Lex Fridman Podcast

Latest Episodes:

#133 – Manolis Kellis: Biology of Disease Oct 25, 2020

Show notes

Manolis Kellis is a computational biologist at MIT. Please support this podcast by checking out our sponsors:
– SEMrush: https://www.semrush.com/partner/lex/ to get a free month of Guru
– Pessimists Archive: https://pessimists.co/
– Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get $200 off
– BetterHelp: https://betterhelp.com/lex to get 10% off

EPISODE LINKS:
Manolis Website: http://web.mit.edu/manoli/
Manolis Twitter: https://twitter.com/manoliskellis
Manolis YouTube: https://www.youtube.com/channel/UCkKlJ5LHrE3C7fgbnPA5DGA
Manolis Wikipedia: https://en.wikipedia.org/wiki/Manolis_Kellis

PODCAST INFO:
Podcast website: https://lexfridman.com/podcast
Apple Podcasts: https://apple.co/2lwqZIr
Spotify: https://spoti.fi/2nEwCF8
RSS: https://lexfridman.com/feed/podcast/
YouTube Full Episodes: https://youtube.com/lexfridman
YouTube Clips: https://youtube.com/lexclips

SUPPORT & CONNECT:
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– Medium: https://medium.com/@lexfridman

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
00:00 – Introduction
08:05 – Molecular basis for human disease
32:04 – Deadliest diseases
37:47 – Genetic component of diseases
46:38 – Genetic understanding of disease
1:02:25 – Unified theory of human disease
1:08:26 – Genome circuitry
1:33:29 – CRISPR
1:45:06 – Mitochondria
1:53:10 – Future of biology research
2:22:46 – The genetic circuitry of disease

#132 – George Hotz: Hacking the Simulation & Learning to Drive with Neural Nets Oct 22, 2020

Show notes

George Hotz (geohot) is a programmer, hacker, and the founder of Comma.ai. Please support this podcast by checking out our sponsors:
– Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 40% & free shipping
– Decoding Digital: https://appdirect.com/decoding-digital
– ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free

EPISODE LINKS:
Comma.ai’s Twitter: https://twitter.com/comma_ai
Comma.ai’s Website: https://comma.ai/
George’s Instagram: https://www.instagram.com/georgehotz
George’s Twitch: https://www.twitch.tv/georgehotz
George’s Twitter: https://twitter.com/realgeorgehotz
Comma.ai YouTube (unofficial): https://www.youtube.com/channel/UCwgKmJM4ZJQRJ-U5NjvR2dg

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
00:00 – Introduction
07:02 – Will human civilization destroy itself?
09:49 – Where are the aliens?
14:36 – Tic Tac UFO and Bob Lazar
17:04 – Conspiracy theories
19:07 – The programming language of life
23:28 – The games that humans play
31:58 – Memory leaks in the simulation
34:29 – Theories of everything
36:14 – Ethereum startup story
44:02 – Cryptocurrency
53:28 – Self-help advice
57:08 – Comma.ai
59:02 – Comma two
1:07:50 – Tesla vs Comma.ai
1:16:53 – Driver monitoring
1:30:34 – Communicating uncertainty
1:32:22 – Tesla Dojo
1:38:50 – Tesla Autopilot big rewrite
1:45:09 – How to install the Comma Two
1:49:44 – Openpilot is Android & Autopilot is iOS
1:58:59 – Waymo
2:10:12 – Autonomous driving and society
2:12:24 – Moving
2:15:29 – Advice to Startups
2:28:32 – Programming setup
2:31:32 – Ideas that changed my life
2:39:37 – GPT-3
2:42:57 – AGI
2:47:00 – Programming languages that everyone should learn
2:53:33 – How to learn anything
2:56:05 – Book recommendations
3:04:28 – Love
3:06:17 – Psychedelics
3:08:38 – Crazy

#131 – Chris Lattner: The Future of Computing and Programming Languages Oct 19, 2020

