products in humans.pmc.ncbi.nlm.nih+1

Sources:

https://pmc.ncbi.nlm.nih.gov/articles/PMC13406227/

https://www.sciencedaily.com/releases/2026/09/260928100551.htm

~~~

Magnesium Changes Vitamin D Metabolism—But Not Always in the Same Direction

Magnesium helps regulate the pathways that process vitamin D, but “more magnesium means more vitamin D” is too simple. In a 12-week randomized trial involving 180 adults, magnesium supplementation changed a measured vitamin D metabolite differently depending on participants’ starting vitamin D levels: the modeled difference was positive at 30 ng/mL and negative at 50 ng/mL. Host Dave Asprey explains why this matters to people tracking supplement stacks and bloodwork, while distinguishing a change in a lab marker from a demonstrated health benefit.pubmed.ncbi.nlm.nih+1

Sources:

https://pmc.ncbi.nlm.nih.gov/articles/PMC6693398/

https://pubmed.ncbi.nlm.nih.gov/29480918/

https://www.sciencedaily.com/releases/2018/02/180226122548.htm

This episode is designed for biohackers, longevity enthusiasts, pet owners, parents, and anyone trying to separate a compelling biological mechanism from a proven health intervention. Host Dave Asprey examines brain stimulation and memory, what cat cancers could teach human researchers, how genes and environment contribute to cognitive similarity, whether mulberry’s microbiome effects translate beyond mice, and why nutrient interactions are rarely as simple as a supplement headline suggests. Several studies discussed here predate this week’s coverage; this is a research roundup, not a list of five newly published trials.pmc.ncbi.nlm.nih+4

New episodes every Tuesday, Thursday, Friday, and Sunday.

Keywords: vagus nerve stimulation memory, auricular vagus nerve stimulation, mild cognitive impairment, Alzheimer’s research, locus coeruleus, cat cancer genetics, feline oncogenome, FBXW7 feline mammary cancer, comparative oncology, parent child cognitive ability, TwinLife cognitive ability study, intelligence genetics, shared environment cognition, mulberry gut microbiome, mulberry polyphenols polysaccharides, microbiota transfer mice, magnesium vitamin D metabolism, magnesium supplementation vitamin D, biohacking research roundup

Thank you to our sponsors!

- Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh

- Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com.

- The One Device | Use code DAVE for $10 off at theonedevice.com/dave

- iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE

Resources:

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/

• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/

• Upgrade Labs: https://upgradelabs.com

Timestamps:

00:00 — Intro

00:18 — Vagus Nerve

01:51 — Cat Cancer

03:53 — Genetics & Parenting

05:46 — Mulberries

07:43 — Magnesium & Vitamin D

09:25 — Takeaway

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Dave’s Anti-Aging Skincare Routine: Exosomes, Methylene Blue & NAD+ : 1547 Oct 01, 2026

Show notes

Visit https://www.younggoose.com/ and use code ASPREY10 to save on the skin longevity products discussed in this episode.

Skin Longevity, Cellular Repair, Red Light Therapy & the Biology of Younger Skin with Young Goose

Host Dave Asprey sits down with Amitay Eshel and Anastasia Khodzhaeva, co-founders of Young Goose, to explore the emerging science of skin longevity, cellular aging, mitochondrial function, exosomes, NAD+, red light therapy, and what it may take to keep skin functioning younger for longer.

Anastasia is a biologist, biohacker, and co-CEO of Young Goose who began her career in biomedical research focused on liver fibrosis and breast cancer before moving into wellness, product development, and longevity-focused skincare. Amitay is co-founder and CEO of Young Goose and host of the Biohacking Beauty podcast, with more than a decade of experience across health, wellness, beauty, and business development. Together, they focus on applying longevity science and performance optimization to skin health.

Amitay and Anastasia explain why wrinkles may be only one visible sign of a much deeper biological process involving declining cellular energy, weakened barrier function, oxidative stress, senescence, and changes in how skin cells repair themselves. They break down how newer approaches to skincare are moving beyond surface-level hydration toward targeting the cellular mechanisms associated with aging.

