The Human Upgrade: Biohacking for Longevity & Performance

Latest Episodes:

The New Science Behind Psychedelics, Exotic Shrooms, & Daily Flow-States | Matt Zemon : 1280 May 13, 2025

Show notes

Your brain has a gear you’ve never touched. Psychedelics can shift you into it.

In this episode of The Human Upgrade, Dave Asprey uncovers how high-performance psychedelic mushrooms help you access flow states, rewire your brain, and enhance clarity, energy, and emotional resilience. This is next-level biohacking rooted in real science.

You will learn how to use psychedelics with intention. When to microdose. When to go deep. How to stack them with nootropics for even stronger results. Dave breaks down the latest research on psilocybin, brain plasticity, trauma release, and how to turn ancient compounds into modern performance tools.

What You Will Learn in This Episode:

• How psychedelic shrooms unlock flow, focus, and creative power

• Why psilocybin boosts neuroplasticity, mood, and emotional healing

• Microdosing vs. full-dose: what works, when, and how

• How to stack psychedelics with nootropics and other biohacks

• The newest research on brain optimization and long-term benefits

• How to use psychedelics safely, strategically, and for real results

• Why shrooms may be the strongest mental upgrade in your toolkit

Thank you to our sponsors!

-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.

-fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• Matt’s Website – https://mattzemon.com/

• Matt's Instagram - https://www.instagram.com/matt.zemon/

• 2025 Biohacking Conference: https://biohackingconference.com/2025

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

• Own an Upgrade Labs: https://ownanupgradelabs.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com

Timestamps:

• 00:00 – Trailer

• 01:00 – Intro

• 06:01 – Personal Psychedelic Journeys

• 07:39 – Psychedelics and Self-Discovery

• 11:59 – Safe Use and Smart Navigation

• 29:09 – Psychedelics and Society

• 36:40 – Building Trust in the Process

• 37:14 – Facing Inner Fear

• 37:38 – Choice and Healing

• 37:51 – Diet and Conscious Decisions

• 38:55 – Judgment and Relationships

• 39:29 – Spirituality and Psychedelics

• 40:07 – The Entheogenic Reformation

• 41:29 – Past Lives and Expanded States

• 43:44 – Where Science Meets Spirituality

• 49:59 – Gratitude and Compassion in Healing

• 01:01:47 – The Power of Apologies

• 01:04:56 – Psychedelics in Therapy

• 01:08:57 – Final Thoughts on Psychedelics and Culture

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Why Oral Testosterone Is the Ultimate Upgrade for Energy, Mood and Longevity (Men AND Women) | Shalin Shah : 1279 May 09, 2025

Show notes

Low testosterone is sabotaging your health, motivation, and longevity. Diet alone will not fix it.

In this episode of The Human Upgrade, Dave Asprey sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to expose the truth about testosterone decline in both men and women. They break down why testosterone is crashing worldwide, why natural fixes almost always fail, and how the latest science finally makes testosterone therapy safer, simpler, and more effective than ever before.

You will discover why testosterone is essential for dopamine, brain function, sleep, muscle, libido, and mitochondrial health. Fixing your levels can reverse fatigue, brain fog, poor motivation, and slow aging itself.

Shalin reveals how new oral testosterone technology (Kyzatrex®) overcomes the dangers of old therapies and restores natural hormone rhythms without needles, creams, or dangerous side effects.

What You Will Learn in This Episode:

• Why testosterone matters for men and women at every age

• The real causes of the global testosterone crash

• Why diet, sleep, and exercise cannot fully fix low testosterone

• How testosterone drives dopamine, motivation, and longevity

• The breakthrough that makes oral testosterone safe and effective

• How Kyzatrex® lowers SHBG and boosts free testosterone naturally

• Why maintaining youthful testosterone levels protects brain, muscle, libido, and lifespan

• How to safely use testosterone therapy without suppressing fertility or causing side effects

** Visit livethrive.co/asprey to get a discount on your first month's supply! **

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• Purchase Kyzatrex® – https://livethrive.co/?utm_campaign=11813552-Asprey

• Shalin’s Instagram - https://www.instagram.com/themetabolicceo/

• 2025 Biohacking Conference: https://biohackingconference.com/2025

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

• Own an Upgrade Labs: https://ownanupgradelabs.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com

Timestamps:

