VJOncology Podcast

Latest Episodes:

Evolving role of ctDNA in breast cancer Oct 26, 2022

Show notes

With the advent of next-generation sequencing technologies, circulating tumor DNA (ctDNA) has now become an important player in the diagnosis, treatment, and management of breast cancer. In early breast cancer, the clearance of ctDNA is associated with improved pathological complete response following neoadjuvant therapy and may be important in treatment selection in patients with advanced disease. Continued efforts will likely lead to improvements in the use of liquid biopsy approaches and widespread routine clinical practice.

In this podcast, we will hear from Oleg Gluz, MD, Evang. Krankenhaus “”Bethesda”” Klinik, Mönchengladbach, Germany, Marla Lipsyc-Sharf, MD, Dana-Farber Cancer Institute, Boston, MA, and Michail Ignatiadis, MD, PhD, Institut Jules Bordet who explore the use of ctDNA in breast cancer.

The Breast Cancer Podcasts on VJOncology are supported by Seagen. Seagen have no influence over the production of the content.

The post Evolving role of ctDNA in breast cancer appeared first on VJOncology.

Updates in Immuno-Oncology from ITOC 2022 Oct 24, 2022

Show notes

The Immunotherapy of Cancer Conference (ITOC) 2022 brought together experts in the field of immuno-oncology to hear the latest findings and discuss how to advance oncology drug development and delivery.

In this podcast, we hear from Prof. Mascha Binder (Martin-Luther-Universität Halle-Wittenberg, Halle, Germany) discussing whether it is beneficial to combine immunotherapy with chemotherapy and Professor Chong Xian (Harvard Medical School, Boston, MA) on the pan synergistic antitumor activity of pan-PI3K inhibition and immune checkpoint blockade in bladder cancer. We also hear from Professor Sebastian Kobold (Ludwig-Maximilians-Universität München, Munich, Germany), Thaddäus Strzalkowski (Ludwig-Maximilians-Universität München, Munich, Germany) and Florian Markle (Ludwig-Maximilians-Universität München, Munich, Germany) discussing various approaches to overcoming the challenges associated with CAR-T cells in solid tumors.

The post Updates in Immuno-Oncology from ITOC 2022 appeared first on VJOncology.

ESMO 2022: Updates in Sarcoma Oct 14, 2022

Show notes

The European Society for Medical Oncology Annual Meeting 2022 brought together thousands of experts in oncology to hear new data and discuss how to improve the diagnosis and treatment of patients with cancer.

In this podcast, we hear from some of the leading experts in sarcoma, as they discuss the biggest trials and hot topics from the meeting.

Tom Wei-Wu Chen (National Taiwan University Hospital, Taipei, Taiwan), discusses biomarker analyses from the LEADER (NCT03526679) trial, which investigated lenvatinib plus eribulin for patients with leiomyosarcoma and liposarcoma. Patrick Schöffski (KU Leuven, Leuven, Belgium) discusses recent advances in the management of soft tissue sarcoma (STS), and Erlinda Gordon (Cancer Center of Southern California/Sarcoma Oncology Center, Santa Monica, CA) explains the rationale of using the combination therapy of ipilimumab plus nivolumab plus trabectedin in the first-line for patients with advanced leiomyosarcoma. Lastly, Radwa Sharaf (Foundation Medicine Inc, Cambridge, MA) provides an overview of an investigation into genomic determinant of high telomeric content beyond the canonical ATRX/DAXX alterations in sarcoma.

The post ESMO 2022: Updates in Sarcoma appeared first on VJOncology.

GI Cancer Sessions: ESMO Highlights with Geoffrey Ku and Sam Klempner Oct 12, 2022

Show notes

Following an exciting day at the ESMO 2022 meeting in Paris, France, leading gastrointestinal cancer experts get together to share their highlights. Join Geoffrey Ku and Sam Klempner as they dissect key updates in upper GI cancer. Topics covered include updates from DESTINYGastric-02 (NCT04014075) and MOONLIGHT (NCT03647969), as well as discussions on the optimal use of immunotherapy for patients with upper GI cancers. We also hear about research into potential novel biomarkers that could help with overcoming the immunosuppressive tumor microenvironment.

The post GI Cancer Sessions: ESMO Highlights with Geoffrey Ku and Sam Klempner appeared first on VJOncology.

