Paul Saladino MD podcast - Paul Saladino, MD

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87. The Omega-6 Apocalypse, are seed oils to blame for diabetes, heart attacks, and chronic disease ? Jan 11, 2021

Show notes

Dr. Knobbe began his practice of ophthalmology in 1994, after completing his residency training at the University of Colorado Health Sciences Center, in Denver, Colorado, USA. He was certified by the American Board of Ophthalmology in 1997 and has remained board-certified since then.

Eye physician and surgeon, Chris A. Knobbe, MD, had been in practice nearly 20 years when, in 2013, he asked himself the question, “Could macular degeneration be a ‘Westernized disease’? Could AMD be a disease that is the result of a Westernized diet?” That question would forever change his life.

The hypothesis that Dr. Knobbe would proffer holds that macular degeneration, which is the leading cause of irreversible vision loss and blindness in developed nations, is not only preventable but treatable in the early to moderate stages, with an ancestral diet.

Time Stamps:

0:09:24 Podcast Begins

0:12:39 200 years of nutritional research

0:23:09 Needs a title 60-sec audiogram

0:30:09 Timeline for Processed Food Introductions

0:36:44 Non-negotiable: Animal fats are essential

0:44:17 150 years of Vegetable Oil Consumption

0:49:07 Who's the real culprit?

0:51:46 Heart Disease Deaths vs Sturated fat and Vegetable Oil

1:05:32 Can linoleic acid contribute to coronary artery disease? https://www.researchgate.net/publication/15005994_Can_linoleic_acid_contribute_to_coronary_artery_disease

1:08:12 Why do we blame the carbs?

1:11:35 Sweden vs US adipose Linoleic Acid and obesity

1:14:02 The Case Of Japan

1:27:20 The problem is neither calories nor carbs

1:33:49 Is processed sugar harmful in and of itself? | What carbs to eat

1:43:36 The Case Of Okinawa

1:55:41 Diets could prevent many diseases Https://www.researchgate.net/publication/10673140_Diets_could_prevent_many_diseases

2:02:50 Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467319/

Controversial Thoughts: Could coffee worsen fibromyalgia? And other reasons to avoid it on an Animal-Based diet. Jan 08, 2021

Show notes

What could be more controversial than suggesting that coffee might not be the elixir of life it’s cracked up to be?

86. How to have the best poop of your life. Lucy Mailing PhD returns! Jan 04, 2021

Show notes

Lucy Mailing, Ph.D. received her Bachelor’s in Biology from Kalamazoo College and her Ph.D. in Nutritional Sciences from the University of Illinois, where her dissertation research focused on the effects of diet and exercise on the gut microbiome in states of health and disease. Lucy has authored several peer-reviewed journal articles related to the microbiome and health and was named an Emerging Leader in Nutritional Sciences by the American Society for Nutrition in 2017. Lucy has also served as a staff research associate for the Kresser Institute for Functional and Evolutionary Medicine since 2015.

Lucy is the founder and sole author of lucymailing.com, a site dedicated to evidence-based articles about the microbiome, gut and skin health, and nutrition. She is regularly invited to speak on gut health around the country and has been recognized as one of the most trusted experts in the integrative health space. Lucy plans to continue her academic training and begin a postdoc in 2020 after a gap year dedicated to writing and other projects.

Time Stamps:

0:08:47 Podcast begins

0:09:55 What is a healthy gut microbiome?

0:12:43 The Microbiome of the Hadza

0:14:25 Enterocyte-Associated Microbiome of the Hadza Hunter-Gatherers https://www.frontiersin.org/articles/10.3389/fmicb.2016.00865/full

0:18:36 Figure: Typical major phyla and genera of the human gut microbiome https://www.researchgate.net/figure/Typical-major-phyla-and-genera-of-the-human-gut-microbiome-reproduced-with-permission_fig1_331990159

0:22:05 Seasonal cycling in the gut microbiome of the Hadza hunter-gatherers of Tanzania https://science.sciencemag.org/content/357/6353/802#:~:text=The%20data%20reveal%20annual%20cyclic,reappear%20in%20a%20subsequent%20season.&text=These%20data%20indicate%20that%20some,and%20abundance%20in%20modernized%20populations.

0:24:38 Pervasive bias in research

0:30:10 Gut microbiome of the Hadza hunter-gatherers https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996546/

0:31:11 Microbiological dark matter and the infancy of gut microbiology

0:38:17 The Story of Butyrate

0:42:19 Mitochondrial dysfunction in inflammatory bowel disease alters intestinal epithelial metabolism of hepati

Controversial thoughts: Which alcohol is the least toxic? And how to fix a hangover! Dec 30, 2020

Show notes

Happy New Year to all!

I’m not a drinker, but I know there are many who will be enjoying alcohol to celebrate the end of this crazy year, and the beginning of one we all hope will be a bit better than 2020.

