Science

The Feldman Protocol

Dave Feldman hosts the Feldman Protocol, a long form, in-person podcast largely covering science, nutrition, and technology – with a lot of personal stories, interests and pop culture mixed in.

Latest Episodes:

Maria Emmerich on PCOS, Keto Cookbooks, and Why She Now Adds Carbs Back In Oct 29, 2026

Show notes

In this episode of The Feldman Protocol, what does nearly three decades of low-carb living actually look like when life keeps throwing curveballs? Maria Emmerich (nutritionist and author of 24 cookbooks) joins Dave to share how a PCOS diagnosis at 16 set her on an unconventional path long before keto entered the mainstream. They discuss lipotoxicity, the protein-sparing modified fast approach, LDL in the context of high-fat diets, hormones and HRT, and the role of coaching in long-term dietary adherence.

📎 Mentioned in this episode:

• 27:30 – Maria Emmerich's book series: The Art of Eating Healthy: `https://keto-adapted.com/product-category/ebooks/`

• 28:22 – Maria Emmerich's book: Keto Adapted: `https://www.amazon.com/Keto-Adapted-Maria-Emmerich-ebook/dp/B00GTU9AJC`

• 1:22:44 – Maria Emmerich's website: ketomaria.com: `https://ketomaria.com/`

• 1:48:58 – Maria Emmerich's book: The Art of Metabolic Health: `https://www.amazon.com/Art-Metabolic-Health-METABOLIC-RESILIENCE/dp/B0GWWK9HLC`

• 2:18:42 – Maria Emmerich's YouTube channel: `https://www.youtube.com/channel/UCyZia0TtezGqjGcXwXJhDoQ`

🔥 This episode is sponsored by us --

Own Your Labs 👉 `https://ownyourlabs.com/sp/58`

Private blood testing services

🩸Over 300 blood tests

💰Extremely affordable

❤️ We love our customers

(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)

🔗 CONNECT WITH DAVE FELDMAN:

Main Channel: `https://youtube.com/@realDaveFeldman`

X/Twitter: `https://x.com/realDaveFeldman`

Instagram: `https://instagram.com/realDaveFeldman`

Website: `https://thefeldmanprotocol.com`

⏱ Chapters

0:00 – Cold open & introduction

3:59 – PCOS diagnosis at 16 and diet origins

13:07 – Starting a nutrition business from scratch

18:39 – Adoption journey and financial hardship

33:09 – Craig's Lyme disease diagnosis

43:15 – How Dave and Maria first met

51:56 – Protein-sparing modified fast explained

1:00:01 – Family carnivore experiment and homeschooling

1:05:12 – LDL, saturated fat, and dietary adjustments

1:11:11 – Lipotoxicity and personal fat threshold

1:27:21 – Maria's ICU hospitalizations and electrolytes

1:32:07 – Gluconeogenesis and carb reintroduction

1:43:48 – GLP medications and the community's future

1:55:21 – Hormones, HRT, and testosterone in women

2:03:12 – Physical and emotional wellbeing; whale surfing

2:07:57 – Bow hunting story and patience

2:10:39 – Cookbooks in eldercare and closing reflections

2:17:16 – AI, creativity, and wrapping up

#FeldmanProtocol #DaveFeldman #MariaEmmerich #Keto #LowCarb #MetabolicHealth #ProteinSparingModifiedFast #Lipotoxicity #PCOS #LDL #HRT #Carnivore #CookbookAuthor #NutritionCoaching #IntermittentFasting #GLP1 #BloodWork #Hormones #WeightLoss

Why a 575-Pound Man Had Perfect Metabolic Labs – Craig Emmerich Oct 26, 2026

Show notes

In this episode of The Feldman Protocol, can individual biology shape whether a given diet or protocol actually works — or does one approach fit everyone? Craig Emmerich (co-author and nutrition researcher alongside Maria Emmerich) makes the case for bioindividuality in metabolic health, discussing his decade-long journey with chronic Lyme disease and ankylosing spondylitis, the protein-sparing modified fast as a weight-loss tool, a fat-cell–centric view of insulin resistance, oxidative priority of fuel sources, and whether AI may reshape personalized medicine.

