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    Science & Medicine

    The Inner Workings of Cells, Winter 2008

    Cellular function lies at the root of all complex and simple biological systems. This course will expose you to the fundamental mechanisms that allow cells to maintain the system of proteins and biomolecules required for them to replicate with high fidelity, to maintain stable functional states, to differentiate in response to external cues and to ultimately form complex organizations of cells (i.e., tissues). We will apply an experimental approach to a classic problem in cell biology. We will master “blackboard” experimental techniques to allow us to explore the remarkable transformation of a monolayer of cells after being “wounded.” Under such conditions, cells surrounding the wound change their organization and programming in order to migrate, divide, and differentiate to fill in the wound.

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    Copyright: © Copyright The Regents of the University of California, Davis campus, 2010. All Rights Reserved.

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    Latest Episodes:
    Microtubles and Cell Motility Feb 27, 2008
    Show notes

    Lecture 20: Kaplan wraps up of the cytoskeleton, relation of microtubles to cell motility, introduction to cell division.

    Microtubules Feb 25, 2008
    Show notes

    Lecture 19: In this class, microtubule dynamics and stability and how these aspects of microtubules are controlled to produce energy and force for processes such as mitosis.

    Intermediate Filaments Feb 22, 2008
    Show notes

    Lecture 18: In a continued discussion of intermediate filaments, Kaplan talks about their relation to other cytoskeletal filaments and microtubule dynamics.

    Intermediate Filaments Feb 20, 2008
    Show notes

    Lecture 17: This class covers actin polymerization, and an introduction to other parts of the cytoskeleton, such as the intermediate filaments.

    Filament Dynamics Feb 15, 2008
    Show notes

    Lecture 16: Kaplan continues talking about actin, how it can lead to cell motility, as well as how it and other filament dynamics are regulated within the cell.

    Cell Movement Feb 13, 2008
    Show notes

    Lecture 15: Kaplan discusses how cytoskeletal elements of a cell are involved in cell movement, such as actin.

    Review for Midterm 1 Feb 10, 2008
    Show notes

    Review for Midterm 1: This class covers cell biology techniques, cell compartmentalization, cell membranes, the secretory pathway and protein trafficking.

    Review of Protein Trafficking Feb 08, 2008
    Show notes

    Lecture 14: The professor wraps up protein trafficking and non-secretory transport.

    Vesicular Transport Feb 04, 2008
    Show notes

    Lecture 12: Kaplan gives an in-depth discussion of in-vitro coupled translation and translocation.

    ER Reactions Feb 01, 2008
    Show notes

    Lecture 11: Kaplan reviews glycosylation and gives an in-depth look at the work done to understand protein translocation and examples of protein trafficking.

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