00:00 Trailer

00:52 Introduction

01:29 Global Decline in Testosterone Levels

02:27 Symptoms of Low Testosterone

03:48 Personal Journey with Testosterone Therapy

05:06 The Role of Testosterone in Overall Health

06:18 Testosterone Levels in Men and Women

08:48 Challenges and Innovations in Testosterone Delivery

16:25 The Importance of Circadian Rhythm in Testosterone Therapy

19:19 The Future of Testosterone Therapy

32:00 Investment and Development in Testosterone Therapy

34:57 Introduction to FDA and Hormone Replacement

35:31 FDA’s Impact on Women’s Health

36:10 Testosterone and Cardiovascular Risk

39:05 Testosterone and Depression

40:30 Testosterone Testing and Misconceptions

44:58 The Testosterone Project and Female Hormone Therapy

47:51 Testosterone’s Role in Longevity and Health

55:37 Cost and Accessibility of Testosterone Therapy

01:04:03 Conclusion and Final Thoughts

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The Deadliest Room in Your House — And How to Detox It for Better Health | Aly Cohen MD : 1278 May 08, 2025

Show notes

Your environment is rewiring your hormones, fertility, and long-term health without your consent.

In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Aly Cohen, board-certified rheumatologist, integrative medicine specialist, and environmental health educator. Together they expose how common toxins in plastics, pesticides, drinking water, personal care products, and food packaging are hijacking your biology.

Dr. Cohen explains how daily chemical exposures contribute to autoimmune disease, thyroid dysfunction, hormone imbalance, infertility, obesity, cancer, and accelerated aging. You will learn how to identify hidden endocrine disruptors, spot surprising sources of microplastics and PFAS (“forever chemicals”), and apply science-backed detox strategies to protect your hormones, fertility, metabolism, and longevity.

What You’ll Learn in This Episode:

• How chemicals in household, cleaning, and beauty products disrupt hormones

• The link between environmental toxins, autoimmune disease, thyroid issues, and infertility

• Hidden sources of microplastics and PFAS chemicals and how to eliminate them

• Affordable, practical steps to detox your home, water, and personal care routine

• Dr. Cohen’s top biohacks to protect fertility, balance hormones, and build toxin resilience

THANK YOU TO OUR SPONSORS!

-BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off.

-ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order.

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• Aly’s Website – https://thesmarthuman.com/

• Aly's Website - https://alycohenmd.com/

• Aly’s New Book – Detoxify: https://alycohenmd.com/books

• 2025 Biohacking Conference: https://biohackingconference.com/2025

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

• Own an Upgrade Labs: https://ownanupgradelabs.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com

Timestamps:

00:00 Trailer

02:01 Introduction

02:15 Rheumatism and Rheumatology

03:36 Autoimmune Diseases and Toxins

04:17 Chemical Impact on Health

04:49 Personal Health Journey

06:15 Microplastics and Immune Disruption

08:21 Resilience and Lifestyle Changes

21:45 Nutritional Deficiencies

26:48 Lab Results and Assessments

34:40 Detoxification and Resilience

41:14 Personal Journey Continued

42:22 Clean Drinking Water

44:20 Travel Hacks for Water

46:15 Hotel Room Detox Tips

50:06 EPA Water Standards

53:06 Restaurant Toxins and Home Safety

55:36 Top Toxic Household Items

01:08:31 Synthetic Materials Impact

01:13:30 Final Thoughts and Book

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Biohacking Your Heart Health: The Life-Saving Molecule You NEED to Know | Dr. Anurag Singh : 1277 May 06, 2025

Show notes

What if you could reverse the age of your heart...without leaving home?

In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Anurag Singh, Chief Medical Officer of Timeline, to reveal groundbreaking science that targets cardiovascular aging at the cellular level. You’ll discover how mitochondrial decline drives heart failure, why postmenopausal women face skyrocketing cardiac risks, and how one powerful molecule, Urolithin A, can rejuvenate your heart’s energy systems.

Dr. Singh shares clinical research showing how Urolithin A improves mitochondrial function, boosts endurance, and may even reverse biological aging markers in the heart. You’ll also learn how simple lifestyle biohacks, combined with cellular nutrition, can protect your cardiovascular health and extend your healthspan.

What You’ll Learn in This Episode:

• The link between mitochondrial decline and heart failure

• Why women’s cardiac risk skyrockets after menopause

• How Urolithin A stimulates mitophagy and energy renewal

• New human clinical data on reversing cardiac aging markers

• Biohacking strategies to fortify your cardiovascular health

• How to optimize endurance, recovery, and heart resilience

THANK YOU TO OUR SPONSORS!