📎 Mentioned in this episode:

• 23:34 – Craig & Maria Emmerich — The Art of Metabolic Health (book): `https://www.amazon.com/Art-Metabolic-Health-METABOLIC-RESILIENCE/dp/B0GWWK9HLC`

• 1:46:03 – Craig & Maria Emmerich — Carnivore Cookbook (book): `https://www.victorybelt.com/the-carnivore-cookbook`

• 1:48:59 – Podcast episode: Craig Emmerich on Judy Cho's podcast: `https://podcasts.apple.com/us/podcast/nutrition-with-judy-carnivore-diet/id1529951307`

• 2:32:25 – Maria Emmerich — ketomaria.com (books, blog, social media hub): `https://ketomaria.com/`

🔥 This episode is sponsored by us --

Own Your Labs 👉 `https://ownyourlabs.com/sp/`

Private blood testing services

🩸Over 300 blood tests

💰Extremely affordable

❤️ We love our customers

(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)

🔗 CONNECT WITH DAVE FELDMAN:

Main Channel: `https://youtube.com/@realDaveFeldman`

X/Twitter: `https://x.com/realDaveFeldman`

Instagram: `https://instagram.com/realDaveFeldman`

Website: `https://thefeldmanprotocol.com`

⏱ Chapters

0:00 – Introduction & cold open

1:18 – Craig's background and origin story

5:00 – Engineering path and college years

8:41 – Honeywell: defense tech & Land Warrior

14:15 – Traveling the world in chip testing

21:26 – Publishing the first low-carb cookbook

32:18 – Meeting Dave & low-carb conference circuit

38:24 – Chronic pain and the road to diagnosis

45:13 – Ankylosing spondylitis and Lyme co-infections

54:40 – Diet as symptom management vs. root cause

1:01:43 – Hip replacement and recovery

1:07:08 – Protein-sparing modified fast explained

1:22:18 – Fat cells, insulin resistance & personal fat threshold

1:35:29 – Lipodystrophy, leptin & ectopic fat

1:47:32 – Carnivore as elimination protocol

1:59:01 – Insulin, weight loss & the carbohydrate debate

2:09:52 – Oxidative priority of fuels

2:17:00 – Listener Q&A and closing thoughts

#FeldmanProtocol #DaveFeldman #CraigEmmerich #MariaEmmerich #LowCarb #Ketogenic #ProteinSparing #InsulinResistance #LymeDisease #AnkylosingSpondylitis #MetabolicHealth #FatCells #PersonalFatThreshold #OxidativePriority #Carnivore #ProteinPrioritized #Bioindividuality #ChronicPain #NutritionScience

Sameer Dossani on Gut Health, Carnivore Transition, and Cholesterol Science Oct 23, 2026

Show notes

In this episode of The Feldman Protocol, how should researchers and clinicians weigh insulin resistance against lipid markers when assessing cardiovascular risk? Dave Feldman sits down with Sameer Dossani (PhD, anthropology; health coach specializing in autoimmune and gut conditions) to explore human evolutionary dietary history, the origins of metabolic disease across ancient cultures, the lean mass hypersponder phenotype and ketone production, challenges in science communication, and the role of AI in personalized health.

📎 Mentioned in this episode:

• 1:23:33 – Bradford Hill 1965 — 'Environment and Disease' (criteria paper): `https://pmc.ncbi.nlm.nih.gov/articles/PMC1898525/`

• 1:33:20 – Ramsden 2015 re-analysis — Minnesota Coronary Experiment & Sydney Diet Heart Trial: `https://doi.org/10.1136/bmj.i1246`

• 2:23:35 – Zero-fiber vs high-fiber constipation RCT (2012) — discussed by Nick Norwitz: `https://www.wjgnet.com/1007-9327/full/v18/i33/4593.htm`

• 3:04:05 – Sameer Dossani's Linktree (all links): `https://linktr.ee/SameerDossani`

• 3:04:07 – Sameer Dossani's YouTube channel — @meatheels: `https://www.youtube.com/@MeatHeals`

🔥 This episode is sponsored by us --

Own Your Labs 👉 `https://ownyourlabs.com/sp/56`

Private blood testing services

🩸Over 300 blood tests

💰Extremely affordable

❤️ We love our customers

(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)

🔗 CONNECT WITH DAVE FELDMAN:

