The Human Upgrade: Biohacking for Longevity & Performance

Latest Episodes:

The Foods That Starve Cancer | William Li : 1481 Jun 09, 2026

Show notes

Dr. William Li: Eat to Beat Disease, Extend Longevity, and Hack Your Vascular Health

Your body already has a built-in cancer defense system, and the foods you eat can rival prescription drugs at activating it. In this episode, you'll discover what 720,000 living centenarians reveal about longevity, why microplastics are reaching your brain through your nose, and how your blood vessels hold the real key to biological aging.

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with Dr. William Li, an internationally renowned physician, scientist, and two-time New York Times bestselling author of "Eat to Beat Disease" and "Eat to Beat Your Diet." As President and Medical Director of the Angiogenesis Foundation, Dr. Li's groundbreaking research has led to the development of more than 40 new medical treatments impacting care for over 70 diseases including diabetes, heart disease, blindness, and obesity. His TED Talk, "Can We Eat to Starve Cancer?", has surpassed 11 million views, making him one of the most trusted voices at the intersection of functional medicine and food as medicine science.

Together they dig into the biology of SuperAgers, the vascular markers that predict how long you'll live, and why flow-mediated dilation may be the most underrated biohacking measurement tool available today. Dave shares what happened after four separate gene therapies, including klotho and VEGF, and Dr. Li explains why your metabolism, mitochondria, and gut microbiome show up in the data on every centenarian ever studied. They also get into the microplastic crisis, the cribriform plate pathway that delivers airborne particles directly to your brain, and why your tongue is the first place your body quietly stores fat.

You'll Learn:

What centenarian research reveals about immune function, gut health, and vascular resilience
Why 50% of food extracts matched or outperformed cancer drugs in head-to-head angiogenesis testing
How microplastics travel through your nose directly to your central nervous system
What flow-mediated dilation and pulse wave velocity tell you about your true biological age
Why your hind-third tongue fat is an overlooked early warning sign for sleep apnea and metabolism problems
What Dave's four gene therapies (klotho, VEGF, follistatin) actually did to his body
How the vagus nerve connects gut health to brain optimization, stress resilience, and longevity
Why genetics now accounts for roughly half of longevity outcomes, and what that means for the future of gene therapy
How to use biohacking tools to compound your health the same way you compound financial returns

Thank you to our sponsors!

- Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com.

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- Calroy | Go to Calroy.com/DAVE for exclusive discounts on Arterosil HP, Vascanox HP and all Calroy products.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: William Li, Dr. William Li, Eat to Beat Disease, angiogenesis, food as medicine, centenarians, SuperAgers, longevity, anti-aging, biohacking, vascular health, flow-mediated dilation, pulse wave velocity, microplastics, cribriform plate, gene therapy, klotho, VEGF, follistatin, mitochondria, metabolism, gut health, vagus nerve, sleep apnea, functional medicine, human performance, brain optimization, cancer prevention, inflammation, immune system

Resources:

• Learn More About Dr. Li’s Work At: https://drwilliamli.com

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/

• Upgrade Labs: https://upgradelabs.com

Timestamps:

00:00 – Trailer

02:33 – William's Background

06:21 – Food vs. Cancer Drugs

14:09 – Gene Therapy

23:50 – Centenarian Research

27:41 – Stress & the Vagus Nerve

37:31 – Vascular Health

42:34 – Microplastics

53:19 – Novel Biomarkers

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I Drink Fat To Look Shredded (Lost 100lbs) : 1480 Jun 07, 2026

Show notes

I used to weigh 300 pounds. I tried every restrictive diet, became a vegan, and trained 90 minutes a day for 18 months with absolute zero results. Everything changed when I drank a cup of yak butter tea at 18,300 feet in Tibet. Within 30 seconds, my severe brain fog lifted, and my metabolism completely shifted.

In this video, I break down exactly why adding sugar to your morning coffee is destroying your metabolism, spiking your insulin, and keeping you fat. I explain the hard science behind the alternative: blending "fat cubes" (grass-fed butter) and MCT oil into your coffee. I reveal how this specific combination of butyrate, CLA, and medium-chain triglycerides bypasses traditional digestion to go straight to your liver, instantly converting into ketones for pure brain fuel. You'll learn how eating more fat actually trains your body to burn its own stored fat, allowing me to hit 4.8% body fat at 50 years old with a biological age in my 30s—without hunger, without a 3 PM crash, and without living in the gym.

Thank you to our sponsors!

Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today
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iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

Timestamps:

0:00 – Intro

00:42 – Pancreatic Cancer Halted by Virus Injection

01:44 – Teens & AI Therapy Chatbots

03:13 – GLP-1 Drugs Cut Breast Cancer Risk

04:30 – Russia's $26B Longevity Program

06:18 – Sauna vs. Cold Plunge

09:10 – Closing

Connect with Dave Asprey!

