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    Health & Fitness

    RealTalk MS

    Jon Strum cuts through all the jargon and breaks down the latest multiple sclerosis news. You’ll meet the scientists who are creating tomorrow’s MS treatments today. You’ll hear from the experts discussing how the latest tweaks and changes to our healthcare laws will impact your MS treatment. And we’ll be talking to the courageous MS warriors who are out there advocating on behalf of the MS community every day, as well as the men and women who are committed to living their best lives with MS and living their best lives as MS caregivers. If you’re dealing with multiple sclerosis in your life — as a patient, caregiver, family member, or friend — join us each week for RealTalk MS.

    Advertise

    Copyright: © Copyright 2020. All rights reserved.

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    Latest Episodes:
    Episode 418: The Importance of Developing a Growth Mindset When You're Living With MS with Dr. Mirian Franco Sep 01, 2025
    Show notes

    Living with MS means living with uncertainty, possible physical disability or cognitive dysfunction, bouts of crushing fatigue, mood changes, and let's not forget the very real irritation of well-meaning people telling you how healthy you look. Just processing the world around you can feel challenging.

    In this episode, psychologist Dr. Miriam Franco joins me to discuss how developing a growth mindset can make all the difference in how you experience your MS journey.

    We're also sharing a real-world example of how the drastic cuts in federal funding are already impacting MS care.

    We'll tell you about the first country in the world to approve Tolebrutinib, a new disease-modifying therapy for nonrelapsing secondary progressive MS. And we'll explain why people are particularly excited about this medication.

    We'll share details about the MS Clinical Imaging and Data Resource that's been launched by the International Progressive MS Alliance.

    We'll tell you how and where to catch the MS Standup Comedy Benefit next Monday in New York.

    And we're reminding you about your opportunity to impact future MS therapies by helping the FDA better understand what living with MS is really like.

    We have a lot to talk about! Are you ready for RealTalk MS??!

    This Week: Developing a growth mindset :22

    How those federal research funding cuts are impacting MS patient care 1:30

    United Arab Emirates becomes the first country in the world to approve Tolebrutinib for nonrelapsing secondary progressive MS 5:05

    The International Progressive MS Alliance launches an MS Clinical Imaging and Data Resource open to the MS research community 8:32

    The MS Standup Comedy Benefit takes place next Monday in New York 10:15

    Add your voice and participate in the Shaping Tomorrow Together initiative 11:04

    Dr. Miriam Franco discusses what it means to have a growth mindset when you're living with MS 14:50

    Share this episode 34:11

    Next week's episode 34:31

    SHARE THIS EPISODE OF REALTALK MS

    Just copy this link & paste it into your text or email: https://realtalkms.com/418

    ADD YOUR VOICE TO THE CONVERSATION

    I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts!

    Email: jon@realtalkms.com Phone: (310) 526-2283

    And don't forget to join us in the RealTalk MS Facebook group!

    LINKS

    If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com

    PARTICIPATE: Take the Shaping Tomorrow Together Survey https://s.alchemer.com/s3/Perspectives-on-MS

    REGISTER: Attend the virtual Shaping Tomorrow Together meeting with the FDA https://nmss.quorum.us/event/25463

    VIDEO: Dr. Robert Fox, Principal Investigator in the Phase 3 Clinical Trial for Tolebrutinib and Secondary Progressive MS https://youtu.be/tJQ93qdlXrU?si=S5jREy5ixVcE7ol-

    VIDEO: Dr. Jiwon Oh, Principal Investigator in the Phase 3 Clinical Trial for Tolebrutinib and Relapsing-Remitting MS https://youtu.be/zcBmAHRTotA?si=n86KRjB9Xt9sdZMg

    The International Progressive MS Alliance Clinical Imaging and Data Resource https://progressivemsalliance.org/ms-clinical-and-imaging-data-resource

    ATTEND: MS Stand-Up Comedy Benefit https://msstandup.org

    Join the RealTalk MS Facebook Group https://facebook.com/groups/realtalkms

    Download the RealTalk MS App for iOS Devices https://itunes.apple.com/us/app/realtalk-ms/id1436917200

    Download the RealTalk MS App for Android Deviceshttps://play.google.com/store/apps/details?id=tv.wizzard.android.realtalk

    Give RealTalk MS a rating and review http://www.realtalkms.com/review

    Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com.