-STEMREGEN | Head to https://www.stemregen.co/dave for 20% off your first order.

-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• Timeline Website – https://www.timeline.com/partners/dave-asprey

• Timeline Instagram - https://www.instagram.com/timeline_longevity/

• 2025 Biohacking Conference: https://biohackingconference.com/2025

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

• Own an Upgrade Labs: https://ownanupgradelabs.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com

Timestamps:

• 00:00 — Trailer

• 02:11 — Supplements that help

• 03:05 — Long-term benefits

• 04:38 — Stacking with lifestyle

• 22:19 — Heart health connection

• 29:39 — Mitochondria & brain function

• 33:04 — Glymphatic system & Alzheimer’s

• 33:53 — Bed height & brain health

• 34:18 — Why mitochondria matter

• 35:43 — Inflammation & dysfunction

• 38:12 — Transplants & consciousness

• 39:19 — Meditation’s effects

• 40:33 — The ultimate biohacking stack

• 43:06 — Creatine for sleep & focus

• 50:00 — Fertility insights

• 57:23 — Skin health

• 01:00:28 — Final thoughts

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

How Laser Therapy Boosts Mood, Mental Clarity, and Consciousness with Dr. Brandon Crawford : 1276 May 01, 2025

Show notes

What if a laser could help a child speak for the first time—or reverse an “incurable” brain condition?

In this episode of The Human Upgrade, Dave Asprey talks with Dr. Brandon Crawford, a leading neurotherapist and founder of 528 Innovations, about the emerging science of laser therapy for the brain and body. You’ll learn how light—when precisely pulsed and targeted—can rewire brainwaves, heal trauma, and even influence states of consciousness.

Dr. Crawford explains how specific laser frequencies are being used to modulate brain states, activate the vagus nerve, improve mood, restore gut-brain communication, and support recovery from conditions like autism and ALS. From EEG shifts to structured water and mitochondrial signaling, this conversation dives deep into biohacking’s most advanced light-based tech.

What You’ll Learn in This Episode:

• How laser therapy rewires brainwaves for mood, focus, and clarity

• The exact brain regions linked to embodiment, intuition, and flow

• Why pulsing patterns matter more than power in laser tech

• How light influences trauma recovery and vagus nerve activation

• The role of structured water and infrared light in cellular repair

• How patients with ALS and autism responded to 528 protocols

** Get 30% off GA Virtual Tickets for the Biohacking Conference this May with code ‘528i30’ at checkout! **

THANK YOU TO OUR SPONSORS!

-Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.

-LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/DAVE.

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• 528 Innovations Website and used code ‘UPGRADE10’ at checkout – https://528innovations.com/dave

• 528 Innovations Instagram - https://www.instagram.com/528innovations/

• 2025 Biohacking Conference: https://biohackingconference.com/2025

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

• Own an Upgrade Labs: https://ownanupgradelabs.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com

Timestamps:

• 00:00 – Trailer

• 02:00 – Intro

• 02:26 – New breakthroughs in laser therapy

• 03:07 – Why laser tech needed reinvention

• 04:21 – How laser light influences the brain

• 08:03 – Holograms, light, and reality

• 09:02 – Telepathy and autism connections

• 12:03 – Rewiring the brain with light

• 20:01 – Quantum signaling between cells

• 22:33 – Biohacking and yogic practices

• 22:54 – Testosterone and natural living

• 23:37 – Boosting testosterone with lasers

• 25:21 – Mitochondria and higher awareness

• 27:35 – Laser benefits across the body

• 30:29 – Advanced brain stimulation tech

• 36:19 – ALS recovery and healing cases

• 40:48 – Closing thoughts and next steps

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Conscious Bacteria? The Secret New Science of Cellular Intelligence | Zach Bush : 1275 Apr 29, 2025

Show notes

What if mitochondria weren’t just energy engines — but conscious beings guiding your survival and evolution?

In this episode, Dave Asprey sits down with Zach Bush, MD, to uncover a radical new science of cellular intelligence. Together, they reveal how your mitochondria, microbiome, and genetic memory do far more than support survival—they actively shape consciousness, drive healing, and accelerate human evolution.

You’ll discover why chronic disease, fatigue, brain fog, and emotional trauma often trace back to lost cellular communication—and how restoring that network can unlock radical resilience, deeper energy, and true longevity.

Through the lens of soil health, vibrational biology, light frequencies, and ancient microbial wisdom, Zach Bush shows why the future of biohacking demands reconnection to the deeper intelligence already alive inside you.

