PeerView Clinical Pharmacology CME/CNE/CPE Audio Podcast

Latest Episodes:

Benjamin M. Greenberg, MD, MHS / Jiwon Oh, MD, PhD, FRCPC - BTK Inhibition as an MS Treatment Modality: Where Do We Stand and Where Are We Headed? Mar 28, 2023

Show notes

Go online to PeerView.com/YCW860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. An evolving understanding of the role of B cells in pathophysiology of multiple sclerosis (MS) and the demonstrated success of other B cell–targeted therapies have led to great interest in the promise of Bruton tyrosine kinase (BTK) inhibitors as a novel MS treatment class. Compared with anti-CD20 monoclonal antibodies, BTK inhibitors are understood to offer the promise of greater selectivity that leaves healthy B cells intact, as well as the ability to cross the blood–brain barrier and affect both the peripheral and central nervous systems. Four BTK inhibitors are now in phase 3 trials, with others in earlier stages of investigation. In this activity, based on a recent live symposium, expert speakers review the pathophysiologic rationale for BTK inhibition and discuss the emerging trial data on these agents. Upon completion of this activity, participants should be better able to: Explain the pathophysiologic rationale for Bruton tyrosine kinase (BTK) inhibition in multiple sclerosis (MS) management; Assess emerging evidence on the efficacy, safety, and tolerability of BTK inhibitors being studied for the treatment of MS; and Identify patients who may benefit by treatment with BTK inhibitors, based on current evidence and individual treatment needs and priorities

Jacob Sands, MD - Facilitating Progress in the Treatment of SCLC: How to Optimize the Use of Current Systemic Options and Accelerate the Clinical Transition of Investigational Approaches Mar 28, 2023

Show notes

Go online to PeerView.com/FSN860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. After many years of slow progress, the treatment arsenal has finally expanded and more hope is on the horizon for patients with small cell lung cancer (SCLC). Notable advances such as chemo-immunotherapy in the first-line setting and lurbinectedin in the second-line setting have now become guideline-recommended standards of care and propelled the treatment of SCLC forward. Further research efforts are focused on understanding the underlying biology and potential subtypes of SCLC, what biomarkers may be useful in refining treatment selection, and evaluation of novel therapeutic options and rational combinations. In this PeerView Live Candid Conversations & Clinical Consults symposium, based on a recent live symposium, leading experts weave together the latest evidence on standard-of-care therapies and the evolving data on new/emerging approaches to provide a big-picture overview of the present and future management of SCLC and how to accelerate further progress in this challenging disease. These discussions are framed with illustrative patient cases to highlight evidence-based strategies to improve care and outcomes in SCLC. Upon completion of this activity, participants should be better able to: Analyze the role and use of current and emerging therapies for SCLC and the evidence supporting their use; Implement multidisciplinary strategies and shared decision-making to ensure early diagnosis, rapid initiation of therapy, and optimal care throughout the disease continuum for each patient with SCLC; Incorporate current standard-of-care therapies into individualized treatment plans for eligible patients with SCLC based on the latest evidence, guideline recommendations, and patient needs/preferences; and Recommend enrollment in clinical trials evaluating current and new/emerging therapies to eligible patients with SCLC to facilitate progress and improve outcomes

Robert Z. Orlowski, MD, PhD - "House Rules" for Innovative Therapy in Multiple Myeloma: Guidance on Integrating Monoclonal Antibodies and BCMA and Non-BCMA Options Into Patient Care Mar 28, 2023

Show notes

Go online to PeerView.com/DFQ860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Novel antibody platforms—including agents directed against targets such as CD38 and BCMA—have proven efficacy in a range of multiple myeloma (MM) treatment settings and have clear treatment roles across the spectrum of care, from newly diagnosed MM to relapsed/refractory disease. Additionally, a new wave of immune-based treatments in the form of bispecific T-cell–engaging antibodies shows a great deal of promise and may soon add another layer of complexity to the selection and use of antibody platforms in MM. This activity features a panel of hematology-oncology experts illustrating the clinical implications of current and emerging evidence that supports an expanded role for therapeutic use/planning of antibody and immunotherapy options in MM. Upon completion of this activity, participants should be better able to: Summarize current evidence and guideline recommendations surrounding the use of novel antibody platforms in multiple myeloma (MM); Integrate established and emerging immunotherapy options, including monoclonal antibodies, antibody–drug conjugates, and bispecific antibodies, into treatment plans for patients with MM based on guideline recommendations and the latest clinical data; and Address practical aspects of immunotherapy options in MM, including unique safety considerations and effective sequential use of antibody-based therapy

Thomas G. Martin, III, MD, Krina Patel, MD, MSc - Hitting the BCMA Target in Multiple Myeloma: Insights on CAR-T Therapy and Innovative Antibody Options Mar 28, 2023