    RealTalk MS Episode 418 Guest: Dr. Miriam Franco

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    Episode 417: Music and the Body with Emmy Award-Winning Composer Jeff Beal Aug 25, 2025
    Show notes

    If you've watched the critically acclaimed series, House of Cards, on Netflix, or the OCD detective series, Monk, on the USA Network, you've already listened to some of five-time Emmy award-winning composer Jeff Beal's work.

    This week, Jeff joins me to discuss his journey as an artist and as someone living with MS. We're also sharing all the details about the free event taking place at the Broad Stage in Santa Monica, California, on September 1, when Jeff joins conductor Leonard Slatkin and the Los Angeles Chamber Orchestra for a free concert featuring three of Jeff's works, including a world premiere!

    We're also explaining a newly introduced AI-based model of MS that replaces the MS subtypes (relapsing-remitting, secondary progressive, primary progressive) with a continuum that tracks four different states.

    We'll tell you about a study that identified specific gut bacteria that may determine whether an individual is susceptible to MS.

    And we'll share the details of a study that identified the first genetic marker that can accurately predict how someone will respond to a disease-modifying therapy.

    We have a lot to talk about! Are you ready for RealTalk MS??!

    This Week: Emmy award-winning composer Jeff Beal discusses his work and his MS journey :22

    An AI-based model of MS 1:18

    A study identifies specific gut bacteria that may be linked to MS susceptibility 4:49

    A study identifies the first genetic marker for accurately predicting an individual's response to MS treatment 6:29

    Composer Jeff Beal discusses his journey as an artist and as someone living with MS 9:57

    Share this episode 30:36

    Coming next week 30:56

    SHARE THIS EPISODE OF REALTALK MS

    Just copy this link & paste it into your text or email: https://realtalkms.com/417

    ADD YOUR VOICE TO THE CONVERSATION

    I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts!

    Email: jon@realtalkms.com Phone: (310) 526-2283

    And don't forget to join us in the RealTalk MS Facebook group!

    LINKS

    If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com

    PARTICIPATE: Take the Shaping Tomorrow Together Survey https://s.alchemer.com/s3/Perspectives-on-MS

    REGISTER: Attend the virtual Shaping Tomorrow Together meeting with the FDA https://nmss.quorum.us/event/25463

    ATTEND: Music + The Body https://realtalkms.com/musicandthebody

    An AI-Driven Reclassification of Multiple Sclerosis Progression https://nature.com/articles/s41591-025-03901-6

    STUDY: Multiple Sclerosis and Gut Microbiota: Lachnospiraceae From the Ileum of MS Twins Trigger MS-Like Disease in Germfree Transgenic Mice -- An Unbiased Functional Study https://www.pnas.org/doi/10.1073/pnas.2419689122

    PARTICIPATE: International MS Microbiome Study https://www.nationalmssociety.org/how-you-can-help/get-involved/participate-in-research-studies/other-studies/international-ms-microbiome

    STUDY: HLA-A*03:01 As Predictive Genetic Biomarker for Glatiramer Acetate Treatment Response in Multiple Sclerosis: A Retrospective Cohort Analysis https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(25)00317-2/fulltext

    Join the RealTalk MS Facebook Group https://facebook.com/groups/realtalkms

    Download the RealTalk MS App for iOS Devices https://itunes.apple.com/us/app/realtalk-ms/id1436917200

    Download the RealTalk MS App for Android Deviceshttps://play.google.com/store/apps/details?id=tv.wizzard.android.realtalk

    Give RealTalk MS a rating and review http://www.realtalkms.com/review

    Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com.

    RealTalk MS Episode 417 Guest: Jeff Beal

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    Episode 416: The Updated McDonald Diagnostic Criteria for MS with Dr. Andrew Solomon Aug 18, 2025
    Show notes

    Since 2001, clinicians have relied on the McDonald Diagnostic Criteria as the gold standard for diagnosing someone with multiple sclerosis. As science continues to add to our understanding of MS, the McDonald Criteria have been updated in 2005, 2010, 2017, and most recently in 2024.

