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    Personal Journals

    MeSsy with Christina Applegate & Jamie Lynn Sigler

    On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.

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    Latest Episodes:
    Our Favorite Bravo Men Jun 09, 2026
    Show notes

    This week, we are revisiting conversations with some of our favorite Bravo men - Jesse Solomon, Carl Radke, and Andy Cohen. They share moments that were challenging, helped them grow, and changed their perspectives on life.


    Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

    Audio Engineer: Josh Windisch


    This episode is sponsored by:

    Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

    Jones Road - Use code MESS at jonesroadbeauty.com to get a Free Gift with your first purchase! #JonesRoadBeauty #ad

    Rythm - Right now, Rythm is offering our listeners 15% off your first month and free shipping at https://rythm.health/messy Stop guessing, start testing. Rythm DOT HEALTH slash messy

    NOCD - If you're struggling with OCD or unrelenting intrusive thoughts, NOCD can help. Book a free 15 minute call to get started https://learn.nocd.com/messy


    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.


    Aida Turturro Jun 02, 2026
    Show notes

    This week, Jamie sits down with the one and only Aida Turturro. They reflect on their years together on The Sopranos, and Aida discusses living with rheumatoid arthritis since childhood, perspective, and finding gratitude during difficult times.

    Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

    Audio Engineer: Josh Windisch


    This episode is sponsored by:

    Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.


    Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod

    Q30 - For a FREE sleeve with your order, head to https://Q30.com/MESSY and use code MESSY.
    Ridge - Upgrade your wallet today! Get up to 40% off @Ridge during their Father’s Day Sale when you go to https://www.Ridge.com/MESSY #Ridgepod


    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.


    What the F*ck Is Normal Anyway? May 26, 2026
    Show notes

    This week, Jamie reads listener emails and discusses what it means to feel seen, the complicated balance between grief and gratitude, and why you don’t have to be “perpetually positive” to keep moving forward.

    Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

    Audio Engineer: Josh Windisch


    This episode is sponsored by:

    Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.


    MudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR with code MESSY at https://mudwtr.com/messy! #mudwtrpod

    OneSkin - Get 15% off OneSkin with the code MESSY at https://www.oneskin.co/MESSY#oneskinpod

    Rythm - Right now, Rythm is offering our listeners 15% off your first month and free shipping at https://rythm.health/messy Stop guessing, start testing. Rythm DOT HEALTH slash messy

    NOCD - If you're struggling with OCD or unrelenting intrusive thoughts, NOCD can help. Book a free 15 minute call to get started: https://learn.nocd.com/messy

    Veracity - For up to 65% off your order, head to https://VeracityHealth.co and use code MESSY.



    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.


    Lena Hall May 19, 2026
    Show notes

    This week, Jamie is joined by Tony Award-winning actress and singer Lena Hall. They discuss being present in grief, the power of healing, finding your way back to yourself, and more.


    Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

    Audio Engineer: Josh Windisch


    This episode is sponsored by:

    Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

    Ridge - Upgrade your wallet today! Get up to 40% off @Ridge during their Father’s Day Sale when you go to https://www.Ridge.com/MESSY #Ridgepod

    Q30 - For a FREE sleeve with your order, head to https://Q30.com/MESSY and use code MESSY.

    Lola - Get 40% off select Lola Blankets products at https://Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets.

    k18 - Shop at Sephora or get 10% off your first purchase at https://k18hair.com with code MESSY. That’s code MESSY at https://k18hair.com

    Zoc Doc - Stop putting off those doctors appointments and go to https://Zocdoc.com/MESSY to find and instantly book a doctor you love today.


    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.


    Revisiting Our Convo with Martin Short May 12, 2026
    Show notes

    In honor of 'Marty, Life is Short,' we are revisiting our conversation with Martin Short. He reminisces, shares funny stories, discusses colonoscopy parties, and more.


    Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

    Audio Engineer: Josh Windisch


    Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

    Jones Road - Use code MESS at https://jonesroadbeauty.com to get a Free Gift with your first purchase! #JonesRoadBeauty #ad

    NOCD - Go to https://NOCD.com to book a free 15-minute call.

    OneSkin - Get 15% off OneSkin with the code MESSY at https://www.oneskin.co/MESSY#oneskinpod


    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.


    A Conversation with Jamie’s Therapist May 05, 2026
    Show notes

    This week, Jamie sits down with her therapist, Ana Maria Rodriguez, who is a licensed clinical mental health therapist and the founder and owner of Selva Wellness Collective. They discuss how she helped Jamie through processing what came up while writing her memoir, the way the body stores trauma, ketamine therapy, and much more.


    Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

    Audio Engineer: Josh Windisch


    This episode is sponsored by:

    Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.
    Honey - loveSave 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod

    Fatty15 - Get an additional 15% off their 90-day subscription Starter Kit by going to https://fatty15.com/messyand using code MESSY at checkout.


    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.


    The Friendship Episode Apr 28, 2026
    Show notes

    This week, Jamie is joined by her two best friends, Becca Tobin and Odette Annable. They discuss navigating friendships in all seasons of life, giving grace to yourself and others, finding your people, and more.


    Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

    Audio Engineer: Josh Windisch


    This episode is sponsored by:

    Novartis in neuroscience

    Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

    Tumble - Machine Washable Rugs, Made Better. For a limited time only, our listeners get 10% off + free shipping at https://tumbleliving.com/MESSY #Tumble #ad

    MudWtr - Start your new morning ritual & get up to 43% off your @MUDWTR with code MESSY at https://mudwtr.com/MESSY! #mudwtrpod

    One Skin - Get 15% off OneSkin with the code MESSY at https://www.oneskin.co/MESSY #oneskinpod
    Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy#honeylovepod


    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.


    A Conversation with Jamie's Husband Apr 21, 2026
    Show notes

    This week, Jamie is joined by her husband, Cutter Dykstra. They discuss his experience as her partner and caregiver, the role he's played in Jamie's acceptance and outlook, advice for other partners, and more.


    Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

    Audio Engineer: Josh Windisch


    This episode is sponsored by:

    Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.


    Fatty15 - Get an additional 15% off their 90-day subscription Starter Kit by going to ⁠https://fatty15.com/messy⁠and using code MESSY at checkout.

    Lola - Get 40% off your entire order at ⁠https://Lolablankets.com⁠ by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets.

    Honeylove - Save 20% Off Honeylove by going to ⁠https://honeylove.com/messy⁠#honeylovepod

    Jones Road - Use code MESS at ⁠https://jonesroadbeauty.com⁠ to get a Free Shimmer Face Oil with your first purchase! #JonesRoadBeauty

    Zoc Doc - Stop putting off those doctors appointments and go to Zocdoc.com/MESSY to find and instantly book a doctor you love today.


    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.


    A MeSsy Update! Mar 31, 2026
    Show notes

    We’re taking a short break for the next few weeks while Jamie and Christina focus on their book launches. We’ll be back soon with brand new episodes!


    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.


    Olivia Munn Mar 24, 2026
    Show notes

    This week, Christina and Jamie are joined by Olivia Munn. They discuss Olivia’s breast cancer diagnosis, how she was finally able to shed her armor, why you shouldn’t tell someone going through something to look on the bright side, and more.


    Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

    Audio Engineer: Josh Windisch


    This episode is sponsored by:

    Veracity - Head to https://VeracityHealth.coand use code MESSY for up to 60% off your order.

    Jones Road - Use code MESSY at https://jonesroadbeauty.com to get a Free Shimmer Face Oil with your first purchase #JonesRoadBeauty #ad


    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.


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