Lex Fridman Podcast

Latest Episodes:

#153 – Dmitry Korkin: Evolution of Proteins, Viruses, Life, and AI Jan 11, 2021

Show notes

Dmitry Korkin is a professor of bioinformatics and computational biology at WPI. Please support this podcast by checking out our sponsors:
– Brave: https://brave.com/lex
– NetSuite: http://netsuite.com/lex to get free product tour
– Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off
– Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings

EPISODE LINKS:
Dmitry’s Website: http://korkinlab.org/
Dmitry’s Twitter: https://twitter.com/dmkorkin

PODCAST INFO:
Podcast website: https://lexfridman.com/podcast
Apple Podcasts: https://apple.co/2lwqZIr
Spotify: https://spoti.fi/2nEwCF8
RSS: https://lexfridman.com/feed/podcast/
YouTube Full Episodes: https://youtube.com/lexfridman
YouTube Clips: https://youtube.com/lexclips

SUPPORT & CONNECT:
– Check out the sponsors above, it’s the best way to support this podcast
– Support on Patreon: https://www.patreon.com/lexfridman
– Twitter: https://twitter.com/lexfridman
– Instagram: https://www.instagram.com/lexfridman
– LinkedIn: https://www.linkedin.com/in/lexfridman
– Facebook: https://www.facebook.com/LexFridmanPage
– Medium: https://medium.com/@lexfridman

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) – Introduction
(07:21) – Proteins and the building blocks of life
(14:23) – Spike protein
(21:11) – Coronavirus biological structure explained
(26:09) – Virus mutations
(32:39) – Evolution of proteins
(42:25) – Self-replicating computer programs
(50:02) – Origin of life
(57:34) – Extraterrestrial life in our solar system
(59:31) – Joshua Lederberg
(1:05:30) – Dendral
(1:08:24) – Why did expert systems fail?
(1:10:35) – AlphaFold 2
(1:32:13) – Will AI revolutionize art and music?
(1:39:12) – Multi-protein folding
(1:43:39) – Will AlphaFold 2 result in a Nobel Prize?
(1:46:10) – Will AI be used to engineer deadly viruses?
(2:01:17) – Book recommendations
(2:11:00) – Family
(2:13:38) – A poem in Russian

#152 – Dan Gable: Olympic Wrestling, Mental Toughness & the Making of Champions Jan 09, 2021

Show notes

Dan Gable is one of the greatest Olympic athletes and wrestling coaches of all time. Please support this podcast by checking out our sponsors:
– Tryolabs: https://tryolabs.com/lex
– ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free
– Grammarly: https://grammarly.com/lex to get 20% off premium
– SimpliSafe: https://simplisafe.com/lex and use code LEX to get a free security camera

EPISODE LINKS:
Dan’s Twitter: https://twitter.com/dannygable
Dan’s Website: https://dangable.com/
Dan’s Books: https://amzn.to/2VK5nbn

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) – Introduction
(09:31) – Russian wrestling
(11:09) – Coaching the science, art, and toughness of wrestling
(18:05) – The pain of defeat and the tattoo of a hawk clawing out the heart
(21:04) – Roger Bannister and the 4 minute mile
(24:09) – The dream of becoming an Olympic champion
(26:38) – The day in 1972 of the Olympic final
(30:10) – Sauna story
(31:39) – Match against the Russian
(37:13) – The role of fear in wrestling
(42:14) – The line between physical wrestling and anger
(46:53) – Tragic loss of Dan’s sister
(54:21) – The role of family in wrestling
(59:43) – Wrestling being voted out of the Olympics
(1:04:26) – To beat the best you must study the best
(1:09:39) – The role of luck (Old Man and the Sea)

#151 – Dan Kokotov: Speech Recognition with AI and Humans Jan 04, 2021

Show notes

Dan Kokotov is VP of Engineering at Rev.ai, an automatic speech recognition company. Please support this podcast by checking out our sponsors:
– Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil
– Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium
– Business Wars: https://wondery.com/business-wars/
– Cash App: https://cash.app/ and use code LexPodcast to get $10

