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    Alternative Health

    Mastering Nutrition

    Welcome to the Mastering Nutrition podcast.

    Mastering Nutrition is hosted by Chris Masterjohn, a nutrition scientist focused on optimizing mitochondrial health, and founder of BioOptHealth, a program that uses whole genome sequencing, a comprehensive suite of biochemical data, cutting-edge research and deep scientific insights to optimize each person’s metabolism by finding their own unique unlocks.

    He received his PhD in Nutritional Sciences from University of Connecticut at Storrs in 2012, served as a postdoctoral research associate in the Comparative Biosciences department of the University of Illinois at Urbana-Champaign’s College of Veterinary Medicine from 2012-2014, served as Assistant Professor of Health and Nutrition Sciences at Brooklyn College from 2014-2017, and now works independently in science research and education.

    Advertise

    Copyright: ยฉ All contents copyright of Chris Masterjohn.

    • Apple Podcasts
    • Google Play
    • Spotify

    Latest Episodes:
    Ask Us Anything About Hormones with Dr. Carrie Jones, May 10, 2019 | Mastering Nutrition #67 Oct 19, 2019
    Show notes

    On May 10, members of the CMJ Masterpass joined me and Dr. Carrie Jones in a live Zoom meeting to ask us anything about hormones, and here's the full recording!

    We talk about things like:

    • What time of day is best to take T4 and/or T3?
    • How to use pregnenolone to manage perimenopausal insomnia?
    • Is insomnia different between people who are and aren't on HRT?
    • Estrogen's effect on the kynurenine pathway could be keeping you up at night.
    • What about men with high estrogen?
    • Over-the-counter supplements to lower SHBG and increased free testosterone?
    • Mycotoxins
    • Iodine, fatigue, and "detox" reactions.
    • Loss of libido and sexual sensation with the LEEP procedure: could progesterone and vitamin E help? What else?
    • Should I be on testosterone replacement therapy?
    • Supporting hormones with nutrition.
    • Why is early morning waking a characteristic symptom of depression and what other conditions have early waking as a symptom?
    • Causes for night sweats in men?
    • Nutritional advice for breast cancer prevention, and the HRT question.
    • Water retention near menstruation.
    • Why would a woman have no cycle? Why would a woman have an anovulatory cycle?
    • What can be done to reverse hypothyroidism other than taking thyroid hormone?

    All this and much more!

    If you'd like to participate in the next Q&A, consider joining the CMJ Masterpass. Use this link to get a 10% lifetime discount: https://chrismasterjohnphd.com/masterpass/masteringnutrition

    This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order."

    This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral

    In this episode, you will find all of the following and more:

    04:20 Introduction

    07:55 Guidance on what time of day it is best to take T4 and/or T3?

    10:37 The use of pregnenolone to manage perimenopausal symptoms, particularly insomnia

    12:30 Insomnia is different between people who are and aren't on HRT?

    14:15 Estrogen and kynurenine pathway

    19:02 Aromatizing in Men

    21:40 Over-the-counter supplements to lower SHBG and increased free T, boron, zinc, various herbs

    24:20 Discussion about Mycotoxin.

    28:48 Discussions in Iodine and mild fatigue and detox.

    35:14 Discussion on soft tissue calcification.

    40:40 Discussion on LEEP Procedure

    45:53 Discussion on testosterone

    54:30 Suggestions on supplements to assist with delayed onset muscle soreness.

    55:48 How does the body make hormones and what nutrients and foods do they need to do this?

    59:29 Know more about hormone production.

    1:09:00 Why is early morning waking a characteristic symptom of depression and what other conditions have imbalances of early waking as a symptom?

    1:17:00 When should you consider increasing progesterone or estrogen.

    1:20:30 Causes for night sweats in men.

    1:25:00 Dietary nutritional advice for breast cancer prevention, macronutrient ratios, micronutrient intakes, et cetera. Also any thoughts on risks and benefits of HRT in perimenopause relative to breast cancer risk?

    1:28:29 Discussions on Methylation

    1:34:35 Struggles with water retention around period.

    1:39:23 Why would a woman have no cycle? Why would a woman have an anovulatory cycle?

    1:45:02 What can be done to reverse hypothyroidism other than taking thyroid medicine?

    Access the show notes, transcript, and comments here:

    https://chrismasterjohnphd.substack.com/p/067-ask-us-anything-about-hormones


    Pantothenic Acid, Part 2 (Testing, Food, and Supplements) | Mastering Nutrition #66 Oct 09, 2019
    Show notes

    This is part 2 of the pantothenic acid Mastering Nutrition podcast. Pantothenate is also known as vitamin B5! It supports your mood, mental health, skin clarity, energy, sleep, and comfort.

    Alex Leaf and I team up again, this time to how to get B5 from foods and supplements, and how to know when you're getting enough.

