Sapio with Buck Joffrey

110: Unique Framework for Nutrition and Longevity Nov 18, 2024

In this episode, Buck dives into the groundbreaking work of Dr. David Raubenheimer and Professor Stephen Simpson, renowned nutritional scientists from the University of Sydney. They unpack the "Geometric Framework for Nutrition," a holistic and visual approach that examines how nutrients interact to shape health and aging. From protein leverage to balancing macronutrients for longevity, this conversation challenges conventional calorie counting and offers profound insights into optimizing diet across the lifespan.

109: Red Light in Mitochondrial Health Nov 11, 2024

Buck and Prof Glen Jeffery dive deep into the science of red light therapy, revealing how it boosts mitochondrial function and potentially slows aging. He shares groundbreaking insights from clinical trials, showing how red light can recharge cellular energy and improve vision health. We get into practical tips on using red light therapy—where to get it, when to use it, and what to watch out for in devices.

108: Diving Deep on Lipids and Heart Disease Nov 04, 2024

Buck interviews Dr. Dennis Hughes, a concierge physician with a special interest in lipidology. They discuss the complexities of cholesterol, the importance of understanding lipid profiles, and the role of various lipoproteins in cardiovascular health. Dr. Hughes emphasizes the need for modern medicine to move beyond outdated notions of 'good' and 'bad' cholesterol, advocating for a more nuanced understanding of lipid management. The discussion also covers key lab tests, the significance of apolipoprotein B, and the future of pharmacotherapy in lipid management.

04:51 Understanding Cholesterol: Beyond Good and Bad 08:25 Key Lab Tests for Lipid Management 11:12 The Role of Apolipoprotein B in Cardiovascular Health 14:44 The Complexities of HDL and Its Functions 19:11 The Misconceptions Around LDL and HDL Ratios 34:42 Pharmacotherapy: Statins and Beyond

Do You Have Your Longevity Roadmap? Oct 28, 2024

107: Longevity Supplements - The Novos Approach Oct 28, 2024

Dr. Diogo Barardo, Director of Research and Development at Novos, joins Buck to discuss Novos’ innovative approach to longevity supplements, unpacking the differences between biological and epigenetic aging and the impact of the Drug Age database. He details how Novos evaluates compounds for safety and efficacy, the unique ingredients in their flagship NovoScore, and the promising roles of lithium microdoses and NAD precursors. Their conversation also delves into the latest in longevity science, from the controversies around resveratrol to mitophagy’s role in cellular health, the complexities of supplement dosages, and the potential of aging biomarkers and AI-driven research for consumer longevity solutions.

Learn more about Dr. Barardo and NOVOS: https://novoslabs.com/

00:00 Introduction to Longevity Research and Novos 02:04 Understanding Biological and Epigenetic Aging 09:20 The Drug Age Database and Its Significance 10:37 Longevity Compounds and Their Efficacy 20:58 The Role of Lithium and NAD Precursors 26:44 The Role of Mitochondria in Aging 36:14 Leveraging AI in Longevity Research

106: Nitric Oxide - The X Factor in Longevity? Oct 21, 2024

Buck and Dr. Nathan Bryan delve into the pivotal role of nitric oxide in human physiology, with a particular focus on cardiovascular health and aging. Dr. Bryan breaks down the body’s nitric oxide production processes, how everyday lifestyle choices impact its levels, and what happens when there’s a deficiency. He also explores the surprising connection between oral hygiene and nitric oxide, the risks associated with proton pump inhibitors, and the promise of emerging products designed to boost nitric oxide levels. Additionally, Dr. Bryan addresses genetic factors such as MTHFR polymorphisms that can impact nitric oxide synthesis, shedding light on their broader implications for health and longevity.

00:00 The Role of Nitric Oxide in Human Physiology 02:54 Age-Related Decline of Nitric Oxide and Cardiovascular Health 05:49 Understanding Nitric Oxide Production Pathways 09:03 The Impact of Oral Health on Nitric Oxide Levels 12:11 Proton Pump Inhibitors and Their Effects on Nitric Oxide 15:12 Pharmaceutical Approaches to Increase Nitric Oxide 18:03 Innovations in Nitric Oxide Delivery Systems 21:25 The Role of Nitric Oxide as a Hormone 23:02 Nitric Oxide in COVID-19 Treatment 25:58 MTHFR Gene and Nitric Oxide Production 29:05 Cardiovascular Disease and Nitric Oxide 31:53 Safety and Regulation of Nitric Oxide 34:05 Cholesterol Myths and Nitric Oxide's Importance

105: Understanding Heart Rate Variability Oct 14, 2024

Buck speaks to Dr. Torkil Færø, a Norwegian general practitioner, emergency physician, and seasoned traveler with Doctors Without Borders, to discuss the crucial relationship between stress, heart rate variability (HRV), and overall health. Dr. Færø delves into how HRV serves as a key indicator of our body’s autonomic nervous system balance, showing how lifestyle factors, particularly chronic stress, can undermine well-being. He highlights practical strategies, from breathwork to dietary adjustments, aimed at optimizing HRV and promoting long-term health.

00:12 What is Heart Rate Variability?

05:34 The Normal Range of HRV

08:39 Contributing Factors that Impact Your HRV

23:18 Tactics to Improve HRV

104: The Real Science Behind Mitochondrial Health Oct 07, 2024

Buck discusses the implications of mitochondrial dysfunction on aging, and the unique genetics of mitochondrial DNA. He also explores innovative approaches to enhance mitochondrial health, including gene therapy and the use of specific pharmaceuticals and supplements. Buck emphasizes the importance of understanding mitochondrial function in the context of health and longevity, while also addressing the potential challenges posed by medications like statins and conditions such as long COVID.

02:07 What are Mitochondria?

05:05 Mitochondrial Dysfunction and Aging

12:13 Mitochondrial Genetics and Inheritance

14:54 Innovative Approaches to Mitochondrial Health

17:58 Pharmaceuticals and Supplements for Mitochondrial Support

103: Microplastics and Your Health - One More Thing to Worry About Sep 30, 2024

Buck delves into the pervasive issue of microplastics, exploring their sources, health risks, and potential strategies for detoxification and exposure reduction. He discusses how microplastics infiltrate our food, water, and air, and the alarming health implications they pose, including chronic inflammation and potential links to cancer, as well as practical steps to minimize exposure to microplastics in daily life.

102: Everything You’ve Been Told About Fat Loss is a Lie – Layne Norton Exposes the Truth Sep 23, 2024

In this episode of Longevity Junky, Buck and Nikki tackle one of the most contentious and polarizing areas of longevity, diet with Bio Layne founder Dr. Layne Norton.

Learn more about BioLayne and Dr. Layne Norton: https://biolayne.com/coach/layne-norton/

Full episode in video available on YouTube: https://www.youtube.com/channel/UCh6LlBjtOy7lldU7Ldjw0cw

Questions? Send us a message at: www.longevityjunky.com

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Tiktok: https://www.tiktok.com/@longevityjunkypodcast

101: Can we see mental illness on brain scans? Sep 16, 2024

Buck introduces his brand new podcast, Longevity Junky.

In this episode of Longevity Junky, Buck and co-host Nikki Leigh sit down with renowned psychiatrist and brain disorder specialist, Dr. Daniel Amen, founder of Amen Clinics, to discuss groundbreaking brain imaging techniques like SPECT scans. Dr. Amen shares insights on diagnosing mental health issues through brain mapping and the role of brain health in overall longevity.

100: What is Flow? Sep 09, 2024

Dr. Susan Jackson discusses the concept of flow and its impact on quality of life and performance. Flow is an optimal psychological state where individuals are fully focused on a task and experience a loss of self-consciousness. It enhances the quality of our experience and can positively shape the quality of our lives. Flow can be experienced in various domains, including sports, creativity, and everyday activities. Mindfulness meditation can help access flow by improving focus and attention. The book 'Experiencing Flow' explores the relationship between mindfulness and flow and provides practical strategies for accessing flow in daily life.

00:13 The Definition of Flow

04:05 How Do We Have Flow?

08:25 Gettign In and Out of Flow

14:07 Mindfulness vs Flow

99: What is a Retinal Detachment? A First Person Narrative Sep 02, 2024

Buck shares his recent experience with a retinal tear and detachment, emphasizing the importance of early diagnosis and treatment to prevent permanent vision loss. He explains the anatomy of the eye, the process of vitreous detachment, and the symptoms of retinal tear and detachment. Buck also discusses the risk factors for these conditions, including high myopia and previous eye surgery. He describes his surgical experience and the use of a gas bubble to reattach the retina.