EPISODE LINKS:
Rev: https://www.rev.com
Rev.ai: https://www.rev.ai

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) – Introduction
(09:17) – Dune
(12:34) – Rev
(18:33) – Translation
(25:22) – Gig economy
(34:02) – Automatic speech recognition
(44:53) – Create products that people love
(53:02) – The future of podcasts at Spotify
(1:14:41) – Book recommendations
(1:16:02) – Stories of our dystopian future
(1:19:45) – Movies about Stalin and Hitler
(1:24:59) – Interviewing Putin
(1:30:56) – Meaning of life

#150 – Michael Malice: The White Pill, Freedom, Hope, and Happiness Amidst Chaos Dec 31, 2020

Show notes

Michael Malice is a political thinker, podcaster, and author. Please support this podcast by checking out our sponsors:
– NetSuite: http://netsuite.com/strategy to get free product tour
– Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil
– Sun Basket: https://sunbasket.com/lex and use code LEX to get $35 off
– Cash App: https://cash.app/ and use code LexPodcast to get $10

EPISODE LINKS:
Michael’s Twitter: https://twitter.com/michaelmalice
Michael’s Community: https://malice.locals.com/
Michael’s YouTube: https://www.youtube.com/channel/UC5tj5QCpJKIl-KIa4Gib5Xw
Michael’s Website: http://michaelmalice.com/about/
Your Welcome podcast: https://bit.ly/30q8oz1
The New Right (book): https://amzn.to/34gxLo3
Dear Reader (book): https://amzn.to/2HPPlHS
Podcast (Round 1): https://www.youtube.com/watch?v=BIk1zUy8ehU

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) – Introduction
(09:47) – Conversation with Alex Jones and Tim Pool
(18:31) – Michael’s outfit
(26:53) – Self-publishing a book
(36:41) – The white pill
(48:05) – What did the volcano say to his true love?
(49:28) – Myth of Sisyphus
(53:09) – Journalism failed to stop Stalin and Hitler
(1:00:53) – Good Germans
(1:04:49) – Richard Wolff
(1:08:20) – Could United States have stayed out of World War II
(1:11:12) – Trump Derangement Syndrome
(1:12:58) – Nazism and Antisemitism
(1:15:40) – Knock knock
(1:22:20) – Putin
(1:30:00) – The evil of Kim Jong-il and North Korea
(1:38:32) – Dark humor
(1:43:18) – Comedy is tragedy plus timing
(1:50:34) – Interviewing difficult guests
(2:00:06) – Curtis Yarvin (Mencius Moldbug)
(2:16:24) – Violence under anarchism
(2:31:58) – Ayn Rand
(2:35:07) – Secession in United States
(2:44:46) – Politics over next 4 years
(2:52:14) – Mars
(2:56:17) – UFOs
(2:59:12) – Psychedelics
(3:03:08) – What is love?

#149 – Diana Walsh Pasulka: Aliens, Technology, Religion, and the Nature of Belief Dec 28, 2020

Show notes

Diana Walsh Pasulka is a professor of philosophy and religion at UNCW and author of American Cosmic: UFOs, Religion, and Technology. Please support this podcast by checking out our sponsors:
– LMNT: https://drinkLMNT.com/lex to get free shipping
– Grammarly: https://grammarly.com/lex to get 20% off premium
– Business Wars: https://wondery.com/business-wars/
– Cash App: https://cash.app/ and use code LexPodcast to get $10

EPISODE LINKS:
Diana’s Website: https://uncw.edu/par/faculty/faculty-pasulka.html
American Cosmic (book): https://amzn.to/3aK2kaj

