Infectious Disease Puscast

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Infectious Disease Puscast #27 May 02, 2023

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On episode #27 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 4/13 – 4/25/23.

Hosts: Daniel Griffin and Sara Dong

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Prevalence, clinical severity, and seasonality of Adenovirus 40/41, Astrovirus, Sapovirus, and Rotavirus among children with moderate-to severe diarrhea (CID)
Antibiotic-prescribing practices for management of childhood diarrhea in 3 sub-Saharan African countries (CID)
Drivers of decline in diarrhea mortality (CID)
Breastfeeding among people with HIV in North America (CID)
Wearable sensor-based detection of Influenza in presymptomatic and asymptomatic individuals (JID)
Emergence of erythromycin-resistant invasive group a Streptococcus (EID)
Piperacillin-Tazobactam compared With Cefoxitin as antimicrobial prophylaxis for pancreatoduodenectomy (JAMA)
VE303 for prevention of recurrent Clostridioides difficile infection (JAMA)
Geographic patterns of antimicrobial susceptibilities for Bacteroides species worldwide (IJAA)
Intravenous to oral antibiotic switch therapy among patients hospitalized with community-acquired pneumonia (CID)
Clinical impact of syndromic molecular point-of-care testing for gastrointestinal pathogens in adults hospitalized with suspected gastroenteritis (The Lancet)
Treatment of pulmonary mucormycosis with adjunctive nebulized amphotericin B (Mycoses)
Giardia detection and codetection with other enteric pathogens in children in the vaccine impact on diarrhea in Africa (CID)
Feasibility of training community health workers to use smartphone-attached microscopy for point-of-care visualization of soil-transmitted helminths (AJTMH)
Compassionate use of bacteriophages for failed persistent infections (OFID)

Music is by Ronald Jenkees

Infectious Disease Puscast #26 Apr 19, 2023

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On episode #26 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 3/30 – 4/12/23.

Hosts: Daniel Griffin and Sara Dong

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Fatal rabies infection with failure of post-exposure prophylaxis following a zoonotic exposure (CID)
Bivalent perfusion F vaccine in pregnancy to prevent RSV in infants (NEJM)
Adeno-associated virus type 2 in US children with severe hepatitis (Nature)
Genomic investigations of unexplained hepatitis in children (Nature)
Antiretroviral treatment of HIV/AIDS during pregnancy (JAMA)
Rapid PCR for respiratory viruses reduces time to result and improves clinical care (JOI)
Postexposure doxycycline to prevent bacterial sexually transmitted infection (NEJM)
Survey on antimicrobial resistance genes of used probiotic bacteria (EURO)
Structured immune work-up in healthy children with episode of severe bacterial infection (JID)
Antibiotic prescribing in U.S. nursing homes (JID)
Syndromic panel testing among patients with infectious diarrhea (OFID)
Early predictors of infected pancreatic necrosis in severe pancreatitis (DD)
Management of nontuberculous mycobacteria in lung transplant cases (ERJ)
Impact of extended-infusion piperacillin-tazobactam (Infectious Medicine)
Camber Pharmaceuticals issues nationwide recall of atovaquone oral suspension due to potential Bacillus cereus contamination (FDA)
Cluster of Blastomycosis among neighborhood residents (CDC)
Risk factors for late-onset Pneumocystis jirovecii pneumonia in liver transplant recipients (IJID)
Hyponatremia predicts cryptococcal meningitis and mortality in HIV-Positive asymptomatic individuals with cryptococcal antigenemia (OFID)
Investigation of donor-derived Strongyloides stercoralis infection in multiple solid organ transplant recipients (TID)
Promising new malaria vaccine for kids approved in Ghana (AP)

Music is by Ronald Jenkees

Infectious Disease Puscast #25 Apr 04, 2023

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On episode #25 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 3/23 – 3/29/23.