Show notes

Go online to PeerView.com/FNM860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Find out if you are updated on the latest evidence and management considerations on the use of BCMA antibodies and CAR-T cell therapy for the management of multiple myeloma (MM) in this new PeerView learning CME video recorded at the 2023 Tandem Meetings. Watch the MM experts clarify the most recent practice-changing evidence with BCMA-directed treatments and hear them provide insight on rapidly emerging future applications. Throughout, the experts deliver take-homes on the selection and sequential use of BCMA options, their use in earlier lines of therapy, and management of unique safety considerations. Get informed and see if you are hitting the target when it comes to your patients with MM! Upon completion of this activity, participants should be better able to: Summarize new and emerging evidence with novel BCMA-targeting platforms, including ADCs, bispecifics, and CAR-T cell therapy, across several lines of treatment in MM; Apply evidence-based treatment plans with BCMA-targeting platforms for the sequential management of patients with MM; and Utilize proven tools to address practical aspects and safety considerations associated with the use of novel BCMA-targeted platforms, including dosing, scheduling, adherence, and AE management

Matthew I. Milowsky, MD, FASCO - Fresh Perspectives on Moving Toward Personalized Care for Bladder Cancer: Tips, Tools, and Strategies for Leveraging the Latest Advancements Across the Disease Spectrum Mar 28, 2023

Show notes

Go online to PeerView.com/KPE860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Management of advanced/metastatic urothelial cancer has undergone a significant transformation with the addition of PD-1– and PD-L1–targeting immune checkpoint inhibitors (ICIs) to the treatment armamentarium. These advances are quickly moving into early-stage disease, including emerging bladder-sparing and perioperative approaches, which has recently led to the first regulatory approval of an ICI as adjuvant therapy in high-risk muscle-invasive bladder cancer (MIBC). In this activity, based on a recent live symposium, experts use real-world cases and mini lectures to illustrate practical tips and treatment selection strategies for patients with MIBC or NMIBC (non–muscle-invasive bladder cancer), including clinical trial opportunities, bladder-preservation options, and perioperative regimens. This activity also examines approaches for personalized care in metastatic urothelial cancer (mUC), both in the frontline setting and in progressive disease. Upon completion of this activity, participants should be better able to: Assess new evidence on therapeutic strategies for bladder cancer management across the disease continuum based on innovative drug delivery approaches, modern immunotherapy regimens, and novel targeted agents; Implement novel and emerging therapeutic approaches into personalized treatment plans for patients with varying stages of bladder cancer considering the available evidence, current guidelines, and principles of multidisciplinary and patient-centered care; and Integrate evidence- and team-based management protocols to address the unique suite of adverse events associated with novel therapeutics for bladder cancer

Nicole Lamanna, MD - Building a Safety-Centric Culture in B-Cell Cancers: Interprofessional Insights on Optimizing BTKi Efficacy Through Safety Management Mar 28, 2023

Show notes

Go online to PeerView.com/TBV860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. BTK inhibitors have transformed the medical management of chronic lymphocytic leukemia (CLL) and led to similar advances for patients with mantle cell lymphoma (MCL) and other B-cell malignancies. These therapeutics have dramatically improved outcomes for patients but have also introduced challenges regarding optimal AE management because BTK inhibitors have unique safety profiles that differ from increasingly outdated immunochemotherapy regimens. In this activity, a panel of hematology-oncology experts utilize short lectures and case-based discussions to illustrate how the interprofessional, multidisciplinary team can use safety considerations to select therapy, manage unique and challenging AEs, educate and counsel patients, and ensure vastly improved outcomes for patients with CLL, MCL, and other B-cell cancers. Upon completion of this activity, participants should be better able to: Summarize current safety considerations with first- and second-generation BTK inhibitors, including mechanistic aspects that affect toxicity, head-to-safety data, and general class-wide AE issues; Manage and mitigate toxicity associated with BTK inhibitors, including through active interventions and judicious treatment selection; and Develop team strategies for safety management that include multidisciplinary collaboration, safety-informed treatment selection, and outreach to patients with B-cell cancers receiving BTK inhibitor therapy

Janis Taube, MD, MSc - Refining Best Practices in Cancer Immunotherapy Biomarker Testing and Pathologic Response Assessment Mar 28, 2023

Show notes

Go online to PeerView.com/FTC860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. As the cancer immunotherapy arsenal and its impact on patient care continues to expand, it’s more important than ever to refine testing for predictive biomarkers to guide patient selection and clinical decisions about treatment. Assessments of PD-L1 expression and MSI/MMR or TMB status have a role in some tumor types and treatment settings, but a number of challenges related to testing and interpretation of results remain, and better predictive tools are needed. There is also an increasing need for new ways to measure response to immunotherapies as they transition to early-stage, curative-intent settings in different solid tumors. Pathologic response assessment has emerged as a promising approach for evaluating the impact of neoadjuvant immunotherapy in lung, breast, and other cancers. However, limited guidance has been available on how to define and measure pathologic response, and report and apply assessment results. In this educational activity, experts provide up-to-date instruction and practical guidance on how to improve predictive immunotherapy biomarker testing and establish best practices for pathologic response assessment after neoadjuvant immunotherapy based on the evolving evidence, new guidelines, and illustrative case scenarios. Upon completion of this activity, participants should be better able to: Describe the recommendations and practical considerations for cancer immunotherapy biomarker testing and pathologic response assessment in different tumors and treatment settings; Perform appropriate immunotherapy biomarker testing and pathologic response assessment to cancer immunotherapies according to the latest evidence, requirements, and best practice recommendations across different tumors and treatment settings; and Implement effective strategies for multidisciplinary communication, collaboration, and coordination among pathologists, oncologists, pulmonologists, surgeons, and other care team professionals regarding selection and interpretation of immunotherapy biomarker tests and pathologic response assessment to guide clinical decision-making across different tumors and treatment settings