    When you aren't getting enough, you may suffer from fatigue, apathy, discomfort, uneasiness, or pain. You may get numbness and tingling in the hands and feet. You may get depressed, quarrelsome, childish, or want to spend all day in bed. Your pulse may get higher than you'd expect after minor exertion. Your sleep gets trashed. You get muscle cramps and abdominal cramps, you fart more, and when things get real bad you might throw up.

    The best test for measuring B5 status is urinary pantothenic acid. Currently, the only place I know where to get this is the Great Plains OAT test. Hopefully someone will offer it as a standalone. Blood tests are not very useful. ๐Ÿ˜”

    Official recommendations suggest we only need about 5 milligrams per day. In the podcast we discuss why some people might need GRAMS per day.

    โ—โ—โ—There aren't ANY supplements on the market that have the major forms of B5 found in food. There is good reason to think that food B5 is superior to supplements such as pantothenic acid and pantethine.โ—โ—โ—

    I recommend shooting for 10 milligrams per day from food, and then supplementing more when necessary:

    • 2 heaping tablespoons of unfortified nutritional yeast gives you 10 mg.
    • 2 100-gram servings of roasted sunflower seeds or the livers of chicken, beef, lamb, or veal will give you this, but I recommend limiting liver to two servings per week.
    • 3 100-gram servings of gjetost cheese, black and red caviar, kidney from lamb imported from New Zealand, pork liver (and most products made from it), shiitake mushrooms, or canned grape leaves will do the trick.
    • Most fresh cuts of muscle meat give you enough in somewhere between 3-5 100-gram servings, though some require up to four pounds and the data is pretty messy.
    • Five 100-gram servings of any of the following will work: eggs, duck, goose, emu, fresh salmon or trout, raw avocado, canned chilli, peanuts, peanut butter, cashews, white or portabella mushrooms, liver pate (limit to 5 servings per week), giiblets or heart from chicken or turkey, beef thymus or heart, pork kidney or brain, or lamb brain.
    • The following can give you enough if you eat four pounds of them: whole grains, most natural dairy products besides butter, most seafood that isn't canned, most beans that aren't canned, raw coconut, most nuts and seeds, and most processed meats.

    Here are a few reasons to supplement:

    • One gram of pantothenic acid from sodium or calcium pantothenate has been used for rheumatoid arthritis, and 2-10 grams per day have been used for acne. In acne, a topical cream containing dexpanthenol (a cream-soluble form of B5, the cream usually marketed as wound-healing cream) is combined with the oral dose.
    • 300 mg pantethine 3 times per day lowers cholesterol.

    These doses appear extremely safe, with only a very small proportion of people experiencing minor side effects even at these very high doses.

    This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral

    This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order."

    More details in this huge podcast! Listen in below!

    In this episode, you will find all of the following and more:

    01:14 Recap of Part 1

    06:39 Cliff Notes

    14:51 The case for why urinary pantothenic acid is the only legitimate marker of nutritional status and why blood concentration is not a useful marker

    28:23 How the Adequate Intake for pantothenic acid was established

    29:42 The idea of pantothenic acid balance and comparing it to nitrogen balance

    41:38 What I think the recommended pantothenic acid intake should be

    45:06 The effect of different forms of food processing on loss of B5 from foods

    50:21 Dietary sources of B5, divided into five tiers

    54:11 The contribution of the gastrointestinal microbiome to B5 status

    01:06:12 Causes of suboptimal status or deficiency of pantothenic acid

    01:11:59 Prevalence of suboptimal pantothenic acid status

    01:12:32 When I think supplementation with high doses is warranted

    01:13:10 What are some of the benefits, besides fixing deficiency, that we might get from supplementing with pantothenic acid or its derivatives?

    01:13:26 The use of pantethine as a therapeutic for dyslipidemia

    01:23:01 Comparison of pantethine supplementation to high-dose niacin for lowering blood lipids

    01:25:33 Topical dexpanthenol for skin health and wound healing

    01:29:13 The effect of pantothenic acid supplementation on acne

    01:32:42 The effect of pantothenic acid supplementation on sports performance

    01:40:58 The effect of pantothenic acid supplementation on hair health

    01:42:34 The effect of pantothenic acid supplementation on arthritis

    01:48:31 Summary of pantothenic acid supplementation

    01:52:28 Is there any reason to use pantothenic acid specifically versus other forms such as pantethine?

    01:54:49 Does it matter if you take pantothenic acid in divided doses or all at once?

    01:57:08 Does it matter if you take pantothenic acid with food?

    01:58:51 Two insightful quotes from papers on pantothenic acid

    02:04:08 Pantothenate should be known as the B vitamin that we know the least about, not the B vitamin that we are least likely to become deficient in.

    Access the show notes, transcript, and comments here:

    https://chrismasterjohnphd.substack.com/p/066-pantothenic-acid-part-2-foods


    Ask Me Anything About Nutrition, March 8, 2019 | Mastering Nutrition #65 Sep 06, 2019
    Show notes

    On March 8, members of the CMJ Masterpass joined me in a live Zoom meeting to ask me anything about nutrition, and here's the full recording!