    This latest iteration of the McDonald criteria will be published in September, and today, Dr. Andrew Solomon is giving us a preview of what these changes are, what they mean, and how they're going to improve the process of diagnosing someone with MS.

    We'll also share results of a study that show MS may actually start 15 years before someone experiences their first MS symptom.

    We'll tell you about a study that shows a decline in the number of people with MS who are progressing to secondary progressive MS.

    We'll give you all the details so you can participate in the Shaping Tomorrow Together initiative with the FDA.

    And we'll remind you that Burgers to Beat MS Day is just two days away!

    We have a lot to talk about! Are you ready for RealTalk MS??!

    This Week: Updated criteria for diagnosing MS :22

    Study results show that MS actually starts many years before the first symptom 1:21

    Study shows a decline in the number of people progressing to secondary progressive MS 7:40

    A unique opportunity for you to impact future treatments and share your experience of living with MS with the FDA 9:51

    We're just 2 days away from Burgers to Beat MS Day! 13:06

    Dr. Andrew Solomon shares a preview of the updated McDonald Diagnostic Criteria for MS 14:40

    Share this episode 26:20

    Coming next week 26:41

    SHARE THIS EPISODE OF REALTALK MS

    Just copy this link & paste it into your text or email: https://realtalkms.com/416

    ADD YOUR VOICE TO THE CONVERSATION

    I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts!

    Email: jon@realtalkms.com Phone: (310) 526-2283

    And don't forget to join us in the RealTalk MS Facebook group!

    LINKS

    If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com

    PARTICIPATE: Take the Shaping Tomorrow Together Survey https://s.alchemer.com/s3/Perspectives-on-MS

    REGISTER: Attend the virtual Shaping Tomorrow Together meeting with the FDA https://nmss.quorum.us/event/25463

    STUDY: Health Care Use Before Multiple Sclerosis Symptom Onset https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2837128

    STUDY: Health Care Use Before Multiple Sclerosis Symptom Onset (PLAIN ENGLISH VERSION) https://tremlettsmsresearchexplained.wordpress.com/2025/08/05/healthcare-use-before-multiple-sclerosis-symptom-onset-explained

    STUDY: Multiple Sclerosis From Onset to Secondary Progression: A 30-Year Italian Register Study https://researchgate.net/publication/392714813_Multiple_sclerosis_from_onset_to_secondary_progression_a_30-year_Italian_register_study

    DONATE: Burgers To Beat MS https://burgerstobeatms.ca

    Join the RealTalk MS Facebook Group https://facebook.com/groups/realtalkms

    Download the RealTalk MS App for iOS Devices https://itunes.apple.com/us/app/realtalk-ms/id1436917200

    Download the RealTalk MS App for Android Deviceshttps://play.google.com/store/apps/details?id=tv.wizzard.android.realtalk

    Give RealTalk MS a rating and review http://www.realtalkms.com/review

    Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com.

    RealTalk MS Episode 416 Guest: Dr. Andrew Solomon

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    Episode 415: Your Money -- Ways to Earn and Hold Onto More of It When You're Living with MS with Beth Scott and Paula Cole Aug 11, 2025
    Show notes

    Living with MS is expensive. Very expensive. It's estimated that the average cost of living with MS is over $88,000 per year. How, in the midst of financial stress and uncertainty, can you formulate a financial plan that takes MS into account?

    Paula Cole lives with MS, and she also lives with a lot of financial planning savvy. Paula joins the podcast to share tips and strategies for establishing a personal financial plan for you and your family -- even while you're coping with MS.

    And Beth Scott, the director of case management at the Patient Advocate Foundation, joins us to explain how you can take advantage of work incentive programs that allow an individual to keep working or even try returning to work while they're receiving Social Security Disability cash benefits.

    We have a lot to talk about! Are you ready for RealTalk MS??!

