On The Pen GLP-1 News

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On The Pen: The Weekly Dose 6.11.24 Jun 11, 2024

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Ro.co/supply-tracker
FDA shortage update (tiktok video):
Link:https://www.accessdata.fda.gov/scripts/drugshortages/dsp_ActiveIngredientDetails.cfm?AI=Tirzepatide%20Injection&st=c

EASL (European Association for the Study of the Liver) 2024 in Milan Italy
Link: https://investor.lilly.com/news-releases/news-release-details/lillys-tirzepatide-was-superior-placebo-mash-resolution-and-more
Link: https://www.biospace.com/article/mash-clash-between-lilly-and-boehringer-zealand-takes-center-stage-at-easl24/

Walgreen:
Link: https://www.benefitspro.com/2024/06/03/walgreens-will-conduct-clinical-trials-for-boehringer-ingelheims-new-obesity-drug/?slreturn=20240610103336

Kroger (tiktok video):
Link: https://www.aol.com/news/kroger-health-revamps-weight-management-132122808.html

Eli Lilly Clinical trial:
Link: https://clinicaltrials.gov/study/NCT06373146?term=tirzepatide&aggFilters=status:act%20rec&rank=6

Eli Lilly CFO:
Link: https://www.prnewswire.com/news-releases/lilly-announces-departure-of-anat-ashkenazi-chief-financial-officer-302163882.html

China:
Link: https://www.benzinga.com/news/24/06/39197516/chinese-generic-ozempic-wegovy-versions-could-put-novo-nordisk-at-the-risk-of-stiff-competition-in-k

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Decoding GLP-1 Book
Decoding GLP-1: A Guide for Friends and Family of Those On The Pen
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Thank you for tuning in! If you found this content valuable, make sure to like, share, and subscribe to my youtube channel for more updates on GLP-1, obesity, type 2 diabetes, and the latest news on Mounjaro, Zepbound, Wegovy, and Ozempic. Stay informed and entertained with my unique blend of breaking news, humor, and my personal journey. For in-depth articles and resources, visit onthepen.com.

On The Pen: The Weekly Dose 6.4.24 Jun 04, 2024

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https://ro.co/weight-loss/supply-tracker
https://www.youtube.com/watch?v=mL_krAas70k
Novo Nordisk Advertising:

Novo Nordisk launches new advertising campaign "The Power of Wegovy"
This advertisement includes the new indication for reduction of cardiovascular risk
For 2023, the #5 advertising spend for a drug was Rybelsus at $191 million. The #6 advertising spend was Ozempic at $187.4 million (increase of 6% from 2022). More than 40% of the 2023 ad spend for Ozempic went to online video platforms (i.e. social media like youtube)
Link: https://www.youtube.com/watch?v=dhretLXYkZ4

Structure Therapeutics GSBR-1290

GSBR-1290 is a small molecule GLP-1 pill
In a 12-week phase 2 clinical study, a tablet formulation of GSBR-1290 had a weight-loss of 6.9%. This is comparable to Eli Lilly's phase 2 results for olforglipron
At Week 12, 67% of GSBR-1290 treated participants achieved ≥6% weight loss and 33% achieved ≥ 10% weight loss, compared to 0% for placebo
Also developing next generation combination GLP-1 candidates together with GIP, amylin, glucagon and apelin oral small molecules
Link (Madison Muller): https://www.bloomberg.com/news/articles/2024-06-03/structure-reports-early-oral-weight-loss-drug-data-adding-allure

Elon musk tweet:

Elon Musk tweeted: Just make a lot of Ozempic/Mounjaro. It’s not inherently expensive. The health benefits of reducing obesity far exceed the downside of GLP-1 inhibitors. We evolved under starving conditions and now make food that is plentiful and delicious. Whether that food is “processed” does matter, but is not a game changer
This tweet has currently been seen 325,500 times

Shanghai Stem Cell Type 2 Diabetes Treatment
https://www.scmp.com/news/china/science/article/3263878/chinese-scientists-report-world-first-they-cure-patients-diabetes-cell-therapy

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OTP EPS 68: Ro CEO Zach Reitano Talks GLP-1 Supply Tracker May 31, 2024

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Zachariah Reitano is the founder of Ro, a telehealth company that has a vision of giving consumers more power over their health, he joins #OnThePen to talk all things #mounjaro #zepbound #wegovy #ozempic
Reitano is the founder of Ro, a telehealth company that has a vision of giving consumers more power over their health.
https://ro.co/weight-loss/supply-tracker/

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On The Pen: The Weekly Dose 5.28.24 May 28, 2024

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On The Pen News: https://www.onthepen.com/blog
SHOW NOTES:
Ozempic study in New England Journal of Medicine:
Link: https://www.bloomberg.com/news/articles/2024-05-24/novo-s-ozempic-slashes-risk-of-death-in-kidney-disease-study

Compounding (tiktok video)
Link: https://www.abc.net.au/news/2024-05-22/compound-pharmacies-banned-weight-loss-drugs-replica-ozempic/103861108

Zealand Pharma:
Link: https://www.biospace.com/article/zealand-touts-phase-i-results-for-glp-1-glp-2-candidate-despite-modest-weight-loss-/

Inhaled GLP-1 medications
Link: https://www.biostock.se/en/2024/05/iconovo-initiates-development-of-inhaled-obesity-treatment/

Oral version of tirzepatide (tiktok video):
Link: https://ca.finance.yahoo.com/news/lexaria-awards-contract-third-glp-130500555.html