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) – Introduction
(08:28) – What is real?
(13:56) – Can beliefs become reality?
(18:59) – Donald Hoffman
(22:57) – Immanuel Kant’s Critique of Pure Reason
(26:27) – Ayn Rand
(33:25) – How do religions start?
(48:38) – Religion is an evolutionary advantage
(53:59) – Religion used in propaganda
(58:32) – What did Nietzsche mean by “God is Dead”?
(1:03:59) – American Cosmic
(1:07:45) – What do aliens look like?
(1:16:28) – History of space programs
(1:19:30) – Jacques Vallee
(1:28:55) – Artificial intelligence
(1:34:25) – Ufology community
(1:45:38) – Psychedelics
(1:49:35) – Tic Tac UFO
(1:58:09) – Roswell UFO incident
(2:09:14) – Bob Lazar
(2:12:50) – Monoliths in the desert
(2:23:39) – Humans will co-evolve with AI
(2:26:58) – Neuralink
(2:31:48) – Singularity
(2:41:39) – Books: Nietzsche
(2:46:44) – Books: Hannah Arendt
(2:51:43) – Fear of death
(2:56:11) – Meaning of life

#148 – Charles Isbell and Michael Littman: Machine Learning and Education Dec 26, 2020

Show notes

Charles Isbell is the Dean of the College of Computing at Georgia Tech. Michael Littman is a computer scientist at Brown University. Please support this podcast by checking out our sponsors:
– Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil
– Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings
– MasterClass: https://masterclass.com/lex to get 2 for price of 1
– Cash App: https://cash.app/ and use code LexPodcast to get $10

EPISODE LINKS:
Charles’s Twitter: https://twitter.com/isbellHFh
Charles’s Website: https://www.cc.gatech.edu/~isbell/
Michael’s Twitter: https://twitter.com/mlittmancs
Michael’s Website: https://www.littmania.com/
Michael’s YouTube: https://www.youtube.com/user/mlittman

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) – Introduction
(07:51) – Is machine learning just statistics?
(12:14) – NeurIPS vs ICML
(14:30) – Data is more important than algorithm
(20:14) – The role of hardship in education
(28:57) – How Charles and Michael met
(33:30) – Key to success: never be satisfied
(36:47) – Bell Labs
(48:15) – Teaching machine learning
(58:25) – Westworld and Ex Machina
(1:06:24) – Simulation
(1:13:14) – The college experience in the times of COVID
(1:41:52) – Advice for young people
(1:48:44) – How to learn to program
(2:00:07) – Friendship

#147 – Dmitri Dolgov: Waymo and the Future of Self-Driving Cars Dec 20, 2020

Show notes

Dmitri Dolgov is the CTO of Waymo, an autonomous vehicle company. Please support this podcast by checking out our sponsors:
– Tryolabs: https://tryolabs.com/lex
– Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium
– BetterHelp: https://betterhelp.com/lex to get 10% off
– Cash App: https://cash.app/ and use code LexPodcast to get $10

EPISODE LINKS:
Waymo’s Twitter: https://twitter.com/waymo
Waymo’s Website: https://waymo.com

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) – Introduction
(07:46) – Computer games
(12:52) – Childhood
(15:24) – Robotics
(16:14) – Moscow Institute of Physics and Technology
(18:26) – DARPA Urban Challenge
(28:46) – Waymo origin story
(44:27) – Waymo self-driving hardware
(53:00) – Connected cars
(58:53) – Waymo fully driverless service in Phoenix
(1:03:14) – Getting feedback from riders
(1:11:28) – Creating a product that people love
(1:17:18) – Do self-driving cars need to break the rules like humans do?
(1:24:03) – Waymo Trucks
(1:29:41) – Future of Waymo
(1:42:53) – Role of lidar in autonomous driving
(1:55:53) – Machine learning is essential for autonomous driving
(1:59:55) – Pedestrians
(2:06:32) – Trolley problem
(2:11:00) – Book recommendations
(2:22:26) – Meaning of life

#146 – Michael Mina: Rapid Testing, Viruses, and the Engineering Mindset Dec 19, 2020

Show notes

Michael Mina is an immunologist, epidemiologist, and physician at Harvard. Please support this podcast by checking out our sponsors:
– Brave: https://brave.com/lex
– Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil
– ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free
– Cash App: https://cash.app/ and use code LexPodcast to get $10