Hosts: Daniel Griffin and Sara Dong

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Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates (Nature)
First evidence of locally acquired Dengue infection (CDC)
Respiratory viral infections in recipients of cellular therapies (OFID)
Evolving Japanese encephalitis situation in Australia (JTM)
Attainment of target antibiotic levels by oral treatment of left-sided infective endocarditis (CID)
Utility of PCR vs serology based testing in immunocompromised patients with Bartonella (OFID)
Source-associated mobile genetic elements to identify zoonotic coli infections (OneHealth)
The risk of urinary tract infection in vegetarians and non-vegetarians (Nature)
Hydrocortisone in severe community acquired pneumonia (NEJM)
Adjunctive dexamethasone treatment in adults with Listeria monocytogenes meningitis (The Lancet)
Worsening spread of Candida auris in the United States (AIM)
Origin, resistance, and spread of the emerging human fungal pathogen Candida auris (PLOS)
Emergence of Candida auris (mBio)
Invasive aspergillosis in liver transplant recipients (Transplant ID)
Trends in reported babesiosis cases (CDC)
PCR assay for diagnosis of tick-borne infections in children (OFID)
Molecular evidence of widespread benzimidazole drug resistance in Ancylostoma caninum (PLOS)
Emphasis of diversity, equity and inclusion on U.S Adult Infectious Disease Fellowship program websites (JID)

Music is by Ronald Jenkees

Infectious Disease Puscast #24 Mar 21, 2023

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On episode #24 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 3/1 – 3/22/23.

Hosts: Daniel Griffin and Sara Dong

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Re-emergence of Parechovirus: 2017-2022 national trends of detection in CSF (OFID)
Screening and testing for hepatitis B virus infection (CDC)
Changing epidemiology of carbapenemases among carbapenem-Resistant Enterobacterales (OFID)
Comparison of a short vs long-course antibiotic therapy for ventilator-associated pneumonia (eClinicalMedicine)
The impact of timing of infectious disease consultation for Staphylococcus aureus bacteremia (CID)
Intravenous doxycycline, azithromycin, or both for severe scrub typhus (NEJM)
Cronobacter sakazakii infections in two infants linked to powdered infant formula and breast pump equipment (CDC)
Piperacillin/tazobactam vs cefepime or carbapenems for cefoxitin-non-susceptible bacteraemia in immunocompromised patients (JAC)
Positive impact of [18F) FDG-PET/CT on mortality in patients with Staphylococcus aureus bacteremia (CID)
Association of antibody immunity with cryptococcal antigenemia and mortality in a South African cohort with advanced HIV (CID)
Practical guide to antifungal susceptibility testing (JPIDS)
Risk of COVID-19 associated pulmonary aspergillosis based on corticosteroid duration in ICU patients (OFID)
Emergence and Persistence of Candida auris in Western New York with no epidemiologic links (OFID)

Music is by Ronald Jenkees

Infectious Disease Puscast #23 Mar 07, 2023

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On episode #23 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 2/16 – 2/28/23.

Hosts: Daniel Griffin and Sara Dong

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Association between cytomegalovirus infection and tuberculosis disease (JID)
In-depth virological and immunological characterization of HIV-1 cure after allogeneic hematopoietic stem cell transplantation (Nature)

Algorithm-based Clostridioides difficile testing as a tool for antibiotic stewardship(CMI)

Clinical utility of nasal surveillance swabs in ruling-out MRSA infections in children (JPIDS)
Antimicrobial for 7 or 14 days for febrile UTI in men (CID)
Treatment strategy for rifampin-susceptible TB (NEJM)
Current pyuria cut-offs promote inappropriate UTI diagnosis in older women (CID)
Efficacy of doxycycline for mild-to-moderate community-acquired pneumonia in adults (CID)
Hospitalizations for unspecified mycoses and implications for fungal disease burden estimates (OFID)
Invasive mold infections following Hurricane Harvey (OFID)
Cryptococcal meningitis and clinical outcomes in persons with HIV (CID)
Rapid range shifts in African Anopheles mosquitoes over the last century (Biology Letters)
Neuroangiostrongyliasis: Rat lungworm invades Europe (ASTMH)
Balamuthia mandrillaris encephalitis presenting as a symptomatic focal hypodensityin an immunocompromised patient (OFID)
Low rates of antibiotics prescribed during telehealth primary-care visits persisted during COVID19 (ICHE)

Music is by Ronald Jenkees

Infectious Disease Puscast #22 Feb 21, 2023

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On episode #22 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 2/2 – 2/15/23.