The conversation goes deep into testing, including a metabolomics-based approach designed to assess skin metabolic age from a small blood sample and analyze 17 different metabolites. They also discuss emerging proteomics testing that can examine thousands of proteins involved in processes such as collagen production, oxidative stress, mitochondrial function, and cellular repair.

Dave, Amitay, and Anastasia explore some of the most unusual compounds now being used in skin longevity, including methylene blue, NAD+ precursors, spermidine, ergothioneine, superoxide dismutase, copper peptides, ectoin, and gotu kola. They explain how these compounds may interact with mitochondrial energy production, oxidative stress, mitophagy, collagen signaling, and the broader hallmarks of aging.

They also break down red light therapy and why combining light with certain topical compounds may influence the response. The discussion covers methylene blue and electron transport, copper peptides and mitochondrial biogenesis, light-activated DNA repair enzymes, photodamage, reactive oxygen species, and why dose and timing may matter when using red or near-infrared light.

The episode also dives into platelet-derived “Vampire Exosomes,” how exosomes carry cellular instructions through microRNAs, why formulation and stability matter, and how these signaling particles may influence skin repair, inflammation, collagen production, and senescence. Dave and the Young Goose team also discuss growth factors, klotho, senomorphic strategies, cellular longevity, and why extending the functional life of healthy cells may become an important frontier in longevity science.

They also explore practical skincare routines, including how to layer products, what Dave uses while traveling, how airplanes and dry environments affect skin, why aggressive acids may not always fit a long-term skin longevity strategy, and how AI-based skin analysis could make skincare increasingly personalized.

This is essential listening for anyone interested in skin longevity, anti-aging skincare, exosomes, methylene blue, NAD+, red light therapy, mitochondrial health, senescent cells, collagen, peptides, cellular repair, metabolomics, proteomics, biohacking, and the future of personalized skincare.

You’ll Learn:

Why wrinkles may be a downstream sign of deeper cellular aging
How skin metabolic age can be assessed using metabolomics and multiple biological markers
What methylene blue may do inside mitochondria and why it pairs with red light
How NAD+ precursors, spermidine, copper peptides, SOD, and ergothioneine may support skin biology
Why platelet-derived “Vampire Exosomes” are being studied for cellular signaling, repair, and senescence
How red light therapy interacts with mitochondrial function, oxidative stress, and DNA repair
Why some traditional acids and surface-level skincare strategies may not address long-term skin function
How proteomics and AI could change the way skincare is measured and personalized
What Dave and the Young Goose team use to support skin during travel and other high-stress environments

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Amitay Eshel, Anastasia Khodzhaeva, Young Goose, Biohacking Beauty, skincare, anti-aging skincare, skin longevity, skin aging, younger skin, exosomes, vampire exosomes, platelet-derived exosomes, methylene blue, NAD+, NAD precursors, red light therapy, mitochondria, mitochondrial health, mitochondrial dysfunction, cellular aging, cellular repair, senescent cells, senescence, senomorphics, collagen, copper peptides, GHK-Cu, spermidine, ergothioneine, superoxide dismutase, SOD, ectoin, gotu kola, mitophagy, metabolomics, proteomics, skin metabolic age, klotho, oxidative stress, peptides, skin barrier, DNA repair, photodamage, biohacking, longevity

Resources:

• Visit https://www.younggoose.com/ and use code ASPREY10 to save on the skin longevity products discussed in this episode.

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/davetube

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

Thank you to our sponsors!

- Download Dave’s Free Peptide Guide at daveasprey.com/peptide-guide.

- Neuronic | Go to www.neuronic.online Code DAVE for $100 off

