The Human Upgrade: Biohacking for Longevity & Performance

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Alternative Health
**The Human Upgrade: Biohacking for Longevity & Performance**

For more than a decade, **Dave Asprey – the Father of Biohacking and creator of Bulletproof Coffee –** has redefined what’s possible for the human mind and body. After more than a thousand episodes of *Bulletproof Radio*, he’s taking it to the next level with **The Human Upgrade™** – a masterclass in **biohacking, longevity, and performance optimization.**

Each episode explores **cutting-edge science, advanced technology, and proven biohacks** to help you **upgrade your energy, focus, metabolism, and resilience.** You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in **mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity,** and more.

This isn’t just self-improvement – it’s **human enhancement backed by data.**

Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.

Join **The Human Upgrade™ with Dave Asprey** – and learn how to **live longer, think faster, and perform better.**

Latest Episodes:

Analyze Your Gut to Fix Your Health: Here’s How – Naveen Jain : 917 Mar 17, 2022

Show notes

Nature’s Nootropic: https://trukava.com, use code DAVE15 to get 15% off

CARBON60 for Brain & Body: https://wizardsciences.com, use code DAVE for an exclusive discount on C60 products

Trigger Autophagy: https://spermidinelife.us/dave, use code DAVE25 for 25% off your first month’s order

Special offer for The Human Upgrade listeners: Go to https://www.viome.com/daveasprey, use code DAVE to get $20 off a Health Intelligence™ Test.

IN THIS EPISODE OF THE HUMAN UPGRADE™...

Dave’s good friend, entrepreneur and philanthropist Naveen Jain, joins the show to talk about the future of human biology and wellness. What’s new right now, what’s emerging, and what’s on the horizon. He’s been a guest several times before (see the Links & Resources section below!) and there’s always something new to learn when he and Dave get together. This time, they explore testing the human biome.

Naveen’s a guy with enormous vision who builds companies and partners with others to tackle and solve the gnarliest problems affecting the health of our people and planet.

He always encourages curiosity and big thinking: ““Curiosity is what drives the humanity forward. The day you stop being curious is the day you die.”

In this discussion, you’re going to learn ways innovation can change human biology from a micro and macro level—from your cellular health to broader planetary issues. You’ll also learn how you can test to find out what’s happening within your gut, cells and immune system. With that knowledge and personalized recommendations, you’ll have the power to change your health for the better.

Naveen founded, Viome, the worlds’ largest database of microbial gene expression. Its AI-driven personalized therapeutics platform and applications identifies predictive markers of chronic diseases. Viome does this by using a functional analysis of microbial, mitochondrial and human gene expression. “We actually see everything,” Naveen explains. “As long as an organism is alive, we see it. So whether it is a bacteria, virus, fungus, mold, it doesn't matter. We see everything.”

In particular, Viome’s Health Intelligence™ Test looks at:

gut microbiome
mitochondrial function
immune cell function
cellular health
stress response
biological age

The more data can inform what’s happening inside of you, the more resources you’ll have to improve your health.

More about Naveen Jain:

Naveen wrote the award-winning book, Moonshots: Creating a World of Abundance and created Mindvalley, Masterclass programs. He’s behind XPrize, a global future positive movement and is on the board of Singularity University.

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How to Treat Body-Based Anxiety – Dr. Ellen Vora : 916 Mar 15, 2022

Show notes

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

… Ellen Vora, M.D., takes a functional medicine approach to mental health that considers the whole person and addresses imbalance at the root.

She’s a Yale and Columbia University educated holistic psychiatrist board-certified in psychiatry and integrative holistic medicine. She’s also an acupuncturist and yoga teacher.

In her new book, “The Anatomy of Anxiety: Understanding and Overcoming the Body's Fear Response,” she takes on anxiety, which hits more than 40 million people in any given year. The pandemic drove that number up even more. Even if math isn’t your strong suit, you can understand these numbers:

An estimated one out of every nine people, or 800 million people, suffer from a mental health disorder, the most common of which is anxiety.
Up to 33.7 percent of Americans are affected by an anxiety disorder in their lifetime.

Conventional medicine tends to view anxiety as a “neck up” problem of brain chemistry and psychology. Dr. Vora disagrees. She suggests that various physiologic inputs influence anxiety symptoms.

“What we've been indoctrinated with is this idea that our mental health is genetically determined chemical imbalance,” Dr. Vora says. “There's some validity to that, although I think, for the most part, any chemical imbalance is often a downstream effect of a state of imbalance happening elsewhere in the physical body.”

In this episode, you’ll learn:

the difference between avoidable, purposeful, false and true anxiety;
simple strategies for tuning into “true” anxiety and using its benefits;
how your body may be physiologically out of balance (immunity, gut health, inflammation);
how “hanxiety” means that blood sugar is affecting your anxiety;
actionable lifestyle factors to bring yourself back into balance;
how to manage medication withdrawl; and
how to reframe your understanding of, and relationship with, anxiety.