    This Week: Ways to earn and hold onto more money when you're living with MS :22

    Beth Scott explains how you can benefit from work incentive programs while you're receiving Social Security Disability cash benefits :35

    Paula Cole shares tips and strategies for establishing a personal financial plan for you and your family when you're living with MS 12:48

    Share this episode 27:47

    Next Week: The new criteria for diagnosing MS 28:07

    SHARE THIS EPISODE OF REALTALK MS

    Just copy this link & paste it into your text or email: https://realtalkms.com/415

    ADD YOUR VOICE TO THE CONVERSATION

    I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts!

    Email: jon@realtalkms.com Phone: (310) 526-2283

    And don't forget to join us in the RealTalk MS Facebook group!

    LINKS

    If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com

    Become an MS Activist https://nationalmssociety.org/advocacy

    Join the RealTalk MS Facebook Group https://facebook.com/groups/realtalkms

    Download the RealTalk MS App for iOS Devices https://itunes.apple.com/us/app/realtalk-ms/id1436917200

    Download the RealTalk MS App for Android Deviceshttps://play.google.com/store/apps/details?id=tv.wizzard.android.realtalk

    Give RealTalk MS a rating and review http://www.realtalkms.com/review

    Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com.

    RealTalk MS Episode 415 Guests: Beth Scott, Paula Cole

    Privacy Policy


    Episode 414: Finding Peace in the Midst of Uncertainty with Andrea Arzt, LCSW, MSCS Aug 04, 2025
    Show notes

    Living with MS has always meant living with uncertainty. Left unchecked, that uncertainty can lead to anxiety, which can make your MS symptoms feel worse.

    This week, Licensed Clinical Social Worker, Andrea Arzt, joins me to share tips and strategies for finding peace in the midst of uncertainty.

    You'll also meet the CEO of the MS International Federation, Dr. Lydia Makaroff.

    And you'll hear how artist Gordon Keith is combining his art with philanthropy in support of MS Canada.

    We have a lot to talk about! Are you ready for RealTalk MS??!

    This Week: Finding peace during uncertain times :22

    Dr. Lydia Makaroff discusses the work that the MS International Federation is involved in on behalf of the global MS community :58

    Gordon Keith discusses his life as an artist and how he's using his art to raise funds for MS Canada 10:43

    Licensed Clinical Social Worker, Andrea Arzt, offers strategies for finding peace of mind while facing uncertainty 21:40

    Share this episode 32:12

    Next Week: It's all about the money! 32:32

    SHARE THIS EPISODE OF REALTALK MS

    Just copy this link & paste it into your text or email: https://realtalkms.com/414

    ADD YOUR VOICE TO THE CONVERSATION

    I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts!

    Email: jon@realtalkms.com Phone: (310) 526-2283

    And don't forget to join us in the RealTalk MS Facebook group!

    LINKS

    If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com

    Become an MS Activist https://nationalmssociety.org/advocacy

    Join the RealTalk MS Facebook Group https://facebook.com/groups/realtalkms

    Download the RealTalk MS App for iOS Devices https://itunes.apple.com/us/app/realtalk-ms/id1436917200

    Download the RealTalk MS App for Android Deviceshttps://play.google.com/store/apps/details?id=tv.wizzard.android.realtalk

    Give RealTalk MS a rating and review http://www.realtalkms.com/review

    Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com.

    RealTalk MS Episode 414 Guests: Dr. Lydia Makaroff, Gordon Keith, and Andrea Arzt

    Privacy Policy


    Episode 413: How AI Will Impact MS Patient Care with Dr. Brad Willingham Jul 28, 2025
    Show notes

    We're witnessing the early stages of a paradigm shift, as artificial intelligence is beginning to impact virtually every aspect of healthcare, from research to patient care. And there's much, much more to come.

    This week, Dr. Brad Willingham, the Director of MS Research at Shepherd Center in Atlanta, joins me to discuss how AI will impact MS patient care.

    We'll also share the encouraging results from a Phase 2 open-label extension study for Fenebrutinib, an investigational disease-modifying therapy.