Website: https://daveasprey.com

TikTok: https://www.tiktok.com/@daveaspreyofficial

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YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Danger Coffee: https://dangercoffee.com/DAVE15

Dave Asprey’s BEYOND Conference: https://beyondconference.com/

Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

Upgrade Labs: https://upgradelabs.com

40 Years of Zen: https://40yearsofzen.com

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Putin Longevity, Pancreatic Cancer Cure, AI Therapy, GLP-1 Breast Cancer... : 1479 Jun 05, 2026

Show notes

Pancreatic Cancer Halted by Virus Injection

Researchers injected an engineered virus directly into pancreatic tumors in three patients — the virus replicated inside malignant cells, triggered an immune response, and stopped tumor growth and spread at an intentionally low early dose. Host Dave Asprey breaks down why oncolytic viruses can do what chemotherapy can't, how the tumor's dense biological wall becomes less of an advantage when a virus can replicate inside it directly, and why a measurable response at a safety dose is the kind of early signal that changes how he's watching this field.

Sources:

https://www.newscientist.com

AI Chatbots and Teen Mental Health

A new survey shows roughly one in five adolescents and young adults are now going to AI chatbots when they feel sad, anxious, nervous, or stressed, with usage heaviest in the 18–21 range. Host Dave Asprey explains why general-purpose language models designed to be engaging are dangerous as a substitute for real mental health support, why false reassurance from a chatbot may make the pipeline to real care harder to reach, and why this is a health systems story masquerading as a tech adoption story — and what parents need to do about it.

Sources:

https://www.nbcnews.com

GLP-1 Drugs Cut Breast Cancer Risk

Penn Medicine published a retrospective analysis of over 111,000 women finding GLP-1 exposure associated with about 35% lower odds of breast cancer in the full cohort and around 30% lower in a matched comparison group. Host Dave Asprey breaks down why this isn't just a weight loss story — it's a metabolic dysfunction story — explains the insulin resistance, inflammation, and hormonal environment mechanisms that may be driving the signal, and makes the case that this finding should be reshaping how oncologists and OBGYNs think about high-risk patients right now.

Sources:

https://www.pennmedicine.org

Putin's $26 Billion Longevity Program

The Wall Street Journal reports that Russia has made anti-aging research a Kremlin-level national priority through a $26 billion program including gene therapy, organ bioprinting, and xenotransplantation, led by Putin's daughter Maria Vorontsova and physicist Mikhail Kovalchuk. Host Dave Asprey breaks down what's geopolitical theater, what's legitimately frontier science, and why the real question is whether any findings will make it out to the broader research community or get locked inside a state program.

Sources:

https://www.wsj.com https://www.france24.com

Sauna vs. Cold Plunge

A landmark Finnish study tracked over 2,300 men for nearly 21 years and found increasing sauna frequency associated with dramatically lower cardiovascular and all-cause mortality — strongest at four or more sessions per week. Host Dave Asprey settles the debate with the actual data, explains what heat shock proteins and cold shock proteins actually are and why the evidence base behind them is nowhere near equivalent, and calls out the wellness marketing presenting early-stage mouse model research as the cold water equivalent of two decades of human mortality outcomes.

Sources:

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2521522

This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on cancer treatment breakthroughs, adolescent mental health and AI, metabolic drivers of disease, geopolitical longevity science, and the real evidence behind popular recovery modalities. Host Dave Asprey connects emerging clinical research, objective epidemiological data, and real-world optimization protocols into actionable frameworks for extending healthspan, sharpening performance, and staying ahead of the science.

New episodes every Tuesday, Thursday, Friday, and Sunday.

Keywords: oncolytic virus pancreatic cancer, engineered virus tumor treatment, AI chatbot teen mental health, adolescent AI emotional support, GLP-1 breast cancer risk, semaglutide cancer prevention, metabolic dysfunction root cause disease, Putin longevity program Russia, New Health Preservation Technologies, anti-aging biotech geopolitics, sauna longevity mortality data, cold plunge cold shock proteins, RBM3 heat shock proteins, sauna vs cold plunge evidence, biohacking news 2026, longevity research, Dave Asprey, The Human Upgrade

Thank you to our sponsors!

- Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today

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- iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

Resources:

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/

• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/

• Upgrade Labs: https://upgradelabs.com

Timestamps:

00:00 – Intro

00:42 – Pancreatic Cancer Halted by Virus Injection

01:44 – Teens & AI Therapy Chatbots

03:13 – GLP-1 Drugs Cut Breast Cancer Risk

04:30 – Russia's $26B Longevity Program

06:18 – Sauna vs. Cold Plunge

09:10 – Closing

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

How to Get Microplastics Out of Your Body | Mara Labs : 1478 Jun 04, 2026

Show notes

Sulforaphane, Detox Pathways, and the Science of Microplastic Removal

Microplastics are building up inside your brain, blood, and reproductive tissue, and most detox protocols do nothing to remove them. This episode gives you the cellular science behind why toxins accumulate, which three detox pathways control your ability to excrete them, and what the latest research shows actually moves microplastics, heavy metals, BPA, and benzene out of your body..

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

-For next week, 25% off all Mara Labs products when you go to www.mara-labs.com/DAVE and use code DAVE at checkout. After June 11th, the code will return to the standard 15% off.

Host Dave Asprey sits down with Dr. John Gildea, a Johns Hopkins-trained PhD with 60 scientific publications and over 20 NIH-funded studies, and David Roberts, co-founder of Mara Labs and co-creator of BrocElite, the only naturally derived stable form of sulforaphane available in a capsule. Together they bring decades of research-backed biohacking and functional medicine insight into one of the most pressing longevity conversations of our time.

They break down the lysosome, your cell's built-in incinerator, and explain exactly why it gets clogged with microplastics, advanced glycation end products, and other toxins that won't break down. New research shows that sulforaphane triggers a process called lysosomal surface translocation, which releases those trapped particles so your body can finally excrete them. An in-house Mara Labs study confirmed the excretion pathway: microplastics come out in feces. In the original study, the individual measured the highest microplastic levels ever recorded, and a repeat study a year later showed dramatically lower baseline microplastic levels, suggesting consistent use compounds the benefit over time.

You'll Learn:

Why microplastics accumulate inside lysosomes and what sulforaphane does to release them
How the three detox pathways, glutathione, glucuronidation, and sulfation, work together to remove every major class of toxin
What an in-house study revealed about how and where microplastics actually leave the body
How toxic estrogen metabolites form and why sulforaphane is the most effective natural tool to reroute them
Why berberine supports sleep optimization, ketosis, and blocks a cancer growth pathway most drugs cannot touch
How sulforaphane boosts BDNF and neuroplasticity at the cellular level
What microplastic sources in your home, including your dryer, rugs, and receipts, are doing to your toxin load daily
Why losing weight releases stored toxins and what to take to protect your brain and metabolism during fat loss
How sulforaphane activates the same AMPK longevity pathways triggered by fasting without restricting food

Thank you to our sponsors!

- iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

- HeartMath | Go to https://www.heartmath.com/dave to save 15% off.

- Timeline | Go to timeline.com/dave and you’ll get an additional 20% off your first month

- Our Place | Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Dr. John Gildea, David Roberts, Mara Labs, BrocElite, sulforaphane, microplastics, microplastic removal, lysosome, lysosomal surface translocation, detox pathways, glutathione, glucuronidation, sulfation, Nrf2 pathway, AMPK, TFEB1, BDNF, neuroplasticity, heavy metals, BPA, benzene, estrogen metabolism, toxic estrogen, xenoestrogens, berberine, BerbaLite, ResveraLite, c-Myc, cancer and estrogen, sleep optimization, ketosis, broccoli sprouts, isothiocyanates, PEITC, watercress, phase two detox, microplastic excretion, indoor air quality, HEPA filter, dryer lint microplastics, BPA receipts, endocrine disruptors, fat loss and toxins, autism and sulforaphane, ADHD and focus, vivid dreams and BDNF, fasting mimicry, anti-aging, biohacking, longevity, functional medicine, supplements, human performance, brain optimization, metabolism, cellular detox

Resources:

• For next week, 25% off all Mara Labs products when you go to www.mara-labs.com/DAVE and use code DAVE at checkout. After June 11th, the code will return to the standard 15% off.

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/

• Upgrade Labs: https://upgradelabs.com

Timestamps:

0:00 – Trailer

1:55 – Intro & Context

4:48 – Microplastics & Sulforaphane

12:39 – Broccoli Sprouts Formulation

15:20 – Lab Origin Story

26:01 – Reducing Toxin Exposure

37:06 – Estrogen, Hormones & Berberine

52:46 – Autism, ADHD & Brain Health

59:01 – Wrap-Up

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Peptide Power Without Needles: Smarter Dosing for Longevity | Justin Kirkland : 1477 Jun 02, 2026

Show notes

Needle-Free Peptides, US Manufacturing, BPC-157, Thymosin Alpha-1, GLP-1s, Microneedle Patches, and How to Avoid Contaminated Peptides

Peptides are one of the most powerful tools in biohacking and anti-aging medicine, and until now, most people couldn't access them safely, legally, or without a needle. This episode changes that.