98: Big Tech’s Vision of an Aging Population Aug 26, 2024

Buck discusses the role of big Tech and the elderly with Keren Etkin, founder of TheGerontechnologist.com. Discussion includes the role of robots, implications for social interaction, as well as the additional opportunities for founders to take advantage of the coming geriatric storm. 01:04 Current Tech for Aging 05:17 Tech for Social-Emotional Support 09:03 The Driving Force Behind the Development 12:00 The Impact of Increasing Longevity 13:54 Affordability of Aging Tech 17:08 Cyborgification

97: Buck’s Boston Heart Cholesterol Balance Test Aug 19, 2024

Link to Buck's Results:

https://drive.google.com/file/d/19BJaZNYwBxlPx4nR9695Q2NC3nNpgW6y/view?usp=sharing

https://drive.google.com/file/d/1br1ikAJKmgKev9X3jkS7nUPdXpAqMzYd/view?usp=sharing

Section 1: Overview of Cholesterol Metabolism

Cholesterol in the Body:
- Cholesterol is essential for cell membrane integrity, hormone synthesis, and bile acid production.
- It is produced endogenously in the liver and absorbed exogenously from dietary sources.
Endogenous Production:
- Cholesterol is synthesized in the liver through the mevalonate pathway.
- Key intermediates: Lathosterol and Desmosterol, indicators of cholesterol production rate.
Exogenous Absorption:
- Dietary cholesterol is absorbed in the intestines along with plant sterols like Beta-sitosterol and Campesterol.
- These sterols compete with cholesterol for absorption, reflecting dietary cholesterol absorption levels.

Section 2: Detailed Analysis of the Test Components

Production Markers:
- Lathosterol:
  - Precursor in the cholesterol biosynthesis pathway.
  - Elevated levels indicate increased hepatic cholesterol synthesis (overproduction).
  - Example: Lathosterol level of 329 µmol x 100/mmol in my study indicates hyperactive cholesterol production.
- Desmosterol:
  - Another precursor in the synthesis pathway, contributing to total cholesterol production.
  - High levels reinforce the diagnosis of increased cholesterol production.
  - Example: Desmosterol level of 74 µmol x 100/mmol in my study supports elevated production.
Absorption Markers:
- Beta-sitosterol:
  - Plant sterol absorbed in the intestines, competes with cholesterol.
  - High levels suggest increased absorption of dietary cholesterol.
  - Example: Beta-sitosterol level of 120 µmol x 100/mmol indicates borderline absorption.
- Campesterol:
  - Similar to Beta-sitosterol, reflects cholesterol absorption efficiency.
  - Elevated levels indicate increased absorption.
  - Example: Campesterol level of 113 µmol x 100/mmol within normal limits but suggests absorption could be a factor.
Cholesterol Balance Score:
- Ratio of production to absorption markers.
- A higher score indicates predominant cholesterol production; a lower score indicates absorption as the main issue.
- Example: Score of 2.4 suggests overproduction is the dominant issue.

Section 3: Clinical Implications and Treatment Strategies

Frequency of Overproduction vs. Overabsorption:
- Common to see patients with either overproduction or overabsorption, but less commonly both.
- Overproducers: Significant portion of hypercholesterolemia patients, especially those with genetic conditions like Familial Hypercholesterolemia.
- Overabsorbers: Often have high-cholesterol diets or genetic predispositions.
Treatment Implications:
- Overproducers: Statins are first-line treatment; they inhibit HMG-CoA reductase in cholesterol synthesis.
- Overabsorbers: Ezetimibe, which inhibits intestinal cholesterol absorption, can be effective.
- Combination Therapy: Considered for mixed dyslipidemia cases.
Case Examples:
- Example of a patient with high production markers but borderline absorption: Statin therapy may be appropriate, with potential addition of Ezetimibe.
- Example of a patient who is a high absorber but not a high producer: Dietary changes and Ezetimibe might suffice without statins.

Section 4: Physiological Mechanisms and Genetic Considerations

Pathophysiology of Cholesterol Production:
- Overproduction may result from genetic mutations (LDL receptor or PCSK9) or conditions like insulin resistance.
Pathophysiology of Cholesterol Absorption:
- Increased absorption could be due to genetic polymorphisms (NPC1L1 gene), leading to higher dietary cholesterol absorption.

Section 5: Practical Application in Clinical Practice

Incorporating the Test into Clinical Workflow:
- Integrate the Boston Heart Cholesterol Balance Test for patients with unexplained hypercholesterolemia or non-responders to standard therapy.
- Tailor treatment based on whether a patient is an overproducer, an over absorber, or both.
Patient Communication:
- Explain test results in an understandable way, emphasizing personalized treatment plans.

96: Cardiovascular Risk Management: Calcium Scores, Lp(a), and Colchicine Aug 12, 2024

Buck shares his experience visiting a cardiologist and discusses his family history of heart disease. He explains the importance of coronary calcium CT scans and the significance of calcium scores. Buck also highlights the role of lipoprotein little a (Lp(a)) in cardiovascular disease and the potential for new medications to target and lower Lp(a) levels. He explores the use of low-dose colchicine as an anti-inflammatory treatment for coronary artery disease and atrial fibrillation.

01:23 Understanding Coronary Calcium CT and Early Interventions 02:48 Advanced Cardiovascular Testing and Treatments 06:01 The Role of Lipoprotein Little A in Heart Disease 13:42 Inflammation and Coronary Artery Disease

95: What is Atherosclerosis and How to Prevent it Aug 05, 2024

This week's episode is about atherosclerosis, a condition that leads to cardiovascular disease. Buck explains the role of cholesterol and lipoproteins in the development of atherosclerosis. He emphasizes the importance of understanding this topic as cardiovascular disease is the leading cause of death. The conversation covers the different types of lipoproteins, such as HDL and LDL, and their association with atherosclerosis. Buck also discusses the significance of apolipoprotein B (APO-B) in measuring the risk of cardiovascular disease. He explains how APO-B can penetrate the blood vessel wall and trigger an immune response, leading to the formation of plaque and potential heart attacks. Buck recommends keeping APO-B levels below 60 milligrams per deciliter to reduce the risk of atherosclerosis. He also mentions the importance of testing for lipoprotein little A (Lp(a)) levels, as high levels of Lp(a) are a major risk factor for atherosclerotic cardiovascular disease.

94: Intermittent vs Prolonged Fasting Jul 29, 2024

Buck explains the difference between intermittent fasting and prolonged fasting, highlighting the benefits and potential pitfalls of each.

93: Alzheimer’s Disease vs Age-Related Cognitive Decline Jul 22, 2024

Buck interviews Dr. Ken Frumkin on his own journey of aging and cognitive decline.

92: Gene Editing 101 Jul 15, 2024

In this episode, Buck discusses gene editing and its potential implications for human health and longevity. He explains the basics of gene editing, including the structure of DNA and how genes are transcribed into proteins, then dives into the history and development of gene editing techniques, focusing on the game-changing CRISPR-Cas9 technology. He also explores the practical applications of gene editing, such as its use in treating sickle cell anemia and other genetic diseases, as well as the potential for human longevity, including targeting genes associated with aging and reversing epigenetic age.

91: Ask the Doctor 07/08 Jul 08, 2024

Topics include:

00:25 Protein Intake for Longevity

12:40 Tips to Improve Sleep Quality

22:52 Is Robert F. Kennedy Jr. Controlled by a Worm

90: Ask the Doctor 07/01 Jul 01, 2024

Topics include:

00:40 Is Weightloss Simply Calories In and Out?

07:10 Stem Cell Injections for NBA Players?

14:60 Statins for Lowering Cholesterol

23:19 The Impact of Nature and Nurture on Longevity

89: The Nine Pillars of Resilience with Stephen Sideroff, PhD Jun 24, 2024

Buck Joffrey, MD discusses the concept of resilience with Stephen Sideroff, PhD. Topics include bouncing forward from stress and practical techniques to restore balance, nurture growth, and slow down the aging process.

01:35 Defining Resilience and the Ability to Adapt

08:21 Physical Balance and Mastery: Restoring Balance in the Nervous System

15:26 Self-Relationship: How It Changes Your Physiology

21:47 Resilience and Longevity

23:16 Emotion Balance and Mastery

88: Stem Cells - Myth vs Reality with Hans Keirstead, PhD Jun 17, 2024

I've been hearing about stem cells for decades. When I was a medical student going into neurosurgery, I seriously considered focusing my research on neuroregeneration with stem cells. As it turns out, few advancements were made in that arena for many years until Hans Keirstead and his team did some groundbreaking work on quadriplegics. Now Hans is focused on longevity. Hans may have found a new type of treatment for what I call inflammaging. His company, Immunis, isolates various proteins and growth factors from pluripotent stem cells that can then be used to treat pretty much all types of inflammatory-related disease (which is just about everything). I encourage you to listen to the show because there is so much snake oil in the field of stem cells that it's good to get a grasp on fact vs fiction. Timestamps:

02:00 Stem Cells 101

08:18 The Mechanism Behind

16:47 Stem Cells For Cancer

29:22 How Do Stem Cells Make You Live Longer?

46:25 FDA Indications

50:30 The Price

87: The Longevity Clinic Paradigm Jun 10, 2024

Buck discusses the concept of longevity clinics with the CEO of Humanaut.

Show Notes:

03:53 What Does Humanaut Do?

06:07 The Team Behind Humanaut

14:49 How Does the Program Work?

86: The Science of Human Attraction Jun 03, 2024

Buck Joffrey, MD reviews the literature on the topic of human attraction. Topics include the brain, perception of beauty, specific aspects of beauty, and sexual dimorphism.