Show notes

Chris Lattner is a world-class software & hardware engineer, leading projects at Apple, Tesla, Google, and SiFive. Please support this podcast by checking out our sponsors:
– Blinkist: https://blinkist.com/lex and use code LEX to get a free week of premium
– Neuro: https://www.getneuro.com and use code LEX to get 15% off
– MasterClass: https://masterclass.com/lex to get 15% off annual sub
– Cash App: https://cash.app/ and use code LexPodcast to get $10

EPISODE LINKS:
Chris’s Twitter: https://twitter.com/clattner_llvm
Chris’s Website: http://nondot.org/sabre/

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
00:00 – Introduction
07:12 – Working with Elon Musk, Steve Jobs, Jeff Dean
12:42 – Why do programming languages matter?
18:42 – Python vs Swift
29:35 – Design decisions
34:53 – Types
38:41 – Programming languages are a bicycle for the mind
41:13 – Picking what language to learn
47:12 – Most beautiful feature of a programming language
56:36 – Walrus operator
1:06:03 – LLVM
1:11:15 – MLIR compiler framework
1:15:21 – SiFive semiconductor design
1:27:56 – Moore’s Law
1:31:09 – Parallelization
1:35:37 – Swift concurrency manifesto
1:46:26 – Running a neural network fast
1:52:03 – Is the universe a quantum computer?
1:57:44 – Effects of the pandemic on society
2:14:56 – GPT-3
2:19:15 – Software 2.0
2:32:41 – Advice for young people
2:37:24 – Meaning of life

#130 – Scott Aaronson: Computational Complexity and Consciousness Oct 12, 2020

Show notes

Scott Aaronson is a quantum computer scientist. Please support this podcast by checking out our sponsors:
– SimpliSafe: https://simplisafe.com/lex and use code LEX to get a free security camera
– Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get $200 off
– ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free
– BetterHelp: https://betterhelp.com/lex and use code LEX to get 10% off

EPISODE LINKS:
Scott’s Blog: https://www.scottaaronson.com/blog/
Our previous episode: https://www.youtube.com/watch?v=uX5t8EivCaM

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
00:00 – Introduction
07:46 – Simulation
12:38 – Theories of everything
18:18 – Consciousness
40:32 – Roger Penrose on consciousness
50:44 – Turing test
54:31 – GPT-3
1:03:02 – Universality of computation
1:09:33 – Complexity
1:15:38 – P vs NP
1:27:57 – Complexity of quantum computation
1:40:03 – Pandemic
1:53:49 – Love

#129 – Lisa Feldman Barrett: Counterintuitive Ideas About How the Brain Works Oct 04, 2020

Show notes

Lisa Feldman Barrett is a neuroscientist, psychologist, and author. Please support this podcast by checking out our sponsors:
– Athletic Greens: https://athleticgreens.com/lex and use code LEX to get free vitamin D3/K2
– Magic Spoon: https://magicspoon.com/lex and use code LEX to get free shipping
– Cash App: https://cash.app/ and use code LexPodcast to get $10

EPISODE LINKS:
Seven and a Half Lessons About the Brain (book): https://amzn.to/2Sp5ar9
How Emotions Are Made (book): https://amzn.to/2GwAFg6
Lisa’s Twitter: https://twitter.com/LFeldmanBarrett
Lisa’s Website: https://lisafeldmanbarrett.com/

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
00:00 – Introduction
06:35 – Are we alone in the universe?
08:03 – Life on Earth
12:55 – Collective intelligence of human brains
21:43 – Triune brain
27:52 – The predicting brain
35:48 – How the brain evolved
41:47 – Free will
50:40 – Is anything real?
1:03:13 – Dreams
1:09:00 – Emotions are human-constructed concepts
1:34:29 – Are women more emotional than men?
1:43:05 – Empathy
2:14:46 – Love
2:18:40 – Mortality
2:20:16 – Meaning of life

#128 – Michael Malice: Anarchy, Democracy, Libertarianism, Love, and Trolling Oct 02, 2020