    We talk about things like:

    • What to do if zinc causes nausea?
    • When on a ketogenic diet, it is a problem if ketones are going up to 5 to 6 millimoles per liter?
    • What if I'm on a ketogenic diet, and I can't get my ketone levels up higher than 1 millimole per liter when my primary reason for being on the ketogenic diet is that I'm trying to control blood glucose better?
    • Advice for what to do after suffering a transient ischemic attack.
    • Nutrients important for neuroregeneration.
    • What causes sinus congestion, and what can help?
    • Nutrition for children with ADHD.
    • Nutritional recommendations for MTR and MTRR polymorphisms.
    • Why the main problem with hyperglycemia is not glucose but rather advanced glycation end products, and why the main determinant of advanced glycation end products is low insulin signaling.
    • Does the difference between cyanocobalamin, hydroxocobalamin, and methylcobalamin matter, and does the difference between sublingual, oral, and intramuscular injection matter?
    • Could fat malabsorption be driven by genetic polymorphisms that lower activity the PEMT enzyme? And could fat malabsorption in general be causing not only mineral deficiencies but also hyperabsorption of oxalate from foods?
    • Why am I always sneezing first thing in the morning?
    • What if I cannot get my ferritin up and supplementing iron actually raises my serum iron well above the normal range?
    • A rant on why many people use "MTHFR" to slap a label on their health problems.

    All this and much more!

    If you'd like to participate in the next Q&A, consider joining the CMJ Masterpass. Use this link to get a 10% lifetime discount: https://chrismasterjohnphd.com/masterpass/masteringnutrition

    This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order."

    This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral

    This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order."

    This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral

    In this episode, you will find all of the following and more:

    00:43 Cliff Notes

    11:13 Introduction

    13:23 Should blacks and whites have different normal ranges for their HDL cholesterol? And general principles we should keep in mind when thinking about interracial differences or differences between groups.

    17:24 Are there any solutions to getting nauseated from zinc supplements even at low doses and even when the zinc comes as oysters?

    22:35 When on a ketogenic diet, it is a problem if ketones are going up to 5 to 6 millimoles per liter?

    26:17 Advice for what to do after suffering a transient ischemic attack

    35:57 Nutrients important for neuroregeneration

    39:26 What causes sinus congestion, and what can help?

    42:36 Do MTHFR polymorphisms other than the famous C677T and A1298C matter at all?

    44:54 Nutrition for children with ADHD

    57:07 How to address orthostatic hypotension

    58:53 Nutritional recommendations for MTR and MTRR polymorphisms

    01:10:54 Do you know anything about the value of lithium for ADHD?

    01:11:08 Information about my free Vitamins and Minerals 101 class

    01:13:30 Why the main problem with hyperglycemia is not glucose but rather advanced glycation end products, and why the main determinant of advanced glycation end products is low insulin signaling.

    01:24:19 Thoughts on nutrition and breast health

    01:33:03 Is it useful to measure urine pH?

    01:39:57 What would be a high dose of iodine?

    01:41:29 Recommended dose of glycine

    01:43:31 Does the difference between cyanocobalamin, hydroxocobalamin, and methylcobalamin matter, and does the difference between sublingual, oral, and intramuscular injection matter?

    01:53:10 Are bilirubin and uric acid useful markers of antioxidant defense and oxidative stress? What are better markers?

    01:58:25 Could an elevated BUN indicate protein malabsorption and low stomach acid?

    02:03:31 What if I'm on a ketogenic diet, and I can't get my ketone levels up higher than 1 millimole per liter when my primary reason for being on the ketogenic diet is that I'm trying to control blood glucose better?

    02:04:39 Could fat malabsorption be driven by genetic polymorphisms that lower activity the PEMT enzyme? And could fat malabsorption in general be causing not only mineral deficiencies but also hyperabsorption of oxalate from foods?

    02:08:18 How to manage blood levels of omega-3 and omega-6 fatty acids

    02:09:57 Why am I always sneezing first thing in the morning?

    02:12:03 Follow-up to question about ketone levels

    02:12:48 What if I cannot get my ferritin up and supplementing iron actually raises my serum iron well above the normal range?

    02:19:25 What about pyroluria and measuring kryptopyrroles?

    02:22:51 Are there safety concerns in supplementing cyanocobalamin rather methylcobalamin in those with MTHFR polymorphisms? And a rant on why many people use "MTHFR" to slap a label on their health problems.

    02:34:14 Advice for patient with hypercholesterolemia, elevated fasting glucose and insulin, ferritin of 194, and iron saturation of 33%

    02:45:31 What to do about high fasting glucose that only seems to improve with long sleep

    02:48:00 What should the upper limit of fatty fish intake be?

    Access the show notes, transcript, and comments here:

    https://chrismasterjohnphd.substack.com/p/065-ask-me-anything-about-nutrition

    Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.


