Paul Saladino MD podcast - Paul Saladino, MD

Latest Episodes:

Controversial Thoughts: Animal Fats Prevent Cancer?! Oct 02, 2020

Show notes

In case you needed more reasons to love Suet (and tallow) allow me to share with you a few more studies showing some really cool benefits including colon cancer prevention in animal models, and odd chain fatty acids like C:15 (pentadecanoic acid) which appear to have significant health benefits that are found only in animal foods! Nose to tail for the win yet again!

Welcome to The Remembering...

Check us out at Heart & Soil (www.heartandsoil.co) if you need more nose to tail nutrition in your life!

72. Are Excess Polyunsaturated Fats (PUFAs) to blame for the epidemic of Chronic Diseases? With Chris Knobbe, MD Sep 28, 2020

Show notes

Dr. Knobbe began his practice of ophthalmology in 1994, after completing his residency training at the University of Colorado Health Sciences Center, in Denver, Colorado, USA. He was certified by the American Board of Ophthalmology in 1997 and has remained board-certified since then.

Eye physician and surgeon, Chris A. Knobbe, MD, had been in practice nearly 20 years when, in 2013, he asked himself the question, “Could macular degeneration be a ‘Westernized disease’? Could AMD be a disease that is the result of a Westernized diet?” That question would forever change his life.

The hypothesis that Dr. Knobbe would proffer holds that macular degeneration, which is the leading cause of irreversible vision loss and blindness in developed nations, is not only preventable, but treatable in the early to moderate stages, with an ancestral diet.

Time stamps:

0:11:08 Podcast Begins

0:12:15 Chris Knobbe's Background

0:19:07 The History of macular degeneration and human diets

0:37:32 Chronic illness and obesity was once virtually nonexistent

0:48:41 When did PUFAs come onto the scene?

0:55:40 Increase in adipose tissue linoleic acid of US adults in the last half centuryhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642429/

0:57:18 Is olive oil healthy?

0:58:47 PUFA's are the cause of chronic illness

1:02:29 The best health advice anyone could give

1:09:35 Dietary Stearic Acid Leads to a Reduction of Visceral Adipose Tissue in Athymic Nude Micehttps://www.researchgate.net/publication/265650090_Dietary_Stearic_Acid_Leads_to_a_Reduction_of_Visceral_Adipose_Tissue_in_Athymic_Nude_Mice

1:14:41 Why you need animal fats

1:17:32 Effects of diets enriched in linoleic acid and its peroxidation products on brain fatty acids, oxylipins, and aldehydes in micehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180905/

1:18:41 Beef tallow increases apoptosis and decreases aberrant crypt foci formation relative to soybean oil in rat colonhttps://pubmed.ncbi.nlm.nih.gov/15572298/

1:21:56 Role of Physiological Levels of 4-Hydroxynonenal on Adipocyte Biology: Implications for Obesity and Metabolic Syndrome https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038367/

1:23:26 Fat and essential fatty acid in mammary carcinogenesishttps://academic.oup.com/ajcn/article-abstract/45/1/218/4694942?redirectedFrom=fulltext

Controversial Thougths: Welcome to The Remembering Sep 25, 2020

Show notes

Animal-based diets, like a nose to tail carnivore diet, are about much more than food. They are a stepping stone to remembering where we have come from as humans.

Forgetting this history has led to myriad health and social ills today.

Check us out at www.Heartandsoil.co for the finest desiccated organ pills out there- get more nose to tail nutrition and thrive! Firestarter and Gut & Digestion are out now in addition to Beef Organs and Bone Marrow & Liver.

You can also always email me at drpaul@heartandsoil.co with questions!

71. The keys to weight loss and hormonal health for women (and men!) of all ages with Karen Martel Sep 21, 2020

Show notes

Karen Martel is a Transformational Nutrition Coach who is a leading expert in ancestral nutrition, weight loss resistance and women’s hormone health. Host of the top-rated women’s health podcast The Other Side of Weight Loss and founder of the revolutionary program OnTrack, a membership community that has helped thousands of women to balance their hormones and lose weight.

After struggling with her own health issues, Karen was determined to bring her knowledge to others with a bold new approach to women’s health and weight management. Karen's passion lies in helping women breakthrough weight loss resistance and find their personal weight loss code through hormone optimization. Karen is a health leader and researcher determined to revolutionize weight loss for modern women and men.