What You’ll Learn in This Episode:

• How mitochondria act as conscious messengers—not just energy factories—and why that changes everything about health and aging

• Why rebuilding gut microbiome intelligence strengthens immune function, brain health, and emotional resilience

• How disrupted cellular communication fuels chronic inflammation, autoimmune disease, and premature aging

• How emotional trauma imprints onto genetic expression and triggers mitochondrial collapse

• Why viruses and bacteria serve as evolutionary partners—not enemies—and how they upgrade your biology

• How “cellular safety” activates healing, regeneration, and peak human performance

• How carbon cycles, soil health, and light frequencies repair DNA and extend human lifespan

• Simple daily practices that rebuild cellular coherence, boost energy, and reconnect you to your innate intelligence

This conversation will rewire how you think about health, disease, and human potential—giving you the tools to upgrade your biology at the deepest level.

**Check out Zach's exclusive offer for The Human Upgrade listeners at https://intelligenceofnature.com/ and use code ‘DAVE10” for a discount!**

SPONSORS

- ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order.

- Apollo Neuro | To get an Apollo wearable, go to https://apolloneuro.com/Dave and save 15%.

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• Zach’s Website – https://zachbushmd.com/

• Zach’s Instagram - https://www.instagram.com/zachbushmd/?hl=en

• 2025 Biohacking Conference: https://biohackingconference.com/2025

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

• Own an Upgrade Labs: https://ownanupgradelabs.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com

Timestamps:

• 00:00 Trailer

• 00:52 Intro: Microbiome and Human Connection

• 03:07 Microbiome’s Role in Nutrition and Health

• 05:48 Chemical Farming’s Impact on Soil and Health

• 09:23 Mitochondria and Cellular Communication

• 26:00 Viruses, Exosomes, and Evolution

• 34:36 The Observer Effect and Reality

• 40:08 Tech vs. Nature in Healing

• 41:04 Light, Mitochondria, and Cellular Energy

• 42:01 Choosing Tech or Natural Regeneration

• 43:44 The Miracle of Life and Human Potential

• 45:05 Healing Generational Trauma

• 47:38 Shamanic States and Connection

• 01:05:48 Sacred Geometry and Group Healing

• 01:12:48 Rational vs. Mystical Perspectives

• 01:14:52 Finding Common Ground

• 01:15:10 Inside the Supplement Room

• 01:15:47 Emerging Tech in Biohacking

• 01:15:58 Non-Tech Health Upgrades

• 01:16:11 Stem Cell Concerns and Cautions

• 01:17:31 Nature Deficit and Health Impacts

• 01:19:09 Curiosity and Personal Growth

• 01:20:56 Generational Shifts and Gender

• 01:24:20 Strengthening Relationships Through Differences

• 01:28:31 Storytelling’s Power Over Data

• 01:38:24 Longevity and Embracing Elderhood

• 01:44:47 Final Thoughts and Future Visions

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The End of Cardio? Burn Fat & Boost VO₂ Max in Just 8 Minutes a Week – with REHIT | Ulrich Dempfle : 1275 Apr 25, 2025

Show notes

You’ve probably heard of HIIT—but have you heard of “REHIT?” This isn’t just another workout trend...it’s a new science-backed way to train with maximum efficiency and zero wasted time. If you’re still jogging, you’re wasting hours for minimal results.

In this episode of The Human Upgrade, Dave Asprey sits down with Ulrich Dempfle, German-trained engineer and co-founder of CAROL Bike, to dismantle outdated cardio advice and introduce the 5-minute protocol that’s obliterating fitness myths.

Forget the treadmill grind. REHIT (Reduced Exertion High-Intensity Training) exercising delivers:

• 12% VO₂ max increase

• 6x the fitness gains of daily jogging

• 62% drop in diabetes risk

• 5x more BDNF for brain power

—all with just 8 minutes of effort per week.

But was it? Ulrich unpacks the hard data, crushes the Zone 2 obsession, and shows how a brand-new way of exercising is giving explosive results—no matter your age or fitness level.