Show notes

Michael Malice is a political thinker, podcaster, and author. Please support this podcast by checking out our sponsors:
– SEMrush: https://www.semrush.com/partner/lex/ to get a free month of Guru
– DoorDash: https://doordash.com/ and use code LEX to get $5 off
– MasterClass: https://masterclass.com/lex to get 15% off annual sub

EPISODE LINKS:
Michael’s Twitter: https://twitter.com/michaelmalice
Michael’s Community: https://malice.locals.com/
Michael’s YouTube: https://www.youtube.com/channel/UC5tj5QCpJKIl-KIa4Gib5Xw
Michael’s Website: http://michaelmalice.com/about/
Your Welcome podcast: https://bit.ly/30q8oz1
The New Right (book): https://amzn.to/34gxLo3
Dear Reader (book): https://amzn.to/2HPPlHS

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
00:00 – Introduction
04:15 – Sponsors
07:58 – Putin and the Russian soul
15:01 – Love and trolling
25:31 – Problem with government
31:03 – Anarchism
53:07 – Politics
54:59 – Are most people capable of thinking deeply?
1:02:08 – Willy Wonka and Albert Camus view of life
1:08:08 – Trolling
1:12:26 – Conspiracy theories
1:29:43 – Donald Trump and the Election
1:36:58 – Trump Biden presidential debates
1:41:15 – Journalism is broken
1:47:56 – Communism
1:54:02 – Presidential candidates
2:04:34 – Libertarian party
2:14:56 – Objectivism
2:24:17 – Trolling
2:35:21 – The New Right
2:43:29 – Cancel culture
3:13:17 – Book recommendations
3:18:08 – Fear of mortality
3:21:08 – Meaning of life

#127 – Joe Rogan: Conversations, Ideas, Love, Freedom & The Joe Rogan Experience Sep 26, 2020

Show notes

Joe Rogan is a comedian, UFC commentator, and the host of the Joe Rogan Experience. Please check out our sponsors to get a discount and to support this podcast:
– Neuro: https://www.getneuro.com and use code LEX
– Eight Sleep: https://eightsleep.com/lex and use code LEX
– Dollar Shave Club: https://dollarshaveclub.com/lex

Episode Links:
Joe’s Instagram: https://www.instagram.com/joerogan
Joe’s Twitter: http://twitter.com/joerogan
JRE (Spotify): https://open.spotify.com/show/4rOoJ6Egrf8K2IrywzwOMk
JRE (Apple): https://podcasts.apple.com/us/podcast/the-joe-rogan-experience/id360084272
JRE (YouTube): https://www.youtube.com/channel/UCzQUP1qoWDoEbmsQxvdjxgQ

If you would like to get more information about this podcast go to https://lexfridman.com/podcast or connect with @lexfridman on Twitter, LinkedIn, Facebook, Medium, or YouTube where you can watch the video versions of these conversations. If you enjoy the podcast, please rate it 5 stars on Apple Podcasts, follow on Spotify, or support it on Patreon.

Here’s the outline of the episode. On some podcast players you should be able to click the timestamp to jump to that time.

OUTLINE:
00:00 – Introduction
05:17 – Fear of mortality
06:48 – Chaos of 2020 and beyond
10:32 – Are we going to be okay?
19:30 – Violence, competition, and Sober October
26:45 – Mike Tyson
27:49 – Managing obsession
30:13 – Jiu jitsu game
35:55 – Best martial art for self defense
39:30 – Guns
43:59 – Memorable JRE moments
49:31 – Ideas breed in brains of humans
56:08 – Advice for Lex
1:06:09 – Long-form conversation
1:12:28 – Meaning of life

#126 – James Gosling: Java, JVM, Emacs, and the Early Days of Computing Sep 24, 2020

Show notes

James Gosling is the founder and lead designer of the Java programming language. Please check out our sponsors to get a discount and to support this podcast:
– Public Goods: https://publicgoods.com/lex and use code LEX
– BetterHelp: https://betterhelp.com/lex
– ExpressVPN: https://www.expressvpn.com/lexpod

Here’s the outline of the episode. On some podcast players you should be able to click the timestamp to jump to that time.