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- Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount.

Timestamps:

00:00 — Trailer

01:09 — Skin Testing & Metabolomics

04:48 — Longevity Skincare Paradigm

07:50 — Airplane Skincare Routine

11:15 — Tardigrade Juice & Antioxidants

16:00 — Mitochondrial Dysfunction

21:00 — Skincare Ingredients: Old vs New

27:20 — Vampire Exosomes

32:30 — Red Light Therapy Stacking

38:00 — Proteomics & Klotho

41:00 — Exosome Safety, Growth Factors & MicroRNAs

44:00 — Senescent Cells & Senomorphics

47:00 — Skin Longevity Takeaways

50:00 — Outro

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The Silent Fatty Liver Epidemic: Why Thin, Sober People Are Still at Risk : 1546 Sep 29, 2026

Show notes

Visit LoveYourLiver.com and use code Dave2026 to access the special offer from de-liver-ance mentioned in this episode.

Host Dave Asprey sits down with Siggi Clavien, Founder and CEO of The Liver Clinic and de-liver-ance, to explore why the liver may be one of the most overlooked organs in metabolism, hormone health, detoxification, brain function, weight management, and longevity.

Siggi explains why fatty liver can develop without obvious symptoms and why someone can appear lean and healthy while still have significant liver fat. Drawing on thousands of liver scans, he shares what his team has observed in people whose blood markers appeared normal despite signs of fatty liver on imaging, and explains how tools such as FibroScan can reveal liver fat, stiffness, and fibrosis.

Dave and Siggi go deep into triglycerides, cholesterol, insulin resistance, brain fog, weight gain, bile production, thyroid hormone activation, testosterone, estrogen metabolism, and liver regeneration. They also explore how alcohol, environmental chemicals, plastics, processed foods, artificial sweeteners, medications, and other exposures may place additional stress on the liver.

The conversation also tackles rapid weight loss and GLP-1 medications, including Siggi’s concerns about compounds released from fat tissue during aggressive weight loss and why protecting muscle, eating enough protein, and supporting liver function may matter during the process.

Dave and Siggi also discuss alcohol, estrogen, hormone replacement therapy, glutathione, choline, bile flow, supplement quality, and why liver health may influence systems throughout the body. The episode takes an unexpected turn into microchimerism and organ transplantation, including donor cells, DNA, cellular memory, and reported changes in behavior or personality after transplantation.

This is essential listening for anyone interested in fatty liver, metabolic health, GLP-1s, weight loss, hormone health, estrogen, testosterone, thyroid function, alcohol, brain fog, insulin resistance, liver scans, longevity, choline, glutathione, bile flow, and biohacking.

You’ll Learn:

Why fatty liver can develop even in people who are thin or rarely drink alcohol
Why normal bloodwork may not always reveal what is happening inside the liver
How liver health connects to metabolism, brain fog, weight gain, hormones, and thyroid function
What rapid weight loss and GLP-1 use may mean for liver function
How alcohol, estrogen, HRT, bile, choline, and glutathione interact with liver health
Why liver scans, nutrition, and supplement quality may matter for long-term health

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Siggi Clavien, de-liver-ance, The Liver Clinic, liver health, fatty liver, fatty liver disease, MASLD, liver detox, liver function, liver scan, FibroScan, liver fibrosis, triglycerides, cholesterol, metabolic health, GLP-1, weight loss, toxins, alcohol, estrogen, HRT, testosterone, thyroid health, brain fog, insulin resistance, bile, choline, glutathione, artificial sweeteners, supplements, longevity, liver regeneration, microchimerism, biohacking

Resources:

• Visit LoveYourLiver.com and use code Dave2026 to access the special offer from de-liver-ance mentioned in this episode.

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/davetube

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

Thank you to our sponsors!

- KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off

- MOD | Visit mod.com for a consultation and get 10% off your first order plus free shipping with promo code DAVE.

- ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.

- Mars Men | For a limited time, our listeners get 50% off for life plus Free Shipping AND 3 Free Gifts when you checkout at MenGoToMars.com.

Timestamps:

00:00 — Trailer

01:00 — Liver Basics & Signs

05:30 — Liver Scan Technology

08:15 — Chemicals & Liver Disease

11:30 — Deliverance Formula Story

17:15 — Estrogen, Alcohol & HRT

22:30 — GLP-1s & Liver Toxicity

28:00 — Bile & Gut Health

33:10 — Chimerism & Transplants

41:30 — Hormesis & Painkillers

50:00 — Sweeteners, Hormones & Thyroid

55:00 — Outro - Discount

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Every Way to Melt Visceral Fat FAST In 14 Minutes : 1545 Sep 27, 2026

Show notes

Try TrueDark glasses: https://truedark.com

Try Danger Coffee: https://dangercoffee.com/discount/davetube

Try Suppgrade Labs: https://shopsuppgradelabs.com/

Try Longevity Gummies: https://www.timeline.com/partners/dave-asprey

This video explains the most effective ways to lose visceral fat, escalating from least to most effective, like a caloric deficit & diet quality (high protein, cut alcohol), Aerobic exercise (cardio), resistance training, sleep optimization, and stress reduction.

If diet and exercise aren't melting stubborn belly fat, fix your sleep first with 300mg of Magnesium 101 before bed, available at https://shopsuppgradelabs.com/discount/DAVETUBE?redirect=/products/magnesium-101 with code DAVETUBE for 15% off.

You'll Learn:

Why protein burns 20–30% of its own calories just to digest — and how that "thermic effect" makes it the most powerful diet lever for cutting visceral fat
Why short, intense workouts (as little as 10–20 minutes a week) beat long cardio sessions for triggering fat-burning hormones
How cold exposure activates brown fat to burn visceral fat as fuel, and why consistency matters more than intensity
Why resistance training is one of the most effective tools for long-term fat loss, not just muscle-building
How poor sleep tanks growth hormone by up to 70% a night and drives up cortisol, both of which directly promote visceral fat storage
Why chronic stress is the single biggest driver of visceral fat, and how it creates a self-reinforcing loop that resists diet and exercise alone

Thank you to our sponsors!

Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh
Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.
iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE

Timestamps:

00:00 — Introduction & Calorie Myth

01:27 — Power of Protein

02:37 — Cut Sugar & Carbs

03:48 — HIIT for Fat Loss

05:44 — Cold Exposure

06:32 — Resistance Training

08:22 — Sleep & Growth Hormone

10:30 — Stress & Cortisol

13:39 — Breaking the Fat Loop

Connect with Dave Asprey!

Website: https://daveasprey.com

TikTok: https://www.tiktok.com/@daveaspreyofficial

Instagram: https://www.instagram.com/dave.asprey/

Facebook: https://www.facebook.com/Daveaspreyofficial/

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TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Upgrade Labs: https://upgradelabs.com

40 Years of Zen: https://40yearsofzen.com

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Ozempic Hair, GLP-1 Kids, Gut-Brain Anxiety, Food Additives, Taurine, and more : 1544 Sep 25, 2026

Show notes

Novo Nordisk Eyes Hair-Loss Market in Consumer-Health Expansion

Novo Nordisk, the company behind Ozempic and Wegovy, is exploring hair loss as one of several possible areas for future expansion, alongside menopause and addiction. The company has not announced a hair-loss drug, clinical trial, acquisition, or partnership, but Chief Scientific Officer Martin Holst Lange pointed to the category during the company's 2026 Capital Markets Day. Host Dave Asprey breaks down why hair loss makes strategic sense for a company already deeply involved in endocrine biology, how emerging treatments are moving beyond traditional options like minoxidil and finasteride, and why sudden shedding during rapid GLP-1 weight loss may be telogen effluvium rather than traditional pattern baldness.

Sources:

https://www.bloomberg.com/news/articles/2026-09-22/ozempic-maker-novo-looks-to-target-hair-loss-in-consumer-push

https://www.novonordisk.com/investors/capital-markets-day-2026.html

https://www.irishexaminer.com/business/companies/arid-41914219.html