Main Channel: `https://youtube.com/@realDaveFeldman`

X/Twitter: `https://x.com/realDaveFeldman`

Instagram: `https://instagram.com/realDaveFeldman`

Website: `https://thefeldmanprotocol.com`

⏱ Chapters

0:00 – Cold open and introduction

1:05 – Sameer's background and credentials

3:42 – Human origins and migration out of Africa

9:20 – Career in international economics and NGOs

15:34 – Ancient medicine and carbohydrate restriction

22:31 – Food culture, comfort eating, and self-soothing

34:12 – Human evolutionary diet: specialist vs. generalist

43:23 – Persistence hunting, sweat glands, and melanin

55:29 – Platform suppression and content challenges

1:03:03 – Sameer's personal health journey and diet shift

1:14:10 – Reaven's insulin resistance study and LDL findings

1:23:30 – Bradford Hill criteria and epidemiological data

1:33:09 – Minnesota Coronary experiment and withheld data

1:43:58 – Ketogenic diets, euketonemia, and fad diet framing

1:54:34 – LMHR study: plaque progression and CLEARLY analysis

2:04:27 – Statin pleiotropic effects and pharmaceutical trade-offs

2:18:20 – Own Your Labs Q&A: protein, muscle, and gut health

2:32:01 – Gut health, sleep, fatigue, and meal timing

2:46:26 – LMHR ketone production explained by Dave

2:52:04 – Changing the narrative: data, science, and next steps

#FeldmanProtocol #DaveFeldman #SameerDossani #LeanMassHyperResponder #InsulinResistance #MetabolicHealth #LDL #Cholesterol #HumanEvolution #AncestralDiet #LowCarb #Ketogenic #AutoimmuneHealth #GutHealth #CholesterolCode #BloodWork #Carnivore #EpidemiologyDebate #ScientificMethod #HealthCoaching

Bronson Dant – Keto and Athletic Performance: What the Studies Miss Oct 16, 2026

Show notes

In this episode of The Feldman Protocol, can the principles of metabolic flexibility reframe how athletes — and everyday people — think about fueling exercise? Dave Feldman sits down with Bronson Dant (metabolic performance coach and doctoral candidate in health science), who makes the case that food is function, not fuel. Bronson discusses his Army nutrition research experience, his carnivore diet journey and its effect on longstanding IBS, the distinction between fitness and health, oxidative priority debates, and emerging research on ketogenic adaptation timelines.

📎 Mentioned in this episode:

• 2:18:58 – Clinical audit of Dr. Mark Cucuzella's VA low-carb nutrition program: `https://journalofmetabolichealth.org/index.php/jmh/article/view/141`

• 3:00:37 – Bronson Dant & colleagues — substrate-corrected VO2 / movement economy paper: `https://journalofexerciseandnutrition.com/index.php/JEN/article/view/212`

• 3:02:58 – Coach Bronson's website / coaching hub (coachbronson.com): `https://coachbronson.com/`

• 3:03:04 – Coach Bronson — YouTube channel: `https://www.youtube.com/@coach.bronson`

🔥 This episode is sponsored by us --

Own Your Labs 👉 `https://ownyourlabs.com/sp/55`

Private blood testing services

🩸Over 300 blood tests

💰Extremely affordable

❤️ We love our customers

(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)

🔗 CONNECT WITH DAVE FELDMAN:

Main Channel: `https://youtube.com/@realDaveFeldman`

X/Twitter: `https://x.com/realDaveFeldman`

Instagram: `https://instagram.com/realDaveFeldman`

Website: `https://thefeldmanprotocol.com`

⏱ Chapters

0:00 – Cold open & intro

1:15 – Bronson's background in fitness

6:36 – Decision to join the Army

11:04 – Army nutrition research at Natick Labs

20:57 – Transition from IT to CrossFit coaching

31:52 – Opening a gym: lessons learned

51:20 – Carnivore as an elimination approach

1:05:04 – IBS resolution and dietary change

1:21:56 – Coaching, identity & behavior change

1:34:22 – The 2020 disruption & rebuilding

1:46:43 – Systems thinking in nutrition science

1:56:37 – Metabolic flexibility: four components

2:04:06 – Ketogenic adaptation & performance research

2:18:09 – Virginia nutrition counseling audit findings

2:30:09 – Nutrition advice across training types

2:41:21 – Oxidative priority and food as function

2:50:26 – Glycogen storage, fat adaptation & RER

3:00:37 – Substrate-corrected VO2 research

3:02:53 – Where to find Bronson & closing thoughts

#FeldmanProtocol #DaveFeldman #BronsonDant #MetabolicFlexibility #CarnivoreDiet #KetogenicDiet #SportsNutrition #LowCarbPerformance #FoodAsFunction #ExerciseScience #IBSRecovery #FatAdaptation #OxidativePriority #CrossFit #MetabolicHealth #NutritionCoaching #BloodWork #HealthOptimization