Olalekan Oluwole, MBBS, MD - The Time Is Now for Outpatient CAR-T: Essential Infrastructure, Lessons From Transplant, and New Evidence Mar 28, 2023

Show notes

Go online to PeerView.com/NEC860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Although chimeric antigen receptor (CAR-T) cell therapy is primarily administered in the inpatient setting, delivery in the outpatient setting likely represents a more convenient and patient-friendly approach that could expand potentially life-saving treatment access for many patients with hematologic cancers. This “Learning Workshop” activity provides learners with the “tools of the trade” for building an outpatient infrastructure that is capable of expanding patient access to CAR-T therapy. Expert panelists discuss the key data supporting CAR-T therapy in hematologic cancers and provide guidance on principles of outpatient cellular therapy, lessons derived from the outpatient experience with stem cell transplantation, and strategies to overcome barriers to patient selection, adverse events, and adequate staffing. Upon completion of this activity, participants should be better able to: Summarize current evidence supporting the integration of CAR-T constructs into the management of hematologic cancers, including in earlier and later lines of care; Cite the infrastructure and design for an outpatient cellular therapy program and the relevant practical experience from home-based transplantation initiatives; Develop strategies for optimal patient selection, staffing, and management of adverse events in the context of an outpatient cellular therapy program; and Employ tools such as quality metrics, telemedicine, and wearable devices in an outpatient cellular therapy program to ensure successful delivery of CAR-T therapy

Sumanta Kumar Pal, MD, FASCO - Breaking New Ground in RCC Management: Expert Guidance on Leveraging Therapeutic Strategies Mar 14, 2023

Show notes

Go online to PeerView.com/FFQ860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. As the number of approved treatment strategies in renal cell carcinoma (RCC) grows, there are new opportunities to provide personalized medicine to patients in a variety of settings. Multi-targeted TKIs, immune checkpoint inhibitors, and combination strategies (dual checkpoint blockade and immune checkpoint inhibitor/TKI combinations) are now options in the frontline treatment of advanced disease, while recent data also show that immunotherapy-based combinations may improve survival in patient subpopulations with poor prognostic features. In this activity, based on a recent live symposium, a panel of experts reviews the latest efficacy and safety evidence for approved and emerging strategies for the treatment of patients with advanced RCC in the frontline and refractory settings and engages in discussions of relevant patient cases that will provide insight on bringing these therapeutic advances into the clinic. Featured topics include treatment selection and sequencing and addressing potential therapy-related toxicities. Upon completion of this activity, participants should be better able to: Assess treatment efficacy and safety of established and emerging therapies for patients with RCC; Design personalized treatments incorporating approved and emerging therapies utilizing current evidence and patient-, disease-, and treatment-specific factors for patients with RCC; and Develop best practices and evidence-based strategies to anticipate, mitigate, and manage various adverse events associated with modern treatments for patients with RCC.

Matthew R. Smith, MD, PhD - Expanding Use of Hormonal Therapeutic Strategies in Prostate Cancer: Clinical Evidence and Practical Considerations for Individualized, Patient-Centered Care Mar 14, 2023

Show notes

Go online to PeerView.com/PNF860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. “Treatment intensification”—or the use of combination treatment strategies—has now become the standard of care for patients with metastatic hormone-sensitive prostate cancer. Shown to extend overall survival beyond single-agent treatment, these combinations of androgen deprivation therapy and other effective treatments such as docetaxel chemotherapy and/or novel androgen axis inhibitors have resulted in regulatory approvals and updates to clinical practice guidelines. Given the range of effective options and more on the horizon, as additional agents and combinations are also being studied in localized and advanced disease, how do clinicians ensure that the right patients are getting the right treatments? In this activity, based on a recent live symposium, expert faculty pair in-depth updates on efficacy and safety data on approved and emerging regimens with case-based discussion of best practices for bringing treatment advances to the clinic. Featured topics include individualizing care based on patient-, disease-, and treatment-related factors, toxicity management, and patient perspectives. Upon completion of this activity, participants should be better able to: Summarize the rationale and clinical evidence for established and emerging hormonal therapeutic approaches for patients with prostate cancer; Employ optimal, individualized treatment plans for patients with prostate cancer that incorporate established and emerging hormonal therapeutics, as appropriate, taking into consideration individual patient-, disease-, and treatment-related factors; and Apply evidence- and team-based strategies to proactively mitigate and manage treatment-related adverse events that may occur in patients with prostate cancer who are receiving established and emerging hormonal therapeutics as part of their care.