If you’re going to imbibe at New Years or any other time, what’s the least toxic sauce to consume? Find out in this Controversial Thoughts video along with why alcohol causes a hangover and what you can do to mitigate it prior and ameliorate it once it’s besieged you. Hint: these answers may have to do with things I’ve discussed before like avoiding toxic seed oils to limit lipid peroxidation in your liver from alcohol byproducts, and making sure to get enough nutrients into your diet on a daily basis to optimize your glutathione and NAD/NADH statuses.

If you’re looking to lose weight, or kick more ass in 2021 you should join us at Heart & Soil for our 30 day animal based reset in January. Go to www.AnimalBased30.com to sign up and become part of the tribe that will be starting off the new year right! There will be lots of content, support, and a chance to win some of our desiccated organ supplements as well as signed copies of my book, The Carnivore Code. Welcome to #theremembering.

85. How to make your immune system strong as heck, Part 2 with James DiNicolantionio, Pharm D Dec 28, 2020

Show notes

Find part 1 of this podcast with James, here.

Dr. James DiNicolantonio, is a Doctor of Pharmacy and a cardiovascular research scientist. A well-respected and internationally known scientist and an expert on health and nutrition, he has contributed extensively to health policy and has testified in front of the Canadian Senate regarding the harms of added sugars. He serves as the associate editor of the British Medical Journal’s Open Heart, a journal published in partnership with the British Cardiovascular Society, and is on the editorial advisory boards of several other medical journals. Dr. DiNicolantonio is the author or coauthor of over 250 publications in the medical literature. He also is the author of three bestselling health books, The Salt Fix, Superfuel and The Longevity Solution, as well as his newest book, The Immunity fix which you can find here. You can follow him on Instagram and Twitter @drjamesdinic and on Facebook at Dr. James DiNicolantonio. You can visit his website at drjamesdinic.com.

Time stamps:

0:08:11 Podcast begins

0:09:16 How to create metabolic health

0:16:54 A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(98)90067-9

0:19:55 Omega six fatty acids and oxidative stress

0:21:07 Premature atherosclerosis associated with monogenic insulin resistance https://www.ahajournals.org/doi/10.1161/01.cir.103.18.2225?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed&

0:22:00 Elevated Serum C-Reactive Protein and Free Fatty Acids Among Nondiabetic Carriers of Missense Mutations in the Gene Encoding Lamin A/C (LMNA) With Partial Lipodystrophyhttps://www.ahajournals.org/doi/10.1161/01.atv.0000047460.27435.b8?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

0:32:46 Answering the fructose question and dispelling keto dogma

0:40:17 What nutrients are required for robust immunity

0:40:17 Is colostrum more effective than vaccines?

0:41:56 Prevention of Influenza Episodes With Colostrum Compared With Vaccination in Healthy and High-Risk Cardiovascular Subjects: The Epidemiologic Study in San Valentino

Controversial Thoughts: How to avoid gaining weight over the holidays!! Dec 23, 2020

Show notes

The next 10 days are your downfall, admit it.

You’re in good company, they are the downfall of most but they don’t have to be! Here are 3 simple but impactful ways to change your eating habits over the next 10 days to prevent weight gain. Come January 1st, you’ll be glad you did these things, trust me.

Cliff notes version:

Avoid seed oils (duh)
Include nutrient-rich organs and animal fat prior to meals
Choose nose to tail animal foods FIRST when you are eating

Voila! And just like that you improved your metabolic health, waistline, energy, sleep, and mood in a time period when most get fat. You’re welcome, and welcome to #theremembering.

84. How to make your immune system strong as heck, Part 1 with James DiNicolantionio, Pharm D Dec 22, 2020

Show notes

Dr. James DiNicolantonio, is a Doctor of Pharmacy and a cardiovascular research scientist. A well-respected and internationally known scientist and an expert on health and nutrition, he has contributed extensively to health policy and has testified in front of the Canadian Senate regarding the harms of added sugars. He serves as the associate editor of the British Medical Journal’s Open Heart, a journal published in partnership with the British Cardiovascular Society, and is on the editorial advisory boards of several other medical journals. Dr. DiNicolantonio is the author or coauthor of over 250 publications in the medical literature. He also is the author of three bestselling health books, The Salt Fix, Superfuel and The Longevity Solution, as well as his newest book, The Immunity fix which you can find here. You can follow him on Instagram and Twitter @drjamesdinic and on Facebook at Dr. James DiNicolantonio. You can visit his website at drjamesdinic.com.

