Real Life Pharmacology &#8211; Pharmacology Education for Health Care Professionals

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Naltrexone Pharmacology Podcast – Episode 307 Dec 28, 2023

Show notes

In this podcast episode, I discuss naltrexone pharmacology, adverse effects, drug interactions, and much more.

Naltrexone is an opioid antagonist and can blunt the effects of opioid agonists. Because of this, the medication can be used to manage opioid use disorder.

Hepatotoxicity is a concern of naltrexone and because of this, it is recommended to monitor LFTs.

There is an injectable, long-acting formulation of naltrexone that can be used for opioid and alcohol use disorder treatment.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

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Acamprosate Pharmacology Podcast – Episode 306 Dec 21, 2023

Show notes

On this podcast episode, I discuss acamprosate pharmacology, adverse effects, drug interactions, and much more!

Acamprosate’s most common adverse effect is diarrhea. It is a primary reason why patients will ask to stop taking this medication.

It is critical to assess renal function prior to using acamprosate. Dose adjustments are recommended when patients have a CrCl of less than 50 ml/min.

Unlike naltrexone, acamprosate avoids liver metabolism making it an alternative option in alcohol use disorder for patients who have liver impairment.

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)

Alfuzosin Pharmacology Podcast Dec 14, 2023

Show notes

On this podcast episode, I discuss alfuzosin pharmacology, adverse effects, drug interactions, and much more!

Alfuzosin is an alpha blocker used to help relieve the symptoms of BPH.

Low blood pressure is a possible adverse effect of alfuzosin and is more likely when combined with PDE-5 inhibitors like sildenafil.

CYP3A4 is an important enzyme in the metabolism of alfuzosin. Inhibitors of CYP3A4 can raise concentrations and increase the chance of alfuzosin toxicity.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)

Methadone Pharmacology Podcast Dec 07, 2023

Show notes

In this podcast episode, I discuss methadone pharmacology, adverse effects, drug interactions, and pharmacokinetics.

Methadone is a full opioid agonist that may be used for pain management and opioid use disorder.

Transitioning from methadone to another opioid is complicated. I discuss conversion in this podcast episode.

Methadone can increase the risk of QTc prolongation and also has a lot of drug interactions. I discuss them in detail in this podcast episode.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)

Meperidine Pharmacology Podcast Nov 30, 2023

Show notes

On this podcast episode, I discuss meperidine pharmacology, adverse effects, pharmacokinetics, drug interactions, and much more!

Meperidine is an opioid that is seldom used due to neurotoxicity. I describe how this can happen in this podcast episode.

Meperidine has numerous drug interactions and using a CYP3A4 inhibitor may increase the risk for toxicity.

Seizures are a risk with meperidine due to its neurotoxic metabolite normeperidine. I discuss this further in this podcast episode.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)

Guanfacine Pharmacology Podcast Nov 23, 2023

Show notes

On this episode of the podcast, I cover guanfacine pharmacology, adverse effects, drug interactions, and much more.

Guanfacine is a central acting alpha-2 agonist that has the brand names of Tenex and Intuniv.

Because of guanfacine’s mechanism of action, it suppresses the sympathetic response leading to a drop in pulse and blood pressure.

It is important to remind patients that the onset of action is slow in the management of ADHD with guanfacine. I discuss this further in this podcast episode.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)

Fluvastatin Pharmacolgy Podcast Nov 16, 2023

Show notes

On this podcast episode, I discuss fluvastatin pharmacology, adverse effects, pharmacokinetics, and much more.

Fluvastatin is only a low to moderate-intensity statin which explains its limited use compared to rosuvastatin or atorvastatin.

I discuss drug interactions in the podcast but one important one to recognize is drugs that can inhibit CYP2C9.

Fluvastatin is considered a lipophilic statin. I have previously discussed this on the Meded101 blog which you can find here.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)

Oxymorphone Pharmacology Podcast Nov 09, 2023

Show notes

In this episode, I discuss oxymorphone pharmacology, adverse effects, drug interactions, and more!

Oxymorphone is approximately 3 times more potent than morphine. I break down some common opioid comparisons in this episode.

Oxymorphone avoids many of the CYP interactions. I discuss some of the common interactions in this episode.

I discuss histamine release in relation to opioids and oxymorphone and specifically how this may impact our patients.

Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!

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Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated)

Guide to Drug Food Interactions (Amazon Best Seller)