    We'll tell you about study results that show exercise interventions that follow physical activity guidelines for MS can have a significant impact on MS-related depression.

    And we're sharing the results of a study that illustrate what can happen when you delay starting a disease-modifying therapy.

    We have a lot to talk about! Are you ready for RealTalk MS??!

    This Week: How AI will impact MS patient care :22

    Fenebrutinib shows positive results after one-year extension study 1:33

    MS-related depression can be significantly eased through exercise intervention that follows physical activity guidelines for MS 3:36

    What happens when you delay starting disease-modifying therapy? 8:46

    Dr. Brad Willingham discusses how artificial intelligence is impacting all aspects of healthcare 14:29

    Share this episode 33:18

    Have you downloaded the free RealTalk MS app? 33:38

    SHARE THIS EPISODE OF REALTALK MS

    Just copy this link & paste it into your text or email: https://realtalkms.com/413

    ADD YOUR VOICE TO THE CONVERSATION

    I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts!

    Email: jon@realtalkms.com Phone: (310) 526-2283

    And don't forget to join us in the RealTalk MS Facebook group!

    LINKS

    If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com

    Become an MS Activist https://nationalmssociety.org/advocacy

    STUDY: Safety and Efficacy of Fenebrutinib in Relapsing Multiple Sclerosis (FENopta): A Multicentre, Double-Blind, Randomised, Placebo-Controlled, Phase 2 Trial and Open-Label Extension https://thelancet.com/journals/laneur/article/PIIS1474-4422(25)00174-7/abstract?rss=yes

    STUDY: Effects of Meeting Exercise Guidelines on Depression and Anxiety in Multiple Sclerosis: A Systematic Review and Meta-Analysis https://tandfonline.com/doi/full/10.1080/09593985.2025.2518261

    Exercise and Physical Activity Recommendations for ALL People with MS https://nationalmssociety.org/news-and-magazine/news/exercise-and-physical-activity-recommend

    STUDY: Delayed Access and Adherence are Real-World Challenges That Compromise Effectiveness of Natalizumab in Multiple Sclerosis https://sciencedirect.com/science/article/abs/pii/S2211034825003694

    Join the RealTalk MS Facebook Group https://facebook.com/groups/realtalkms

    Download the RealTalk MS App for iOS Devices https://itunes.apple.com/us/app/realtalk-ms/id1436917200

    Download the RealTalk MS App for Android Deviceshttps://play.google.com/store/apps/details?id=tv.wizzard.android.realtalk

    Give RealTalk MS a rating and review http://www.realtalkms.com/review

    Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com.

    RealTalk MS Episode 413 Guest: Dr. Brad Willingham

    Privacy Policy


    Episode 412: Understanding Late-Onset MS with Dr. Jacqueline Nicholas Jul 21, 2025
    Show notes

    More people over the age of 50 are being diagnosed with MS than ever before. When you consider the other health conditions that often develop as we age, and you add the fact that our immune system changes with age, there's a lot to think about when it comes to diagnosing and treating late-onset MS.

    This week, Dr. Jacqueline Nicholas, the System Chief of Neuroimmunology and Multiple Sclerosis at the OhioHealth Multiple Sclerosis Center, joins me to help us better understand late-onset MS.

    We'll also tell you about research results that could lead to a simple blood test that can predict MS years before someone experiences a single symptom.

    You'll learn about an ultra-high resolution brain imaging tool that could open the door to precision neuroscience and revolutionize the treatment of neurological disorders

    The FDA wants to talk with people about what living with MS is like, and what they're looking for in future treatments. We'll tell you how and where to register for an informational webinar that will give you all the details about the Shaping Tomorrow Together initiative.

    And if you're in or around Northern California, we'll remind you that you can join us this Saturday in Napa Valley at Crush MS!

    We have a lot to talk about! Are you ready for RealTalk MS??!