~~~

Nearly One in Six Pediatric GLP-1 Users Diagnosed With a Nutritional Deficiency

A study of 2,031 children and adolescents ages 10 to 17 who were prescribed GLP-1 receptor agonists found that 16.88% received a new diagnosis related to a nutritional deficiency within one year. Vitamin D deficiency was the most common, appearing in about 12.4% of the group, while smaller numbers were diagnosed with nutritional anemia or iron deficiency anemia. Host Dave Asprey explains why the study does not prove GLP-1 drugs caused these deficiencies, but highlights a bigger concern: only about 5% of the children had documented nutrition counseling within the first 30 days, even though appetite suppression during adolescence can reduce intake of protein, iron, calcium, vitamin D, B vitamins, and other nutrients needed for growth.

Sources:

https://doi.org/10.1177/21532176261486979

https://www.sciencedaily.com/releases/2026/09/260923035926.htm

https://pharmaceutical-journal.com/article/news/children-taking-glp-1s-can-be-at-risk-of-nutritional-deficiencies-study-finds

~~~

Stronger Stomach-Brain Synchrony Associated With Poorer Mental Health

Researchers studying the electrical rhythm of the stomach alongside brain activity found an unexpected relationship: stronger synchronization between gastric signals and certain brain networks was associated with worse mental health measures, including higher anxiety, depression, stress, and fatigue. The strongest associations appeared in networks involved in attention and cognitive control. Host Dave Asprey explains why the findings do not prove stomach-brain synchronization causes mental health problems, but expand the gut-brain conversation beyond the microbiome to include electrical activity, neural signaling, hormones, immune pathways, and metabolites.

Sources:

https://www.nature.com/articles/s44220-025-00468-6

https://health.au.dk/en/display/artikel/the-stomachs-brain-is-more-in-sync-with-the-mind-during-mental-distress

https://medicalxpress.com/news/2025-08-stomach-brain-sync-mind-mental.html

~~~

Food Preservatives and Additive Mixtures Associated With Cardiovascular Risk

A large French NutriNet-Santé study involving more than 112,000 adults found that higher exposure to total preservatives was associated with a higher incidence of hypertension, while several individual additives were also linked to elevated risk. A newer September 2026 analysis from the same cohort examined combinations of additives people commonly consume together and found several mixtures associated with higher rates of hypertension, cardiovascular disease, or coronary heart disease. Host Dave Asprey explains why these observational findings cannot prove that preservatives cause cardiovascular disease, but raises a larger question about whether evaluating food additives one compound at a time accurately reflects the mixtures people consume in real packaged foods.

Sources:

