JAMA Clinical Reviews

Latest Episodes:

Oral Antibiotics for Appendicitis Jan 11, 2021

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A new trial reports that a third of emergency department patients presenting with appendicitis admitted for oral antibiotic treatment had outcomes no different from those admitted for intravenous antibiotic treatment. Paulina Salminen, MD, PhD, professor of surgery at the University of Turku in Finland, discusses the findings.

Related Article(s):

Effect of Oral Moxifloxacin vs Intravenous Ertapenem Plus Oral Levofloxacin for Treatment of Uncomplicated Acute Appendicitis

Understanding the New SARS-CoV-2 Mutation Found in England Jan 08, 2021

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Gregory Armstrong, MD, director of the Advanced Molecular Detection Program for the CDC, explains what is currently known about the new mutations of SARS-CoV-2.

Next-Generation Sequencing of Infectious Pathogens

Next Generation Sequencing of Infectious Pathogens in Public Health and Clinical Practice

Understanding SARS-CoV-2 Genetic Variants

Next Generation Sequencing of Infectious Pathogens in Public Health and Clinical Practice (Repost) Jan 06, 2021

Show notes

Next-generation sequencing is a catchall term for new, high-throughput technologies that allow rapid sequencing of a full genome. It can be used to sequence a patient's DNA in diagnosing a genetic disorder or characterizing a cancer, but it can also be used to sequence the genome of a pathogenic bacteria, virus, fungi, or parasites. In this JAMA clinical review podcast, we talk with authors Marta Gwinn, MD, MPH, and Gregory L. Armstrong, MD, from the CDC, about how next-generation sequencing of infectious pathogens is being implemented in clinical practice and in public health surveillance for infectious disease.

Related Article(s):

Next-Generation Sequencing of Infectious Pathogens

Podcast originally published 2/14/19.

COVID-19 Vaccine Safety–Anaphylaxis and Allergic Reactions Jan 06, 2021

Show notes

Tom Shimabukuro, MD, MPH, MBA, and Sara Mbaeyi, MD, MPH, from the CDC discuss rare allergic complications in patients who received the first dose of the Pfizer-BioNTech vaccine between December 14-23, 2020.

Patent Foramen Ovale and Secondary Stroke Prevention Jan 05, 2021

Show notes

Patent foramen ovale (PFO) is an often overlooked cause of acute ischemic stroke. JAMA Associate Editor Jeffrey Saver, MD, professor of neurology at UCLA, discusses new recommendations from a 2020 AAN Practice Advisory about use of mechanical PFO closure and anticoagulant vs antiplatelet therapy to prevent subsequent strokes in patients with a PFO and an initial event.

Management of Patients With a Patent Foramen Ovale With History of Stroke or TIA

Crohn Disease Management Jan 05, 2021

Show notes

New therapies have greatly improved outcomes for patients with Crohn disease. Peter Higgins, MD, from the University of Michigan, discusses advances in management and treatment protocols.

Related Article: Management of Crohn Disease

Understanding SARS-CoV-2 Genetic Variants Dec 31, 2020

Show notes

Adam Lauring, MD, PhD, from the University of Michigan Division of Infectious Diseases, an expert on the evolutionary biology of RNA viruses, explains the new genetic variants recently found in SARS-CoV-2 and their importance.

Nursing Homes and COVID-19 Dec 30, 2020

Show notes

Elderly persons and residents of nursing homes have been the hardest hit in the COVID-19 pandemic. Harvard geriatrician Sharon Inouye, MD, discusses the effect COVID-19 has had on nursing homes and what should be done about it.

Association of Nursing Home Ratings on Health Inspections, Quality of Care, and Nurse Staffing With COVID-19 Cases

Managing Chronic Medical Conditions for Homeless Patients Presenting to the Emergency Department Dec 22, 2020

Show notes

Homeless patients with chronic medical conditions who need long-term care often repeatedly present to emergency departments to receive treatment. Following a performance improvement analysis, clinicians at UCSF developed an emergency department–based team who work with the community to provide care for this challenging population. Hemal Kanzaria, MD, and Jack Chase, MD, discuss how UCSF has addressed this clinical problem.

Related Article(s):

Caring for Emergency Department Patients With Complex Medical, Behavioral Health, and Social Needs

Parental Relationships with Children During COVID-19 Pandemic-Related Lockdowns Dec 15, 2020

Show notes

JAMA Fishbein Fellow Kristin Walter, MD, interviews Craig Garfield, MD and Richard Weissbourd, EdD, about parental relationships during the COVID-19 pandemic.

Related Article(s):

Considerations for Young Children and Those With Special Needs as COVID-19 Continues

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