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

-Go to Aminoinnovations.com and use “asprey20” for a discount through the next 7 days

Host Dave Asprey sits down with Justin Kirkland, a longevity medicine expert with over 30 years in drug development and pharmaceutical innovation. Kirkland holds multiple drug synthesis and formulation patents, has founded multiple pharmaceutical companies, and is one of the few people in the world manufacturing peptides entirely on US soil, controlling every step of the synthesis process from raw amino acids to finished product. If you want to understand what is really inside your peptides and why it matters for your longevity and human performance, he is the person to listen to.

Dave and Justin go deep on why most peptides on the gray market contain dangerous residual compounds that can spike liver enzymes and cause real harm, why Chinese-sourced APIs are not always what they claim to be, and how a new generation of needle-free delivery systems including microneedle patches and auto-injectors is making peptide therapy accessible to anyone serious about longevity and human performance. They also cover how AI and functional medicine are converging to make peptide protocols personalized based on genetics and microbiome status, why the thymus gland is one of the most overlooked anti-aging targets in the body, and what the suppression of peptide research reveals about who really controls your access to health tools.

You Will Learn:

Why many gray market peptides contain toxic residual acids that damage the liver and how to identify clean products
How microneedle patches and auto-injectors are replacing traditional injections for peptide delivery
Which peptides are most effective for longevity, immune system repair, and human performance including BPC-157, Thymosin Alpha-1, and growth hormone secretagogues
Why your genetics and gut microbiome determine whether a peptide will work for you at all
How the thymus gland controls your immune system and why it disappears by your mid-20s
What the suppression of peptide research tells you about Big Pharma's control over your supplement and nootropics access
Why US-manufactured peptides represent a new standard for safety and quality in biohacking
How AI is transforming personalized peptide protocols in functional medicine
Which peptides are overhyped and which ones actually move the needle on anti-aging and recovery
How to store, mix, and dose peptides correctly to avoid the mistakes most people using them are making right now

Thank you to our sponsors!

- Danger Coffee | Grab yours at DangerCoffee.comand use code DAVEPOD at checkout for 15% off.

- The One Device | Use code DAVE for $10 off at theonedevice.com/dave

- Fatty15 is on a mission to support Healthy Aging for All, including all ages and stages of life. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com DAVE and using code DAVE at checkout.

- ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to ENERGYbits.com and use code ASPREY for 20% off your order.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Justin Kirkland, peptides, needle-free peptides, microneedle patch, BPC-157, Thymosin Alpha-1, ipamorelin, CJC-1295, PT-141, KPV peptide, Dihexa, growth hormone secretagogue, peptide purity, TFA contamination, gray market peptides, US manufactured peptides, oral peptides, transdermal delivery, thymus gland, anti-aging, biohacking, longevity, functional medicine, peptide auto-injector, compounding pharmacy

Resources:

• Go to Aminoinnovations.com and use “asprey20” for a discount through the next 7 days

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/

• Upgrade Labs: https://upgradelabs.com

Timestamps:

00:00 – Intro & Guest Welcome

01:55 – Censorship & Platform Bans

06:20 – Peptide Science & Bioavailability

07:20 – Delivery Methods

14:30 – Supply Chain & US Manufacturing

17:01 – Manufacturing Risks & Contamination

24:43 – Peptide Stacks

28:41 – Immune Peptides & Thymus

30:57 – Overhyped Peptides

41:00 – Alternative Delivery (Patches, Nasal, Rectal)

47:25 – Side Effects & Risk

50:30 – Mixing & Storage Tips

54:05 – Wrap-Up & Where to Buy

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Brain Fog Starts in Your Feet (Scientifically Proven) : 1476 May 31, 2026

Show notes

I lived with severe brain fog for 15 years. I couldn't focus, my words didn't come easily, and I spent a fortune trying to fix it from the top down...little worked until I realized the problem wasn't in my head—it was in my feet.

In this video, I break down the scientifically proven connection between your feet, your circulation, and your cognitive decline. We cover how your brain requires a massive 20% of your body's oxygen to function, and why sitting at a desk all day weakens the calf muscles that act as a "second heart" to pump that oxygenated blood back up to your skull. I also explain how modern cushioned shoes act as sensory deprivation chambers, muffling the critical signals your feet send to your brain. This sensory lack forces your nervous system into a constant, low-level survival state that completely kills your executive function. You don't need another brain supplement to get your mental edge back. You need to fix your foundation. I share the exact barefoot walking and foot-strengthening protocols I used to lift the fog and restore my cognitive sharpness.

Thank you to our sponsors!

Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today
Essentia | Go to https://myessentia.com/daveand use code DAVE for $100 off The Dave Asprey Upgrade.
iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

Timestamps:

00:00 – Personal Experience

00:47 – Root Cause: Not in Your Head

01:05 – Blood Flow and Brain Function

02:10 – The Calf Pump

03:52 – Foot Sensory Signals

04:26 – Nervous System Impact

06:22 – How to Fix It

07:51 – Personal Results

Connect with Dave Asprey!

Website: https://daveasprey.com

TikTok: https://www.tiktok.com/@daveaspreyofficial

Instagram: https://www.instagram.com/dave.asprey/

Facebook: https://www.facebook.com/Daveaspreyofficial/

X: https://x.com/daveasprey

YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Danger Coffee: https://dangercoffee.com/DAVE15

Dave Asprey’s BEYOND Conference: https://beyondconference.com/

Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15

Upgrade Labs: https://upgradelabs.com

40 Years of Zen: https://40yearsofzen.com

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

NASCAR Death, Steroid Olympics, Genetic Age Truth, and Gut Depression... : 1475 May 29, 2026

Show notes

Enhanced Games Debut in Las Vegas as the First Openly Drug-Enabled "Biohacker Olympics"

The inaugural Enhanced Games took place in Las Vegas with more than 40 elite athletes competing openly while using performance-enhancing drugs, a $25 million prize pool, and a $1 million world record bonus on the table. Host Dave Asprey, who serves on the advisory board of the Enhanced Games, breaks down why this event is less a sports story than a cultural signal: enhancement has moved from underground to prime time, and the institutions that spent decades controlling that conversation through drug testing and bans watched it happen on a stage in Las Vegas. Dave explains why WADA has always existed to protect institutions rather than athletes, why bodily sovereignty is the real issue at the center of this debate, and what it means that even with full transparency about what every athlete was taking, the records didn't fall quite the way you'd expect. The Enhanced Games are the closest thing yet to a public beta test for extreme human enhancement, and the data it generates will matter far beyond sport.

Sources:

https://www.nytimes.com/athletic/7302319/2026/05/23/enhanced-games-athletes-world-records-doping-steroids/

https://www.npr.org/2026/05/24/nx-s1-5831252/enhanced-games-steroids-olympics-trump

https://www.bbc.com/news/articles/cedpz1zqp8po

https://www.wusf.org/2026-05-24/the-enhanced-games-are-sunday-heres-what-to-know-about-the-controversial-event

Kyle Busch's Death Showed How Severe Pneumonia Can Rapidly Escalate Into Fatal Sepsis

NASCAR driver Kyle Busch died after severe pneumonia progressed into sepsis, a condition most people hear about but few truly understand until it is too late. Host Dave Asprey breaks down the biology of what happens when the immune system stops containing an infection and starts attacking the body systemwide, why sepsis can escalate from manageable symptoms to a life-threatening emergency faster than most people expect, and why even someone with great biomarkers and a dialed-in health stack can be blindsided by an acute inflammatory crisis. The warning signs matter: worsening breathing, confusion, rapid decline, and a sense that something is badly wrong are emergency symptoms, not signals to wait and see. Longevity is not only about optimization rituals. It includes knowing when your biology is in crisis and acting before the window closes.

Sources:

https://www.cnn.com/2026/05/24/health/what-is-sepsis-kyle-busch-wellness

https://www.cnn.com/2026/05/26/health/video/sepsis-kyle-busch-medical-care-lead-jake-tapper

https://www.michiganmedicine.org/health-lab/nascar-stars-death-shows-how-sepsis-can-kill-anyone-if-not-caught

https://www.huffpost.com/entry/what-is-sepsis-kyle-busch_l_6a15a9c1e4b0ddcc84641f34

Menin Loss in the Hypothalamus May Be a Central Switch That Accelerates Aging

New research in mice found that a protein called Menin in the hypothalamus may function as a central coordinator of biological aging across the whole body. When Menin declined, aging accelerated. When researchers restored it in older mice, memory improved and lifespan increased. Host Dave Asprey explains why this finding challenges the dominant wear-and-tear model of aging, what it means that the hypothalamus may be running a coordinated aging program rather than simply accumulating damage over time, and why a control-room model of aging points toward fundamentally different intervention strategies than chasing downstream symptoms like fatigue and memory loss. The research connects aging to neuroinflammation, which has direct implications for how biohackers think about hypothalamic health right now. It is still animal research, but the mechanistic case is strong and the implications for longevity science are significant.