Time Stamps:

0:07:19 Podcast Begins
0:08:16 The role of animals in pandemics
0:14:22 Regenerative agriculture will save the world
0:18:06 The nutrient-density of regenerative beef
0:19:46 The power of sunlight and fresh air
0:23:29 Salty air and hypertonic salt solutions
0:28:41 What determines poor Covid 19 outcomes
0:33:45 Fixing metabolic health with a strict diet.
0:39:10 Should we trust in the Covid 19 vaccine?
0:45:20 How does the immune system get disordered
0:47:29 Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357061/
0:49:42 Impact of Obesity and Metabolic Syndrome on Immunity https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717890/
0:50:17 Understanding cross-sensitivity of coronaviruses

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Controversial Thoughts: Should you include dairy on your Animal-Based diet? Dec 18, 2020

Show notes

In short, yes (as long as you tolerate it)!

Milk, yogurt, butter, ghee and colostrum are amazing sources of nutrients that have been highly valued by many indigenous groups for millenia. Dairy has a long tradition in Northern Europe, and among hunter-gatherer groups like the Maasai, or historically among groups like the Mongols (think warriors whose diets were basically milk, meat, and organs).

Dairy isn’t for everyone, and some may have issues with lactose (a deficiency on the lactase enzyme), or the casein and whey proteins within it. Personally I can’t tolerate dairy, but I am incredibly jealous of all of you who can because it’s delicious and nutrient-rch.

In this controversial thoughts video I discuss evidence linking dairy with cancer (most observational studies suggest an inverse correlation, i.e. higher intakes are associated with better outcomes), most of which suggests dairy is totally safe. I also discuss colostrum (the immunoglobulin-rich first milk from mammals) in detail. This stuff is chocked FULL of unique peptides, immunoglobulins, and growth factors that aid in gut healing, wound healing, and immune fortification.

Colostrum has even been studied in comparison to flu vaccinations in small studies and found to be just as effective at preventing influenza. More research is needed here but the findings from at least two studies are intriguing.

If you have questions about dairy in your diet, this video is for you! #theremembering

83. How our love affair with toxic chemicals is killing us, with Frank Von Hippel PhD Dec 14, 2020

Show notes

Frank A. von Hippel is a professor of ecotoxicology at Northern Arizona University. Frank was born and raised in Alaska, received his A.B. in biology at Dartmouth College in 1989, and his Ph.D. in integrative biology at the University of California, Berkeley in 1996. He taught for Columbia University (1996-1999) and the University of Alaska Anchorage (2000-2016) before moving to Arizona in 2016. Frank has taught ecology field courses in over twenty countries, and conducted research in the Americas, Africa and Australia. Frank’s research has been widely covered in the press, including The New York Times, National Public Radio, The Economist, the BBC, and many other media outlets. Frank is the author of The Chemical Age (University of Chicago Press, 2020), he hosts the Science History Podcast, and he loves to write about science for both technical and general audiences.

Time Stamps:

0:08:58 Podcast begins

0:09:58 Are humans wise now than we were 600 years ago?

0:17:02 The history of chemical fertilizers

0:24:24 Is the modern human infrastructure sustainable?

0:36:54 The history and burden of pesticide use

0:47:12 The value of exclusively eating grass-finished beef

0:47:12 The value of exclusivesly eating grass-finished beef and organic produce

0:53:57 Agent orange and modern pesticides

1:02:07 All about glyphosate

1:11:50 Why you should stop using plastic immediately (and drinking Topo Chico)

1:22:45 Louisiana’s Cancer Alley Visualized https://www.ourdailyplanet.com/story/louisianas-cancer-alley-visualized%E2%80%8B/

1:23:35 Hadley Cells https://www.seas.harvard.edu/climate/eli/research/equable/hadley.html#:~:text=Hadley%20Cells%20are%20the%20low,control%20low%2Dlatitude%20weather%20patterns.

1:43:14 Where is the cleanest place to live?

1:48:33 The worst mistake in human history

1:54:30 What's the solution to this ecological nightmare?

2:01:13 Where to find Frank von Hippel

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Controversial Thoughts: Think red meat causes cancer? Think again! The full breakdown with Ivor Cummins Dec 11, 2020

Show notes

I get the “doesn’t red meat cause cancer” question ALL. THE. TIME. What better way to address it yet again (there’s a whole chapter about in my book, The Carnivore Code), than with my man, Ivor (see multiple previous podcasts including a recent debunk of the COVID response- Fundamental Health).

In this extra nutrient dense edition of controversial thoughts we address the WHO (looking mighty sketch these days), TMAO, neu5gc, and much more about how we’ve been misled regarding meat and cancer. Watch/listen/learn and never again not have an answer for your clueless friend who thinks meat causes cancer.

Red meat and organs have been at the center of the human diet for millions of years. They are also the most nutrient-rich foods on the planet. Does it make even one iota of sense that they would cause harm to us? Nope. Welcome to #theremembering.

If you need more nose to tail nutrition in your life, check us out at heartandsoil.co. Our newest product, Heart of the Warrior just released today, and our grass-fed colostrum (the immunoglobulin rich first milk from mammals), Immunomilk, will be available next week!

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