Time Stamps:

0:10:43 Podcast begins

0:12:56 Karen's story

0:22:06 Breaking down the menstrual cycle

0:35:50 Reasons for weight-gain

0:40:15 Heavy metal toxicity

0:52:36 Is environmental toxicity really the problem?

0:56:30 The onset of perimenopause

1:00:11 Effects of Macronutrient Distribution on Weight and Related Cardiometabolic Profile in Healthy Non-Obese Chinese: A 6-month, Randomized Controlled-Feeding Trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672080/

1:04:39 The progesterone steal and the importance of LDL

1:12:05 Low carb diets

1:16:18 Low carb is no panacea

1:19:17 Addressing the root cause of metabolic dysfunction

1:23:44 Carbohydrate and workout timing for women

1:27:33 How to structure a diet as a woman

1:32:07 Where zero carb goes all wrong

1:37:41 Where to find Karen Martel

1:38:27 Karen's radical hot springs adventure

Heart & Soil is now a reality! This is my passion company founded to help a few million more people reclaim their ancestral birthright to radical health through nose to tail nutrition. We are making grass fed, grass finished desiccated organ capsules from regenerative farms in New Zealand. Check us out at: www.heartandsoil.co, @heartandsoilsupplements on Instagram

Belcampo: www.belcampo.com Use the code “carnivoremd” for 20% off your order!

Nutrisense (Continuous Glucose Monitor- CGM): www.Nutrisense.io,

BluBlox: www.blublox.com use the code CarnivoreMD for 15% off your order

Controversial Thoughts: Hunter-gatherers don’t like fiber! Sep 18, 2020

Show notes

Do the Hadza really consume 100g of fiber per day? Do we really know what a healthy gut microbiome is? Doubt it! When asked to rank their preferences for food (their diets are essentially meat, honey, berries, baobab fruit, and tubers) they consistently rank honey as their favorite and tubers last! In this video, I break down a number of articles looking at how the Hadza eat, their predilection for honey and meat, their oral health, and the seasonal cycling of their microbiota. I challenge the notion that we know what a "healthy" gut microbiome really is and suggest that this is better defined by clinical outcomes rather than myopic interpretations of individual species/phyla. I also share my own gut results on a nose to tail carnivore diet with honey in it.

Check us out at Heart & Soil (www.heartandsoil.co) if you need more nose to tail nutrition in your life! Firestarter (our high stearic acid tallow from suet) and Gut & Digestion are out now.

You can also follow us at @heartandsoilsupplements on IG.

70. How Linoleic Acid is making you fat and Stearic Acid might just be the remedy with Brad Marshall, aka “The Croissant Diet Guy”z Sep 14, 2020

Show notes

Brad Marshall is the author of the Blog Fire In A Bottle and the creator of The Croissant Diet. Mildly obsessed with food and its history, his work focuses on trying to place current ideas about diet, including keto and carnivore diets into the framework of traditional Dietary patterns.

Brad has a genetics degree from Cornell, a certificate from The French Culinary Institute, has studied cancer at Memorial Sloan-Kettering Cancer center and worked as a programmer for the Berkeley Drosophila Genome Project. He spent the last 15 years raising rotationally grazed pastured pork on his farm in upstate New York while running a butcher shop, local food restaurant and USDA inspected meat processing facility.

Brad is also the founder of Firebrand Meats, which is dedicated to producing pork and poultry products that are low in Linoleic acid, the n6 polyunsaturated fat (PUFA) whose intake has seen a dramatic worldwide increase in the last century.

https://reddit.com/r/SaturatedFat

Time Stamps:

0:13:55 Podcast Begins

0:15:14 Emmy's story https://fireinabottle.net/emmys-story/

0:15:16 Change your fat, change your life

0:20:55 Disastrous Trends In American Bacon https://fireinabottle.net/polyunsaturated-fat-pufa-in-pork-and-chicken/

0:23:55 The problem with pork and chicken in the US

0:30:12 Brad's fascinating background

0:36:19 The croissant diet

0:45:27 Stearic acid vs linoleic acid

0:47:32 Plateaus on a ketogenic diet

0:53:54 Linoleic acid is the likely culprit

0:55:25 The shortcomings of the ketogenic understanding

0:58:58 The feasting mimicking diet

1:04:46 ROS is Satiation https://fireinabottle.net/ros-is-satiation/

1:08:18 How linoleic acid affects blood glucose and satiety

Controversial Thoughts: What’s the deal with Stearic Acid- Magical or Hype? Sep 11, 2020

Show notes

Stearic acid is an 18 carbon saturated fat that has intriguing effects on the human body. It's been shown to positively affect mitochondrial activity, and diets that are low in cause mitochondria to change activity and phenotype in negative ways. Mouse models of this fatty acid also suggest some profoundly powerful effects on glucose tolerance and visceral fat when compared to oleic acid (18C monounsaturated fat), and linoleic acid (18C polyunsaturated fat). I break it all down in this video and share my RBC fatty acid levels as well as a compelling n=1 case study of Emmy's weight loss with dietary shifts away toward more stearic acid and less linoleic acid.

