PeerView Clinical Pharmacology CME/CNE/CPE Audio Podcast

Latest Episodes:

Prof. Mohamad Mohty, Christine N. Duncan, MD - New Rules for VOD/SOS: Modern Risk Assessment, Diagnostic Principles, and Innovative Treatment Mar 14, 2023

Show notes

Go online to PeerView.com/CUN860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Are you prepared to apply the “new rules” of management to veno-occlusive disease (VOD)/sinusoidal obstruction syndrome (SOS) for your patients at risk for this hematopoietic stem cell transplantation (HCT) complication? Find out in this PeerView Clinical Consult video recorded at the 2023 Tandem Meetings. Watch as our panelists give the latest guidance on VOD/SOS management, while discussing adult and pediatric case scenarios designed to inform on risk assessment, diagnostic confirmation, severity grading, and treatment. Throughout, the experts will highlight how modern care principles can confirm a diagnosis, determine the presence of organ dysfunction, and prompt the initiation of timely supportive care and pharmacologic treatment. Don’t miss this opportunity to get the latest, most effective approaches to VOD/SOS management and received CME credit! Upon completion of this activity, participants should be better able to: Develop effective strategies for VOD risk assessment and diagnosis, including in the immediate pre- and post-HCT setting; Establish the presence of organ dysfunction in patients with a VOD diagnosis using currently available management tools; and Select appropriate treatment options for adult and pediatric patients with VOD in the post-HCT setting, including supportive and pharmacologic measures.

Jennifer Woyach, MD - Real-World Challenges and Solutions with BTKi in CLL: Therapeutic Insights for Community Practice Mar 14, 2023

Show notes

Go online to PeerView.com/DWY860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. First- and second-generation Bruton tyrosine kinase (BTK) inhibitors have transformed the standard of care in many different chronic lymphocytic leukemia (CLL) settings—from treatment-naïve to relapsed disease, as well as in high-risk settings—but are you prepared to fully integrate established and emerging BTKi options into clinical practice, including in the context of community-based care? Find out by viewing this activity, which highlights the clinical decision-making of an academic and a community specialist. Throughout, the panelists will use a series of real-world cases to demonstrate the practicalities of using modern BTKi therapy, provide guidance on the use of next-generation agents, and offer a strong grounding for updated AE management protocols that can ensure safe delivery of care. Upon completion of this activity, participants should be better able to: Summarize evidence from pivotal clinical trials and practice guidelines on BTK inhibitor efficacy, safety, and mechanistic/selectivity differences, including as single-agent approaches or as part of novel combinations; Recommend personalized BTK inhibitor therapy for patients with treatment-naïve CLL based on prognostic information, the presence of comorbidities, and safety considerations; Select individualized, sequential BTK inhibitor options for the management of patients with relapsed/refractory CLL or for individuals who develop therapeutic intolerance; and Manage adverse events associated with the use of novel targeted approaches with BTK inhibitors in the CLL setting.

Professor Perry Elliott, MBBS, MD, FRCP, FESC, FACC - Medicine in Motion: Visual Guide to a New Generation in Care for Patients With Hypertrophic Cardiomyopathy Mar 10, 2023

Show notes

Go online to PeerView.com/KYU860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. The visual guide to hypertrophic cardiomyopathy (HCM) you’ve been waiting for is here! In contemporary care, patients with HCM have options that may reduce the need for invasive treatments. This engaging presentation is perfect for both visual and auditory learners to update their understanding of HCM, tune in to the signs and symptoms that should raise suspicion, and learn best practices to confirm a diagnosis of HCM. Once diagnosed, you’ll need to know the latest data on cardiac myosin inhibitors and practical guidance for integrating them into patient care. This activity delivers on all of the above—set aside some time and click “play” today! Upon completion of this activity, participants should be better able to: Recognize clinical characteristics and/or features that suggest the presence of HCM; Accurately diagnose patients with suspected HCM using expert guidance and the latest recommendations to promote early identification and treatment; and Personalize the medical treatment of HCM using strategies with disease-modifying potential based upon the latest efficacy and safety evidence and consistent with current prescribing and monitoring recommendations to ensure long-term patient safety and improve clinical outcomes.

Ravin Ratan, MD, M.Ed - Addressing Key Questions About the Latest Diagnostic and Therapeutic Advances in Desmoid Tumors Mar 10, 2023