Also included is a discussion on the role of human pheromones and attraction.

Show Notes:

01:20 Facial Attraction & Cues

08:30 Facial Symmetry

11:12 The Averageness of Facial Features

13:59 Clear and Unblemished Skin

15:44 Sexual Dimorphic Traits

22:23 Smell and Pheromone

85: Fasting, Protein, and Full Body MRI with Dr. Matt Brill May 27, 2024

Buck has a conversation with fellow physician, Dr. Matt Brill, on the topic of intermittent fasting. They bring up the American Heart Association study as well as associated studies of breakfast skippers to reconsider the issue of eight-hour time-restricted feeding. Also discussed are the topics of ideal, protein, intake, and full-body MRI.

Show Notes:

01:33 8 Hours Or Less Fasting Window = Higher Chance of Cardiovascular Disease?

04:58 Why the Study that Claimed the Correlation Was Wonky

08:02 Why There May Be Some Truth in the Studies

14:03 What to Do With Mixed Data and Opinions?

15:49 The Best Protein Intake?

22:32 Why Full Body MRI?

84: Keto Diet 101 May 20, 2024

Buck Joffrey, MD discusses the basics of the keto diet with Amy Berger, a certified nutrition specialist. Topics include the definition of the diet, its health benefits and its role in the treatment of various disease processes including type 2 diabetes and Alzheimer’s Disease.

Show Notes:

03:08 Why the Keto Diet?

04:15 How Does the Keto Diet Help You Lose Weight?

05:51 Other Benefits of the Keto Diet

09:14 How Does High Blood Sugar Result in Insulin Resistance?

11:44 What Defines a Keto Diet

16:13 Lifestyle VS Intervention

19:02 The Concern with High Cholesterol with the Keto Diet

24:11 Treating Alzheimer’s with the Keto Diet

83: Sexually Transmitted Cancer May 13, 2024

Buck Joffrey, MD reviews what is known about sexually transmitted cancers. Discussion includes HIV and Hepatitis but focuses on Human Papilloma Virus which Buck believes is grossly underappreciated by people and by physicians.

01:18 HIV

05:26 Hepatitis

09:20 HPV

82: Intro to the Microbiome May 06, 2024

Buck Joffrey, MD provides an introduction to the microbiome and discusses its importance. Topics also include prebiotics, probiotics, and postbiotics.

81: Ask the Doctor 04/29/24 Apr 29, 2024

Buck Joffrey, MD, takes questions from the audience. Topics include human growth hormones, the potentially harmful effects of an MN, 40 Hz therapy, and visceral fat.

Show Notes:

00:47 Is It Fine That I Sleep Too Much?

08:08 The 40hz Gamma Frequency and How It Relates to Brain Health

13:28 The Anti-Aging Effects of Human Growth Hormone

20:31 Reconsideration of How to Fast

29:22 Potentially Harmful Effect of NMN

33:08 Visceral vs Subcutaneous Fat

80: The Longevity Diet with Valter Longo, PhD Apr 22, 2024

Buck Joffrey, MD, discusses the fasting regimen with Dr. Valter Longo, PhD. Dr. Longo is a world, renowned researcher in longevity and the author of: The Longevity Diet.

Show Notes:

01:10 Types of Fasting

03:31 Why Fasting is Beneficial From a Cellular Level

07:00 Intermittent Fasting VS Fast Mimicking Diet

14:05 How Does Fasting Help Cancer Patients

20:37 What Is in the Fast Mimicking Diet

33:38 Pills and Supplements for Fasting Mimicking Diet

41:23 Time-Restricted Feeding Based on Circadian Rhythm

79: Lies Taught in Medical School: Robert Lufkin, M.D. Apr 15, 2024

Buck Joffrey, MD interviews Robert Lufkin, MD about his book Lies I Taught in Medical School: And the Truths That Can Save Your Life Topics include metabolic syndrome, intermittent fasting, and various outdated information still used in mainstream medicine that may have deleterious effects on people’s health.

Show Notes:

01:35 Dr. Lufkin’s Personal Journey to Question the Medicine Establishment

04:14 When Did People Start to Take Metabolic Syndrome Seriously?

08:33 What Exactly is Metabolic Syndrome from a Physiological Standpoint?

10:21 The Balance Between Building and Breaking Down in the Metabolic System

14:41 Time-Restricted Feeding and Ketogenic Diet

28:31 The Role of Medications and Supplements

30:51 Lifestyle and Exercise as Intervention

78: The Age of Data-Driven Wellness is Here Apr 08, 2024

Dr. Buck Joffrey, M.D. interviews, Dr. Nathan Price, PhD from Thorne about a new paradigm in medicine driven by data, technology, and self-empowerment.

Show Notes:

00:58 What Really is Healthspan?

05:06 Biological Age VS Chronological Age

07:41 The Factors that Determine Biological Aging

12:08 What Happens When You Artificially Suppress These Factors

16:58 What is Phenomics and how can it predict diseases?

24:21 How Can You Do Self Tests?

77: Ask the Doctor (April Fools Edition) Apr 01, 2024

In this April Fools special, Buck answers the burning questions of his number one fan, Phil Ferragamo.

76: Intermittent Fasting Correlated to Higher Risk of Cardiovascular Death Mar 25, 2024

In this episode of Sapio, Dr. Buck Joffrey, MD addresses the recent American Heart Association study correlating intermittent fasting/time restricted, feeding to higher rates of cardiovascular death. Buck breaks down what we already know about the data behind intermittent fasting in both animals and in humans and tries to put the most recent study into context. He provides feedback on the study itself, including some suggestions on how to use this new information.

Show Notes:

02:01 Intermittent fasting vs caloric restriction

06:57 Why Intermittent Fasting Improves Metabolic Health

10:19 Intermittent fasting while maintaining a healthy diet

12:32 The study

19:35 What does this study mean to Buck?

75: Stress, Cortisol and Prevention Strategies Mar 18, 2024

Buck Joffrey, MD talks to Romie Mushtaq, MD regarding stress, cortisol levels and prevention strategies including meditation and anti-inflammatory diets.

Show Notes:

02:14 The definition of stress

13:16 Why does stress disrupt circadian rhythms and sleep

16:08 How do we treat stress?

21:23 Nootropics

24:39 Vagal nerve stimulator

28:34 Digital detox and meditation

33:02 Diet for stress

74: Aggressive Male TRT Approach, Erectile Dysfunction Drugs, and Alzheimer’s Disease Mar 11, 2024

Buck Joffrey MD speaks to Justin Houman MD who is a urologist regarding the idea of aggressive testosterone treatment to decrease the risk of metabolic syndrome and therefore multiple other disease processes that are downstream. Other topics disgust include erectile dysfunction, early treatment with ED meds and the correlation with Alzheimer’s disease.

Show Notes:

1:27 Is it true that the testosterone in men in general has gone down?

02:43 Common symptoms of low testosterone

05:15 Normal level of testosterone

07:19 Testosterone and metabolic syndrome

12:49 Testosterone replacement therapy and cancer

16:03 Downside of testosterone replacement therapy

19:18 Different options to supplement testosterone

29:03 What’s on the horizon?

32:50 ED and cardiovascular diseases

38:35 Should all 40+ men be on daily Cialis?

40:43 Penile pump

73: Is a Vegan Diet Healthy? Mar 04, 2024

Buck Joffrey, MD and Linda Tyler, PhD discuss the topic of plant-based only/Vegan diets. The conversation includes topics on inflammation and nutritional concerns.

Show Notes:

2:55 A plant-based diet for better health?

11:53 Balancing nutritions for the plant-based diet

20:39 Accessibility of the plant-based diet

22:30 Processed plant-based food

72: A Different Framework for Health? Feb 26, 2024

Buck Joffrey, MD interviews Anoop Kumar, MD on his perspective on health and wellness. Dr. Kumar is an emergency medicine doctor who is also knowledgeable about traditional Indian Philosophy and medicine.

Show Notes:

00:43 Near-Death Experience and Shift in Perspective

07:04 The Three Minds Framework

23:03 Reevaluating the Model of Human Anatomy

27:20 The Four Engines: Nutrition, Movement, Connection, and Rest

39:24 The Four Engines of Health and Healing

41:01 Harnessing the Placebo Effect and Self-Healing

71: Ask the Doctor 02/19 Feb 19, 2024

In this episode, Buck addresses questions from listeners. Topics include:

00:34 What is a healthy range in your weight?

04:28 The dangerous kind of fat

07:53 Male hormone replacement and cancer

13:12 How long does it take for the circadian rhythm to adjust to a new time zone?

18:35 The risk of cell phones?

70: The Science Behind Music and Mental Health Feb 12, 2024

Buck Joffrey, MD interviews Dr. Daniel Bowling from Stanford University on the science behind music and mental health. Bowling discusses the fundamentals of musicality and the research that has been done in this relatively new field of music as treatment for health-related issues.

Show Notes:

02:59 What is musicality?

04:47 What is tonality?

07:05 How does music affect the brain?

11:20 Music as treatment for mental health

22:22 Does music sharpen our intellect?