What You’ll Learn in This Episode:

• Why Zone 2 cardio is outdated advice for most people

• The science of REHIT and how 2 sprints beat 2-hour workouts

• The shocking data on VO₂ max, insulin sensitivity, and lifespan

• How CAROL uses AI to personalize exercise for any age or ability

• Why most people fail at fitness—and how to fix it

• The real role of lactate, BDNF, and HRV in recovery and resilience

• How perimenopausal women benefit more from REHIT than HIIT or jogging

• Why adherence—not intensity—is the #1 predictor of results

• What to do when you’re traveling or don’t have access to the tech

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• CAROL Bike Website and use code ‘DAVE’ for a discount – https://carolbike.com/

• CAROL Bike Instagram - https://www.instagram.com/thecarolbike/?hl=en

• 2025 Biohacking Conference: https://biohackingconference.com/2025

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

• Own an Upgrade Labs: https://ownanupgradelabs.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com

Timestamps:

• 00:00 Introduction to REHIT Training

• 00:24 Meet Ulrich Dempfle: The Mind Behind CAROL Bike

• 00:51 The Science and Benefits of REHIT

• 01:44 Comparing Traditional Cardio to REHIT

• 02:32 Dave Asprey’s Personal Fitness Journey

• 03:43 The Efficiency of REHIT Training

• 05:03 Practical Applications and Accessibility of REHIT

• 08:22 Addressing Common Concerns and Misconceptions

• 11:25 The Future of Fitness: REHIT and Beyond

• 18:29 Scientific Validation and Real-World Results

• 31:53 Clinical Trials and Tech Integration

• 32:06 Upgrade Labs and CAROL Bike

• 33:00 Mitochondrial Effectiveness and Insulin Sensitivity

• 36:05 Zone Two Training vs. High-Intensity Training

• 42:02 REHIT for Perimenopausal Women

• 48:18 AI and Personalized Exercise

• 57:52 Lactate and Exercise Benefits

• 01:01:48 Interval Walking Training

• 01:04:01 Conclusion and Future Insights

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The Real Reason You Still Feel Tired—Even When Your Bloodwork Looks Perfect | Dr Pompa : 1273 Apr 24, 2025

Show notes

Your bloodwork looks normal. Your doctor says you’re fine. But you still feel exhausted, inflamed, anxious—or worse.

In this episode, Dave Asprey talks with Dr. Daniel Pompa, a leading voice in cellular detox and root-cause healing, to expose the hidden stressors hijacking your energy, hormones, and metabolism—even when your labs say you’re healthy.

Dr. Pompa shares his personal health collapse and reveals how cellular dysfunction, neurotoxicity, and hormone resistance drive the chronic fatigue epidemic. If you’ve ever felt dismissed by “perfect” bloodwork, this conversation will rewire how you think about sickness—and show you how to reclaim real, lasting wellness.

What You’ll Learn in This Episode:

• Why your bloodwork can be “perfect” while your cells are on fire

• The overlooked hormone resistances sabotaging your energy and metabolism

• The 3-legged stool of chronic illness—and what actually drives disease

• What “upstream detox” really means, and why most cleanses make you worse

• Why toxins trigger genetic expression (and how to shut that down)

• How to fix unexplainable fatigue, anxiety, and weight gain from the inside out

• Why true healing starts with fixing the cell, not the symptom

It’s time to stop chasing symptoms—and start upgrading from the root.

**Check out Dr. Pompas EXCLUSIVE protocol built for The Human Upgrade listeners at davetestkit.com and use code ‘10OFF’ for a discount!**

SPONSORS

-Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.

-Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• Dr. Pompa’s Website – https://drpompa.com/

• Dr. Pompa’s Instagram - https://www.instagram.com/drpompa/?hl=en

• 2025 Biohacking Conference: https://biohackingconference.com/2025

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

• Own an Upgrade Labs: https://ownanupgradelabs.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com

Timestamps:

• 00:00 Trailer

• 00:55 Intro

• 01:10 Healthy Is the New Sick

• 02:27 Bloodwork & Hormone Resistance

• 04:32 Dr. Pompa’s Health Collapse

• 08:38 Toxins & Environmental Triggers

• 15:01 Why Most Detox Fails

• 29:16 The 5 Rs of Cellular Healing

• 37:06 Olive Oil: Cure or Concern?

• 38:11 Fat Balance for Energy

• 42:13 Cholesterol & Saturated Fat

• 46:26 Restoring Cellular Energy

• 51:08 The Power of Diet Variation

• 56:57 Plant Toxins Explained

• 01:03:28 Emotional & Spiritual Detox

• 01:13:55 Final Thoughts

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The $500 Billion Secret: Why Top Leaders Chase Stress | Sébastien Page : 1272 Apr 22, 2025

Show notes

Most people run from stress. The world’s highest performers run toward it.