    Riboflavin for Strange Unresolved Health Problems | Chris Masterjohn Lite # 153 Jul 09, 2019
    Show notes

    Got any strange, unresolved health problems? ๐Ÿคญ

    High-dose riboflavin might help!

    MIGHT. ๐Ÿ˜ฌ

    This episode is a shot in the dark, but covers how high-dose riboflavin could help with a lot of mystery issues.

    This episode is brought to you by Vitamins and Minerals 101. This is my new, free, 30-day course that covers the basics of each nutrient, including why it's important, how to get it from food, how to know if you need more, when you should think about supplementing, and concerns for special diets or special populations. You can get it delivered by Facebook Messenger or email. The Messenger version is taught by Chris Masterbot, my baby bot, is more interactive, and has more jokes and emojis. This requires no background beyond high school and is made for the beginner, but even many experts find it a great refresher and find little golden nuggets in each lesson. Sign up for free at https://chrismasterjohnphd.com/101

    This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. I've been through the pain and suffering of embracing a diet because I *thought* it was healthy, only for it to wreck my body and mind. I've been through the path of healing, only to make the mistakes of thinking that what worked best for me would work for everyone, and that what I did to heal would be something I would need to do forever. I've learned the hard way that each of us is unique, and that we all change with time. Your needs are not mine, mine are not what they were ten years ago, and yours won't be in ten years what they are now. That's why we need a recipe to know exactly what's missing, what's there in excess, and what's out of balance. It is my mission to empower you to know exactly what your body needs, and to make exactly the right decisions to nourish it. Make the cheat sheet your secret weapon, and use the code LITE20 to get 20% off, at https://chrismasterjohnphd.com/cheatsheet

    To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10

    Here's a massive podcast I did on riboflavin with Alex Leaf, which has 50 scientific references:

    https://chrismasterjohnphd.com/2019/02/16/manage-riboflavin-status/

    Here are some previous posts on riboflavin:

    Your "MTHFR" is Just a Riboflavin Deficiency (written version)

    https://chrismasterjohnphd.com/riboflavinmthfr

    Your "MTHFR" is Just a Riboflavin Deficiency (video version)

    https://chrismasterjohnphd.com/2019/03/26/mthfr-just-riboflavin-deficiency-2/

    How to Know If You Need More Riboflavin

    https://chrismasterjohnphd.com/lite-videos/2019/06/04/know-need-riboflavin

    Sunlight and Tanning Beds Hurt Your Riboflavin Status

    https://chrismasterjohnphd.com/lite-videos/2019/06/06/7758

    Riboflavin and Tanning Beds for Fungal Infections?

    https://chrismasterjohnphd.com/lite-videos/2019/06/11/riboflavin-tanning-beds-fungal-infections

    High-Fat Diets Make You Need More Riboflavin

    https://chrismasterjohnphd.com/lite-videos/2019/06/13/high-fat-diets-make-need-riboflavin

    Exercise and Dieting Make You Need More Riboflavin

    https://chrismasterjohnphd.com/lite-videos/2019/06/18/exercise-dieting-make-need-riboflavin

    How to Get Enough Riboflavin From Food

    https://chrismasterjohnphd.com/lite-videos/2019/06/20/7774

    The Best Blood Test for Riboflavin

    https://chrismasterjohnphd.com/blog/2019/06/25/best-blood-test-riboflavin

    Riboflavin Supplements: Free B2 Is Better Than FMN or Riboflavin 5'-Phosphate

    https://chrismasterjohnphd.com/2019/06/18

    Riboflavin for Iron-Deficiency Anemia

    https://chrismasterjohnphd.com/lite-videos/2019/07/02/riboflavin-iron-deficiency-anemia

    High-Dose Riboflavin for Migraines

    https://chrismasterjohnphd.com/lite-videos/2019/07/04/high-dose-riboflavin-migraines

    Access the show notes, transcript, and comments here.

    Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.


    High-Dose Riboflavin for Migraines | Chris Masterjohn Lite #152 Jul 04, 2019
    Show notes

    Got migraines? ๐Ÿ˜ฃ

    You may need a LOT of riboflavin! ๐Ÿ˜ฎ

    This episode covers what dose to use, and how to time the dosing.