Mounjaro approved for China (tiktok video):
Link: https://www.bloomberg.com/news/articles/2024-05-21/china-clears-eli-lilly-s-weight-loss-drug-tirzepatide-only-for-diabetes

Eli Lilly announces capacity increase (tiktok video)
Link: https://investor.lilly.com/news-releases/news-release-details/lilly-increases-manufacturing-investment-9-billion-newest

GLP-1 usage by young people:
From 2020 to 2023, the number of U.S. adolescents and young adults using GLP-1 increased 600 percent — from roughly 8,700 peo

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On The Pen Live Eps 67: Survodutide Trial Participant Tells All! May 25, 2024

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In this week’s episode of On The Pen Live, guest Scott Liberto of PlanetScott.com joins to discuss his experience in the Survodutide clinical trial.
Survodutide is an investigational dual agonist targeting both the glucagon and GLP-1 receptors, developed by Boehringer Ingelheim in collaboration with Zealand Pharma. This novel drug is designed to treat obesity and metabolic dysfunction-associated steatohepatitis (MASH).

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On The Pen: The Weekly Dose 5.21.24 May 21, 2024

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😎 NERDS ONLY: LEARN ABOUT OTHER GLP-1 MEDS:
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SHOW LINKS:
Novo Nordisk fire:
Link: https://www.wsj.com/livecoverage/stock-market-today-dow-jones-earnings-05-16-2024/card/fire-at-novo-nordisk-construction-site-gives-investors-a-scare-eSSAtdDDhxYwUw3bGDZI?mod=lctimeline_finance

New CagriSema drug trial
Link: https://clinicaltrials.gov/study/NCT06409130

Wegovy Heart Benefits:
Link: https://www.cnn.com/2024/05/13/health/wegovy-trial-analysis/index.html
CT-488 Phase 1 Results:
Link: https://www.fiercebiotech.com/biotech/roches-27b-carmot-bet-pays-phase-1-weight-loss-success

Nothing contained in this podcast is medical advice. Please consult your liscensed p

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On The Pen: The Weekly Dose 5.14.24 May 14, 2024

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MY WORK RELIES ON YOUR GENEROSITY, BECOME A MEMBER HERE:
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😎 NERDS ONLY: LEARN ABOUT OTHER GLP-1 MEDS:
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🚨📰 ALL THE LATEST MOUNJARO NEWS:
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SHOW NOTES:
Update on Bernie Sander's fight against high prices for GLP-1 medicationsLink: https://www.msn.com/en-us/health/other/novo-asks-for-more-time-to-answer-sanders-on-ozempic-s-price/ar-BB1lZ0P2

CFO of Viking Therapeutics sold stock
Link: https://www.investing.conews/company-news/viking-therapeutics-cfo-sells-over-49-million-in-company-stock-93CH-3419573

Novo Nordisk bond sale (Bloomberg article):
Link: https://www.bloomberg.com/news/articles/2024-05-13/ozempic-maker-novo-nordisk-plans-bond-sale-to-fund-expansion?embedded-checkout=tru

Why companies should cover obesity mediation
Link: https://ca.news.yahoo.com/obese-people-more-likely-time-22010

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Threats to Lilly's Zepbound & Mounjaro Printing Press May 11, 2024

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Roche Pharmaceuticals has acquired Carmot Therapeutics along with three obesity and type 2 diabetes candidates: CT-868 / CT-368 / CT-986
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https://www.youtube.com/watch?v=aplFxNOv77g&list=PLtOcNl0C8quWo7PWY9j_HilhWIRuedyiO
😎 NERDS ONLY: LEARN ABOUT OTHER GLP-1 MEDS:
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🚨📰 ALL THE LATEST MOUNJARO NEWS:
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On The Pen: The Weekly Dose 5.7.24 May 08, 2024

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MY WORK RELIES ON YOUR GENEROSITY, BECOME A MEMBER HERE: https://www.youtube.com/channel/UCDocQ-4IhVS3ihy_dW7nSKw/join
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LINKS
Life Update Blog: Link: https://www.onthepen.com/post/i-m-tired-we-are-tired
Wegovy released in Canada:
Link: https://www.msn.com/en-ca/health/other/weight-loss-drug-wegovy-available-in-canada-starting-may-6/ar-AA1o1lZz
Madison Muller at Bloomberg (friend of our community) had article "Why Weight-Loss Drugs Wegovy, Zepbound Are in Short Supply"
Link: https://www.bloomberg.com/news/articles/2024-05-02/why-weight-loss-drugs-wegovy-zepbound-are-facing-shortages?srnd=undefined&embedded-checkout=true
Interviewed on radio station KXEL
Link: https://www.youtube.com/watch?v=V0YyMwtMuxs
Optum RX Irony alert:
Link: https://www.managedhealthcareexecutive.com/view/glp-1-tiering-agreement-reached-says-optum-rx-president
FTC is challenging Novo Nordisk's patents on Ozempic
Link: https://www.ftc.gov/system/files/ftc_gov/pdf/novo-nordisk-ozempic-saxenda-victoza-_4302024.pdf
FTC requested additional information on Novo Nordisk's acquisition of Catalent:
Link: https://www.msn.com/en-us/money/markets/us-ftc-seeks-more-information-on-novo-nordisk-parent-catalent-deal/ar-AA1o6gHU

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Lilly Earnings Call: Zepbound and Mounjaro Updates May 01, 2024

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Dave Knapp does a deep dive into todays Eli Lilly earnings call.
https://www.onthepen.com/post/zepbound-vial-watch-eli-lilly-earnings-q1-2024
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