    This Week: Understanding Late-Onset MS :22

    How a simple blood test may predict MS years before someone experiences any symptoms 1:34

    How a new ultra-high resolution brain imaging tool may revolutionize the treatment of neurological disorders 6:40

    Are you interested in telling the FDA what it's like living with MS, and what you want in future treatments? 8:53

    Are you ready to support MS research while spending the afternoon in a Napa Valley vineyard? Get all the details to attend Crush MS 10:29

    Dr. Jacqueline Nicholas discusses what's different and what's the same in treating late-onset MS 12:09

    Share this episode 29:26

    Have you downloaded the free RealTalk MS app? 29:46

    SHARE THIS EPISODE OF REALTALK MS

    Just copy this link & paste it into your text or email: https://realtalkms.com/412

    ADD YOUR VOICE TO THE CONVERSATION

    I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts!

    Email: jon@realtalkms.com Phone: (310) 526-2283

    And don't forget to join us in the RealTalk MS Facebook group!

    LINKS

    If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com

    Become an MS Activist https://nationalmssociety.org/advocacy

    STUDY: Early Identification of Individuals at Risk for Developing Multiple Sclerosis by Quantification of EBNA-1-381-452-Specific Antibody Titers https://nature.com/articles/s41467-025-61751-9

    REGISTER: Informational Webinar on the FDA "Shaping Tomorrow Together" Listening Session https://nmss.zoom.us/webinar/register/WN_hHdHhEE3TBmPJ2glcgME0Q#/registration

    EVENT: Crush MS https://crushms.org

    Join the RealTalk MS Facebook Group https://facebook.com/groups/realtalkms

    Download the RealTalk MS App for iOS Devices https://itunes.apple.com/us/app/realtalk-ms/id1436917200

    Download the RealTalk MS App for Android Deviceshttps://play.google.com/store/apps/details?id=tv.wizzard.android.realtalk

    Give RealTalk MS a rating and review http://www.realtalkms.com/review

    Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com.

    RealTalk MS Episode 412 Guest: Dr. Jacqueline Nicholas

    Privacy Policy


    Episode 411: An Encouraging Clinical Trial for Progressive MS with Jason Tardio Jul 14, 2025
    Show notes

    Back in Episode #401, we reported promising results from a Phase 2 clinical trial for vidofludimus calcium and its impact on progressive MS. This therapy is being developed by Immunic Therapeutics, and this week, Jason Tardio, Immunic's President and Chief Operating Officer, joins me to share some of the specifics of that clinical trial.

    Jason will also shed light on why Immunic believes that vidofludimus calcium goes beyond merely slowing disability, potentially offering vital neuroprotection for MS patients, making it a potential game-changer.

    We're also sharing the encouraging results from a study that focused on the efficacy of neural stem cell transplantation as a remyelination therapy.

    We'll tell you about a study in the U.K. that measured disability progression among people with MS five years after undergoing autologous hematopoietic stem cell transplantation (aHSCT).

    You'll learn about an AI tool that can predict whether someone living with MS is likely to experience progression independent of relapse activity (PIRA) with a high degree of accuracy.

    We'll tell you where you can catch the International Progressive MS Alliance webcast featuring a panel of experts discussing the future role of digital tools in MS research.

    We'll explain how one of the less publicized aspects of the One Big Beautiful Bill Act will impact future MS care.

    And Crush MS is less than two weeks away! We're sharing all the details!

    We have a lot to talk about! Are you ready for RealTalk MS??!

    This Week: Encouraging results from a clinical trial for progressive MS. :22

    How a less-publicized aspect of the One Big Beautiful Bill Act will impact future MS patient care 1:18

    A study looked at the efficacy of neural stem cell transplantation as a remyelination therapy 4:31

    A study in the U.K. analyzed disability progression among people with MS five years after receiving autologous hematopoietic stem cell therapy (aHSCT) 7:42

    Can AI accurately predict who will experience progression independent of relapse activity (PIRA)? 10:45

    Don't miss the International Progressive MS Alliance webcast featuring experts discussing the future role of digital tools in MS research 12:40

    Are you ready to support MS research while spending the afternoon in a Napa Valley vineyard? Get all the details to attend Crush MS 13:45

    Jason Tardio, President and Chief Operating Officer of Immunic Therapeutics, discusses the recent Phase 2 clinical trial for vidofludimus calcium as a therapy for progressive MS 15:03

    Share this episode 30:03

    Have you downloaded the free RealTalk MS app? 30:23

    SHARE THIS EPISODE OF REALTALK MS

    Just copy this link & paste it into your text or email: https://realtalkms.com/411

    ADD YOUR VOICE TO THE CONVERSATION

    I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts!