27:05 Musical vs pharmaceutical interventions

30:38 How to get started on music therapy

69: Glutathione: The Master Antioxidant Feb 05, 2024

Buck Joffrey, MD welcomes pharmacist and glutathione expert Dr. Nayan Patel. This podcast discusses the role of glutathione as an antioxidant including why it is known as the "master" antioxidant. The discussion reviews the physiology of glutathione in the body focussing on disease prevention and also discusses different mechanisms of supplementation.

Show Notes:

00:48 What is oxidative stress?

04:12 What is an antioxidant and how does it work?

10:24 Glutathione and its relationship to longevity

29:12 Dr. Patel’s Auro Wellness

68: Food Allergy 101 with Tina Sindher, MD Jan 29, 2024

Buck welcomes Tina Sindher, a specialist in food allergy from Stanford University Medical Center to discuss the basics of food allergy. Topics include root causes of food allergy, prevention, diagnosis, and treatment.

Show Notes:

04:33 Does where you live affect your allergies?

06:46 How do you know you have an allergy and not something else?

09:40 Life-threatening allergies explained

13:41 Does allergy develop from childhood?

16:28 What makes some foods trigger allergies?

20:22 Rising gluten sensitivity

23:03 Are restrictive food policies increasing cases of allergies

26:20 The relationship between eczema and allergy

29:00 Microbiome

32:43 Desensitizing allergies

67: The Silent Global Epidemic Killer Jan 22, 2024

Buck Joffrey, M.D. discusses metabolic syndrome which affects 1/4 of the global adult population and how it underlies the development of virtually every other major cause of death.

Show Notes:

00:13 Understanding Metabolic Syndrome

05:29 Criterias of Metabolic Syndrome

23:40: Insulin Resistance and Hyperinsulinemia

24:49: Metabolic Syndrome and Diabetes

37:49: Recommended Lab Tests

42:05: The Health Implications of Liposuction

50:42: The Importance of HSCRP

66: What is the common cold and how do you treat it? Jan 17, 2024

Buck talks about the common cold. He discusses the etiology, the role of cold weather, prevention and treatment of this common and frustrating problem.

65: Aging Skin and How to Fight It Jan 15, 2024

Buck interviews Dr. Corey Frucht, MD, PhD, a board-certified dermatologist on the topic of aging skin and skin cancer. This episode explores the causes of aging skin and skin cancer, as well as what we can do to combat the inevitable effects of skin aging.

Show Notes:

00:00:50:12 How and why can skin look young or old?

00:03:51:20 Why does the skin of people of color age slower?

00:05:14:09 How exactly does UV light damage your skin?

00:07:05:01 Sunscreen 101

00:11:41:08 Physical blockers vs chemical blockers

00:13:41:00 Can you get tan without damaging your skin?

00:14:16:06 How to keep your skin young

00:29:24:14 Skin Cancer

63: A Look Back at 2023 Jan 01, 2024

In this special New Year episode, Buck reviews some of the concepts discussed on the show in 2023.

62: Ask the Doctor 12/25 Dec 25, 2023

In this episode, Buck addresses questions from listeners. Topics include oral hygiene, Alzheimer’s disease, and Matthew Perry’s ketamine-related death.

61: Wisdom Wednesday: Surviving vs Winning Dec 20, 2023

Buck talks about mindset and the self-inflicted limits of the “survivor.”

60: Inflammaging Dec 18, 2023

Buck Joffrey, MD summarizes his literature search on what the data says in regards to the mechanisms by which the most common diseases of age such as cardiovascular disease and cancer might be correlated with chronic inflammation. There is also a discussion around the role of therapeutics and supplements as it relates to treating chronic inflammation and aging related disease.

59: How Much Exercise Is Too Much For Longevity? Dec 13, 2023

In this brief video, Buck Joffrey discusses literature suggesting that there is a "Goldilocks" zone for exercising for longevity. He also talks about the research on ultramarathoners suggesting that the once an upper limit of exercise is exceeded, risks to health potentially outweigh the benefits.

58: A Review on the Risks and Benefits of Human Growth Hormone Supplementation Dec 11, 2023

Buck reviews the physiology behind human growth, hormone in humans. He discusses normal growth hormone patterns as people age, pathologies and studies of people with both growth, hormone deficiencies and excess. Buck also discusses the risks and benefits of human growth hormone supplementation in otherwise normal middle-aged adults.

57: How Stress Impacts Your Body Dec 06, 2023

Stress is an unavoidable element in modern society. Inherently, We know it’s bad for us. In this episode of Sapio, Buck looks at the scientific and medical literature to drill down on the real health implications of health and offers some proven stress relief strategies. 00:00:27:24 What happens in your body when you get stressed? 00:06:26:03 How to decrease your level of stress?

56. Ask the Doctor (December 2023) Dec 04, 2023

In this episode of Sapio with Buck Joffrey, Buck welcomes back Dr. Alan Viglione of Montecito Concierge Medicine. Dr. Viglone discuss several topics based on audience questions including:

00:03:01:15 Is moderate alcohol intake good or bad for you?

00:09:08:02 Pills for alcohol cravings

00:15:40:20 Is the carnivore diet healthy?

00:22:20:22 Optimal exercise for endurance runners

00:30:43:04 Where and why you should get genetic testing done to prevent disease?

00:36:46:13 Can you do anything about your gene that makes you prone to Alzheimer’s diease?

00:40:24:09 Is human growth hormone or sermorelin bad for you?

55: Engaging Your Subconscious For Success Nov 29, 2023

In this episode of Sapio with Buck Joffrey, Buck discusses the importance of setting clear goals and truly believing they can be achieved.

He emphasizes the need to honestly evaluate if one's current plans will achieve their goals, and make adjustments if needed.

54: What Supplements Does Buck Take? Nov 27, 2023

In this episode of Sapio with Buck Joffrey, Buck reveals the supplements and drugs that he takes for the purpose of longevity. In addition to providing specific drugs and supplements, he talks about the reasoning for each and the big picture around how he looks at longevity regimens. Show Notes:

00:03:38:01 A legit source of information for supplements

00:04:17:24 Supplements for cardiovascular diseases

00:10:10:19 Supplements for all organs

00:14:21:07 Supplements for longevity

53: How to Avoid Blood Clots During Holiday Travel Nov 22, 2023

Buck provides ways to prevent getting deep venous thrombosis during long flights and drives. Deep Venous thrombosis refers to clots in the deep veins of the legs that can break free and cause a life threatening emergency called pulmonary embolism which represents blood clots in the arteries of the lungs.

52: What You Need to Know About Protein and Longevity Nov 20, 2023

In this episode of Sapio, Buck drills down on the importance of adequate levels of protein in a diet designed for longevity.

Buck talks about the concept of Sarcopenia and the relationship between inadequate protein and chronic disease processes. He also talks about sources of protein, including the difference between animal and plant protein sources. He concludes with some recommendations based on individual needs when considering how much protein, and what source of protein to use including supplementation strategies. Show Notes:

00:01:03:21 Proteins: what is it and what’s the big deal?

00:03:02:04 Where do we get amino acids?

00:03:49:04 Protein, sarcopenia, and mortality

00:06:45:07 How much protein should you eat?

00:09:15:20 Why the carnivore diet may not be the best for longevity

00:12:06:09 Does it matter if your protein supplements are animal or plant based?

51: Part 2: Alzheimers’s Disease: Risk Factors, Prevention and Treatment Nov 15, 2023

In our last episode of Sapio with Buck Joffrey, Neurologist Dr. John Foley took us through the diagnosis and pathophysiology behind Alzheimer’s disease

He also told us about the risk factors for getting Alzheimer’s disease—both avoidable and not.

In this episode, we talk about what we can do to mitigate the risk of developing Alzheimer’s disease, even if you are genetically predisposed to it. We talk about everything from Saunas to supplements. We also take a look at the cutting-edge research and new therapies that might actually be able to treat Alzheimer’s disease that may be right around the corner.

Again, this is a must listen for anyone who wants to live a long healthy life with all of their cognitive abilities and memories intact. It is relevant to you and probably to someone in your family and I’m hopeful that by listening to this show, you will be able to come away with actionable information for you or your loved ones to play offense against this brutal disease.

By the way, if you want to see what Dr. Foley is up to with his neuro-optimization clinic, make sure to check out his website for cerepro bioscience at cereprobio.com

50: Part 1: Alzheimers’s Disease: Risk Factors, Prevention and Treatment Nov 13, 2023

In the next two episodes of Sapio with Buck Joffrey, we are going to talk about Alzheimer’s disease.

If you have never seen someone progress through the different stages of Alzheimer’s disease, consider yourself lucky.

This is a heartless disease that robs people of their most prized possession: their memories of their loved ones and of everything else about their lives. It also robs them of their ability to function in this world.

Over the next 2 episodes of Sapio, you are going to learn what Alzheimer’s disease is, what the risk factors are, the steps we can take to minimize our risk of getting Alzheimer’s disease in the future, and even potential cures on the horizon.

My expert guest for these discussions is my friend Dr. John Foley. Dr. Foley is a neurologist who is at the cutting edge of the clinical and scientific advances in the treatment of Alzheimer’s disease and MS.

