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    Health & Fitness

    JACC Specialty Journals

    In this podcast series, editors-in-chief from the JACC family of specialty journals provide highlights and summarize key findings for select issues. Published by the American College of Cardiology, the JACC Journals publish peer-reviewed articles on all aspects of cardiovascular disease, including original clinical studies, translational investigations with clear clinical relevance, state-of-the art papers, and review articles. They are top ranked for impact factor and their manuscripts are among the most covered by media outlets, most talked about on social media, and most read online.

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    Latest Episodes:
    A 4-Decade Population-Based Registry of Thoracic Aortic Dissection Causing Sudden Death in the Young | JACC: Advances Feb 25, 2026
    Show notes

    Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on A 4-Decade Population-Based Registry of Thoracic Aortic Dissection Causing Sudden Death in the Young.

    Long-Term Cardiovascular Health Trajectories Associated With Cardiovascular Disease and Mortality in Older Adults | JACC: Advances Feb 25, 2026
    Show notes

    Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Long-Term Cardiovascular Health Trajectories Associated With Cardiovascular Disease and Mortality in Older Adults.

    Risk Score Development to Predict Postpartum Cardiovascular Disease Incorporating Pregnancy and Nonpregnancy Factors: A Canada-Wide Study | JACC: Advances Feb 25, 2026
    Show notes

    Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Risk Score Development to Predict Postpartum Cardiovascular Disease Incorporating Pregnancy and Nonpregnancy Factors: A Canada-Wide Study.

    Increasing Awareness and Reducing Occupational Hazards in the Cardiac Catheterization and Electrophysiology Laboratories: Working to Eliminate Lead and Complications of Radiation in Cardiovascular Team Study | JACC: Advances Feb 25, 2026
    Show notes

    Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Increasing Awareness and Reducing Occupational Hazards in the Cardiac Catheterization and Electrophysiology Laboratories: Working to Eliminate Lead and Complications of Radiation in Cardiovascular Team Study.

    Multisite, External Validation of an AI-Enabled ECG Algorithm for Detection of Low Ejection Fraction | JACC: Advances Feb 25, 2026
    Show notes

    Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Multisite, External Validation of an AI-Enabled ECG Algorithm for Detection of Low Ejection Fraction.

    Device-Removal, Reinfection, and Mortality After Staphylococcus aureus Bacteremia in Patients With Cardiac Implantable Electronic Devices | JACC: Advances Feb 25, 2026
    Show notes

    Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Device-Removal, Reinfection, and Mortality After Staphylococcus aureus Bacteremia in Patients With Cardiac Implantable Electronic Devices.

    The Transmural Activation Interval in Dilated Cardiomyopathy: A New Mapping Tool for Intramural VT Substrates | JACC: Clinical Electrophysiology Feb 18, 2026
    Show notes

    Commentary by JACC: Clinical Electrophysiology Deputy Editor Francis Marchlinski, MD.

    Polygenic risk for cardiometabolic and cardiovascular disease in a multi-ethnic cohort of breast cancer survivors | JACC: CardioOncology Feb 17, 2026
    Show notes

    Polygenic risk scores showed associations with several cardiometabolic outcomes in breast cancer survivors but did not improve prediction beyond traditional clinical factors. Their performance varied across ancestry groups and was weakened in patients exposed to cardiotoxic therapies, highlighting limits of current genetic risk tools.

    Atrial Fibrillation Following Autologous Stem Cell Transplantation in Multiple Myeloma: Incidence, Predictors, and Prognostic Impact | JACC: CardioOncology Feb 17, 2026
    Show notes

    This study of 801 multiple myeloma patients found that atrial fibrillation occurred in 5.5% within 90 days after autologous stem cell transplantation—nearly double previously reported rates—indicating disease‑specific risks. AF strongly predicted mortality from non‑relapse causes and may serve as a marker of physiological vulnerability, emphasizing the value of expanded pre‑transplant cardiac assessment and monitoring.

    CRISPR/Cas9 screens implicate RARA and SPNS1 in doxorubicin cardiotoxicity | JACC: CardioOncology Feb 17, 2026
    Show notes

    Researchers used genome‑wide CRISPR/Cas9 loss‑of‑function screens in cardiomyocytes to identify RARA and SPNS1 as key modulators of doxorubicin cardiotoxicity, highlighting pathways that influence both injury susceptibility and intracellular drug handling. Activation of RARA reduced toxicity without impairing anticancer effects, while SPNS1 loss caused harmful drug accumulation, offering new mechanistic insights and potential therapeutic targets.

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