Dr. Vora also confronts what she calls techxiety. This can include a boundaryless workplace, how the posture of screen use signals your body for anxiety, and, of course, social media. Research shows social media is associated with higher rates of anxiety and depression. Just 20 minutes of Facebook can impact mood.

So much of how you live your life as an adult profoundly impacts how your mental health manifests, and that's the part you can control.

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Hacking Inflammation – Interventions With Dave – Cindy Fraley-Hunter : 915 Mar 11, 2022

Show notes

IN THIS EPISODE OF THE HUMAN UPGRADE™...

… Dave talks with Cindy Fraley-Hunter about system-level inflammation and her fear of having an early heart attack like her father because they have such similar genes.

Cindy thought she was healthy until after the birth of her daughter at 42. She was constantly tired. Her physician told her that was just to be expected because she was a geriatric pregnancy. That unhelpful advice ignored her body functioning and lacked actionable solutions.

She then survived a case of MRSA and received Hashimoto’s and rheumatoid arthritis diagnosis. She continued to have high cholesterol and a high CAD calcium heart score. She’s scared her life will be cut short.

Feeling like conventional medicine is failing her, Cindy has turned to supplements instead of prescription drugs. She says she’s “embracing biohacking to save my life.”

In this “Interventions With Dave” episode, Dave walks Cindy through her most recent labs and other test results. They look at her health concerns through a new lens and discuss actionable next steps. Don’t miss the “Links & Resources” section of episode web page #915 for specific information.

Note: The "Interventions With Dave” recommendations are designed to help you upgrade yourself and your biology so you can perform better at everything you do. They are not, however, a substitute for advice or treatment by a trained medical professional that may be needed for specific health conditions, illness or injury.

Listen to the Interventions With Dave series:

Coffee & Bohacking with Dave Asprey

(coffee + minerals) - toxins = power: Discover the energy and high performance that come from Danger Coffee, designed with your biology in mind. https://dangercoffee.com

8th Annual Biohacking Conference: Come join like-minded people September 15, 16 & 17 in Beverly Hills, Calif., for three days of awesome! You’ll learn from dozens of experts at an amazing event that’s designed to upgrade every area of your life.https://biohackingconference.com

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Synthetic Biology to Become a Major Economic Driver, Part 2 – Amy Webb : 914 Mar 10, 2022

Show notes

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Biostack for High Performance: https://vatellia.com, use code DAVE2022 to save 10% or subscribe and save 15% + receive a free bottle of Kale Buster

IN THIS EPISODE OF THE HUMAN UPGRADE™...

… you’ll get a look at synthetic biology (SYNBIO) through the lens of quantitative futurist Amy Webb in Part 2 of a special two-part episode. The Part 1 episode #913 explores the scientific perspective with microbiologist and geneticist Andrew Hessel.

Amy and Andrew recently authored, “The Genesis Machine: Our Quest to Rewrite Life in the Age of Synthetic Biology.” SYNBIO is the promising and controversial technology platform that combines biology and artificial intelligence. Amy investigates what SYNBIO means for people, commerce and the planet.

“This is a book about science,” Amy describes, “but I did not want to write a science book. This is also a business book. It's an understanding-your-own-body book.”

She’s a futurist who works with data and does predictive modeling. Her academic background includes game theory and economics

Amy founded the Future Today Institute to help companies understand the forces that will shape their futures. She’s a professor of strategic foresight at the NYU Stern School of Business and a Visiting Fellow at Oxford University’s Säid School of Business. She writes extensively about biotechnology, artificial intelligence, technology policy, and business strategy.

“This emerging field of science—synthetic biology—promises to reveal how life is created and how it can be recreated, for many varied purposes, as explained in “The Genesis Machine:”

to help us heal without prescription medications,
to grow meat without harvesting animals, and
to engineer our families when nature fails us.

With SYNBO developments come a slew of considerations about how to manage it responsibly.

“For the most part, in the US, the regulation is on the end product,” Amy says. “Nobody wants to regulate the process, because we don't want to hamper innovation. However, it does start to raise some gnarly questions when we're talking about alternative uses or different uses for some of these technologies, or cross-border use.”

“There's some alignment globally on what's called germline editing, which is when you edit the genome to make it heritable. So whatever that is passes on. At the moment, just about 190 countries have aligned [to agree] that they don't want that to happen. But outside of that, there's a lot of confusion.”