Make sure to tune in to this show. I guarantee you that it’s relevant to you or to someone you love.

Show Notes:

00:02:49:20 What is dementia?

00:03:49:21 How to Make a Diagnosis of Alzheimer’s Disease

00:05:46:19 The Story of Alois Alzheimer

00:07:22:06 What is Alzheimer’s

00:10:22:14 Why do people get Alzheimer’s?

00:13:05:15 The Risk Factors

00:23:14:09 What is sleep fragmentation and how does an understanding of it help with Alzheimer’s?

00:29:25:03 The Genetics of Alzheimer’s

00:35:41:20 How do hearing loss and hearing aid relate to Alzheimer’s?

Learn more about Dr. John Foley at cereprobio.com

49: 3 Eating Tips to Live Longer Nov 08, 2023

48: Living Longer for Busy People Nov 06, 2023

Buck discusses his new book, Living Longer for Busy People in a question/answer session with producer, Ben Hyatt.

47: Exercising for Longevity and More with Dr. Tom Walters | 2 of 2 Nov 01, 2023

Sapio with Buck Joffrey Episode 47 is part 2 of a 2 part episode with Dr. Tom Walters, DPT, OCS. Tom is a Doctor of Physical Therapy, former Kinesiology Professor, author of the bestselling book "Rehab Science: How to Overcome Pain and Heal From Injury". He is also an Instagram and YouTube creator with with more than 1.6 million combined followers, with a focus on "Alleviating Pain and Moving Better". In part 2 of this 2 part episode Tom and Buck discuss supplements, sleep, pain and the things you should be doing to help you live longer and stay healthier.

Make sure to check out episode 46 as well to get the whole conversation.

Tom can be found on Instagram (@rehabscience) and YouTube. His book is available on Amazon, Barnes & Noble and Target. Find links to other resources including a free Injury Prevention Program at https://rehabscience.com/links/.

46: Exercising for Longevity and More with Dr. Tom Walters | 1 of 2 Oct 30, 2023

Sapio with Buck Joffrey Episode 46 is part 1 of a 2 part episode with Dr. Tom Walters, DPT, OCS. Tom is a Doctor of Physical Therapy, former Kinesiology Professor, author of the bestselling book "Rehab Science: How to Overcome Pain and Heal From Injury". He is also an Instagram and YouTube creator with with more than 1.6 million combined followers, with a focus on "Alleviating Pain and Moving Better". In part 1 of this 2 part episode Tom and Buck discuss excercise and the things you should be doing to help you live longer and stay healthier. Also discussed in detail is pain. These are both very important topics for overall quality of life and longevity. The things you do today will impact your overall well being for decades to come.

Don't miss part 2 (episode 47) which drops Wednesday.

Tom can be found on Instagram (@rehabscience) and YouTube. His book is available on Amazon, Barnes & Noble and Target. Find links to other resources including a free Injury Prevention Program at https://rehabscience.com/links/.

45: WHEN to Sleep to Reduce Your Risk of Alzheimer's Disease Oct 25, 2023

It's not just how much you sleep but WHEN you sleep that can affect your chances of getting Alzheimer's Disease. Buck Explains.

44: This Old Gout Drug May Help You Live Longer Oct 23, 2023

In Episode 44 of Sapio with Buck Joffrey, Buck discusses research that shows this old drug can be repurposed to fight the number one killer.

43: Make This One Simple Change To Improve Your Sleep Oct 18, 2023

In this Medical Update, Buck talks about one quick thing you can do to significantly improve the quality of your sleep. It goes against what we've been told but everyone should do it. The data backs it!

42: Ask The Doctor Oct 16, 2023

In our latest "Ask The Doctor" episode, Dr. Alan Viglione joins Buck for a conversation that includes how to find a doctor that's right for you, the placebo effect and suplements.

41: FDA Panel: Popular Cold Medicine Doesn't Work Oct 11, 2023

In this medical update Buck discusses news from the FDA about some of the most popular drugs at your pharmacy. Buck also discusses some alternatives to the medication.

40: Full Body MRI: Avoiding Health Time Bombs Oct 09, 2023

In this Sapio with Buck Joffrey episode Buck talks to Dr. Sean London from Prenuvo. A company revolutionizing healthcare with it's full body MRI scans. This is all about Medicine 3.0. Early detection is key in fighting many diseases including cancer for example. Buck recently had the procedure and Dr. London goes through some of the findings - one of which was a bit of a surprise.

39: Tipping the Scales: A Closer Look at Wegovy & Ozempic for Weight Loss Oct 04, 2023

🎧 Dive deep into the world of weight loss solutions in this eye-opening episode of Sapio with Buck Joffrey. As the buzz around Wegovy and Ozempic intensifies, we dissect the promises and pitfalls. Can it truly tip the scales in favor of those battling the bulge? Join us for an exploration of this groundbreaking treatment.

👍 Like, share, and weigh in: Would you consider Wegovy as a weight loss solution? #SapioPodcast #BuckJoffreyInsights #WegovyExplained #TippingTheScales #WeightLossInnovation #BeyondTheBuzz #HealthTrends #ModernMedicine #WeightLossJourney #DiabetesToDiet #Wegovy #Ozempic #semaglutide

38: What is your TRUE age? Biological VS Chronological Oct 02, 2023

In this Sapio with Buck Joffrey Episode Short, Buck discusses Biological Age and how it is different than Chronological Age. Which of the two should be the true measure of a person's age?

37: Psilocybin: Evidence that a Psychedelic May Treat Depression Sep 27, 2023

In this Sapio with Buck Joffrey Medical Update, Buck discusses depression and the psychedelics being used to treat it including Psilocybin and Ketamine. Depression can have a series negative impact on longevity and impacts millions of people.

36: Cold Therapy: Real Science or Cool Trend? Sep 25, 2023

🎧 New Episode of Sapio with Buck Joffrey: The world is buzzing about the benefits of cold therapy, but is it all it's cracked up to be? 🧊 Buck delves deep into the icy waters of this wellness trend, separating fact from fiction and exploring whether the chills are worth the hype. Tune in for an eye-opening discussion and decide for yourself!

👍 Like, share, and let us know your thoughts on cold therapy! #SapioPodcast #BuckJoffreyInsights #ColdTherapyTruths #WellnessDebunked #HealthySkepticism #WellnessTrends #FactOrFiction #HealthMyths

35: Is Hearing Loss Connected to Dementia? Sep 20, 2023

In this Sapio with Buck Joffrey Medical Update, Buck discusses new reasearch that connects hearing loss and dementia. If you or a loved one is suffering from hearing loss you are going to want to take action.

34: Female Sexual Dysfunction Sep 18, 2023

In this episode of Sapio with Buck Joffrey Dr. Duncan Turner joins Buck for a conversation on women's health, sexual dysfunction and what can be done about it.

33: The Cutting Edge Science of Age Reversal - Part 2 Sep 13, 2023

The exploration into the secrets of aging continues in this much-anticipated second part of our conversation with Dr. Joel Rothman from UCSB's Center for Aging and Longevity Studies (CALS).

Join Buck as they dive further into the fascinating breakthroughs that are setting the stage for a potential revolution in human longevity. Tune in to episode 33 for a straightforward, yet enlightening discussion on the future of aging.

00:00:53 - Understanding Mitochondria
00:04:32 - Mitochondria and Aging
00:04:56 - Mitochondrial DNA
00:09:15 - Mitochondrial Dysfunction
0:09:48 - Removing Damaged Mitochondria
0:13:54 - Mitochondrial DNA and Aging
0:15:57 - Epigenetics and Aging
0:17:36 - Exploring Other Mechanisms Related To Longevity
0:19:08 - Understanding Stress Response
0:19:25 - Types of Stress
0:20:32 - Stress Response Systems in Cells
0:21:08 - Manipulating Stress Response
0:21:54 - Artificially Activating Stress Response
000:22:38 - Stress Response and Aging
00:23:43 - Hormesis and Longevity
00:24:32 - Heat and Cold Stress
00:25:29 - Interplay of Different Factors
00:26:07 - Studying Aging in Worms
00:26:28 - Debate on Aging Research
00:32:36 - Ethical Implications of Longevity Research
00:34:14 - Addressing Ethical Concerns
00:35:40 - Potential Issues with Extended Lifespan
00:38:18 - Longevity and Population Growth
00:39:28 - Ethical Considerations of Extending Lifespan
00:40:42 - Impact on Population Growth
00:42:02 - Predictions for Future Access to Technology

32: The Cutting Edge Science of Age Reversal - Part 1 Sep 11, 2023

In this can't-miss episode, Buck engages in a riveting conversation with the Dr. Joel Rothman, the Founding Director at UCSB's Center for Aging and Longevity Studies (CALS). Prepare to be transported into the cutting-edge world of scientific discoveries that are reshaping our understanding of aging, potentially unlocking the secrets to unprecedented human longevity.

This is only the beginning! Be sure to catch the continuation of this talk in episode 33, where we delve even deeper into the groundbreaking breakthroughs at the frontier of aging research including the research being done at CALS.

