VJOncology Podcast

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Predictive and prognostic biomarkers in breast cancer Apr 07, 2021

Show notes

Following a breast cancer diagnosis, the most immediate challenges in patient management are the determination of prognosis and identification of the most appropriate adjuvant systemic therapy, the most valid of these tests include Oncotype DX and MammaPrint. In the identification of new predictive and prognostic markers, research efforts are focusing on the clinical utility of circulating and tumor DNA as well as the predictive significance of tumor-infiltrating lymphocytes (TILs).

In this exclusive podcast, VJOncology spoke with Judy Garber, MD, MPH, of the Dana-Farber Cancer Institute, Boston, MA, Martine Piccart, MD, PhD, of the Université Libre de Bruxelles, Brussels, Belgium, and Sherene Loi, MBBS, PhD, FRACP, FAHMS from the Peter MacCallum Cancer Centre at the University of Melbourne, Melbourne, Australia, who outline the role of genetic testing in patients with breast cancer, genomic predictors of response and how a greater understanding of genomics can inform treatment approaches.

The Breast Cancer Podcasts on VJOncology are supported by Seagen. Seagen have no influence over the production of the content.

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The Lung Cancer Sessions: highlights from IASLC WCLC Feb 18, 2021

Show notes

VJOncology has assembled an international panel of leading experts in lung cancer and mesothelioma to bring you the key highlights from the IASLC World Conference on Lung Cancer (WCLC), which was held virtually in January 2021.

Daniel Tan (National Cancer Centre Singapore, Singapore) is joined by Melissa Johnson (Sarah Cannon Research Institute, TN) and Dean Fennell (University Hospitals of Leicester NHS Trust, UK), who offer their perspectives on the exciting data and what research could change practice in the future.

Tune in to this podcast to learn about the latest advances in KRAS G12C inhibitors, antibody-drug conjugates and anti-TIGIT antibodies, as well as the most promising neoadjuvant therapeutic strategies being studied. The panel also consider the use of biomarkers for evaluating response to immunotherapy and the importance of lung cancer screening programs.

The post The Lung Cancer Sessions: highlights from IASLC WCLC appeared first on VJOncology.

The GI Cancer Sessions: Highlights from ASCO GI 2021 Feb 12, 2021

Show notes

The virtual American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium 2021 brought together leading experts in GI cancer who updated the community on the latest data and hot topics in the field.

In this podcast, Tobias Arkenau, MD, PhD, Sarah Cannon Research Institute UK, London, UK, chairs an insightful panel discussion on the some of exciting developments presented at ASCO GI 2021 in colorectal, gastric and bile duct cancer. He was joined by Lizzy Smyth, MD, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK, Nataliya Uboha, MD, PhD, University of Wisconsin, Madison, WI and Kai-Keen Shiu, FRCP, PhD, University College London Hospitals NHS Foundation Trust, London, UK.

Hear the expert panel offer their perspectives on pembrolizumab in colorectal cancer & KEYNOTE-177, the latest studies evaluating therapies targeting FGFR2 and HER2 in both gastric cancer and cholangiocarcinoma, CAR-T advances in GI cancer and how the gut microbiome could be used to predict response to immune-checkpoint blockade.

The post The GI Cancer Sessions: Highlights from ASCO GI 2021 appeared first on VJOncology.

The Breast Cancer Sessions: Highlights from SABCS 2020 Jan 25, 2021

Show notes

The virtual San Antonio Breast Cancer Symposium (SABCS) 2020 brought together leading experts in breast cancer who updated the community on the latest data and hot topics in the field.

In this podcast, Erika Hamilton, MD, Sarah Cannon Research Institute, Nashville, TN, speaks to Matteo Lambertini, MD, PhD, University of Genova, IRCCS Ospedale Policlinico San Martino, Genova, Italy and Sibylle Loibl, MD, PhD, German Breast Group, Neu-Isenburg, Germany to discuss the latest advances.

The expert panel offer their highlights from SABCS 2020, including the latest trials evaluating CDK4/6 inhibitors in early breast cancer, weighing up the reported data from PENELOPE-B, monarchE and PALLAS and what this means for HR+/HER2- early-stage breast cancer. They also discuss the RxPONDER data and the subgroup analysis based on menopausal status and what it may tell us about adjuvant chemotherapy in these patient populations. The panel also consider the range of immunotherapies being studied in breast cancer and how they plan to determine which chemotherapy backbone to combine with each immune checkpoint inhibitor. Other highlights include the safety of pregnancy after breast cancer and the importance of randomized phase III trials.

The post The Breast Cancer Sessions: Highlights from SABCS 2020 appeared first on VJOncology.

SABCS 2020 highlights: immunotherapy, novel agents & trial updates Jan 08, 2021

Show notes

In December, the San Antonio Breast Cancer Symposium (SABCS) 2020 convened virtually and featured key updates in the treatment and management of breast cancer, including the latest data in immune-oncology, novel targeted therapies, and many highly anticipated trial updates.

In this podcast, Sangeetha Reddy, MD, of UT Southwestern Medical Center, Dallas, TX, Bora Lim, of The University of Texas MD Anderson Cancer Center, Houston, TX, and Matteo Lambertini, MD, PhD of IRCCS AOU San Martino (Ospedale Policlinico San Martino), Genova, Italy, discuss treatment approaches in breast cancer, including the latest trial data, as well as immunotherapy and targeted agents currently being explored in this patient population.

The Breast Cancer Podcasts on VJOncology are supported by Seagen. Seagen have no influence over the production of the content.

The post SABCS 2020 highlights: immunotherapy, novel agents & trial updates appeared first on VJOncology.