https://academic.oup.com/eurheartj/article/doi/10.1093/eurheartj/ehag308/8679203

https://link.springer.com/article/10.1186/s12916-026-05132-z

https://www.escardio.org/news/press/press-releases/common-food-preservatives-linked-to-high-blood-pressure-and-heart-disease/

~~~

Taurine Pretreatment Reduces Depression-Like Changes in Chronically Stressed Rats

A 2017 study in male rats found that taurine pretreatment reduced several behavioral and biochemical effects of chronic unpredictable stress. Taurine-treated animals maintained more normal reward-seeking behavior and performed better on some learning and memory measures, while researchers also observed changes in corticosterone, glutamate, serotonin, dopamine, noradrenaline, BDNF, and FGF2. Host Dave Asprey explains why this does not show that taurine treats depression in humans, especially because the taurine was injected and given before the chronic stress began, but uses the study to explore a broader principle: much of stress resilience may be built before the stress ever arrives.

Sources:

https://www.nature.com/articles/s41598-017-05051-3

https://pmc.ncbi.nlm.nih.gov/articles/PMC5504064/

This episode is designed for biohackers, longevity enthusiasts, parents, and high-performance listeners who want emerging health research translated into practical decisions without getting trapped by headline science. Host Dave Asprey explores what rapid weight loss can mean for hair and nutrient status, why the gut-brain axis extends far beyond the microbiome, what food-additive research can and cannot tell us about cardiovascular risk, and why stress resilience may depend as much on what you do before a challenge as what you do after it.

New episodes every Tuesday, Thursday, Friday, and Sunday.

Keywords: Novo Nordisk hair loss, Ozempic hair loss, Wegovy hair shedding, GLP-1 telogen effluvium, minoxidil hair loss, finasteride hair loss, pediatric GLP-1 nutritional deficiencies, GLP-1 vitamin D deficiency, GLP-1 children nutrition, liraglutide adolescents, semaglutide teenagers, stomach brain connection, gastric brain coupling, gut brain axis mental health, electrogastrography anxiety, gut brain depression, food preservatives cardiovascular disease, food additives hypertension, NutriNet-Santé preservatives, ultra-processed foods heart disease, additive mixtures cardiovascular risk, taurine stress resilience, taurine depression study, taurine BDNF, chronic stress taurine, biohacking news 2026

Thank you to our sponsors!

- Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh

- BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.

- iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE

Resources:

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/

• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/

• Upgrade Labs: https://upgradelabs.com

Timestamps:

00:00 — Intro

00:18 — Novo Nordisk & Hair Loss

02:52 — GLP-1s & Kids' Nutrition

05:08 — Stomach-Brain Sync

07:49 — Preservatives & Heart Risk

10:53 — Taurine & Stress Resilience

13:28 — Outro

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The Best Singular Hack To Change EVERYTHING About Your Life : 1543 Sep 24, 2026

Show notes

Back again with one of the best episodes we've done on the channel. So good that we had to play it once more for you! Today you’ll meet Robert Waldinger, M.D., who leads an extraordinary scientific study on happiness that’s still going strong after eight decades. The study set out to understand human health by what made people thrive.

Since 1938, the Harvard Study of Adult Development has tracked two groups of men and their families with the goal of discovering what really makes for a good life. Along the way, thousands of questions were asked, and hundreds of measurements were taken—from brain scans to blood work. Three strong themes emerged from the study:

Social connections are really good for you. Loneliness kills.
It’s the quality of your close relationships that matters.
Good close relationships don’t just protect your body, they protect your brain.

Dr. Waldinger combined those lifelong case studies with modern psychological research in his new book, co-authored with Marc Schulz, Ph.D., “The Good Life: Lessons from the World's Longest Scientific Study of Happiness." This discussion gives you real-life tools to hack your happiness. You’ll learn things like:

how relationships improve your physical, mental and emotional health. (More than you know!)
how to evaluate the effect of your relationships on your well-being. (Don’t be dragged down.)
what social fitness is and how to practice it. (Yes, it’s a flex.)
ways to enliven and energize your relationships. (Energy totally matters.)
why casual and work relationships matter more than you think. (A surprisingly big contribution.)

You'll Learn:

Why loneliness physically harms your body — affecting your brain, immune function, sleep, and pain sensitivity
The likely mechanism behind why relationships improve health: how a good listener helps regulate your stress response
What "social fitness" is and why relationships wither from neglect, even without conflict
The four attachment styles and why knowing yours matters before committing to a relationship
Why intergenerational friendships may be one of the most underused tools for personal growth and happiness

Resources:

• Visit https://metabolismfixbook.com/ to learn more about JJ Virgin’s new book, The Metabolism Fix, and access the bonus resources she created to go with it.

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/davetube

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

Timestamps:

00:00 — Introduction & the Study

04:43 — What Makes a Good Life

08:47 — How Relationships Heal

13:44 — Happiness: Nature vs Nurture

17:59 — Measuring Happiness

23:56 — Life Stages & Happiness

35:34 — Social Fitness

44:30 — Energizing Relationships

56:14 — Attachment & Childhood

1:05:04 — Casual Friends & Legacy

Thank you to our sponsors!

- Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh

- ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.

- BodyHealth | Visit BodyHealth.com and use code DAVE20 for 20% off your first purchase.

- Puori | Use code DAVE at puori.com/DAVE to get 32% off your first Puori CP1 Pure Collagen order when you start a subscription. You save more than $26.

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