MDS Podcast

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Surprise neuropathological findings in LRRK2 mutation carriers Jul 14, 2025

Show notes

Mutations in LRRK2 are a common cause of familial and sporadic Parkinson’s. Though clinical features resemble typical PD, about half of cases lack Lewy pathology. Doctors Hiroaki Sekiya and Nanna Møller Jensen discuss their recent studies on the neuropathology of LRRK2-PD patients. They dive into their methods and how proximity ligation assays may compare to alpha-synuclein seeding assays in identification of alpha-synuclein oligomers. Together they explain their surprising results on how alpha-synuclein oligomers may be a key early feature in LRRK2-PD.
Read the first article.
Read the second article.

tDCS for Tourette syndrome Mar 17, 2025

Show notes

Dr. Sara Schaefer and Dr. Davide Martino discuss his recent paper exploring the use of transcranial direct current stimulation over the supplementary motor area for the suppression of tics in patients with Tourette Syndrome. Read the article.

Task-specific brain oscillatory activity in laryngeal dystonia Oct 09, 2023

Show notes

Laryngeal dystonia (LD) is a rare disorder affecting the vocal cords. Dr. Sarah Camargos sits down with Prof. Kristina Simonyan while she breaks down the methodology and findings of her comprehensive study investigating the temporal-spatial signature of LD. Read the article

Sleep and Cognitive Decline | Congress 2023 Sep 18, 2023

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How can sleep predict cognitive decline in Parkinson's disease? Dr. Ron Postuma discusses his viewpoint and findings with Dr. Sarah Camargos at the MDS Congress.

The Basic Science Perspective on Future Therapeutic Targets | Congress 2023 Sep 18, 2023

Show notes

Basic science research for movement disorder therapies is booming. Prof. Tiago Outeiro asks Dr. Lorraine Kalia what therapeutic targets she thinks are stealing the stage at this year's MDS Congress.

The Basic Science Perspective on the Role of Alpha-Synuclein | Congress 2023 Sep 18, 2023

Show notes

The role of alpha-synuclein in various proteinopathies is still unknown. Prof. Poul Henning Jensen discusses this hot topic with Prof. Tiago Outeiro.

Targeting alpha synuclein in early Parkinson's disease. Clinical trials and future perspectives Mar 20, 2023

Show notes

Two clinical trials with antibodies targeting alpha synuclein in early Parkinson's disease have been published in the New England Journal of Medicine. Anthony Lang and Gennaro Pagano, the first authors of the articles share the results and discuss the possible future perspectives with the MDS Podcast editor, Michele Matarazzo. Read the prasinezumab article. Read the cinpanemab article.

Striatal Blood Brain Barrier Opening in Parkinson's Dementia Dec 20, 2022

Show notes

Dr. Sara Schaefer discusses with Dr. Pineda-Pardo using focused ultrasound to temporarily open the striatal blood brain barrier in Parkinson's disease dementia patients, and the implications for the results of this safety and feasibility study including for future treatment options for these patients.
Journal CME is available until December 1, 2023 Read the article.

Tau imaging for the study of corticobasal syndrome: The first steps of in vivo neuropathology Dec 13, 2021

Show notes

Dr. Günter Hoglinger discusses the article he recently published in the Movement Disorders journal on tau imaging in a cohort of corticobasal syndrome patients, along with amyloid PET and CSF analysis to differentiate the neuropathological entity underlying the clinical manifestations. Read the article

Swim for Parkinson: Swimming together to improve together Oct 18, 2021

Show notes

The neurologists Dr. Francesca Morgante and Dr. Nicola Modugno and Cecilia Ferrari, a person with Parkinson's disease, share their experience swimming across the strait of Messina, highlighting the importance of physical activity in PD.

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