Breast Cancer Sessions: Highlights from ESMO 2022 with Elisa Agostinetto & Evandro de Azambuja Oct 10, 2022

Show notes

The European Society for Medical Oncology (ESMO) Annual Meeting, showcased an array of updates in breast cancer care and management, including updates on pivotal trials in the early and metastatic breast cancer settings.

In this podcast, we hear from leading experts, Elisa Agostinetto and Evandro de Azambuja (Jules Bordet, Brussels, Belgium) who discuss the latest advances in breast cancer from ESMO 2022. In hormone receptor-positive HER2-negative breast cancer, overall survival results from the TROPiCS-02 study (NCT03901339) evaluating sacituzumab govetican, and MONARCH-3 (NCT02246621) investigating the addition of abemaciclib is discussed. In addition, findings from the DATA trial (NCT00301457), which evaluated whether extended adjuvant endocrine therapy was associated with significant benefit is discussed. In triple-negative breast cancer, the findings from SYNERGY (NCT03616886) and BELLINI (NCT03815890) trials are also considered, which aim to improve understanding of the role of immunotherapy in breast cancer.

This discussion took place at the European Society for Medical Oncology (ESMO) 2022 Annual Meeting, in Paris, France.

The post Breast Cancer Sessions: Highlights from ESMO 2022 with Elisa Agostinetto & Evandro de Azambuja appeared first on VJOncology.

ESMO 2022: Updates in Colorectal Cancer Sep 30, 2022

Show notes

In this podcast, we hear from some of the leading experts in colorectal cancer, as they discuss the biggest trials and hot topics from the meeting. Dr Sartore-Bianchi discusses overcoming acquired resistance to targeted therapy in colorectal cancer, and Dr Cremolini talks on the influence of sidedness on prognosis and treatment of metastatic colorectal cancer. We also hear from Dr Fang discussing EpCAM-targeted CAR T-cell therapy for advanced colorectal cancer and Dr Cohen on real-world evidence on ctDNA reliably predicting recurrence in resected colorectal cancer. Finally, Prof. Stintzing, Prof. Strickler and Dr Orlandi share key colorectal cancer trial updates presented at the meeting.

The post ESMO 2022: Updates in Colorectal Cancer appeared first on VJOncology.

ESMO 2022: Updates in Breast Cancer Sep 26, 2022

Show notes

In this podcast, we hear from some of the leading experts in breast cancer, as they discuss the biggest trials and hot topics from the meeting. Dr Elisa Agostinetto discusses three of the biggest trials for metastatic breast cancer: TROPiCS02 (NCT03901339), MONARCH 3 (NCT02246621) and SYNERGY (NCT03616886). Prof. Fabrice Andre talks on the monarcHER trial (NCT02675231) and Dr Naoto Ueno explains the patient-reported outcome data from the DESTINY-Breast04 trial (NCT03734029).

The post ESMO 2022: Updates in Breast Cancer appeared first on VJOncology.

ESMO 2022 Daily Round-Ups: Day 4 Sep 12, 2022

Show notes

Catch up on our highlights from Day 4 of ESMO 2022!

We spoke to Toni Choueiri, Erika Hamilton, Jonathan Rosenberg, and Charles Swanton, among many more! Keep an eye on VJOncology for more interviews, podcasts, and roundtable discussions throughout the congress.

The post ESMO 2022 Daily Round-Ups: Day 4 appeared first on VJOncology.

ESMO 2022 Daily Round-Ups: Day 3 Sep 12, 2022

Show notes

Catch up on our highlights from Day 3 of ESMO 2022!

We spoke to Fabrice Andre, Fred Saad, and Solange Peters, among many more! Keep an eye on VJOncology for more interviews, podcasts, and roundtable discussions throughout the congress.

The post ESMO 2022 Daily Round-Ups: Day 3 appeared first on VJOncology.

ESMO 2022 Daily Round-Ups: Day 2 Sep 11, 2022

Show notes

Catch up on our highlights from Day 2 of ESMO 2022!

We spoke to Dirk Schadendorf, Bjorn Henning Gronberg, Oleg Gluz, and Shaheenah Dawood, among many more! Keep an eye on VJOncology for more interviews, podcasts, and roundtable discussions throughout the congress.

The post ESMO 2022 Daily Round-Ups: Day 2 appeared first on VJOncology.

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