Sources:

https://www.sciencedaily.com/releases/2026/05/260524012959.htm

https://www.news-medical.net/news/20230323/Menin-protein-protects-against-aging-and-cognitive-decline.aspx

https://www.eurekalert.org/news-releases/982100

https://www.eurekalert.org/news-releases/1116021

IL-6 Blockade With Tocilizumab Showed Early Promise for Treatment-Resistant Depression

A small pilot randomized trial tested tocilizumab, an anti-inflammatory drug that blocks IL-6 signaling, in people with difficult-to-treat depression and found remission rates of 54% versus 31% with placebo. Host Dave Asprey breaks down why this result reframes depression as an immune biology problem for a meaningful subset of patients rather than a purely neurochemical one, and why the same inflammatory pathway that drives joint destruction in rheumatoid arthritis is showing up in the brains of people who don't respond to antidepressants. The practical implication is not to seek out a biologic drug off-label. It is to recognize that persistent low mood, fatigue, and low resilience may warrant a deeper biological workup than standard screening provides, starting with IL-6, CRP, and a full inflammatory panel. The brain is downstream of the immune system more than most psychiatry has been willing to admit, and this trial is the clearest evidence yet of why that matters.

Sources:

https://www.bristol.ac.uk/news/2026/may/pilot-trial-suggests-anti.html

https://www.eurekalert.org/news-releases/1128678

https://www.medicalxpress.com/news/2026-05-trial-anti-inflammatory-drug-difficult.html

https://clinicaltrials.gov/

New Science Paper Says Intrinsic Human Lifespan May Be About 50% Heritable

A paper published in Science argues that the genetic contribution to human lifespan is roughly 50% heritable, far higher than previous estimates, once researchers correct for deaths caused by accidents, infections, and external causes unrelated to aging biology. Host Dave Asprey explains why this finding is liberating rather than deterministic, what it means that genetics loads the dice on lifespan more than the mainstream has been willing to admit, and why personalized longevity strategy matters far more than generic population-level advice. Your genes load the dice but you still roll them. The study pushes the field toward genetic stratification and biomarker-based personalization, and it validates the core premise that the same intervention will not produce the same outcome in every person. Get your genetics tested and build your strategy from your own baseline, not from what worked for the average person in a study.

Sources:

https://www.science.org/doi/10.1126/science.adz1187

https://pubmed.ncbi.nlm.nih.gov/41610249/

https://www.nature.com/articles/d41586-026-00300-w

https://www.eurekalert.org/news-releases/1113892

This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on human enhancement, acute inflammatory risk, neuroendocrine aging, immune-driven depression, and the genetics of lifespan. Host Dave Asprey connects emerging clinical research, real-world performance culture, and actionable optimization frameworks into a clear picture of where biology actually drives outcomes and where most people are still managing symptoms instead of finding the mechanism.

New episodes every Tuesday, Thursday, Friday, and Sunday.

Keywords: Enhanced Games biohacking, performance enhancement bodily autonomy, WADA elite sport doping, Kyle Busch sepsis death, pneumonia sepsis escalation, sepsis warning signs, Menin hypothalamus aging, brain aging master switch, neuroendocrine aging longevity, tocilizumab depression IL-6, inflammation treatment-resistant depression, immune biology mental health, lifespan heritability genetics, longevity genetics personalization, genetic stratification healthspan, biohacking news 2026, longevity research 2026, healthspan optimization, inflammation testing CRP IL-6

Thank you to our sponsors!

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Resources:

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/

• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

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• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/

• Upgrade Labs: https://upgradelabs.com

Timestamps:

00:00 – Intro

00:38 – Story 1: Enhanced Games

01:49 – Story 2: Kyle Busch Death (Sepsis)

03:09 – Story 3: Menin Protein and Brain Aging

04:37 – Story 4: Inflammation and Depression

06:20 – Story 5: Lifespan Heritability

07:47 – Takeaway

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Combine Creatine With THIS To Fight The Root Cause of Aging | Andrew Salzman : 1474 May 28, 2026

Show notes

How CD38, PARP, and Leaky Gut Are Destroying Your NAD Levels | Dr. Andrew Salzman

Your NAD is being drained by two hidden enzymes, your gut may be the starting point of every aging process in your body, and creatine does something to your mitochondria that has nothing to do with muscle. This episode rewrites what you thought you knew about longevity, anti-aging biology, and how your body actually produces and delivers energy at the cellular level.

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

-Explore all of Wonderfeel’s products at: getwonderfeel.com/dave

They are gifting a complimentary 7-day Youngr™ supply (mini pouch) with every order across any of their products. The code will be DAVE, and the campaign will be active through June 6th.

