MeSsy with Christina Applegate & Jamie Lynn Sigler

Latest Episodes:

Thank God I’m So Neurotic with Cat Cohen Sep 08, 2026

Show notes

This week on MeSsy, Jamie sits down with comedian, actor, and singer Cat Cohen. Cat opens up about having a stroke at 31, navigating health anxiety in the aftermath, and turning one of the scariest experiences of her life into her most fulfilling creative work yet.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by:

Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

Jones Road - Use code MESS at https://jonesroadbeauty.com to get a Free Gift with your first purchase! #JonesRoadBeauty #ad

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

We Fight For Joy with Kelsey Chittick Sep 03, 2026

Show notes

This week on Living With It, Jamie sits down with Kelsey Chittick to talk about losing her husband suddenly, raising two children through grief, and learning to build a life she never expected. They discuss finding humor in the darkest moments, letting go of the life you thought you’d have, the power of community, and how to choose joy.

Novartis in neuroscience

o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

There’s No Place Like Home with Annie Meyers-Shyer Sep 01, 2026

Show notes

This week, Jamie is joined by her longtime friend Annie Meyers-Shyer, the creator behind This Oak House. They talk about Annie’s unexpected second act, finding a new passion and career at 45, and why it’s never too late to bet on yourself. Annie also shares how she creates a home that feels like an exhale, the small ways our spaces can support us through difficult seasons, and how her home carried her through grief.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by:

Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod

ZBiotics - Go to https://zbiotics.com/messy and use MESSYat checkout for 15% off any first time orders of ZBiotics probiotics.

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The Power of Radical Acceptance with Jim Curtis Aug 27, 2026

Show notes

This week on Living With It, Jamie sits down with Jim Curtis, a transformational coach, author, and wellness leader. They discuss how to radically accept the life you have without giving up hope for the life you want, the stories we build around our suffering, and learning to see your body as an ally instead of the enemy. Plus, Jim shares how releasing old beliefs and changing the way we speak to ourselves can open us up to new possibilities.

Novartis in neuroscience

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Jamie's Son Beau Aug 25, 2026

Show notes

This week, Jamie sits down with a very special guest: her 13-year-old son, Beau. They have an honest conversation about what it’s been like growing up with a mom who has MS, how Jamie’s strength has shaped him, and what he wants other kids and parents living with chronic illness to know.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by:

MudWtr -Start your new morning ritual & get up to 43% off your @MUDWTR with code MESSY at https://mudwtr.com/messy! #mudwtrpod

OneSkin - Get 15% off OneSkin with the code MESSY at https://www.oneskin.co/MESSY #oneskinpod

MyAlloy -Try the original estrogen-powered M4 skincare from Alloy. Visit myalloy.com and use code MESSYfor $20 off your first order!

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Accept, Adapt, Appreciate with Odette Annable Aug 20, 2026

Show notes

This week on Living With It, Jamie sits down with her friend Odette Annable. They discuss parenting a neurodivergent child, trusting your instincts, advocating for your family, and learning to let go of the need to have all the answers.

Novartis in neuroscience

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The Courage to Slow Down Aug 18, 2026

Show notes

This week on MeSsy, Jamie opens up about reaching her limit and learning to make rest part of healing. She also reads listener emails about fighting to be heard by doctors, learning to accept help, and the power of knowing you're not alone.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by:

Lola Blankets - Get 40% off select Lola Blankets products at Lolablankets.com by using code MESSY at checkout. Experience the world’s #1 blanket with Lola Blankets.

ZocDoc - Head to https://Zocdoc.com/MESSYto get started and check that appointment off your to-do list!

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Finding Stillness When Life Won’t Slow Down with Bob Roth Aug 13, 2026

Show notes

This week on Living With It, Jamie sits down with Bob Roth, a leading Transcendental Meditation teacher and CEO of the David Lynch Foundation. They discuss what stress does to the body, how meditation can help calm the nervous system, and how finding stillness can help us navigate uncertainty, illness, and everyday life.

Novartis in neuroscience

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

How Death Informs How We Live with Julie McFadden Aug 11, 2026

Show notes

This week, Jamie sits down with hospice nurse Julie McFadden to talk about changing the way we think about death, what she’s learned from those at the end of life, and how accepting our mortality can help us live more fully in the present.

Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

Audio Engineer: Josh Windisch

This episode is sponsored by:

Novartis in neuroscience

Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

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Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Trusting the Journey with Becca Tobin Aug 06, 2026

Show notes

This week, Jamie sits down with one of her best friends, Becca Tobin, for a conversation about infertility, pregnancy loss, surrogacy, and finding hope after years of uncertainty. They explore grief, resilience, the unexpected paths to parenthood, and what it means to keep moving forward when life doesn't unfold the way you imagined.

Novartis in neuroscience

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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