    This episode is brought to you by Vitamins and Minerals 101. This is my new, free, 30-day course that covers the basics of each nutrient, including why it's important, how to get it from food, how to know if you need more, when you should think about supplementing, and concerns for special diets or special populations. You can get it delivered by Facebook Messenger or email. The Messenger version is taught by Chris Masterbot, my baby bot, is more interactive, and has more jokes and emojis. This requires no background beyond high school and is made for the beginner, but even many experts find it a great refresher and find little golden nuggets in each lesson. Sign up for free at https://chrismasterjohnphd.com/101

    This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. I've been through the pain and suffering of embracing a diet because I *thought* it was healthy, only for it to wreck my body and mind. I've been through the path of healing, only to make the mistakes of thinking that what worked best for me would work for everyone, and that what I did to heal would be something I would need to do forever. I've learned the hard way that each of us is unique, and that we all change with time. Your needs are not mine, mine are not what they were ten years ago, and yours won't be in ten years what they are now. That's why we need a recipe to know exactly what's missing, what's there in excess, and what's out of balance. It is my mission to empower you to know exactly what your body needs, and to make exactly the right decisions to nourish it. Make the cheat sheet your secret weapon, and use the code LITE20 to get 20% off, at https://chrismasterjohnphd.com/cheatsheet

    To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10

    Here's a massive podcast I did on riboflavin with Alex Leaf, which has 50 scientific references:

    https://chrismasterjohnphd.com/2019/02/16/manage-riboflavin-status/

    Here are some previous posts on riboflavin:

    Your "MTHFR" is Just a Riboflavin Deficiency (written version)

    https://chrismasterjohnphd.com/riboflavinmthfr

    Your "MTHFR" is Just a Riboflavin Deficiency (video version)

    https://chrismasterjohnphd.com/2019/03/26/mthfr-just-riboflavin-deficiency-2/

    How to Know If You Need More Riboflavin

    https://chrismasterjohnphd.com/lite-videos/2019/06/04/know-need-riboflavin

    Sunlight and Tanning Beds Hurt Your Riboflavin Status

    https://chrismasterjohnphd.com/lite-videos/2019/06/06/7758

    Riboflavin and Tanning Beds for Fungal Infections?

    https://chrismasterjohnphd.com/lite-videos/2019/06/11/riboflavin-tanning-beds-fungal-infections

    High-Fat Diets Make You Need More Riboflavin

    https://chrismasterjohnphd.com/lite-videos/2019/06/13/high-fat-diets-make-need-riboflavin

    Exercise and Dieting Make You Need More Riboflavin

    https://chrismasterjohnphd.com/lite-videos/2019/06/18/exercise-dieting-make-need-riboflavin

    How to Get Enough Riboflavin From Food

    https://chrismasterjohnphd.com/lite-videos/2019/06/20/7774

    The Best Blood Test for Riboflavin

    https://chrismasterjohnphd.com/blog/2019/06/25/best-blood-test-riboflavin

    Riboflavin Supplements: Free B2 Is Better Than FMN or Riboflavin 5'-Phosphate

    https://chrismasterjohnphd.com/2019/06/18

    Riboflavin for Iron-Deficiency Anemia

    https://chrismasterjohnphd.com/lite-videos/2019/07/02/riboflavin-iron-deficiency-anemia

    Access the show notes, transcript, and comments here.

    Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.


    Riboflavin for Iron-Deficiency Anemia | Chris Masterjohn Lite #151 Jul 02, 2019
    Show notes

    Got anemia? ๐Ÿ™‹๐Ÿฝ๐Ÿ™‹๐Ÿผโ€๐Ÿ™‹โ€โ™€๏ธ๐Ÿ™‹๐Ÿฟโ€โ™€๏ธ

    You may need more riboflavin! ๐Ÿ˜ฎ

    This episode covers how to know if your iron-deficiency anemia could be helped by riboflavin, and what to do about it using food and supplements.

    This episode is brought to you by Vitamins and Minerals 101. This is my new, free, 30-day course that covers the basics of each nutrient, including why it's important, how to get it from food, how to know if you need more, when you should think about supplementing, and concerns for special diets or special populations. You can get it delivered by Facebook Messenger or email. The Messenger version is taught by Chris Masterbot, my baby bot, is more interactive, and has more jokes and emojis. This requires no background beyond high school and is made for the beginner, but even many experts find it a great refresher and find little golden nuggets in each lesson. Sign up for free at https://chrismasterjohnphd.com/101

    This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. I've been through the pain and suffering of embracing a diet because I *thought* it was healthy, only for it to wreck my body and mind. I've been through the path of healing, only to make the mistakes of thinking that what worked best for me would work for everyone, and that what I did to heal would be something I would need to do forever. I've learned the hard way that each of us is unique, and that we all change with time. Your needs are not mine, mine are not what they were ten years ago, and yours won't be in ten years what they are now. That's why we need a recipe to know exactly what's missing, what's there in excess, and what's out of balance. It is my mission to empower you to know exactly what your body needs, and to make exactly the right decisions to nourish it. Make the cheat sheet your secret weapon, and use the code LITE20 to get 20% off, at https://chrismasterjohnphd.com/cheatsheet

    To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10

    Here's a massive podcast I did on riboflavin with Alex Leaf, which has 50 scientific references:

    https://chrismasterjohnphd.com/2019/02/16/manage-riboflavin-status/

    Here are some previous posts on riboflavin:

