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    Health & Fitness

    MDS Podcast

    Stay up to date on novel, clinically-relevant research findings in Parkinson’s disease and other movement disorders. Each episode of the International Parkinson and Movement Disorder Society podcast discusses a relevant development in the field, including highlighted journal articles and interviews with the authors.

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    Latest Episodes:
    Setting the TEMPO: What have we learned about D1/D5 dopamine stimulation in Parkinson’s disease? Sep 14, 2026
    Show notes

    Dr. Divyani Garg speaks with Dr. Hubert H. Fernandez about tavapadon, a once-daily selective dopamine D1/D5 receptor agonist, and what the TEMPO clinical development program tells us about its potential role in Parkinson’s disease (PD). They discuss the rationale for D1/D5 stimulation, findings from other TEMPO programs, the magnitude and clinical meaning of the motor benefit, flexible dosing, and the important tolerability and discontinuation findings from TEMPO-2. The conversation also explores where tavapadon might fit relative to levodopa and conventional D2/D3 dopamine agonists, and its potential role across different stages of PD. Read the article.


    Rethinking Parkinson’s: The Somato-Cognitive Action Network (SCAN) hypothesis Mar 23, 2026
    Show notes

    Dr. Michele Matarazzo interviews Prof. Hesheng Liu about his recent Nature paper proposing a major conceptual shift: Parkinson’s disease as a somato-cognitive action network (SCAN) disorder. Together they discuss how a large multimodal dataset suggests a characteristic pattern of hyperconnectivity between SCAN cortical areas and subcortical nuclei in Parkinson’s disease, how this signature changes with effective therapies, and why personalized SCAN targeting may help refine non-invasive stimulation and circuit-guided interventions. The conversation explores implications for biomarkers, patient-specific targeting, and key unanswered questions that will shape the next generation of studies. Read the article.


    Revisiting the 2015 MDS clinical diagnostic criteria for Parkinson's disease Mar 02, 2026
    Show notes

    Dr. Eduardo de Pablo-Fernández is joined by Dr. Susan Fox and Dr. Claudia Trenkwalder to discuss how to improve the current MDS clinical diagnostic criteria for Parkinson's disease. Read the article.


    Shame in Parkinson's disease: An unseen burden Feb 02, 2026
    Show notes

    This episode explores shame as an often-overlooked but impactful non-motor symptom of Parkinson’s disease. Drawing on her team's recent research, Dr. Vanessa Fleury discusses the psychological and clinical determinants of shame, its strong link to quality of life, and why it deserves greater attention in routine care. The conversation highlights how recognizing and addressing shame may open new avenues for more holistic, patient-centered management. Read the article.


    SCA3 & life in the countryside: Exploring the interplay between genetics and environment May 27, 2025
    Show notes

    Dr. Sarah Camargos talks with Prof. Laura Bannach Jardim about how rural living might influence the age at onset of Machado-Joseph disease. Read the article.


    Skin tau as a biomarker of Huntington's disease Dec 06, 2024
    Show notes

    Growing evidence suggests a contributory role of tau protein in the pathogenesis of Huntington's disease. In this episode, Dr. Eduardo de Pablo-Fernández discusses the potential role of skin tau quantification as a biomarker for Huntington's disease with Dr. Jaime Kulisevsky and Dr. Iñigo Ruiz-Barrio. The authors discuss the results of the recent study correlating skin tau quantification with clinical and radiological data, and the role of skin tau in defining HD subtypes. Read the article.


    Rasagiline in PD: Does it change disease progression? And how do we measure it? May 09, 2022
    Show notes

    A recent trial showed no benefit of 1mg rasagiline versus placebo on 1-year progression in an early Parkinson's disease cohort. The investigators used a novel method to track disease progression with MRI, apart from usual clinical standards. Dr. David Vaillancourt shares the results of this trial recently published in the Movement Disorders Journal. Read the article.


    Reviewing case reports and clinical series Apr 18, 2022
    Show notes

    Dr. Daniel Di Luca discusses how to approach and review case reports and case series in movement disorders with Prof. Kailash Bhatia.


    Scar dancing syndrome Jan 09, 2021
    Show notes

    Dr. Yiwen Wu discusses a newly-described peripherally-induced movement disorder (PIMD), and discusses with Dr. Schaefer the potential pathophysiologies of PIMDs. Read the article


    Randomized controlled trial of exercise on objective and subjective sleep in Parkinson's disease Oct 14, 2020
    Show notes

    Dr. Michele Matarazzo interviews Dr. Amy Amara, the first author of the article awarded as "2020 Research Article from Movement Disorders" on the effects of exercise on sleep in Parkinson's disease. Read the article


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