00:02:24 - The Science of Aging: A Deeper Dive
00:04:34 - The Human Lifespan
00:07:04 - The Different Lifespans of Organisms
00:09:12 - Aubrey de Grey Longevity Escape Velocity
00:12:27 - The Brain and Aging
00:13:47 - David Sinclair’s Book Lifespan
00:14:23 - The Role of Epigenome in Aging
00:19:10 - Genes and Epigenome
00:20:41 - DNA Methylation and Chromosome Structure
00:22:02 - Information Theory of Aging
00:24:14 - Proteostasis or removal of defective proteins
00:26:17 - The Horvath Clock and Biological Clocks
00:30:50 - Epigenome Reset
00:33:53 - Yamanaka Factors
00:37:00 - Extending Healthspan through Cocktails
00:41:44 - Challenges in Drug Development

31: What Covid does to your Brain Sep 06, 2023

Episode 31 of Sapio with Buck Joffrey discusses "What Covid does to your Brain". In this short episode Buck discusses his personal experience and the after affects which lasted several weeks after testing negative.

00:00:12 - Buck’s experience with the original COVID strain
00:01:12 - COVID and Depression
00:01:57 - Damage to the Ventral Striatum and Anhedonia
00:02:19 - COVID possibly affecting the Posterior Putamen which is involved with speech, articulation and other cognitive functioning

30: What’s Your Risk of Getting Alzheimer’s Disease? Sep 04, 2023

In this episode of Sapio with Buck Joffrey, Buck discusses a new study out of Oxford that outlines 11 key risk factors for dementia. And the good news - while you can't change everything, many of these factors can be controlled buy modifying behaviors.

If your want to see more info on the study goto: https://www.psych.ox.ac.uk/news/new-dementia-risk-score-helps-identify-people-at-risk.

00:00:02 - The difference between Alzheimer's Disease and Dementia
00:01:02 - Diagnosing Alzheimer's disease
00:01:25 - Causes of Dementia
00:01:48 - Dementia risk factors and how to avoid them
00:03:08 - Parental Dementia
00:03:27 - APOE e4 as a risk factor for Alzheimer’s
00:04:44 - Dementia risk factors you can control

29: Male Sexual Health - Part 2 Aug 30, 2023

In part 2 of this 2 part episode Buck discusses male sexual health with Justin Houman, MD from Tower Urology in Los Angeles. Over half of American men over the age of 40 suffer from erectile dysfunction and other sexual disorders.

00:00:42 - Male Refractory Period
00:01:44 - Erections are going to be weaker as you age
00:02:15 - Medication like Phosphodiesterase that help lower one’s refractory period
00:02:50 - Hormone called Prolactin that can cause increased refractory time
00:07:36 - Dealing with Premature Ejaculation
00:10:24 - Paxil and Tramadol For Premature Ejaculation
00:12:10 - Prostate issues
00:12:37 - Benefits of Cialis and Flomax
00:14:49 - Testosterone Replacement
00:16:17 - Clomid for Hypogonadism and Low Testosterone
00:18:31 - Human Chorionic Gonadotropin (hCG)
00:24:08 - Preserving Fertility
00:26:39 - Testosterone Blood Testing
00:27:44 - Masturbation Effects on Testosterone Levels
00:30:30 - Supplements like Tongkat Ali and Fadogia Agrestis

28: Male Sexual Health - Part 1 Aug 28, 2023

In this two part episode Buck discusses male sexual health with Justin Houman, MD from Tower Urology in Los Angeles. Over half of American men over the age of 40 suffer from erectile dysfunction and other sexual disorders. Buck asks the questions many men are uncomfortable asking.

00:01:44 - The concept of Erectile Dysfunction

00:06:22 - Diagnosing Erectile Dysfunction
00:09:33 - What is sex therapy?
00:10:56 - Main causes of Erectile Dysfunction
00:12:02 - Testosterone Levels
00:15:48 - Venous Leak
00:17:32 - Erectile Dysfunction Treatment
00:20:54 - PDE5 inhibitors
00:26:14 - Erectile Dysfunction and Cardiovascular Disease?
00:31:38 - Intracavernosal injections
00:37:13 - GAINSWave Procedure
00:42:53 - Platelet-Rich Plasma (PRP) Injection

27: Yamanaka Factors - Can Aging Be Reversed? Aug 23, 2023

Buck discusses Yamanaka Factors and recent experiments where a team led by David Sinclair was successful in reversing cellular age applying the concepts in an experiment.

00:00:02 - Is it possible to stop or even reverse the aging process?
00:01:48 - 2012 research by Shinya Yamanaka - Yamanaka Factors
00:02:50 - Pluripotent stem cells
00:03:08 - Revolutionary discovery for the world of regenerative medicine
00:03:28 - Salk Institute study using mice with progeria
00:03:55 - Doxycycline and improvements in signs of aging
00:04:26 - David Sinclair's research to regenerate optic nerves in mice to restore vision
00:04:49 - David Sinclair's book on aging research called Lifespan
00:05:20 - Epigenome and the aging process
00:06:15 - Horvath lab and using Yamanaka factors to reset epigenetic clocks in rats

26: Ask The Doctor P2 of 2 Aug 21, 2023

In this edition of Ask The Doctor Executive Producer asks Buck viewer questions and some of his own. Discussed is continuous glucose monitoring for non-diabetics, cardiac arrest in young athletes, effectiveness of vibrating plates, human growth hormones, jet lag and melatonin. This is Part 2. Listen to episode 24 to hear part 1.

00:01:31 - Question about taking naps to make up for not enough sleep
00:03:06 - REM Sleep and Deep Non-REM Sleep
00:11:54 - Shift work is very detrimental to to health
00:13:11 - Question about reversing aging in cells
00:13:29 - David Sinclair’s book Lifespan
00:15:30 - Stem cells and aging
00:17:22 - Genetically mutated rodents with Progeria and the Yamanaka Factor
00:21:59 - Methylation and the Epigenome
00:22:37 - Biological clocks and changes in the Epigenome
00:23:20 - Sinclair’s study on using a drug cocktail to reverse the cellular aging patterns in aged human cells

25: Heart Rate Variability (HRV) Aug 16, 2023

Buck discusses Heart Rate Variability (HRV). What is it? Why does it matter and how can it effect your overall health in this mini Sapio with Buck Joffrey episode.

00:00:31 - Medicine 3.0: Taking medicine into your own hands
00:01:15 - What is Heart Rate Variability (HRV) anyway?
00:02:16 - The Autonomic Nervous System
00:02:37 - The Parasympathetic Nervous System
00:03:32 - Lower Hrv Has Been Linked To An Increased Risk Of Cardiovascular Diseases
00:04:18 - Ways To Increase Your HRV

24: Ask The Doctor P1 of 2 Aug 14, 2023

In this edition of Ask The Doctor Executive Producer asks Buck viewer questions and some of his own. Discussed is continuous glucose monitoring for non-diabetics, cardiac arrest in young athletes, effectiveness of vibrating plates, human growth hormones, jet lag and melatonin. Part 2 will drop next week as episode 26.

0:01:11 - Question about Continuous Glucose Monitoring and Repatha®
0:04:34 - Where is the glucose coming from in the morning?
0:07:07 - Blood Glucose Spike in the sauna
0:09:43 - Impact on blood sugar of the order of eating food
0:12:18 - Continuous Glucose Monitor App
0:13:29 - A question about avoiding jet lag
0:13:26 - Minimizing Jet Lag and Melatonin
0:16:15 - Adjust your watch to the timezone you are going to be at
0:19:29 - Getting your brain acclimated to the new time
0:22:30 - Warning about taking Melatonin
0:26:59 - A question about Vibration Plates and their benefits
0:27:23 - Vibration Plates and the claim of increasing Growth Hormones
0:32:39 - Back Pain and Vibrating Plates
0:33:47 - What happened to Bronny James?
0:34:27 - Hypertrophic Cardiomyopathy
0:40:54 - Athletes and Heart Disorders

23: Jet Lag and Melatonin Aug 09, 2023

Planning a trip? Jet lag can be a serious impediment to making the most of it. Buck discusses jet lag; what it is and strategies to beat it including the use of Melatonin.

00:00:25 - Desynchronosis - Disruption To Your Circadian Rhythm
00:01:05 - Melatonin
00:02:39 - Bright Light Exposure Is Really Important To Resetting Your Circadian Clock
00:04:48 - Some Negative Effects Of Chronic Melatonin Use

22: Battle of Cardio IQs Part 2 Aug 07, 2023

Buck and Alan Viglione, MD discuss the Cardio IQ® report in detail and battle it out to see has the best numbers in this 2 part episode. This is Part 2. If you missed Part 1, check out episode 20.