Show notes

Go online to PeerView.com/YNZ860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Desmoid tumors are rare but aggressive soft-tissue tumors characterized by locally invasive growth, significant morbidity, and a high rate of recurrence. Considering that they are so rare, there are many challenges related to their recognition and establishment of an accurate diagnosis, and referral to a specialist is essential. Effective therapies have been lacking, but a number of systemic and local therapy options have been assessed in recent trials, with mixed results. Gamma secretase inhibitors are among the most recent promising, rational therapies for desmoid tumors that may transform the management of this disease. Given the transition of care from surgical approaches to more conservative strategies, the emergence of new systemic therapies, and the increasing importance of multidisciplinary coordination of care, there is an urgent need to address key questions and nuances related to modern treatment of patients with desmoid tumors. This educational program comprises a series of short, focused educational modules that hone in on some of the key questions in the diagnosis and treatment of desmoid tumors. Experts provide an update on the evolving evidence base for new and emerging therapies, and offer practical, case-based guidance for the multidisciplinary care team to help facilitate the application of recent advances to practice with the goal of improving patient care and outcomes. Patient perspectives and experiences are also integrated into the activity to highlight the importance of their education and engagement in care decisions. Upon completion of this activity, participants should be better able to: Characterize the epidemiology, predisposing factors, molecular pathogenesis, and clinical characteristics of desmoid tumors; Implement validated strategies that harness multidisciplinary team-based approaches for rapid recognition and accurate diagnosis of desmoid tumors; and Incorporate novel therapeutic approaches, including novel gamma-secretase inhibitors, into practice in the management of patients with desmoid tumors, taking into account the latest evidence, recommendations, and patient needs and preferences.

Seth S. Martin, MD, MHS, FACC, FAHA, FASPC - Medicine in Motion: Smart Approaches for Treating HoFH Mar 03, 2023

Show notes

Go online to PeerView.com/BNB860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this animated activity, an expert on homozygous familial hypercholesterolemia (HoFH) discusses the latest data for novel lipid-lowering therapies and offers strategies for individualizing treatment regimens to improve outcomes for patients with HoFH. Upon completion of this activity, participants should be better able to: Apply standards of care to initiate and escalate lipid-lowering therapies in patients with HoFH; Distinguish the therapeutic characteristics of recently approved HoFH therapies according to their mechanisms of action; and Evaluate the benefits and limitations of approved HoFH therapies to individualize patient care.

Sanjay R. Bhagani, BSc (Hons), MB ChB, FRCP - Improving Outcomes for Hospitalized Patients with COVID-19: Expert Perspectives on Incorporating the Latest Guidelines and Evidence Into Clinical Practice Mar 01, 2023

Show notes

Go online to PeerView.com/SRU860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Despite the availability of testing, vaccines, and treatments, COVID-19 remains a threat—no one can predict when a new strain might surface and many questions remain. The virus that causes COVID-19 is designated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the clinical spectrum of SARS-CoV-2 infection ranges from asymptomatic to critical and fatal illness. Most symptomatic infections are mild; however, a significant number of patients have severe disease requiring hospitalization. Hospitalization and death are more likely in high-risk populations, including older people, individuals with underlying medical problems, and those affected by systemic health and social inequities (ie, minorities, immigrant populations, people of low socioeconomic status, and the disabled). Therapies such as antiviral agents and monoclonal antibodies are available in the United States and Europe for the treatment of COVID-19; however, there are challenges with determining which hospitalized patients may be best suited for which treatment. In this activity, based on a recent live web broadcast, a panel of experts explores strategies to improve outcomes for COVID-19 in the hospital setting, with a focus on designing individualized treatment plans based on current guidelines, evolving evidence, and patient-specific factors. The panel also discusses how differences in drug access and treatment protocols impact the healthcare team in regards to providing individualized treatment programs for patients hospitalized with COVID-19. Upon completion of this activity, participants should be better able to: Assess patients with COVID-19 to make appropriate treatment recommendations based on disease severity; Differentiate therapies for COVID-19 based on the latest safety and efficacy data from clinical trials; Collaborate with the healthcare team to design timely and individualized treatment plans for hospitalized patients with COVID-19 disease based on current guidelines, evolving evidence, and patient-specific factors; and Discuss the clinical implications of prolonged/persistent viral replication in severe COVID-19

Rachna T. Shroff, MD, FASCO - Getting Personal With Advanced BTC: Insights on Personalizing Upfront and Sequential Care With Immunotherapy and Targeted Agents Mar 01, 2023

Show notes

Go online to PeerView.com/FKB860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. New science continues to support a diverse management model for advanced biliary tract cancers (BTCs), including immune-based and targeted platforms, culminating to the first meaningful advancements in frontline therapy for advanced/metastatic BTC in over a decade. Collectively these clinical trends have expanded the use of individualized management strategies, leading to enhanced clinical outcomes for patients with advanced BTC. In this activity, based on a recent live symposium, expert panelists provide data and practical guidance on the current status of care in BTC and new developments related to the use of novel and emerging immunotherapies and targeted options (eg, PD-1 and PD-L1 inhibitors, FGFR, IDH, TRK, and HER2-directed agents). Case presentations explore next-generation care for today’s patients with BTC using personalized upfront and sequential treatment management models. Don’t miss this chance to get personal with advanced BTC! Upon completion of this activity, participants should be better able to: Summarize the latest clinical evidence supporting the use of immunotherapy and targeted platforms for patients with advanced BTCs; Develop personalized management plans for patients with advanced BTCs based on up-to-date clinical evidence on novel immunotherapeutic and targeted approaches, expert recommendations, comorbidities, and other factors at baseline; and Manage unique safety considerations associated with the use of novel targeted and immunotherapy options for BTCs

