Journal of Clinical Oncology (JCO) Podcast

Latest Episodes:

Persistent Use of Opioids After Cancer Surgery Oct 19, 2017

Show notes

Though opioid abuse is clearly an issue for cancer patients post-surgery, many other potential factors were not accounted for and should be included in a more in-depth study that goes beyond database analysis.

Discussion on the Cost–Effectiveness Analysis of the CALGB/Alliance Trial and the Use of Zoledronic Acid Generic in Women With Metastatic Breast Cancer Oct 12, 2017

Show notes

The paper examines the cost-effectiveness of schedules of bone-modifying agents in patients with breast cancer and skeletal metastases and supports the 3-month administration of the generic zoledronic acid in terms of cost and efficacy.

Read the accompanying article on JCO.org.

Can We Simplify the Treatment of Myelofibrosis? Sep 21, 2017

Show notes

In this randomized trial, momelotinib was non-inferior to ruxolitinib for spleen response but was less effective in controlling symptoms.

Lessons to be Learned about the Significance of Educational Level in Adults with Acute Myeloid Leukemia Sep 11, 2017

Show notes

A Danish population based study of adults with acute myeloid leukemia is described, and the potential significance of educational level as a predictor of receipt of allogeneic transplant and overall survival is explored.

Read the associated article on JCO.org.

More Often but Not Early: Hospice Use Among Older Adults With AML Aug 17, 2017

Show notes

With a large database analysis, the authors found an increase in hospice use among older patients with AML at the end of life, but this increase was largely driven by late enrollment.

Read the associated article by Wang et al on JCO.org.

T-cell Therapy for Viral Infections after Stem Cell Transplant Aug 17, 2017

Show notes

T-cell therapies targeting viral diseases have evolved from a patient-specific therapy, targeting a single virus, and requiring multiple months of specialized manufacturing, to readily-available cell banks capable of targeting multiple viruses for many individuals.

Read the associated article by Tzannou et al on JCO.org.

Shared Risk Factors in Cancer and Cardiovascular Disease: Can We Make a Difference? Jul 12, 2017

Show notes

This podcast examines the growing evidence to support the link between risk factors for cardiovascular disease and cancer.

Should Metabolic Imaging to Assess Minimal Residual Disease (MRD) Become a Clinical Endpoint in Multiple Myeloma? Jul 07, 2017

Show notes

Normalization of PET-CT is a strong predictor for progression free survival (PFS) and overall survival (OS) in multiple myeloma (MM)

Considerations in Predicting Neuropsychological Outcomes in Children Treated for ALL Jul 03, 2017

Show notes

Randomization to different methotrexate and steroid treatment strategies was not related to neuropsychological outcome in children treated for B-ALL, but age and insurance status were significant predictors.

Read the associated article "Neurocognitive Functioning of Children Treated for High-Risk B-Acute Lymphoblastic Leukemia (HRALL) Randomized to Capizzi (CMTX) Versus High- Dose Methotrexate (HDMTX): A Report From the Children's Oncology Group (COG)" on JCO.org.

Low-Income Subsidy and Financial Barrier to Access Costly Oral Chemotherapy Drugs for Myeloma Patients Enrolled in Medicare Part D Jun 08, 2017

Show notes

This podcast summarizes the study finding and discuss the clinical and policy implication of an article to appear in JCO that examined the impact of low-income subsidy on the utilization, adherence, and costs of oral immunomodulatory drugs among elderly myeloma patients.

Read the article Subsidies for Oral Chemotherapy and Use of Immunomodulatory Drugs Among Medicare Beneficiaries with Myeloma by Olszewski et al.