    Email: jon@realtalkms.com Phone: (310) 526-2283

    And don't forget to join us in the RealTalk MS Facebook group!

    LINKS

    If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com

    Become an MS Activist https://nationalmssociety.org/advocacy

    STUDY: Remyelination of Chronic Demyelinated Lesions With Directly Induced Neural Stem Cells https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awaf208/8185601

    STUDY: Autologous Haemotopoietic Stem Cell Transplantation in the U.K.: A 20-Year Retrospective Analysis of Activity Haematological Outcomes from the British Society of Blood And Marrow Transplantation and Cellular Therapy https://onlinelibrary.wiley.com/doi/epdf/10.1111/bjh.20199

    STUDY: Deep Learning to Predict Progression Independent of Relapse Activity at a First Demyelinating Event https://academic.oup.com/braincomms/article/7/4/fcaf243/8185588

    WEBCAST: A Discussion From the International Progressive MS Alliance's Digital Tools Workshop https://msif.org/news/2025/07/08/webcast-digital-tools

    EVENT: Crush MS https://crushms.org

    Join the RealTalk MS Facebook Group https://facebook.com/groups/realtalkms

    Download the RealTalk MS App for iOS Devices https://itunes.apple.com/us/app/realtalk-ms/id1436917200

    Download the RealTalk MS App for Android Deviceshttps://play.google.com/store/apps/details?id=tv.wizzard.android.realtalk

    Give RealTalk MS a rating and review http://www.realtalkms.com/review

    Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com.

    RealTalk MS Episode 411 Guest: Jason Tardio

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    Episode 410: From the International Progressive MS Alliance Digital Tools Workshop -- Part Two Jul 07, 2025
    Show notes

    Over the past few months, we've shared news about an algorithm that can accurately predict whether someone living with MS will experience worsening symptoms or a relapse in the weeks ahead.

    You've heard about a three-quarter-of-a-million-dollar investment by the International Progressive MS Alliance to support the development of an AI-based tool that will predict future disability as well as how someone with MS will respond to different disease-modifying therapies.

    Just last week, you learned about a digital tool that can accurately diagnose whether someone has relapsing-remitting MS or progressive MS -- after a five-minute test!

    Digital tools are poised to rewrite the rules when it comes to conducting MS research and providing patient care. Welcome to Part Two of our coverage of the Digital Tools Workshop hosted by the International Progressive MS Alliance.

    In this week's episode, you'll hear Vanessa Fanning share her perspective as someone living with progressive MS on how digital tools can benefit people with progressive MS, while also highlighting some of the challenges that need to be addressed.

    Then, you'll hear neuroimmunologist and data scientist Professor Sergio Baranzini discuss how all the data that digital tools produce will be integrated into MS research and MS care.

    Dr. Ruth Ann Marrie recaps the topics covered at the meeting and describes the next steps necessary to integrate digital tools into MS clinical care.

    And we'll have to take a moment to share the frightening real-world consequences of last week's decision by President Trump and Congress to cut a trillion dollars from Medicaid.

    We have a lot to talk about! Are you ready for RealTalk MS??!

    This Week: The real-world impact of the Big, Beautiful Bill on people with MS and any other chronic illness :22

    An example of how a digital tool could revolutionize MS patient care 7:41

    Vanessa Fanning shares a patient's perspective on how digital tools can benefit people living with progressive MS and reminds us of the challenges that still need to be solved 11:19

    Professor Sergio Baranzini discusses managing big data in the clinic 23:15

    Dr. Ruth Ann Marrie provides a recap of the workshop and describes the next steps to be taken 31:07

    Share this episode 43:21

    Have you downloaded the free RealTalk MS app? 43:41

    SHARE THIS EPISODE OF REALTALK MS

    Just copy this link & paste it into your text or email: https://realtalkms.com/410

    ADD YOUR VOICE TO THE CONVERSATION

    I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts!