0:01:16 - Metabolic Markers and Cardiovascular Risk
0:01:55 - Framingham Risk
0:06:08 - Hemoglobin A1C
0:08:00 - C-peptide
0:09:07 - Homocysteine and the methylation cycle
0:11:50 - Methyl Protect®
0:13:46 - Why is Vitamin D important?
0:21:34 - APOE Genotype
0:24:35 - Alzheimer's Disease Risk
0:28:57 - Colchicine Study

21: Why Did Bronny James Collapse? Aug 02, 2023

Scary news last week when Bronny James, the 18 year old son of Lebron and Savannah James collapsed during a workout at USC. It has been reported that James suffered a cardiac arrest. In September 2022 another seemingly healthy and fit USC basketball player, Vince Iwuchukwu also suffered cardiac arrest.

Thankfully USC was prepared and in both cases they were able to get these young athlete's hearts beating again. Buck discusses why and how it happens.

0:00:11 - Bronny James’ cardiac arrest
0:00:53 - What is cardiac arrest?
0:01:23 - Arrhythmias or abnormal beating of the heart
0:01:48 - Myocardial Infarction or heart attack
0:02:42 - Hypertrophic Cardiomyopathy
0:04:11 - Early detection is key

20: Battle of Cardio IQs Part 1 Jul 31, 2023

Buck and Alan Viglione, MD discuss the Cardio IQ® report in detail and battle it out to see has the best numbers in this 2 part episode. Part 2 will drop as Episode 22.

0:01:31 - What exactly is a Cardio IQ?
0:03:15 - the cost of Cardio IQ
0:05:18 -Lipid panel, Total Cholesterol, HDL, Triglycerides, LDL Cholesterol
0:08:29 - HDL the so-called good cholesterol
0:13:55 - Lipoproteins
0:15:42 - LDL Particle Number
0:22:46 - Apolipoproteins
0:25:40 - Apolyte protein tag
0:27:48 - Apolipoprotein B or apoB
0:28:31 - Lipoprotein(a) or Lp(a)
0:31:41 - Statins: Crestor and Livalo
0:32:41 - How do Statins work?
0:33:11 - Repatha
0:36:58 - Inflammation and Atherogenesis
0:39:39 - High-sensitivity C-reactive protein (hsCRP)
0:40:43 - Lp-PLA2 activity
0:41:43 - Oxidative LDL
0:42:04 - Myeloperoxidase enzyme
0:45:07 - F2-isoprostanes as a marker of risk

19: Snoring and Sleep Apnea: Just Noise or Silent Killers? Jul 26, 2023

In this episode Buck discusses snoring and sleep apnea and why they should be taken seriously.

0:01:17 - Snoring And Sleep Apnea
0:01:45 - Up To 20% Of The Population Has Clinically Relevant Sleep Apnea
0:02:52 - Central Sleep Apnea
0:03:12 - Obstructive Sleep Apnea
0:03:34 - Sleep Apnea Is The Enemy Deep Sleep
0:03:59 - Increased Risk Of Diseases Associated With Sleep Apnea
0:05:32 - Sleep Apnea Screening
0:05:56 - Epworth Sleepiness Scale https://epworthsleepinessscale.com/about-the-ess/
0:06:16 - Apnea/Hypopnea Index
0:06:44 - How to Treat Sleep Apnea
0:07:10 - CPAP Machine
0:07:32 - Mandibular Advancement Device
0:08:53 - Uvulopalatopharyngoplasty (UPPP)

18: Could This Simple Blood Test Revolutionize Early Cancer Detection? Jul 24, 2023

Buck talks with GRAIL President Josh Ofman, MD, MSHS, about their groundbreaking Multi-cancer early detection (MCED) technology and it's promise as a significant new tool in the war on cancer.

0:00:00 - Advancements in Cancer Detection Technology
0:00:35 - GRAIL Galleri test
0:02:11 - About Dr. Josh Ofman
0:05:14 - Cancer really is a disease of the genome
0:12:35 - Various guidelines for early detection of certain cancers
0:16:45 - Cancer Detection in Blood Biology
0:19:03 - Cell-Free DNA
0:23:38 - How many cancers is the GRAIL Galleri test able to detect?
0:27:10 - How accurate is the GRAIL Galleri test?
0:31:49 - Limitations of the GRAIL Galleri test
0:36:18 - Why would oncologists be against this test?
0:40:57 - What happens after one gets a a "cancer signal detected" result?
0:45:13 - GRAIL Galleri test's Impact on Cancer Screening
0:48:42 - The cost of the GRAIL Galleri test

17: Is Your Diet Coke Killing You? Jul 19, 2023

In this Sapio Short Buck discusses the news last week that the World Health Organization (WHO) has declared the artificial sweetener Aspartame a "a possible carcinogen". So what does this classification mean for you and how worried should you be?

0:00:13 - World Health Organization classified aspartame as a possible carcinogenic substance
0:02:03 - Group 2B - the possibly carcinogenic to humans category
0:03:18 - WHO concedes that the upper limit for safe daily consumption of aspartame is equivalent to drinking 9 to 14 cans of Diet Coke per day for the average 150 lb. person.
0:04:10 - Consider another sweetener like Splenda or Stevia

16: Ask the Doctor Jul 17, 2023

In this episode, Alan Viglione, MD joins Buck to answer some of our audience questions.

0:01:08 - How To Prevent The Dawn Phenomenon Or Rise Of Sugar Levels During Sleep Or Early Morning
0:04:44 - Hemoglobin A1C
0:08:00 - What Is Gluconeogenesis?
0:14:24 - Managing Dawn Phenomenon
0:18:04 - A Question About Geroprotectant Supplements
0:19:37 - Nicotinamide Riboside As A Precursor to NAD+
0:26:02 - What Is A Senolytic?
0:29:29 - Benefits Of Senolytics
0:30:27 - Promising Potential Of Quercetin
0:32:30 - Genova NutrEval Test
0:34:11 - The MTHFR Gene Mutation
0:41:56 - A Question About The Kirk Cousins Era With The Minnesota Vikings
0:44:10 - Cholesterol Management For Women
0:54:27 - A Question About Helpful Daily Supplements And How To Tell Which Supplement Companies Are The True Good Guys
0:59:12 - Vitamin D Deficiency And Supplementation
1:01:31 - Discussion On Vitamins, Supplements, And Sleep

15: Essentials of Female Hormone Replacement Jul 13, 2023

In this episode Buck continues his conversation with Rob Hamilton MD from Prestige Regenerative Medicine - this time discussing Female Hormone Replacement. When to get it, why to get it, what to expect and how it plays into Longevity and making you feel optimal.

0:01:14 - Overview Of Some Of The Hormonal Issues That Women Go Through Throughout Their Life
0:03:33 - Average Age When Women Experience Menopause And Perimenopause
0:06:51 - Pharmaceuticals Developed To Address Menopausal Symptoms In Women: Premarin And Provera
0:13:47 - Benefits Of Hormone Replacement Therapy
0:17:12 - Understanding Perimenopause And Testosterone Decline In Women
0:22:55 - The Secret Female Hormone: How Testosterone Replacement Can Change Your Life By Dr. Kathy C. Maupin
0:23:57 - Hormone Pellet Replacement For Women
0:25:02 - Side Effects Of Testosterone Replacement In Women
0:27:09 - Benefits Of Testosterone Replacement In Women
0:30:57 - Acoustic Wave Therapy For Women

14: Essentials of Male Hormone Replacement Jul 12, 2023

Buck discusses Male Hormone Replacement with Rob Hamilton, MD from Prestige Regenerative Medicine. When to get it, why to get it, what to expect and how it plays into Longevity and making you feel optimal. Human Growth Hormone is also discussed in this hour-long discussion.

0:00:12 - Rob Hamilton’s Background
0:04:44 - What Happens With These Kinds Of Male Sex Hormones Over Time?
0:05:46 - Declining Testosterone Levels In Men Aged 35 To 40
0:09:23 - Testosterone Is An Anabolic Hormone
0:11:17 - Testosterone Is An Important Hormone To Maintain Health.
0:18:37 - Replacing Testosterone Even If You Feel Like There's Nothing Wrong With You
0:19:50 - Options For Increasing Testosterone Levels
0:20:28 - Tongkat Ali, Ashwagandha, And Other Supplements For Increasing Testosterone Levels
0:27:55 - Using Clomifene To Increase Testosterone Levels
0:29:20 - How Much Variability On A Day-To-Day Basis Is There In Testosterone In Men?
0:30:53 - Options For Testosterone Replacement
0:32:03 - Topical Testosterone Application And Side Effects
0:33:13 - Injectable Testosterone
0:35:03 - Titrating Testosterone Pellets For Optimal Therapy
0:37:33 - Risks Of Testosterone Replacement Options
0:44:04 - Human Growth Hormones
0:45:59 - The Challenges Of Prescribing Human Growth Hormones
0:50:28 -Testosterone Is A Necessary But Not Sufficient Component Of Good Erectile Function
0:51:02 - Atherosclerotic Cardiovascular Disease
0:52:46 - Phosphodiesterase Inhibitors
0:51:28 - GAINSwave Shockwave Therapy
0:57:05 - Erectile Function And Nerve Regeneration

13: Reprogramming Your Brain with Ketamine and Psychedelics: Part 2 Jul 05, 2023

In part two of a two part episode Buck talks with Dr. Michael Mantz, MD about Ketamine and Psychedlics.