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Controlling Genetic Destiny with Synthetic Biology, Part 1 – Andrew Hessel : 913 Mar 09, 2022

Show notes

Nature’s Nootropic:

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https://paleovalley.com/DAVE, use code DAVE to get 15% off your first order

Franchise Opportunity:

https://ownanupgradelabs.com, to check out the fitness center of the future

IN THIS EPISODE OF THE HUMAN UPGRADE™...

… you’ll learn about the implications of synthetic biology in Part 1 of a special two-part episode.

Andrew Hessel and Amy Webb recently authored, “The Genesis Machine: Our Quest to Rewrite Life in the Age of Synthetic Biology.” This Part 1 episode gets into the scientific perspective with Andrew. Part 2 on episode #914 explores the futurist perspective with Amy.

Ask yourself, if you could edit your genes—to fix infertility, diabetes or even depression—would you do it? That’s the premise, and the promise, of synthetic biology. And a reality you’ll have to wrestle with. To make these decisions intelligently requires a deeper—and urgent—understanding of what’s happening in science.

Right now, scientists are rewriting the rules of our reality. They can use computers to gain access to the cells of any living organism and write new, potentially better, biological code.

Andrew—a microbiologist and geneticist—works on the leading edge of genomics and bioinformatics. He’s been immersed in the world of synthetic biology for years and joins the show to explain new advancements.

As a scientist, communicator, and investor, he explores the future of biology and biotechnology. He co-founded the Center of Excellence for Engineering Biology and the Genome Project-write. The Genome Project-write is an international scientific effort that designs and builds large genomes, including the human genome.

As we embrace that life no longer will be a game of chance, it will be the result of design, selection and choice, morechoices have to be made. Decisions like who gets to program life, create new life forms, and even bring former life back from extinction?

“The Genesis Machine" is a book about science, but it's not written for scientists, Andrew says. “It's about some amazing people and stories and we've got some fun scenarios that help you think about where some of this stuff is going. But really, this is a technology that we're all building day by day.”

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Keto Gets an Upgrade – Dr. Steven Gundry : 912 Mar 04, 2022

Show notes

Control Blood Glucose: https://pendulumlife.com, sign up for membership to get monthly supply delivery, use code DAVE20 to save $20 on your first shipment

Kickstart Autophagy: https://timelinenutrition.com/DAVE, use the code ASPREY10 to get 10% off any plan

NAD+ for Brain Health: https://innovativemedicine.com/DAVE and save 20%

SPECIAL OFFERS FOR THE HUMAN UPGRADE LISTENERS:

Pre-order your copy of “Unlocking the Keto Code” before March 7, 2022, and receive your choice of “The Energy Paradox,” or “The Plant Paradox,” or an early release chapter of “Unlocking the Keto Code,” and an exclusive sneak peek digital recipe guide! Go to https://drgundry.com for details.
Get30% off products at https://gundrymd.com. Use code DAVE30 at checkout.

IN THIS EPISODE OF THE HUMAN UPGRADE™...

… Steven Gundry, M.D., introduces you to the biological mechanism that makes keto diets so successful: a cellular process known as “mitochondrial uncoupling.”

He’s spent the last two decades studying the microbiome and uses diet and nutrition as a key form of treatment for people who want to improve their body health and performance. You may already know Dr. Gundry from his bestselling books like: “The Plant Paradox,” (lectins!) “The Longevity Paradox” and “The Energy Paradox.”

This discussion gets right into new science that’s overhauling what you think you know about a keto diet. In his newest book, “Unlocking the Keto Code: The Revolutionary New Science of Keto That Offers More Benefits Without Deprivation,”Dr. Gundry debunks common myths about keto and explains:

How ketosis actually works,
What’s going on with ketones, and
What your mitochondria has to do with all of this.

You don’t have to restrict all carbs to reap the benefits of ketosis; you simply have to “unlock” mitochondrial uncoupling, Dr. Gundry explains.

He shares eight “keys” that unlock the keto code. You’ll get real food examples of how to ignite this process without the monotonous, limiting, high-fat diet.

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Goal Get It! How to Reflect, Dream and Focus Your Way to Success – Payal Kadakia : 911 Mar 01, 2022

Show notes

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

Entrepreneur, investor and artist Payal Kadakia brings a fresh perspective to your understanding of goals. She knows a lot about setting big goals and reaching them.

She founded ClassPass and over a decade grew it to become the leading fitness and wellness membership service valued at over $1 billion. Mindbody acquired ClassPass in October 2021. At that time, members had logged more than 100 million hours of workouts across 30,000 partner studios in over 30 countries.

We’re going to talk today about how you can upgrade your own goal setting with “LIFEPASS: Drop Your Limits, Rise to Your Potential.”

Using her company Class Pass as an example, Payal highlights the importance of knowing your strengths, your unique talents, who you are, and investing in the right people and mentors to show you the way.