Zachary DiMattia and Dave Feldman Debate LDL, Keto-CTA and Lean Mass Hyper-Responders Oct 09, 2026

Show notes

In this episode of The Feldman Protocol, what does emerging research actually reveal about cardiovascular risk in people who develop extreme LDL elevations on ketogenic diets — and how much remains genuinely unresolved? Zachary DiMattia (nutritional scientist, Penn State) joins Dave to discuss his published review on ketogenic diet–induced LDL elevations in normal-weight adults, presents preliminary findings from his controlled feeding study comparing low- and high-BMI responses to a ketogenic diet, and engages Dave in a frank debate over plaque progression data, the lipid hypothesis, and the novel regressor findings from the Keto-CTA cohort.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/54` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Cold open & key findings preview1:24 – Zachary's background intro5:02 – Path to nutrition research8:01 – Hashimoto's diagnosis journey13:27 – Elimination diet & gluten discovery21:49 – Interest in ketogenic LDL response26:03 – Penn State controlled feeding study design34:12 – Preliminary study results41:40 – Review paper overview51:04 – Lipid hypothesis steel-man debate1:05:49 – LMHR phenotype & clinical context1:18:35 – Proposed mechanisms beyond LEM1:26:14 – Keto-CTA plaque progression data1:40:41 – Regressor findings & noise floor1:49:09 – Miami Heart match analysis2:03:50 – Mechanisms: adiposity & cholesterol2:14:52 – Nature CT study comparison2:43:29 – Audience questions & closing thoughts#FeldmanProtocol #DaveFeldman #ZacharyDiMattia #LeanMassHyperResponder #KetogenicDiet #LDLCholesterol #Cardiovascular #Atherosclerosis #LipidResearch #NutritionalScience #CholesterolResearch #PlaqueProg #KetoCTA #LipidEnergyModel #Cardiometabolic #LowCarbResearch #Bloodwork #HeartHealth

Lauren Kennedy West on Schizoaffective Disorder, Ketogenic Therapy, and Psychiatric Identity Oct 03, 2026

Show notes

In this episode of The Feldman Protocol, can what we eat meaningfully influence the course of serious mental illness? Dave sits down with Lauren Kennedy West (mental health advocate and YouTuber living with schizoaffective disorder) to explore her personal journey from multiple hospitalizations and misdiagnoses to adopting therapeutic ketosis. Lauren makes the case for metabolic psychiatry as a complement to traditional care, discusses the identity challenges of sharing her N-of-1 experiment publicly, reflects on navigating medication tapering, community polarization, the role of AI in personalized care, and the social complexity of restrictive eating.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/53` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Cold open & sucralose reaction1:14 – Lauren introduces herself2:46 – Early symptoms & the teenage years6:00 – First diagnosis journey8:20 – Hospitalizations & ECT11:46 – Dave's reflections on illness identity15:27 – YouTube channel origins19:32 – First attempt at ketogenic diet23:46 – Accessing metabolic psychiatry32:16 – Community reaction to going keto37:54 – Eating disorder concerns & food identity42:14 – The sushi experiment in San Francisco50:38 – Defined by wellness, not illness54:32 – Medication tapering & potentiation1:00:04 – Running, soccer & the ACL injury1:07:53 – Kids, diet, and parenting challenges1:17:00 – Metabolic Mind partnership & the course1:19:18 – Desk questions: dirty keto & sucralose1:23:08 – Meds vs. metabolic therapy: how it feels1:28:52 – Traveling keto & snack strategies1:39:31 – Community building & echo chambers1:47:42 – Social media, nuance & polarization1:58:11 – Platform challenges & demonetization2:05:53 – Patient autonomy & medical humility2:14:05 – Living well: nuance over narrative2:21:26 – AI in diagnostics & mental health care2:31:00 – AI sycophancy & trust concerns2:39:23 – The future of AI-assisted therapy2:46:09 – Parallels: AI guardrails & patient autonomy2:51:55 – Where to find Lauren#FeldmanProtocol #DaveFeldman #LaurenKennedyWest #MetabolicPsychiatry #KetogenicDiet #MentalHealth #Schizoaffective #SchizophreniaAwareness #BrainEnergy #TherapeuticKetosis #MentalWellness #NutritionAndMindHealth #AIInHealthcare #PatientAutonomy #LowCarbLife #ChristopherPalmer #MetabolicMind #MentalHealthAdvocacy