EPISODE LINKS:
Michael’s Twitter: https://twitter.com/michaelmina_lab
Michael’s Time article: https://time.com/5912705/covid-19-stop-spread-christmas/
Rapid Tests: https://www.rapidtests.org/

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) – Introduction
(07:28) – Interacting between viruses and bacteria
(11:42) – Deadlier viruses
(15:13) – Will COVID-19 mutate?
(16:47) – Rapid testing
(34:11) – PCR vs rapid antigen tests
(43:55) – Medical industrial complex
(47:47) – Lex takes COVID test
(54:32) – FDA and cheap tests
(57:17) – Explanation of Elon Musk’s positive COVID tests
(1:04:25) – Role of testing during vaccine deployment
(1:07:54) – Public health policy
(1:17:34) – A weather system for viruses
(1:34:26) – Can a virus kill all humans?
(1:40:05) – Engineering a deadly virus
(1:44:47) – AlphaFold 2 and viruses
(1:50:42) – Advice for young people
(1:58:50) – Time as a Buddhist monk
(2:04:54) – Meditation
(2:12:32) – Meaning of life

#145 – Matthew Johnson: Psychedelics Dec 14, 2020

Show notes

Matthew W. Johnson is a professor and psychedelics researcher at Johns Hopkins. Please support this podcast by checking out our sponsors:
– Brave: https://brave.com/lex
– Neuro: https://www.getneuro.com and use code LEX to get 15% off
– Four Sigmatic: https://foursigmatic.com/lex and use code LexPod to get up to 60% off
– Cash App: https://cash.app/ and use code LexPodcast to get $10

EPISODE LINKS:
Matt’s Twitter: https://twitter.com/Drug_Researcher
Matt’s Website: https://www.hopkinsmedicine.org/profiles/results/directory/profile/0800020/matthew-johnson
Study Website: https://hopkinspsychedelic.org/

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) – Introduction
(06:31) – Introduction to psychedelics
(22:33) – Psychedelics expand the mind
(25:44) – The priors we bring to the psychedelic experience
(29:40) – Elon Musk and first principles thinking
(40:10) – DMT
(51:32) – Joe Rogan and DMT
(57:40) – The nature of drug addiction
(1:11:29) – The economics of drug pricing
(1:17:44) – Should we legalize all drugs?
(1:29:46) – What is the most dangerous drug?
(1:32:20) – Does drug prohibition work?
(1:36:14) – Cocaine and sex
(1:43:15) – Risky sexual decisions
(1:54:12) – Psilocybin helping people quit smoking
(2:00:30) – Young Jamie
(2:22:38) – Participating in a study
(2:29:57) – Psychedelics and the human mind
(2:37:20) – The future of psychedelics
(2:40:01) – Neuralink
(2:49:33) – Consciousness
(3:02:15) – Panpsychism
(3:12:20) – Aliens and DMT
(3:22:24) – Mortality
(3:32:12) – Meaning of life

#144 – Michael Littman: Reinforcement Learning and the Future of AI Dec 13, 2020

Show notes

Michael Littman is a computer scientist at Brown University. Please support this podcast by checking out our sponsors:
– SimpliSafe: https://simplisafe.com/lex and use code LEX to get a free security camera
– ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free
– MasterClass: https://masterclass.com/lex to get 2 for price of 1
– BetterHelp: https://betterhelp.com/lex to get 10% off

EPISODE LINKS:
Michael’s Twitter: https://twitter.com/mlittmancs
Michael’s Website: https://www.littmania.com/
Michael’s YouTube: https://www.youtube.com/user/mlittman

OUTLINE:
Here’s the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.
(00:00) – Introduction
(07:43) – Robot and Frank
(10:02) – Music
(13:13) – Starring in a TurboTax commercial
(23:26) – Existential risks of AI
(41:48) – Reinforcement learning
(1:07:36) – AlphaGo and David Silver
(1:17:15) – Will neural networks achieve AGI?
(1:29:42) – Bitter Lesson
(1:42:32) – Does driving require a theory of mind?
(1:51:58) – Book Recommendations
(1:57:20) – Meaning of life

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