Host Dave Asprey sits down with Dr. Andrew Salzman, a physician, inventor, and biomedical entrepreneur with more than 30 years of experience in drug discovery and development. An alumnus of Harvard Medical School, Yale University, and Columbia University, Dr. Salzman has authored more than 170 scientific publications and holds 50 patents. He invented the original clinical-stage PARP-1 inhibitor, leading to the world's first clinical treatment for raising NAD levels and fighting cancers caused by the BRCA1 and BRCA2 genes. Genentech licensed his breakthrough technology for $600 million. His research into gastrointestinal microbiota, autoimmune disease, oxidative stress, and mitochondrial ATP production now forms the foundation of how millions of patients get treated worldwide.

Dr. Salzman names the two biggest NAD drains in your body, CD38 and PARP, and explains why taking NMN or NR alone is like filling a bathtub with the drain wide open. He breaks down the formulation science behind pairing NAD precursors with CD38 blockers like hydroxytyrosol alongside PARP-reducing antioxidants like ergothioneine, and delivers a paradigm-shifting explanation of creatine as an energy distribution network inside your cells. Rather than a simple muscle supplement, creatine acts as a high-speed ATP shuttle that carries energy from your mitochondria to the precise location and moment your brain, gut, and heart need it most.

You'll Learn:

Why NAD declines with age and which two enzymes are primarily responsible for draining it
How CD38 rises with inflammation rather than NAD levels, and what that means for your supplement strategy
Why creatine is one of the most underrated anti-aging and brain optimization supplements available
How creatine functions as a spatial and temporal energy delivery network for your brain, gut, and heart
Why the gut may be the origin point of the entire aging process and how that cascade unfolds decade by decade
How leaky gut drives systemic inflammation, crashes NAD, and accelerates biological aging throughout the body
What controls tight junction integrity and how ATP, butyrate, creatine, and fasting all play a role
Why most creatine supplements fail to absorb properly and what to look for in a high-quality source
How to rebuild your microbiome in three to four weeks through diet alone, without antibiotics
Why walking immediately after a meal may be doing more harm than good to your gut lining

Thank you to our sponsors!

- Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave.

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- Pique | Go to Piquelife.com/dave for 20% off.

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New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Dr. Andrew Salzman, NAD depletion, CD38 inhibition, PARP inhibition, NMN supplements, creatine ATP shuttle, leaky gut aging, tight junction integrity, inflammaging, lipopolysaccharide gut, flagellin toxin, butyrate gut healing, ergothioneine, hydroxytyrosol, peroxynitrite, superoxide mitochondria, creatine energy distribution, gut origin of aging, NAD bathtub analogy, BRCA PARP inhibitor, Wonderfeel, creatine monohydrate, intestinal permeability, microbiome butyrate, selective digestive decontamination, TMAO nitric oxide

Resources:

• Explore all of Wonderfeel’s products at: getwonderfeel.com/dave

• Order Youngr™: getwonderfeel.com/dave

• Order ChocoCreatin™: getwonderfeel.com/dave

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/

• Upgrade Labs: https://upgradelabs.com

Timestamps:

00:00 – Trailer

01:12 – Introduction & BRCA Background

02:19 – DNA Damage & PARP

04:38 – Free Radicals & Oxidative Stress

11:37 – NAD & Antioxidant Defense

12:34 – CD38 & NAD Depletion

23:31 – The Gut-Aging Hypothesis

30:05 – ATP, Creatine & Energy Distribution

36:41 – Creatine as Energy Shuttle

51:09 – Microbiome & Gut Repair

59:21 – TMAO & Nitric Oxide Interference

1:03:52 – Flagellin & Gut Inflammation Research

1:09:45 – FDA & Pharmaceutical Incentives

1:16:05 – Closing

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The Doctor With Answers To Your Mystery Symptoms | Jessica Peatross : 1473 May 26, 2026

Show notes

The Hidden Causes of Brain Fog, Anxiety, and Chronic Illness: Mold, Parasites, Histamine, and Low Cortisol

If you're exhausted, inflamed, and can't figure out why, the answer might be hiding in your histamine, your hormones, your home, or something living inside you that your doctor will never test for.

Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with Dr. Jessica Peatross, a former hospitalist turned functional medicine powerhouse who walked away from a conventional medical career after discovering that 90% of disease traces back to lifestyle, environment, and the toxins most doctors ignore. After graduating magna cum laude and earning her medical degree from the University of Louisville, Dr. Jess pursued training in functional medicine, nutrigenomics, and alternative therapies, and now helps thousands of patients reverse chronic illness through her KillBindSweat method and WellnessPlus app. She is also the formulator and CMO of Aegis Formulas and a leading voice at international health conferences. If chronic illness, mold toxicity, or hormonal chaos is on your radar, she is the person you want in your corner.