    Your "MTHFR" is Just a Riboflavin Deficiency (written version)

    https://chrismasterjohnphd.com/riboflavinmthfr

    Your "MTHFR" is Just a Riboflavin Deficiency (video version)

    https://chrismasterjohnphd.com/2019/03/26/mthfr-just-riboflavin-deficiency-2/

    How to Know If You Need More Riboflavin

    https://chrismasterjohnphd.com/lite-videos/2019/06/04/know-need-riboflavin

    Sunlight and Tanning Beds Hurt Your Riboflavin Status

    https://chrismasterjohnphd.com/lite-videos/2019/06/06/7758

    Riboflavin and Tanning Beds for Fungal Infections?

    https://chrismasterjohnphd.com/lite-videos/2019/06/11/riboflavin-tanning-beds-fungal-infections

    High-Fat Diets Make You Need More Riboflavin

    https://chrismasterjohnphd.com/lite-videos/2019/06/13/high-fat-diets-make-need-riboflavin

    Exercise and Dieting Make You Need More Riboflavin

    https://chrismasterjohnphd.com/lite-videos/2019/06/18/exercise-dieting-make-need-riboflavin

    How to Get Enough Riboflavin From Food

    https://chrismasterjohnphd.com/lite-videos/2019/06/20/7774

    The Best Blood Test for Riboflavin

    https://chrismasterjohnphd.com/blog/2019/06/25/best-blood-test-riboflavin

    Riboflavin Supplements: Free B2 Is Better Than FMN or Riboflavin 5'-Phosphate

    https://chrismasterjohnphd.com/2019/06/18

    Access the show notes, transcript, and comments here.

    Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.


    Riboflavin Supplements: Free B2 Is Better Than FMN or Riboflavin 5'-Phosphate | CML #150 Jun 27, 2019
    Show notes

    What's the best riboflavin supplement? ๐Ÿคทโ€โ™‚๏ธ

    For years I thought it was riboflavin 5'-phosphate, also known as flavin mononucleotide (FMN). In this episode, I explain why I know believe it is plain old riboflavin.

    This episode is brought to you by Vitamins and Minerals 101. This is my new, free, 30-day course that covers the basics of each nutrient, including why it's important, how to get it from food, how to know if you need more, when you should think about supplementing, and concerns for special diets or special populations. You can get it delivered by Facebook Messenger or email. The Messenger version is taught by Chris Masterbot, my baby bot, is more interactive, and has more jokes and emojis. This requires no background beyond high school and is made for the beginner, but even many experts find it a great refresher and find little golden nuggets in each lesson. Sign up for free at https://chrismasterjohnphd.com/101

    This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. I've been through the pain and suffering of embracing a diet because I *thought* it was healthy, only for it to wreck my body and mind. I've been through the path of healing, only to make the mistakes of thinking that what worked best for me would work for everyone, and that what I did to heal would be something I would need to do forever. I've learned the hard way that each of us is unique, and that we all change with time. Your needs are not mine, mine are not what they were ten years ago, and yours won't be in ten years what they are now. That's why we need a recipe to know exactly what's missing, what's there in excess, and what's out of balance. It is my mission to empower you to know exactly what your body needs, and to make exactly the right decisions to nourish it. Make the cheat sheet your secret weapon, and use the code LITE20 to get 20% off, at https://chrismasterjohnphd.com/cheatsheet

    To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10

    Here's a massive podcast I did on riboflavin with Alex Leaf, which has 50 scientific references:

    https://chrismasterjohnphd.com/2019/02/16/manage-riboflavin-status/

    Here are some previous posts on riboflavin:

    Your "MTHFR" is Just a Riboflavin Deficiency (written version)

    https://chrismasterjohnphd.com/riboflavinmthfr

    Your "MTHFR" is Just a Riboflavin Deficiency (video version)

    https://chrismasterjohnphd.com/2019/03/26/mthfr-just-riboflavin-deficiency-2/

    How to Know If You Need More Riboflavin

    https://chrismasterjohnphd.com/lite-videos/2019/06/04/know-need-riboflavin

    Sunlight and Tanning Beds Hurt Your Riboflavin Status

    https://chrismasterjohnphd.com/lite-videos/2019/06/06/7758

    Riboflavin and Tanning Beds for Fungal Infections?

    https://chrismasterjohnphd.com/lite-videos/2019/06/11/riboflavin-tanning-beds-fungal-infections

    High-Fat Diets Make You Need More Riboflavin

    https://chrismasterjohnphd.com/lite-videos/2019/06/13/high-fat-diets-make-need-riboflavin

    Exercise and Dieting Make You Need More Riboflavin

    https://chrismasterjohnphd.com/lite-videos/2019/06/18/exercise-dieting-make-need-riboflavin

    How to Get Enough Riboflavin From Food

    https://chrismasterjohnphd.com/lite-videos/2019/06/20/7774

    The Best Blood Test for Riboflavin

    https://chrismasterjohnphd.com/blog/2019/06/25/best-blood-test-riboflavin

    Access the show notes, transcript, and comments here.

    Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.