Payal gives insight on how to set boundaries in service to your priorities, and how every minute of the day belongs to YOU, not anyone else. This means you don’t have to hold onto any guilt about doing what's right for you.

You’re more likely to reach your goals when you get to let go of the pressure to achieve a traditional kind of success and instead fuel your life with purpose. And when you focus on a life of creativity, you get to live the life you most want to live.

The 4-step LifePass Method combines intuition, pie-in-the-sky dreams, micro focus, and macro goals.

Reflect: Where have you been?
Dream: Where do you want to go?
Focus: What are your priorities?
Set Goals: What’s the plan?

Payal, an Operations Research and Economics graduate from MIT, been featured in most major news outlets; listed as Fast Company’s 100 Most Creative People; and named to Fortune's 40 under 40 list.

She formerly worked as a consultant at global management consulting firm Bain & Company and was part of Warner Music Group’s Digital Strategy and Business Development Group.

She’s also got an extraordinary artistic side. She founded The Sa Dance Company in 2008 and serves as Artistic Director.

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Mini-Episode: Cool Facts Friday #20 Feb 25, 2022

Show notes

Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month.

Breathing coordinates neuronal activity—even without smell
Mindful breathing in virtual reality can control real pain
Circadian cycle affects immune cells and Alzheimer’s plaques
Brain refresh lags when processing visual stimuli
Medical repression in the days of Ivan the Terrible

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Happiness Starts with Your Brain Type – Dr. Daniel Amen : 910 Feb 25, 2022

Show notes

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

“Americans are the unhappiest they have been since the Great Depression,” says Dr. Daniel Amen. But he’s determined to change that.

He’s a physician and double board-certified psychiatrist who looks at happiness as a brain function. After studying more than 200,000 brain scans of people from 155 countries, Dr. Daniel Amen discovered five primary brain types and seven neuroscience secrets that influence happiness.

“I wanted to spend my time and energy and research on happiness because, ultimately... happiness is a moral obligation because of how you impact other people,” Dr. Amen says. “The big central point [is] the brain is the organ of happiness, and if your brain is not healthy, you are not likely to be happy.”

What makes you happy? The answer lies in knowing your specific brain type and how it’s being influenced by seven specific chemicals.

Happiness originates in distinct brain regions: pleasure in the orbitofrontal cortex; motivation and habit formation in the basal ganglia; and mood and cognitive flexibility in the brain stem.

You may be one or a combination of these five primary brain types: (take this brain assessment to find out yours)

Balanced: you have a very healthy brain

Spontaneous: you have low dopamine

Persistent: you’re often worried, rigid, and inflexible

Sensitive: you need other people and isolation is hard

Cautious: yourGABA levels are low

Learn more about brain types and what actually boosts your happiness according to neuroscience in Dr. Amen’s book, "You, Happier: The 7 Neuroscience Secrets of Feeling Good Based on Your Brain Type.”

“Happiness comes from moving your life forward toward your life goals with meaning and purpose, based on your values, despite whatever obstacles are in your way,” Dr. Amen says. “A happy life doesn’t focus on the past with regret or look to the future with fear.”

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New Developments in Stem Cell Treatments – Dr. Harry Adelson & Dr. Amy B. Killen : 909 Feb 22, 2022

Show notes

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SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Call the phone number listed on the Docere Clinics website: (435) 604-0438. Mention you heard about stem cell treatments on the Dave Asprey podcast and get half off a consultation.

IN THIS EPISODE OF THE HUMAN UPGRADE™...

…you’re going to find out about Dave’s recent stem cell procedure and the newest technology stem cell medicine happening at Docere Clinics in Park City, Utah.

Dr. Harry Adelson was one of the earliest adopters of the use of stem cells for the treatment of chronic musculoskeletal pain. His practice has offered 100% Regenerative Injection Therapy since 2002 and 100% stem cell therapy since 2010. He’s performed more than 6,000 stem cell procedures and invented the Full Body Stem Cell Makeover®, the most comprehensive stem cell upgrade currently available.

His colleague, Dr. Amy B. Killen performs anti-aging and regenerative medical treatments. She’s fellowship trained in Anti-Aging and Regenerative Medicine through the American Academy of Anti-Aging Medicine. She’s also done extensive additional training in aesthetics, platelet rich plasma and stem cells, hair restoration, bio-identical hormones, nutrition, fitness and sexual health.

Drs. Adelson and Killen performed Dave’s original Full Body Stem Cell Makeover®, which used Dave's own stem cells from his fat and bone marrow, as well as extracellular vesicles. This episode gets into new developments in stem cell treatments, like the advent of VSEL (very small embryonic-like stem cells) technology.

Stem cells therapy may be right for you if you’re interested in:

Better skin
Increased sexual performance
Decreased pain
Improved functional body movement
Preventive aging treatment

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