Loretta J. Nastoupil, MD - Innovation Now for Follicular Lymphoma: New Evidence for Immunotherapy, Targeted, and Chemo-Free Options Mar 01, 2023

Show notes

Go online to PeerView.com/SZT860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Are you up to date on the latest evidence with immunotherapy, targeted agents, and chemo-free options for follicular lymphoma (FL)? Find out by accessing this activity, where an expert will interpret new evidence supporting the continued integration of bispecific antibodies, CAR-T cell therapy, EZH2 inhibitors, and PI3K inhibitors across multiple lines of therapy in relapsed/refractory FL. Throughout, the expert shares guidance on therapeutic sequencing, safety management, and the future use of innovative combination platforms. Don’t miss this important update from ASH! Upon completion of this activity, participants should be better able to: Summarize evidence surrounding targeted, epigenetic, and immunotherapy options for R/R FL; Integrate modern, evidence-based sequential treatment plans for R/R FL that include immunomodulatory drugs, targeted therapies, epigenetic agents, bispecific antibodies, and CAR-T constructs; and Manage the unique suite of adverse events associated with the use of novel therapeutics as sequential management options in R/R FL

Shannon N. Westin, MD, MPH - New Horizons for Advanced Endometrial Cancer Treatment: Utilizing Innovative Immunotherapies and Other Novel Approaches Mar 01, 2023

Show notes

Go online to PeerView.com/GEP860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. For patients with recurrent or advanced endometrial cancer, tremendous therapeutic gains have been realized with the incorporation of immune checkpoint inhibitors. Monotherapy and combination approaches have had multiple regulatory approvals in the second-line setting and clinical trials assessing use in the frontline setting are underway. In this CME activity, an expert shares scientific rationale and practical guidance for incorporating molecular testing into patient management to personalize therapeutic selection. Pairing in-depth updates on efficacy and safety data for immunotherapeutic and other novel regimens with case-based discussions of best practices for bringing individualized treatment plans to the clinic, this is a learning opportunity for all in the field of gynecologic oncology. Upon completion of this activity, participants should be better able to: Describe the rationales, therapeutic roles, and key efficacy/safety evidence of immunotherapy-based options, among other novel therapies, for patients with recurrent or advanced endometrial cancer; Integrate new and emerging therapeutic options into personalized treatment plans for patients with recurrent or advanced endometrial cancer, taking into consideration the latest available evidence, current guideline recommendations, and biomarker testing results; and Apply proactive, collaborative strategies to mitigate and manage adverse events in patients with recurrent and advanced endometrial cancers who are receiving novel therapies as part of their care

Jessica Donington, MD, Catherine Shu, MD - EGFR-Targeted Therapy for Early-Stage NSCLC: What Thoracic Surgeons Need to Know Mar 01, 2023

Show notes

Go online to PeerView.com/GQW860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Patients with early-stage lung cancer frequently experience disease recurrence within 1 year of receiving curative-intent surgery, representing a significant unmet medical need. Individualized management of patients with NSCLC is based on a number of considerations, including the molecular profile of the patient’s tumor and the benefits and limitations of therapeutic options in the context of the latest evidence. Continued advances with targeted therapies have sparked substantial interest in expanding their use into earlier disease settings, and adjuvant EGFR-targeted therapy has demonstrated remarkable efficacy in early-stage NSCLC, leading to the first regulatory approval of osimertinib as adjuvant therapy after resection in patients with NSCLC whose tumors have EGFR exon 19 deletions or exon 21 L858R mutations. In addition, results from studies in the neoadjuvant setting are emerging now, as perioperative use of EGFR-targeted therapy continues to demonstrate improved outcomes. Thoracic surgeons are key members of the multidisciplinary care team, playing an essential role in collaborating and coordinating with other specialists to determine the best treatment plan, including incorporating EGFR-targeted therapy into multimodal management strategies. This PeerView educational activity, based on a recent live symposium, focuses on the latest clinical evidence supporting the use of EGFR-targeted therapy in perioperative settings and provides practical guidance for optimally integrating targeted therapies in practice or clinical trials. Multidisciplinary discussions on the latest practice-changing data highlight important implications of utilizing EGFR-targeted therapy as part of multimodal treatment for surgeons and the broader lung cancer care team. Upon completion of this activity, participants should be better able to: Discuss the role of EGFR mutations in NSCLC, advances in EGFR-targeted therapy in earlier disease settings, and the importance of identifying patients who might benefit from these therapies in perioperative settings; Identify patients with early-stage resectable NSCLC who are candidates for adjuvant EGFR-targeted therapy or investigational targeted approaches according to the latest evidence and guidelines; and Implement multidisciplinary and patient-centric strategies to integrate EGFR-targeted therapy into multimodal treatment plans for eligible patients with early-stage resectable NSCLC

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