    The Best Blood Test for Riboflavin | Chris Masterjohn Lite #149 Jun 25, 2019
    Show notes

    This episode covers the best blood test to use for assessing riboflavin status.

    This episode is brought to you by Vitamins and Minerals 101. This is my new, free, 30-day course that covers the basics of each nutrient, including why it's important, how to get it from food, how to know if you need more, when you should think about supplementing, and concerns for special diets or special populations. You can get it delivered by Facebook Messenger or email. The Messenger version is taught by Chris Masterbot, my baby bot, is more interactive, and has more jokes and emojis. This requires no background beyond high school and is made for the beginner, but even many experts find it a great refresher and find little golden nuggets in each lesson. Sign up for free at https://chrismasterjohnphd.com/101

    This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. I've been through the pain and suffering of embracing a diet because I *thought* it was healthy, only for it to wreck my body and mind. I've been through the path of healing, only to make the mistakes of thinking that what worked best for me would work for everyone, and that what I did to heal would be something I would need to do forever. I've learned the hard way that each of us is unique, and that we all change with time. Your needs are not mine, mine are not what they were ten years ago, and yours won't be in ten years what they are now. That's why we need a recipe to know exactly what's missing, what's there in excess, and what's out of balance. It is my mission to empower you to know exactly what your body needs, and to make exactly the right decisions to nourish it. Make the cheat sheet your secret weapon, and use the code LITE20 to get 20% off, at https://chrismasterjohnphd.com/cheatsheet

    To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10

    Access the show notes, transcript, and comments here.

    Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.


    How to Get Enough Riboflavin From Food | Chris Masterjohn Lite #148 Jun 20, 2019
    Show notes

    Here's how to get RIBOFLAVIN from FOOD. ๐Ÿฒ ๐Ÿ˜‹

    This episode covers how to figure out how much you need, and which foods to get it from.

    This episode is brought to you by Vitamins and Minerals 101. This is my new, free, 30-day course that covers the basics of each nutrient, including why it's important, how to get it from food, how to know if you need more, when you should think about supplementing, and concerns for special diets or special populations. You can get it delivered by Facebook Messenger or email. The Messenger version is taught by Chris Masterbot, my baby bot, is more interactive, and has more jokes and emojis. This requires no background beyond high school and is made for the beginner, but even many experts find it a great refresher and find little golden nuggets in each lesson. Sign up for free at https://chrismasterjohnphd.com/101

    This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. I've been through the pain and suffering of embracing a diet because I *thought* it was healthy, only for it to wreck my body and mind. I've been through the path of healing, only to make the mistakes of thinking that what worked best for me would work for everyone, and that what I did to heal would be something I would need to do forever. I've learned the hard way that each of us is unique, and that we all change with time. Your needs are not mine, mine are not what they were ten years ago, and yours won't be in ten years what they are now. That's why we need a recipe to know exactly what's missing, what's there in excess, and what's out of balance. It is my mission to empower you to know exactly what your body needs, and to make exactly the right decisions to nourish it. Make the cheat sheet your secret weapon, and use the code LITE20 to get 20% off, at https://chrismasterjohnphd.com/cheatsheet

    To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10

    Here's a massive podcast I did on riboflavin with Alex Leaf, which has 50 scientific references:

    https://chrismasterjohnphd.com/2019/02/16/manage-riboflavin-status/

    Here are some previous posts on riboflavin:

    Your "MTHFR" is Just a Riboflavin Deficiency (written version)

    https://chrismasterjohnphd.com/riboflavinmthfr

    Your "MTHFR" is Just a Riboflavin Deficiency (video version)

    https://chrismasterjohnphd.com/2019/03/26/mthfr-just-riboflavin-deficiency-2/

    How to Know If You Need More Riboflavin

    https://chrismasterjohnphd.com/lite-videos/2019/06/04/know-need-riboflavin

    Sunlight and Tanning Beds Hurt Your Riboflavin Status

    https://chrismasterjohnphd.com/lite-videos/2019/06/06/7758

    Riboflavin and Tanning Beds for Fungal Infections?

    https://chrismasterjohnphd.com/lite-videos/2019/06/11/riboflavin-tanning-beds-fungal-infections

    High-Fat Diets Make You Need More Riboflavin

    https://chrismasterjohnphd.com/lite-videos/2019/06/13/high-fat-diets-make-need-riboflavin

    Exercise and Dieting Make You Need More Riboflavin

    https://chrismasterjohnphd.com/lite-videos/2019/06/18/exercise-dieting-make-need-riboflavin

    Access the show notes, transcript, and comments here.

    Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.


    Pantothenic Acid, Part 1 (What It Is and Why We Need It) | Mastering Nutrition #64 Jun 19, 2019
    Show notes

    Pantothenic acid is vitamin B5. You use it to make coenzyme A, a molecule that is central to energy metabolism, most famous for forming acetyl CoA, which lies at the intersection of all anabolic (building up) and catabolic (breaking down) reactions.

    Alex Leaf and I team up again, this time to tackle B5.