0:00:29 - What Is Psilocybin?
0:01:42 - The Serotonergic Effects Of Psilocybin
0:04:08 - Exploring The Effects Of Microdosing Psilocybin
0:09:16 - Microdosing And Euphoria
0:12:03 - Exploring Psychedelic Microdosing
0:15:31 - The Fadiman Protocol
0:17:10 - The Stamets Protocol
0:19:59 - Microdosing Ketamine And Serotonergic Function

12: Reprogramming Your Brain with Ketamine and Psychedelics: Part 1 Jul 04, 2023

In this is a two part episode Buck talks with Dr. Michael Mantz, MD about Ketamine and Psychedlics. Part 2 will be online for our regular Wednesday episode drop.

0:00:39 - About Dr. Michael Mantz
0:02:47 - Studying With Famous Herbalists In Utah
0:06:46 - Dr. Mantz's Integrative Approach Combining Nutrition, Exercise And Supplements
0:08:21 - Dr. Mantz's Current Practice: The Santa Barbara Integrative Medicine
0:08:43 - Ketamine Assisted Psychotherapy
0:11:06 - What Are Psychedelics?
0:12:49 - Understanding Ketamine's Mechanism
00:14:47 - Ketamine As A Dissociative Anesthetic
00:16:38 - Effects Of Ketamine On GABA
0:17:53 - Ketamine Working On The Nmda Receptors
0:19:44 - NMDA Receptors And Expanding Consciousness
0:22:23 - Augmenting Psychotherapy With Ketamine
0:28:37 - Placebo Effect And Inflection Points
0:33:35 - Clinical Depression And Its Symptoms
0:35:18 - SIG-E-CAPS And Dysregulations Of Sleep
0:37:24 - Is Depression Physiological Or Psychological?
0:39:56 - The Impact Of Depression On Perception
0:40:10 - Understanding Depression And Medication Options
0:47:39 - Effectiveness Of SSRIS In Treatment
0:52:38 - Ketamine Therapy And Treating Depression
0:54:44 - Western Medicine's Relationship With Psychedelics
1:01:55 - Today's Opioid Epidemic
1:04:26 - Psychedelics In Mental Health

11: Fountain of Youth or Just a Dry Sauna? Jun 28, 2023

Buck discusses studies on the effect of saunas for overall health and longevity.

0:01:35 - What's The Big Deal With Saunas?
0:02:03 - Kuopio Ischemic Heart Disease Study
0:04:44 - Sauna Benefits For The Body
0:04:53 - Heat Shock Proteins
0:07:30 - Increased Expression Of Brain Derived Neurotrophic Factor
0:09:05 - Saunas And Longevity
0:11:08 - Blood Glucose Spikes While In The Sauna
0:12:19 - Optimal Timing For Sauna Usage

10: Longevity Pillar 6: Being Social Helps You Live Longer Jun 26, 2023

Buck and Montecito Concierge Medicine’s Alan Viglione explore compelling studies revealing the profound impact of social connections on our longevity. Join us as we uncover the fascinating evidence that demonstrates how fostering relationships can unlock the secret to a longer, more fulfilling life.

0:00:09 - Last Pillar Of Longevity: Social Relationships
0:01:11 - Tribal Societies And The Common Goal Of Survival
0:01:29 - Human Beings Are Fundamentally Social Creatures
0:03:41 - Social Relationships And Physiological Determinants Of Longevity Across The Human Life Span
0:05:33 - Social Connectedness Is Powerful
0:07:47 - What Happens When You're Lacking Quality Relationships?
0:09:06 - How Social Relationships Have Shown Can Impact Health
0:11:28 - Ortisol: The Classic Stress Hormone
0:12:14 - Oxytocin: The Love Hormone
0:14:22 - Blue Zones As Parts Of The World Where People Seem To Live For A Longer Period Of Time
0:16:46 - Social Relationships Sustain Happiness
0:19:27 - Cortisol And The Obesity Epidemic
0:19:52 - Blue Light At Night And Cortisol Levels
0:20:18 - How Technology Leads To More Isolation

9: Taurine: An Ingredient in Energy Drinks that May Add Years to Your Life! Jun 21, 2023

Buck discusses with Executive Producer Ben Hyatt a study that appeared June 9th, 2023 in Science magazine that linked Taurine with healthy aging and increased lifespan in animal studies.

0:01:30 What we knew about Taurine before the study.
0:03:22 What is Taurine?
0:03:39 What new information did we learn from the study?
0:06:30 Why do multiple models matter when it comes to studies?
0:07:04 What is the mechanism between improvements in health span and longevity?
0:07:30 Cellular Senescence - what is it and why does it matter?
0:09:00 DNA damage in aging.
0:10:30 Connecting the dots between low taurine levels and poor health.
0:11:10 Steps Buck is taking since reading the study.

8: Longevity Pillar 5: Personalized Diagnostics to Monitor Your Own Health Jun 19, 2023

Shownotes:

1:02 What is Diagnostics when it comes to medicine?
2:35 What are some of the traditional Diagnostics used in Medicine 2.0?
4:11 - Summarize the basic screenings you should be getting starting at based on Medicine 2.0 guidelines
6:09 Why are PSA screenings controversial?
8:19 - Cardiovascular testing - medicine 2.0
8:53 - Medicine 3.0
9:26 What’s a Cardio IQ?
18:10 Genetic Screening
19:40 MTHFR Gene Mutation
21:58 APOE e3 and e4
23:00 ACTN Gene
24:06 Galleri® Test
27:27 Whole Body MRI
29.11 How difficult is it to get these tests?
32:07 Self Diagnostics and Medicine 3.0
32:53 Continuous Glucose Monitor
33:18 Medicine 3.0 and the variability between humans
38:13 Key Takeaways
43:51 Q&A
44:46 Cleery heart scan analysis

7: Metformin: Miracle Longevity Drug or Hype? Jun 15, 2023

Shownotes:

0:01:04 Metformin and Diabetes
0:02:48 Metformin Monotherapy
0:06:46 Are There Any Geroprotective Benefits From Taking Metformin?
0:10:50 Benefits of Rapamycin and
0:12:14 Acarbose and Sugar Metabolism
0:16:28 SGL2 inhibitor Jardiance
0:20:37 Glucose Monitoring and Metformin

6: Longevity Pillar 4: Taking Drugs That Can Help You Live Longer Jun 12, 2023

Shownotes:

0:01:54 Geroprotective Medication
0:09:51 Addressing Fear Of Medication
0:12:22 Preventing Cardiovascular Disease
0:15:27 PCSK9 Inhibitors
0:16:48 Cardio IQ Test
0:17:02 Cardiac Risk Algorithm
0:21:10 Metformin
0:26:09 Interventions Testing Program (ITP)
0:27:32 Rapamycin
0:29:52 Acarbose
0:31:46 Invokana
0:39:29 NMN Supplementation

5: Longevity Pillar 3: Sleeping to Live Longer and Healthier Jun 05, 2023

Shownotes:

0:01:31 The Importance Of Sleep For Health
0:03:41 Rapid Eye Movement (REM) Sleep
0:03:57 Non-REM Sleep
0:06:22 Sleep Problems and Links to Alzheimer's and Dementia
0:08:14 Glial–Lymph and Deep Sleep
0:10:14 REM Sleep And Brain Health
0:14:28 Sleep Apnea: Berlin questionnaire and STOP-Bang assessment
0:17:04 Oura Ring
0:17:57 Sleep Disruption and Cancer
0:23:26 Night Shift Work And Health Risks
0:24:28 Suprachiasmatic Nucleus (SCN) and the Sleepway Cycle
0:26:35 Sleep And Longevity
0:33:20 Improving Sleep Quality: Blue Light Avoidance
0:35:25 Adenosine and Caffeine
0:35:47 Improving Sleep Quality And Habits

4: Longevity Pillar 2: Exercise THE RIGHT WAY! May 29, 2023

Our understanding of how to get the most out of exercise has evolved. A combination of cardio training with weight training can have a profound effect on longevity and quality of life. Learn how to get the most out of your exercise and what metrics you can track to measure your fitness!

Shownotes:

0:00:33 Hormesis and Challenging the Body
0:02:48 The Benefits Of Exercise
0:04:07 The Cardiovascular System
0:06:25 Levels Of Cardiovascular Exercise Intensity
0:06:35 Level One: Walking Down The Street
0:07:14 Level Two: A Hike And A Conversation
0:08:34 Level Three: Reaching Anaerobic Threshold
0:12:05 Level Four: Reaching Your Lactate Threshold
0:17:30 Level Five: High Intensity
0:19:16 HIIT training
0:27:06 Glycolysis From Anaerobic Training
0:31:42 VO2 Max As A Way To Test Metabolic Efficiency
0:36:32 Optimizing Exercise By Getting Baseline Labs
0:44:52 Heart Health Metrics

3: Why Hyperglycemia is a KILLER (and what to do about it) May 26, 2023

In this bonus Q&A episode Buck Joffrey dives a little deaper into one of the key Episode 2 topics - blood glucose and how it affects your body with Sapio Executive Producer Ben Hyatt.

Shownotes: