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    Science & Medicine

    The Inner Workings of Cells, Winter 2008

    Cellular function lies at the root of all complex and simple biological systems. This course will expose you to the fundamental mechanisms that allow cells to maintain the system of proteins and biomolecules required for them to replicate with high fidelity, to maintain stable functional states, to differentiate in response to external cues and to ultimately form complex organizations of cells (i.e., tissues). We will apply an experimental approach to a classic problem in cell biology. We will master “blackboard” experimental techniques to allow us to explore the remarkable transformation of a monolayer of cells after being “wounded.” Under such conditions, cells surrounding the wound change their organization and programming in order to migrate, divide, and differentiate to fill in the wound.

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    Copyright: © Copyright The Regents of the University of California, Davis campus, 2010. All Rights Reserved.

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    Latest Episodes:
    Protein Movement Jan 30, 2008
    Show notes

    Lecture 10: In this continued discussion on protein translocation, Kaplan gives emphasis to glycosylation and the Scavenger pathway.

    Protein Movement Jan 28, 2008
    Show notes

    Lecture 09: Kaplan discusses the secretory pathway, with emphasis on protein targeting and translocation.

    Secretory Pathway Jan 25, 2008
    Show notes

    Lecture 08: Kaplan talks about how various proteins are directed to certain areas within the cell and to the plasma membrane.

    Membrane Proteins Jan 23, 2008
    Show notes

    Lecture 07: Kaplan discusses the various classes of membrane proteins and movement of molecules across the membrane.

    Membrane Reactions Jan 18, 2008
    Show notes

    Lecture 06: This is a continued discussion of cellular membranes and their various functions in biochemical reactions.

    Cell Membranes Jan 16, 2008
    Show notes

    Lecture 05: This class wraps up of tools to study complex cellular behavior (including microscopy), and introduces membrane proteins.

    Subcellular Fractionation Jan 14, 2008
    Show notes

    Lecture 04: How to use subcellular fractionation and other techniques to study complex cellular processes and molecules.

    Antibodies Jan 11, 2008
    Show notes

    Lecture 03: This class reviews what characteristics a gene needs to be "necessary and sufficient." A discussion of antibodies and their application to various techniques of cell biologists.

    Goals of Cell Biology Jan 09, 2008
    Show notes

    Lecture 02: Goals of cell biologists and the overall course plan are discussed and students introduced to the question of how to study cells.

    Class Overview Jan 07, 2008
    Show notes

    Lecture 01: Kaplan discusses class mechanics, student questions and the central questions of cell biology.

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