Arthur Agatston (Part 3) on Insulin Resistance, LP(a), and Why He Went Militantly Keto Sep 24, 2026

Show notes

In this episode of The Feldman Protocol, how does metabolic health shape cardiovascular risk — and does the conventional focus on individual biomarkers miss the bigger picture? Dave Feldman sits down with cardiologist Arthur Agatston (MD), creator of the South Beach Diet and the coronary calcium score, to explore blood pressure guideline debates, insulin resistance and preeclampsia, the origins of the South Beach Diet, LP(a) and plaque progression in lean mass hyper-responders, HDL dysfunction, and the lipid energy model's structural hypothesis.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/52` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Introduction & cold open2:02 – Blood pressure monitoring technology6:57 – Dave & Arthur on BP guideline debates9:36 – Cholesterol targets & guideline pressures12:20 – Type 1 diabetes & low-carb care gaps15:26 – Joseph Kraft, insulin, and missed signals21:53 – Inertia in medicine & the role of AI27:06 – Insulin resistance, Kraft test & preeclampsia33:40 – Origins of the South Beach Diet40:17 – Carbohydrate addiction & personal experience51:32 – Elimination diets & unexpected symptom relief57:04 – Fat adaptation & lipoprotein dynamics1:00:00 – Triglycerides, remnant particles & VLDL1:05:11 – Particle size, ApoB & atherogenicity1:11:19 – LP(a) findings in lean mass hyper-responders1:19:45 – FH, plaque progression & LDL context1:33:31 – 4S trial, small dense LDL & statin data1:40:11 – HDL dysfunction & the HDL bump phenotype1:56:21 – Lipid energy model & structural hypothesis2:01:38 – Fat adaptation, F1, and closing reflections#FeldmanProtocol #DaveFeldman #ArthurAgatston #LipidEnergyModel #InsulinResistance #HeartHealth #CalciumScore #LDLCholesterol #MetabolicHealth #LowCarb #KetogenicDiet #ApoB #HDLDysfunction #Preeclampsia #SouthBeachDiet #Lipoproteins #CardiovascularResearch #FunctionalCardiology

Dr. Arthur Agatston (Part 2) - Why Did Most Keto Patients Show Zero Plaque Despite LDL of 250? Sep 21, 2026

Show notes

In this episode of The Feldman Protocol, how does metabolic health shape cardiovascular risk — and what does that mean for interpreting cholesterol markers in lean, low-carb individuals? Arthur Agatston (MD) makes the case for a functional model of atherosclerosis progression, discusses AI-driven advances in cardiac imaging, argues for revisiting how blood pressure is measured and treated, and explores electrolyte management on ketogenic diets — all through a wide-ranging scientific conversation with Dave.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/51` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Cold open & intro7:11 – Late eating & metabolic effects12:37 – Western diet spreading globally18:07 – Personal fat threshold explained23:01 – Lipid energy model & LDL cycling30:26 – Exercise type & lipoprotein uptake38:39 – AI-enhanced cardiac imaging45:17 – Arterial flexibility & plaque burden53:20 – South Beach Diet origins1:00:39 – Scientific uncertainty in medicine1:06:41 – LMHR study: plaque findings1:16:57 – Plaque regression & calcification1:26:57 – Photon CT & next-gen imaging1:33:20 – Hypertension history & FDR1:41:30 – Blood pressure measurement issues1:49:44 – Keto, insulin & sodium loss1:55:09 – Overhydration & electrolyte balance2:00:08 – Electrolyte management on keto#FeldmanProtocol #DaveFeldman #ArthurAgatston #CardiovascularHealth #LowCarbDiet #LeanMassHyperResponder #LipidEnergyModel #HeartHealth #CACScore #KetogenicDiet #Atherosclerosis #BloodPressure #Electrolytes #MetabolicHealth #SouthBeachDiet #CardiacImaging #AIinMedicine #Cholesterol

The Stent Myth: Why Fixing a Blockage Isn’t a Cure - Dr. Arthur Agatston Sep 18, 2026

Show notes

In this episode of The Feldman Protocol, how well do conventional cardiovascular risk metrics actually identify who is truly at risk for a heart attack decades before it happens? Cardiologist Arthur Agatston (MD) makes the case for coronary calcium scoring as an early detection tool, discusses the natural history of atherosclerotic plaque, revisits key moments in lipid science history, explores why stent placement in asymptomatic patients presents a more complex picture than intuition suggests, and shares observations on the evolving role of CT angiography and AI-assisted plaque analysis.