    This is what happens when you don't have enough:

    • You get fatigue apathy, discomfort, uneasiness, or pain.
    • You get numbness and tingling in the hands and feet.
    • You may get depressed, quarrelsome, childish, or want to spend all day in bed.
    • Your pulse gets higher than you'd expect after minor exertion.
    • Your sleep gets trashed.
    • You get muscle cramps and abdominal cramps, you fart more, and when things get real bad you might throw up.

    Much of this can be explained by pantothenic acid's role in working all of this magic:

    • We use it break down fat, protein, and carbohydrate for energy.
    • We use it to synthesize fatty acids, ketones, and cholesterol.
    • We use it to synthesize all of the steroid hormones, including the sex hormones, the glucocorticoids that regulate blood sugar, and the mineralcorticoids that regulate electrolyte balance and blood pressure.
    • We use it to regulate our use of iron properly, including preventing its accumulation in the brain, where it can cause neurological damage.
    • We use it to make melatonin, which tells our body it's time to sleep.
    • We use it to make acetylcholine, a neurotransmitter involved in learning, memory, and cognitive performance during periods of sustained, focused attention.
    • We use it to make mucin, which lubricates the eyes, ears, nose, mouth, vagina, penis, and internal organs.
    • We use it to regulate the fasting/feeding cycle by flipping on the genes for autophagy during fasting and flipping on the genes for repair and antioxidant defense during feeding.
    • We use it for quite a few other things too, like the detoxification of some drugs; the synthesis of hemoglobin to prevent anemia; switching on the urea cycle to help us burn protein for energy cleanly; using folate to synthesize DNA, all the major vitamin-derived carriers in the system of energy metabolism, and glycine, an amino acid that acts as a calming, sleep-promoting neurotransmitter, stabilizes blood sugar, and supports collagen synthesis to make your bones strong and your skin smooth.

    Burning fat only requires 20% more B5 than burning carbs, which is small compared to how these macros affect riboflavin requirements, However, under conditions of stress you can burn carbohydrate without any B5 at all and you cannot do that with fat. In mice with severe deficiencies of coenzyme A, ketogenic diets dramatically worsen the neurological effects of deficiency.

    Although pantothenic acid is named for its presence everywhere and in everything using the Greek word "pantos," and the common dogma is that no one is deficient, Alex and I make the case in this two-part podcast that suboptimal pantothenic acid status might just be the norm.

    And the crazy thing? Official recommendations suggest we only need about 5 milligrams per day. In the podcast we discuss why some people might need GRAMS per day.

    Plus, why the FOOD forms might be superior to anything you can get in any supplements on the market.

    In part 2, to be released on July 5, we'll cover how to get pantothenic acid in foods, blood tests, and supplements.

    This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral

    In this episode you will find all of the following and more:

    00:37 Cliff Notes

    14:02 Symptoms of experimentally induced pantothenic acid deficiency

    15:57 It is thought that pantothenic acid deficiency doesn't occur naturally.

    18:59 Experiments inducing pantothenic acid deficiency

    26:06 Signs and symptoms of suboptimal pantothenic acid status

    26:54 Is there pantothenic acid toxicity?

    30:52 Hypothetical problems of taking high doses of pantothenic acid

    31:53 What pantothenic acid is

    35:28 Comparisons to niacin and riboflavin

    37:14 Roles of coenzyme A

    46:02 Roles of 4'-phosphopantetheine

    48:12 Burning fat requires 20% more vitamin B5 than burning carbohydrate; and why in the context of severe deficiency of B5 or impairment in the metabolism of B5 a high-fat diet could have devastating consequences.

    53:09 The importance of the ratio of acetyl-CoA to free CoA in regulating many metabolic pathways

    01:01:02 There are metabolic disorders, such as fatty acid oxidation disorders, that compromise the pool of coenzyme A.

    01:03:03 Synthesis of coenzyme A

    01:06:47 How coenzyme A synthesis is regulated

    01:11:38 Degradation of coenzyme A

    01:15:44 The physiology of pantothenic acid absorption

    01:25:29 A 2015 paper showed that 4'-phosphopantetheine can cross cell membranes via passive diffusion.

    01:29:00 The physiology of pantothenic acid transport in the blood

    01:32:11 Cellular uptake of pantothenic acid from the blood

    01:33:21 Tissue distribution of pantothenic acid

    01:36:00 There may be a particularly high need for pantothenic acid in adolescence.

    01:37:01 Mothers actively transfer pantothenic acid to their fetuses and into their milk at their own expense.

    01:39:29 Pharmacokinetics of supplementation

    01:48:20 A case for why food is superior to supplements for vitamin B5

    01:52:41 Inborn errors of coenzyme A metabolism include pantothenate kinase-associated neurodegeneration (PKAN).

    Access the show notes, transcript, and comments here:

    https://chrismasterjohnphd.substack.com/p/064-pantothenic-acid-part-1-what

    Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.


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