Together, Dave and Dr. Jess go deep into the hidden drivers of mystery symptoms that functional medicine is finally starting to crack open. They cover why low cortisol is more dangerous than high cortisol, how histamine and mast cell activation syndrome explain everything from anxiety and brain fog to endometriosis and POTS, and why most "Lyme disease" is actually undiagnosed mold toxicity. They also break down the parasite epidemic hiding in plain sight across the United States, the B vitamin mistake making millions of people sicker, and why your metabolism, mitochondria, and mental health are all downstream of things your standard lab panel will never catch.

This episode also gets into the real story behind Dr. Jess surrendering her California medical license rather than comply with a system she believed was working against patient health. Her firsthand account of the medical board process is something every person who cares about medical freedom needs to hear.

You'll Learn:

Why everyone who is chronically sick has a low cortisol awakening response and what to do about it
How histamine drives anxiety, racing thoughts, palpitations, bloating, skin issues, and hormonal chaos
Why 90% of people diagnosed with Lyme disease actually have toxic mold and how to test for both
The parasite epidemic in the U.S. and why standard testing misses most of it
How the spike protein reactivates dormant viruses and feeds the histamine loop behind long COVID
Why synthetic B6 causes the very neuropathy it is supposed to fix, and what to take instead
The cortisol, adrenaline, and blood pressure connection that explains "wired but tired"
How progesterone stabilizes mast cells and why estrogen dominance fuels inflammation and reactivity
Why Dave Asprey uses low-dose cortisol, dexamethasone, and modafinil as part of his daily performance stack
The mold binders that actually work, and which popular ones can harm hypermobile people
How nicotine at low doses blocks spike protein from ACE2 receptors and protects the brain
What the MTHFR gene, methylation, and folic acid have to do with breast cancer, depression, and estrogen detox

Thank you to our sponsors!

- iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

- KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off

- Calroy | Go to Calroy.com/DAVE for exclusive discounts on Arterosil HP, Vascanox HP and all Calroy products.

- Cowboy Colostrum | Get your gut right by going to cowboycolostrum.com/asprey for 25% off of your entire order.

-Amp | If you're ready to make fitness fit into your life, go to amp.ai to check it out

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Dr. Jessica Peatross, functional medicine, mast cell activation syndrome, histamine intolerance, long COVID brain fog, mold toxicity, chronic Lyme disease, parasite testing, low cortisol, cortisol awakening response, MTHFR methylation, B6 toxicity, P5P, folinic acid, estrogen dominance, progesterone therapy, spike protein reactivation, Epstein-Barr reactivation, POTS, wired but tired, Kill Bind Sweat, WellnessPlus, vaccine exemptions, mold binders, nicotine ACE2, adrenal insufficiency, RCCX gene

Resources:

• Go to https://drjessmd.com/ and use code ‘DRJESS’ at checkout

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/

• Upgrade Labs: https://upgradelabs.com

Timestamps:

00:00 – Trailer

00:33 – Releasing Medical License

03:21 – Chronic Illness Root Causes

05:00 – Hospital Nutrition

08:11 – Dave's Health History

10:22 – Parasites

20:02 – Nicotine

23:19 – Low Blood Pressure & Minerals

28:09 – B Vitamins & Methylation

33:45 – Autism & Genetics

40:13 – Toxic Mold

43:11 – ADHD Misdiagnosis

48:27 – Histamine & Mast Cells

50:56 – Long COVID & Spike Protein

58:56 – Cortisol

1:03:56 – Lyme Disease

1:09:58 – Mold Testing & Binders

1:16:37 – Closing

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The EXACT Japanese Formula To Live Past 100+ (Simple Steps) : 1471 May 24, 2026

Show notes

In this video, I break down the exact biological mechanisms keeping men in Okinawa, Japan, physically dominant and mentally sharp past 100. You don't need million-dollar lab work or intense weight training to reverse your biological age. Instead, these centenarians leverage five specific lifestyle protocols to naturally upgrade their biology. I explain the hard science behind how eating to 80% full shuts down the constant growth signaling that accelerates cellular aging. We'll also cover why the modern concept of retirement physically destroys your brain function within 2-3 years, and how specific social structures actually drop inflammatory chemicals in your body by up to 30%.

Thank you to our sponsors!

TRU KAVA | Head to trukava.com and use code DAVE10 for 10% off.
Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade.
iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

Timestamps:

00:00 – Intro

00:47 – Okinawa's Origins

01:28 – Hara Hachibu (80% Full)

02:36 – Ikigai (Purpose)

03:57 – Never Retire

05:19 – Social Bonds (Moai)

07:13 – Stress Resilience

08:54 – The 5 Habits

Connect with Dave Asprey!

Website: https://daveasprey.com

TikTok: https://www.tiktok.com/@daveaspreyofficial