OUTLINE:
0:00 – Introduction
4:45 – Irrational numbers
8:04 – Math and programming
10:36 – Coding style
14:41 – First computer
23:54 – Lisp
27:22 – Write an Emacs implementation in C
35:15 – Early days of the Internet
45:57 – Elon Musk, Steve Jobs, Jeff Bezos
56:13 – Work hard and smart
58:48 – Open source
1:10:25 – Java
1:28:31 – Java virtual machine
1:44:05 – Android
1:47:04 – Advice

#125 – Ryan Hall: Martial Arts and the Philosophy of Violence, Power, and Grace Sep 20, 2020

Show notes

Ryan Hall is a jiu jitsu black belt, UFC fighter, and a philosopher of the martial arts.

Please check out our sponsors to get a discount and to support this podcast:
– PowerDot, use code LEX: https://powerdot.com/lex
– Babbel: https://babbel.com and use code LEX
– Cash App: download app & use code “LexPodcast”

Here’s the outline of the episode. On some podcast players you should be able to click the timestamp to jump to that time.

OUTLINE:
0:00 – Introduction
7:22 – Greatest warrior in history
11:48 – Genghis Khan
17:32 – Nature is metal
21:49 – Cancel culture
36:11 – Sci-fi books and movies
44:50 – Essence of jiu jitsu
51:17 – Jiu jitsu is a language
1:01:12 – How to get started in jiu jitsu
1:14:01 – The value of a good coach
1:25:42 – Lex training with Ryan
1:31:06 – Toxicity on the internet
1:34:41 – Joe Rogan
1:42:25 – Alex Jones
2:07:02 – Donald Trump
2:09:45 – The American ideal
2:17:33 – What does it take to be a jiu jitsu black belt
2:49:06 – Elon Musk
2:57:39 – Fighting BJ Penn
3:04:13 – Conor McGregor
3:12:08 – How to beat Khabib Nurmagomedov
3:16:00 – Top MMA fighters of all time
3:24:41 – Mike Tyson
3:41:13 – Fear of death

#124 – Stephen Wolfram: Fundamental Theory of Physics, Life, and the Universe Sep 15, 2020

Show notes

Stephen Wolfram is a computer scientist, mathematician, and theoretical physicist. This is our second conversation on the podcast.

Please check out our sponsors to get a discount and to support this podcast:
– SimpliSafe: https://simplisafe.com/lex
– Sun Basket, use code LEX: https://sunbasket.com/lex
– MasterClass: https://masterclass.com/lex

Here’s the outline of the episode. On some podcast players you should be able to click the timestamp to jump to that time.

OUTLINE:
00:00 – Introduction
07:14 – Key moments in history of physics
12:43 – Philosophy of science
14:37 – Science and computational reducibility
22:08 – Predicting the pandemic
38:58 – Sunburn moment with Wolfram Alpha
39:46 – Computational irreducibility
46:45 – Theory of everything
52:41 – General relativity
1:01:16 – Quantum mechanics
1:06:46 – Unifying the laws of physics
1:12:01 – Wolfram Physics Project
1:29:53 – Emergence of time
1:34:11 – Causal invariance
1:53:03 – Deriving physics from simple rules on hypergraphs
2:07:24 – Einstein equations
2:13:04 – Simulating the physics of the universe
2:17:28 – Hardware specs of the simulation
2:24:37 – Quantum mechanics in Wolfram physics model
2:42:46 – Double-slit experiment
2:45:13 – Quantum computers
2:53:21 – Getting started with Wolfram physics project
3:14:46 – The rules that created our universe
3:24:22 – Alien intelligences
3:32:29 – Meta-mathematics
3:37:58 – Why is math hard?
3:52:55 – Sabine Hossenfelder and how beauty leads physics astray
4:01:07 – Eric Weinstein and Geometric Unity
4:06:17 – Travel faster than speed of light
4:16:59 – Why does the universe exist at all

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