Sébastien Page manages over $500 billion in global assets. He’s the CIO of one of the world’s largest investment firms, and he wrote The Psychology of Leadership while living under relentless pressure. His secret? He doesn’t avoid stress—he uses it as a tool for performance, clarity, and control.

But here’s the twist: this isn’t just about boardrooms or billion-dollar trades.

Whether you’re running a company, chasing a deadline, or just trying to stop procrastinating on your goals—this conversation will flip what you think you know about pressure, performance, and productivity.

You’ll learn why trying to “relax your way to success” doesn’t work—and how to harness discomfort to create better decisions, higher output, and more resilience in every part of life.

What You’ll Learn in This Episode:

• The psychology of stress and why zero stress leads to burnout

• How procrastination can boost creative performance

• What astronauts, athletes, and leaders have in common

• Why the key to better decisions is strategic patience, not speed

• The stress-performance curve no one taught you in school

• Why losing is the real path to mastery (and what Roger Federer can teach you)

• The difference between being nice vs. being kind—and why it matters

It's time to start turning stress into strategy.

SPONSORS

-fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.

-BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 for 20% off your first order of PerfectAmino.

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• Sébastien’s New Book –The Psychology of Leadership – https://www.psychologyofleadership.net/

• 2025 Biohacking Conference: https://biohackingconference.com/2025

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

• Own an Upgrade Labs: https://ownanupgradelabs.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com

Timestamps:

• 00:00 Intro

• 02:00 Book Launch & Setup

• 02:45 Buy or Sell? Market Insights

• 03:20 Stress and Performance

• 04:28 Sports Psychology Breakdown

• 09:48 Federer & the Power of Losing

• 26:42 Rethinking Feedback

• 31:32 Stress as a Tool

• 44:10 Listening as Leadership

• 44:17 Traits of Great Leaders

• 44:54 Psychology for Entrepreneurs

• 45:37 Leading Beyond Work

• 46:09 Sleep Tracking Anxiety

• 47:39 Channeling Stress

• 49:04 Extreme Pressure Moments

• 50:42 The Corporate Athlete

• 59:08 Vulnerability & Leadership

• 01:05:23 Goal-Induced Blindness

• 01:12:34 Finding Meaning at Work

• 01:18:08 Leadership at Home

• 01:20:27 Final Takeaways

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Web3 & the Future of Genetics: AI, Blockchain & Data Ownership with Nillion : 1271 Apr 17, 2025

Show notes

Your DNA, health data, and digital identity are encrypted, monetized, and weaponized against you.

But what if there was a way to take it back… and hack the system?

In this mind-expanding episode, Dave sits down with two elite hacker-founders—Michael Tiffany, CEO of Fulcra.ai, and Vishakh, founder of Monadic DNA—to explore a radical shift in the way we store, protect, and use our most personal data.

Together, they break down the Web3 tech stack powering this revolution. Enter Nillion, a distributed, privacy-preserving compute network that allows you to share and analyze your encrypted data… without ever giving it away.

From genomic privacy to AI sovereignty, this episode exposes the hidden architecture of control—and how to escape it. You’ll learn how cutting-edge blockchain and cryptography are rewriting the rules of ownership, consent, and even identity itself.

What You’ll Learn in This Episode:

• Why your DNA is already in government databases—and how long they keep it

• How Nillion enables secure computation on private data

• What it means to build a “cybernetic operating system” for your body

• Why Fulcra.ai is building the orchestration layer of human optimization

• How Monadic DNA helps you profit from your genetics—without giving them away

• Why owning your data is the next frontier of biohacking

• The surprising connection between decentralization, health freedom, and consciousness

• How to join the movement toward true data sovereignty

If you’ve ever felt like you’re giving away too much to big tech, big pharma, or just the internet itself—this conversation will change how you see your data… and your body.

**Join the Fulca sleep study today! Visit https://fulcra.ai/sleep to sign up**

**Get a 30% discount on Fulca with code “DAVE”!

SPONSORS

-IGNITON | Go to https://www.biohackingconference.com/ and get your tickets while there are still great discounts available. Go to https://www.igniton.com/DAVE and use code DAVE to save 15%.

-Calroy | Head to https://calroy.com/dave for an exclusive discount.

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• Fulcra Dynamics Website – https://www.fulcradynamics.com/

• MonadicDNA Website: https://monadicdna.com/

• 2025 Biohacking Conference: https://biohackingconference.com/2025

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

• Own an Upgrade Labs: https://ownanupgradelabs.com

• Upgrade Labs: https://upgradelabs.com