🔥 This episode is sponsored by us --

Own Your Labs 👉 `https://ownyourlabs.com/sp/50`

Private blood testing services

🩸Over 300 blood tests

💰Extremely affordable

❤️ We love our customers

(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)

🔗 CONNECT WITH DAVE FELDMAN:

Main Channel: `https://youtube.com/@realDaveFeldman`

X/Twitter: `https://x.com/realDaveFeldman`

Instagram: `https://instagram.com/realDaveFeldman`

Website: `https://thefeldmanprotocol.com`

⏱ Chapters

0:00 – Cold open & introduction

7:46 – Arthur's path into medicine

18:59 – Early cardiology & clinical trials

27:47 – Lipid science history & Ancel Keys

39:04 – Rabbit studies & lipoprotein discovery

47:15 – Ultra-fast CT arrives at Sinai

55:26 – Collateral vessels & total occlusion

1:00:00 – Ischemia trial: stents vs. medical therapy

1:05:01 – Back to the CAC origin story

1:13:09 – Soft vs. calcified plaque progression

1:21:40 – FH patient with zero CAC score

1:26:53 – The Agatston score is named

1:33:51 – Power of zero & plaque burden

1:39:35 – CAC vs. CT angiogram explained

1:44:19 – Resistance to new imaging technology

1:48:34 – Nutrition interest in the 1990s

1:49:25 – Heart Lung AI & plaque ratio research

1:51:11 – Closing reflections

#FeldmanProtocol #DaveFeldman #ArthurAgatston #CoronaryCalcium #HeartHealth #Atherosclerosis #CardiacImaging #CACScore #LDL #Lipids #PlaqueBiology #CTAngiogram #CardiologyResearch #LowCarbDiet #LeanMassHyperResponder #HeartDiseasePrevention #LipidScience #CardiovascularResearch

Isabella Cooper – Part 2 – Ketogenic Diet and Cancer: What the Science Actually Shows Sep 11, 2026

Show notes

In this episode of The Feldman Protocol, how does insulin influence cancer cell behavior — and what does that mean for metabolic approaches to the disease? Dave sits down with Isabella Cooper (PhD) to explore the glucose-ketone index and its practical limits, the role of glutamine alongside glucose in cancer metabolism, how mitochondrial dysfunction and cardiolipin loss may relate to tumor progression, the case for high-dose intravenous vitamin C, osteocyte biology and the surprising systemic roles of osteocalcin, and what makes a rigorous research culture.

🔥 This episode is sponsored by us --

Own Your Labs 👉 `https://ownyourlabs.com/sp/49`

Private blood testing services

🩸Over 300 blood tests

💰Extremely affordable

❤️ We love our customers

(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)

🔗 CONNECT WITH DAVE FELDMAN:

Main Channel: `https://youtube.com/@realDaveFeldman`

X/Twitter: `https://x.com/realDaveFeldman`

Instagram: `https://instagram.com/realDaveFeldman`

Website: `https://thefeldmanprotocol.com`

⏱ Chapters

0:00 – Cold open & intro

1:08 – Cancer metabolism overview

2:24 – Glucose-ketone index explained

5:01 – Lean mass hypersponders & glucose

9:18 – Acetone measurement & respiration

13:49 – Insulin, ketones & cancer signaling

19:05 – Growth factors & VEGF discussion

25:29 – Stomach acidity & nutrient absorption

32:08 – How cancer cells originate

35:43 – Cardiolipin, melatonin & apoptosis

43:05 – Diet quality & food as function

52:14 – Chemotherapy & metabolic protocols

1:03:36 – Patient outcomes & biopsy risks

1:14:32 – IV vitamin C trial findings

1:22:07 – Ideal cancer metabolism trial design

1:29:36 – Sunlight, melanin & mitochondria

1:37:20 – Osteocyte biology & osteocalcin

1:46:43 – Research culture & scientific rigor

1:54:36 – Most underappreciated biomarker

#FeldmanProtocol #DaveFeldman #IsabellaCooper #CancerMetabolism #KetogenicDiet #Mitochondria #Insulin #GlucoseKetoneIndex #Osteocalcin #IntravenousVitaminC #Ketosis #MetabolicHealth #LowCarbScience #CancerResearch #Cardiolipin #Osteocytes #BloodWork #Hyperinsulinemia #MitochondrialHealth #PodcastScience

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