VJOncology Podcast

Latest Episodes:

iwCAR-T session VI: Advances in GI cancers Jul 07, 2023

Show notes

The 5th International Workshop on CAR-T (iwCAR-T) took place in Scottsdale, AZ, on 14 – 16 April 2023, and brought together world-leading experts in CAR-T therapy as they discussed the latest in the field. In this podcast series, you will gain an insight into the sessions that took place at this year’s meeting, which covered the latest updates in CAR-T therapy in solid tumors, as well as associated challenges.

In this engaging discussion, we are excited to be joined by three distinguished experts in the field of oncology, J. Randolph Hecht, MD, from UCLA Santa Monica Medical Center, Santa Monica, CA, who will chair this discussion, Diane Simeone, MD, from NYU Langone Health, New York City, NY, and Xianxin Hua, MD, PhD, from the University of Pennsylvania, Philadelphia, PA. Listen to uncover the cutting-edge techniques and novel strategies employed in CAR-T therapy, all intended to revolutionize the treatment landscape of GI cancers.

The post iwCAR-T session VI: Advances in GI cancers appeared first on VJOncology.

Highlights in bladder cancer at ASCO 2023: NORSE, RAGNAR, and THOR Jun 30, 2023

Show notes

In this episode, we will be covering highly anticipated updates in urothelial carcinoma presented at the American Society of Clinical Oncology (ASCO) Annual Meeting 2023 in Chicago, IL. We are joined by Arlene Siefker-Radtke, MD of The University of Texas MD Anderson Cancer Center. Professor Siefker-Radtke is a leading expert in genitourinary cancer and will be sharing insights and updates from the ASCO 2023 Annual Congress, including a discussion of the NORSE (NCT03473743), THOR (NCT03390504), and RAGNAR (NCT04083976) trials. These trials investigated the use of the FGFR inhibitor, erdafitinib, in comparison or combination with other therapies.

The post Highlights in bladder cancer at ASCO 2023: NORSE, RAGNAR, and THOR appeared first on VJOncology.

ASCO 2023 Highlights: THOR, INDIGO and ADAURA Jun 23, 2023

Show notes

The American Society of Clinical Oncology Annual Meeting 2023 brought together thousands of experts in oncology to hear new data and discuss how to improve the diagnosis and treatment of patients with cancer. In this podcast, we hear from leading experts as they discuss some of the most groundbreaking trials from this year’s meeting. We will be joined by Yohann Loriot (Gustave Roussy, Villejuif, France), Karan Dixit (Northwestern Memorial Hospital, Chicago, IL), Roy S. Herbst (Yale School of Medicine, New Haven, CT), Ticiana Leal (Winship Cancer Institute of Emory University, Atlanta, GA), Jason Luke (University of Pittsburgh, Pittsburgh, PA).

We will hear on the THOR study evaluating erdafitinib in metastatic urothelial cancer with FGFR alterations and the INDIGO trial of vorasidenib in residual or recurrent grade 2 glioma with an IDH1/2 mutation. There will also be discussion on the ADAURA trial investigating adjuvant osimertinib in resected EGFR‑mutated stage IB–IIIA non-small cell lung cancer, the LUNAR trial evaluating Tumor Treating Field therapy with standard of care in metastatic non-small cell lung cancer following platinum failure. The KEYNOTE-716 study, which assessed pembrolizumab in patients with high risk stage IIB or IIC cutaneous melanoma will also be discussed.

The post ASCO 2023 Highlights: THOR, INDIGO and ADAURA appeared first on VJOncology.

iwCAR-T Session III: CAR-T clinical advances in lung cancer Jun 16, 2023

Show notes

In this engaging discussion, we are honored to be joined by three distinguished experts in the field of oncology, Prasad Adusumilli, MD, FACS, from Memorial Sloan Kettering Cancer Center, New York, NY, Adam Schoenfeld, MD, also from Memorial Sloan Kettering Cancer Center, New York, NY, and William Go, MD, PhD, from A2 Biotherapeutics in Agoura Hills, California. Listen to gain a deep understanding of the cutting-edge approaches and novel strategies employed in CAR-T therapy, all aimed at revolutionizing the treatment landscape for lung cancer.

The post iwCAR-T Session III: CAR-T clinical advances in lung cancer appeared first on VJOncology.

iwCAR-T Session II: Cell therapies in GU cancers May 25, 2023

Show notes

Join Vivek Narayan, Saul Priceman, and Nicholas Zorko in this compelling podcast episode recorded during the iwCAR-T meeting. Focusing on genitourinary malignancies, particularly prostate and urothelial cancer, the experts discuss the promises and hurdles of NK cell therapies, unresolved questions surrounding NK cell infiltration and manufacturing as well as obstacles in engineering T cells for the immunologically cold environment of prostate cancer. Insights into the role of lymphodepletion chemotherapy and the advantages of targeting B7-h3 as an antigen in prostate cancer are also explored.

The post iwCAR-T Session II: Cell therapies in GU cancers appeared first on VJOncology.

iwCAR-T Session I: Emerging CARs and future challenges in solid tumors May 19, 2023

Show notes

The 5th International Workshop on CAR-T (iwCAR-T) took place in Scottsdale, AZ, on 14 – 16 April, 2023, and brought together world-leading experts in CAR-T therapy as they discussed the latest in the field. In this podcast series, you will gain an insight into the sessions that took place at this year’s meeting, which covered the latest updates in CAR-T therapy in solid tumors, as well as associated challenges.

Today, experts Julian Molina (Mayo Clinic, Rochester, MN), Mathew Angelos (University of Pennsylvania, Philadelphia, PA), and Sebastian Kobold (Ludwig-Maximilians-University of Munich, Munich, Germany) bring you updates live from iwCART 2023. In considering the latest research and trials in the field of CAR T-cell therapy and the challenges associated with treating solid tumors, these specialists discuss using CAR macrophages in combination with other immunotherapies, manipulating the tumor microenvironment, the genetic engineering of CAR T-cells to add and/or remove specific factors, and tumor heterogeneity.

The post iwCAR-T Session I: Emerging CARs and future challenges in solid tumors appeared first on VJOncology.

Highlights at AACR 2023: mRNA vaccines in melanoma and novel RAF inhibitors May 09, 2023

Show notes

In this podcast, we’ll be covering highlights from the American Association for Cancer Research (AACR) Annual Meeting 2023 in Orlando, FL, including personalized mRNA and neoantigen vaccines, nivolumab with the standard of care in prostate cancer, and BGB-3245, a novel RAF dimer inhibitor, in solid tumors. Hear from Jeffrey Weber, NYU Langone Perlmutter Cancer Center, NY, Mansi Saxena, Icahn School of Medicine at Mount Sinai, New York, NY, John Michael Bryant, Moffitt Cancer Center, Tampa, FL, and Alison Schram, Memorial Sloan Kettering Cancer Center, New York, NY, who will all talk on these exciting advances.

The post Highlights at AACR 2023: mRNA vaccines in melanoma and novel RAF inhibitors appeared first on VJOncology.

Liquid biopsy in lung cancer: precision medicine and MRD Apr 28, 2023

Show notes

In this podcast, we’ll be discussing the use of liquid biopsy in lung cancer, with Professor Klaus Pantel of University Medical Center Hamburg-Eppendorf, in Hamburg, Germany. At the European Lung Cancer Congress (ELCC) 2023, we spoke with Professor Pantel about possible areas where liquid biopsy could be useful, such as clinical trial recruitment, as well as practical considerations for the use of liquid biopsies, and the role of MRD status in the management of non-small cell lung cancer.

The post Liquid biopsy in lung cancer: precision medicine and MRD appeared first on VJOncology.

St. Gallen highlights: controversies in the axilla Apr 14, 2023

Show notes

In this podcast, Icro Meattini (University of Florence, Florence, Italy) and Orit Kaidar-Person (Sheba Medical Center, Ramat Gan, Israel) discuss updates and controversies in the axillary management of breast cancer, live at the St Gallen Breast Cancer Consensus 2023.

The post St. Gallen highlights: controversies in the axilla appeared first on VJOncology.

Radiotherapy Highlights from ASCO GU 2023 with Sophia Kamran, Himanshu Nagar, and Neha Vapiwala Apr 06, 2023

Show notes

In this podcast, hear from GU cancer experts Sophia Kamran (Massachusetts General Hospital and Harvard Medical School, Boston, MA), Himanshu Nagar (Weill Cornell Medicine and New York Presbyterian, New York City, NY), and Neha Vapiwala (Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA) as they discuss the highlights in radiation oncology for GU cancers at the ASCO GU Cancers Symposium 2023.

In prostate cancer, key radiation oncology trials included FORMULA-509 (NCT03141671), RADICALS-HD (NCT00541047), CHHiP, and PACE-A. In bladder cancer, hot topics of discussion included the use of adaptive radiotherapy and a debate on when to use bladder-only or whole-pelvis radiotherapy. Finally, in testicular cancer, a key discussion compared the use of radiotherapy vs surgery vs chemotherapy for the treatment of stage 2a seminoma.

The post Radiotherapy Highlights from ASCO GU 2023 with Sophia Kamran, Himanshu Nagar, and Neha Vapiwala appeared first on VJOncology.

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