Check us out at Heart & Soil (www.heartandsoil.co) if you need more nose to tail nutrition in your life! Firestarter (our high stearic acid tallow from suet) and Gut & Digestion release this week!

You can also follow us at @heartandsoilsupplements on IG.

Controversial thoughts: How to get Omega-3 without Rancid Fish Oil and why Linoleic acid makes you Fat.

With levels of linoleic acid consistent with our evolutionary past, omega-3s aren't an issue if you are eating nose to tail! I also talk about CLA, how linoleic acid makes you fat. Check us out at www.heartandsoil.co and @heartandsoilsupplements on instagram to get nose to tail nutrition!

69. What’s to blame for Insulin Resistance, Carbs or PUFAs? A very friendly debate with Ben Bikman, PhD Sep 08, 2020

Show notes

Benjamin Bikman earned his PhD in Bioenergetics and was a postdoctoral fellow with the Duke-National University of Singapore studying metabolic disorders. Currently, his professional focus as a scientist and professor (Brigham Young University) is to better understand the origins and consequences of metabolic disorders, including obesity and diabetes, with a particular emphasis on the role of insulin. He frequently publishes his research in peer-reviewed journals and presents at international science and public meetings.

Time Stamps

0:11:14 Podcast Begins

0:11:54 Ben's Background

0:17:53 The root of chronic disease

0:25:38 All about insulin

0:31:14 Regulation of free fatty acid metabolism by insulin in humans: role of lipolysis and reesterification https://www.semanticscholar.org/paper/Regulation-of-free-fatty-acid-metabolism-by-insulin-Campbell-Carlson/9be324b8af9ced5a8b7e1902257e3fb9308b4db1

0:31:51 Insulin stops lipolisis

0:34:35 Insulin's affect on the liver

0:40:10 Insulin and muscle cells

0:43:20 Why you want to increase protein as you age

0:48:47 Low Protein Intake is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988204/#:~:text=Low%20Protein%20Intake%20is%20Associated,Younger%20but%20Not%20Older%20Population&text=Cell%20Metab.,Author%20manuscript.

0:51:00 Animal-based diets optimize muscle protein sythesis

0:55:12 Industrial Seed oils have a fantastic publicist

0:58:05 Do carbs drive metabolic dysfunction?

1:07:07 Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man https://link.springer.com/article/10.1007/BF00400466

1:07:42 How linoleic acid drives metabolic dysfunction

1:09:32 How linoleic acid drives metabolic dysfunction.

1:11:47 Low serum insulin in traditiona

Controversial thoughts: How to get Omega-3 without Rancid Fish Oil and why Linoleic acid makes you Fat. Sep 04, 2020

Show notes

68. How to fix your broken Thyroid for optimal sexual health and weight loss, with Elle Russ Aug 31, 2020

Show notes

Elle Russ returns for her second show! She is a bestselling author, TV/Film writer, and seasoned life coach. She is the author of Confident As Fu*k and The Paleo Thyroid Solution – a book which has helped thousands of people around the world reclaim their health. Elle is also the show host for NYT’s bestselling author Mark Sisson’s popular Primal Blueprint Podcast.

Time Stamps:

0:10:44 Beginning of Podcast with Elle Russ

0:12:14 Elle's Story

0:13:50 The outdated "expertise" of thyroid doctors

0:16:17 Understanding the thyroid & reverse T3

https://sproutshealth.com/the-role-of-reverse-t3-in-thyroid-function-part-1/#:~:text=Reverse%20T3%20is%20like%20a,still%20may%20experience%20hypothyroid%20symptoms.

0:24:44 Hypothyroidism Chart

https://www.straighthealthcare.com/hypothyroidism.html

0:27:26 Chemistry of Thyroid Hormones

http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/thyroid/chem.html

0:29:16 Thyroid Hormone Synthesis

http://pathwaymedicine.org/thyroid-hormone-synthesis