    Email: jon@realtalkms.com Phone: (310) 526-2283

    And don't forget to join us in the RealTalk MS Facebook group!

    LINKS

    If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com

    Become an MS Activist https://nationalmssociety.org/advocacy

    Join the RealTalk MS Facebook Group https://facebook.com/groups/realtalkms

    Download the RealTalk MS App for iOS Devices https://itunes.apple.com/us/app/realtalk-ms/id1436917200

    Download the RealTalk MS App for Android Deviceshttps://play.google.com/store/apps/details?id=tv.wizzard.android.realtalk

    Give RealTalk MS a rating and review http://www.realtalkms.com/review

    Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com.

    RealTalk MS Episode 410 Guests: Vanessa Fanning, Professor Sergio Baranzini, Dr. Ruth Ann Marrie

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    Episode 409: From the International Progressive MS Alliance Digital Tools Workshop Jun 30, 2025
    Show notes

    Last week, I was in Philadelphia, attending the Digital Tools Workshop hosted by the International Progressive MS Alliance. Welcome to Part One of our coverage!

    As we look around us, it's hard to imagine a single aspect of our lives that hasn't been impacted by the constant and rapid evolution of technology. Just consider the capabilities of the device you're using to listen to this podcast. This workshop highlighted the ways that emerging digital tools will accelerate MS clinical trials and enhance personalized MS care.

    In this week's episode, you'll hear Dr. Robert Fox, the Chair of the International Progressive MS Alliance Scientific Steering Committee, and Dr. Tim Coetzee, President and CEO of the National MS Society, discuss some of the ways digital tools can impact MS research and care, as well as some of the issues that need to be addressed to ensure that everyone living with MS can benefit from these tools.

    Then, you'll hear the workshop co-chair, Dr. Jennifer Graves, discuss her team's work in developing a digital tool that can accurately determine whether an individual has relapsing-remitting MS or progressive MS -- after a 5-minute test that consists of tapping their fingers and feet!

    You'll hear Dr. Anne Helme, the Head of Research and Access at the MS International Federation, explain how digital tools can boost patient-reported outcomes in MS research.

    And you'll hear Dr. Stefan Gold share the positive results of his study involving an at-home digital intervention designed to treat depression among people with MS.

    We have a lot to talk about! Are you ready for RealTalk MS??!

    This Week: From the International Progressive MS Alliance Digital Tools Workshop :22

    Dr. Tim Coetzee and Dr. Robert Fox discuss how digital tools will impact MS research and care :54

    Dr. Jennifer Graves talks about her team's work in developing a digital tool, and how MS research is being threatened by drastic cuts in federal research funding 9:56

    Dr. Anne Helme discusses how digital tools will boost patient-reported outcomes in MS research 16:26

    Dr. Stefan Gold shares the positive results of his study involving an at-home digital intervention designed to treat depression among people with MS. 24:06

    Share this episode 37:38

    Have you downloaded the free RealTalk MS app? 37:58

    SHARE THIS EPISODE OF REALTALK MS

    Just copy this link & paste it into your text or email: https://realtalkms.com/409

    ADD YOUR VOICE TO THE CONVERSATION

    I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts!

    Email: jon@realtalkms.com Phone: (310) 526-2283

    And don't forget to join us in the RealTalk MS Facebook group!

    LINKS

    If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com

    Join the RealTalk MS Facebook Group https://facebook.com/groups/realtalkms

    Download the RealTalk MS App for iOS Devices https://itunes.apple.com/us/app/realtalk-ms/id1436917200

    Download the RealTalk MS App for Android Deviceshttps://play.google.com/store/apps/details?id=tv.wizzard.android.realtalk

    Give RealTalk MS a rating and review http://www.realtalkms.com/review

    Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com.

    RealTalk MS Episode 409 Guests: Dr. Tim Coetzee, Dr. Robert Fox, Dr. Jennifer Graves, Dr. Anne Helme, Dr. Stefan Gold

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