Key trial updates at SABCS 2020: monarchE, RxPONDER & ASCENT Dec 15, 2020

Show notes

The San Antonio Breast Cancer Symposium (SABCS) 2020 annual meeting took place virtually this year and showcased recent advances in the treatment and management of breast cancer.

In this podcast, Priya Rastogi, MD, of the University of Pittsburgh, Pittsburgh, PA, Sara M. Tolaney, MD, MPH, of the Dana-Farber Cancer Institute, Boston, MA, and Sara Hurvitz, MD, of Ronald Reagan UCLA Medical Center, Los Angeles, CA, outline key trial updates presented at SABCS 2020, including the primary outcome results of the monarchE study (NCT02107703), the practice-changing findings of RxPONDER (NCT01272037), and the updated biomarker analysis of the ASCENT study (NCT02574455). This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).

The post Key trial updates at SABCS 2020: monarchE, RxPONDER & ASCENT appeared first on VJOncology.

Updates in non-small cell lung cancer from ESMO Nov 03, 2020

Show notes

Significant advances have been made in the treatment of non-small cell lung cancer (NSCLC), the most common form of lung cancer. The latest trial updates in oncogene-targeted therapy for patients with advanced ALK-positive NSCLC were presented during the European Society for Medical Oncology (ESMO) 2020 Virtual Congress.

In a planned interim analysis of the Phase III CROWN trial, lorlatinib significantly improved progression-free survival compared with crizotinib. Additionally, insights from sub-analyses of the Phase III ALTA 1L study support the evidence of intracranial efficacy with brigatinib for patients with ALK-positive NSCLC as well as associated quality of life data.

In this podcast, Sanjay Popat, BSc, MBBS, FRCP, PhD, The Royal Marsden NHS Foundation Trust, London, details recent results of both the CROWN and ALTA-1L trials and sheds light on new potential NSCLC front-line treatments.

This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).

The post Updates in non-small cell lung cancer from ESMO appeared first on VJOncology.

Highlights from EADO 2020: novel therapies, neoadjuvant approaches & COVID-19 Oct 29, 2020

Show notes

The 16^th European Association of Dermato-Oncology (EADO) meeting took place virtually this year and provided an opportunity to hear from worldwide recognized experts in the field of skin cancers and melanoma, as well as the impact of the COVID-19 pandemic on cancer care.

In this podcast, Michael Postow, MD, of Memorial Sloan Kettering Cancer Center, New York, NY, Alexander van Akkooi, MD, PhD, of Netherlands Cancer Institute, Amsterdam, The Netherlands, and Bettina Ryll, MD, PhD, of the Melanoma Patient Network Europe, Uppsala, Sweden, discuss novel therapies in melanoma, neoadjuvant approaches and the impact of COVID-19 on the treatment and management of skin cancers in Europe. This interview was recorded via an online conference call with The Video Journal of Oncology (VJOncology).

The post Highlights from EADO 2020: novel therapies, neoadjuvant approaches & COVID-19 appeared first on VJOncology.

The Lung Cancer Sessions: learnings from the ESMO 2020 Science Weekend Oct 14, 2020

Show notes

The European Society for Medical Oncology (ESMO) 2020 Virtual Congress brought together leading experts in oncology who updated the community on the latest data and hot topics in many disease areas, including lung cancer.

In this podcast, Solange Peters, MD, PhD, University Hospital Vaudois, Lausanne, Switzerland, Martin Reck, MD, PhD, German Center of Lung Research, Grosshansdorf, Germany and Sanjay Popat, BSc, MBBS, FRCP, PhD, The Royal Marsden NHS Foundation Trust, London, UK, discuss the latest advances in oncogene-targeted therapy in the first-line treatment of patients with advanced ALK-positive non-small cell lung cancer (NSCLC), reviewing data from the CROWN, ALEX and ALTA-1L studies. The panel also discusses the latest data presented from the ADAURA study in patients with resected EGFR-mutated NSCLC, as well as the outcomes from the LungART study, and the impact of the data presented for guidelines going forward in post-operative radiotherapy in NSCLC. Finally, our expert panel concludes the session by outlining to the latest immuno-oncology updates in NSCLC and small cell lung cancer (SCLC).

The post The Lung Cancer Sessions: learnings from the ESMO 2020 Science Weekend appeared first on VJOncology.

The ONS/EONS Congress Roundtable Discussion with VJOncology and OncoAlert Sep 10, 2020

Show notes

The treatment of cancer continues to evolve rapidly, with expanded therapeutic options and changes to clinical practice. Additionally, the care of patients with cancer has been complicated in 2020 by the COVID-19 pandemic. Oncology nurses are at the forefront of cancer care, looking after patients and their carers day-to-day. It is therefore vital to share information and educate nurses to maintain their knowledge and skills, to ensure the best care for their patients.

In this podcast, Gilberto Morgan, MD, Skåne University Hospital, Lund, Sweden, chairs a thoughtful discussion with Darcy Burbage, DNP, RN, AOCN, CBCN, Oncology Clinical Nurse Specialist, Director-at-Large, Oncology Nursing Society, Christine Ladd, MSN, RN, OCN, Patient Care Services, Sentara Norfolk General & Sentara Independence Infusion Centers, VA, and Helena Ullgren, ONS, MSc Palliative care, PhD Student, Karolinska University Hospital and Regional Cancer Center, Stockholm-Gotland, Sweden, on the most important updates and the latest research in oncology nursing and how it all affects Medical Oncologists. The topics covered include innovative approaches to improve patient care, precision medicine, COVID-19 and cancer care, and supporting informal caregivers.

The post The ONS/EONS Congress Roundtable Discussion with VJOncology and OncoAlert appeared first on VJOncology.

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