Hosts: Daniel Griffin and Sara Dong

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Influence of rapid influenza diagnostic testing on clinician decision-making for patients with acute respiratory infection (CID)
Outbreak of extensively drug-resistant Pseudomonas aeruginosa (CDC)
Epidemiology and clinical outcomes of non-HACEK gram-negative infective endocarditis (OFID)
Azithromycin to prevent sepsis or death in women planning a vaginal birth (NEJM)
Clinical significance of concomitant bacteruria in patients with Staphylococcus aureus bacteremia (EJCM)
Health disparities in hemodialysis associated Staph aureus bloodstream infections (CDC)
Sequential oral antibiotic in uncomplicated Staphylococcus aureus bacteremia (CMI)
Genome-wide analysis of transposon mobility in the human fungal pathogen Cryptococcus deneoformans (PNAS)
Prevalence of ocular candidiasis and Candida endophthalmitis in patients with candidemia (CID)
Prevalence of Ocular Complications in candidemia (CID)
Rapid and spontaneous post-partum clearance of Plasmodium falciparum (JID)
Adoption and utilization of social media among adult and pediatric infectious diseases divisions and fellowship programs (OFID)
Canine detection of chronic wasting disease in laboratory and field settings (Prion)

Music is by Ronald Jenkees

Infectious Disease Puscast #21 Feb 06, 2023

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On episode #21 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 1/18/23 – 2/1/23.

Hosts: Daniel Griffin and Sara Dong

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The impact of cold temperature in the pattern of influenza virus infection (OFID)
Janssen to discontinue Phase 3 Mosaico HIV vaccine clinical trial (JNJ)
Randomized trial of vaccines for Zaire Ebola virus disease (NEJM)
PD-1 blockade and lenalidomide combination therapy for Epstein-Barr virus infection (CMI)
Outcomes of Daptomycin plus Ceftaroline vs alternative therapy for persistent MRSA bacteremia (IJAA)
Detection of a novel strain of multidrug-non-susceptible Neisseria gonorrhoeae (The Lancet)
Impact of a device to reduce blood culture contamination and false-positive central-line bloodstream infections (ICHE)
Addition of anaerobic coverage for treatment of biliary tract infections (JAC)
High dose Cefepime vs Carbapenems for bacteremia caused by Enterobacterales(OFID)
Assessing the diagnostic performance of IGRAs for Mycobacterium tuberculosis (CID)
Infective endocarditis after transcatheter aortic valve replacement (JACC)
Discordant clinical and microbiological outcomes are associated with late clinical relapse in clinical trials for complicated UTIs (CID)
Real-world use of bezlotoxumab and fecal microbiota transplantation for the treatment of Cdiff (OFID)
Blastomycosis in New England (OFID)
Management of invasive candidiasis in hematopoietic cell transplant recipients (TCT)
Short course of Antifungal therapy in patients with uncomplicated Candida Bloodstream infection (OFID)
Parasites and childhood stunting (Cell)
Comparing complication rates of midline catheter vs. PICC line (OFID)
Novel prion strain as the cause of chronic wasting disease in a moose (EID)
Agreement of respiratory viruses' detection between nasopharyngeal swab and bronchoalveolar lavage in adults with pneumonia (CMI)

Music is by Ronald Jenkees

Infectious Disease Puscast #20 Jan 25, 2023

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On episode #20 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 1/4/23 – 1/17/23.

Hosts: Daniel Griffin and Sara Dong

Click arrow to play Download Puscast 019 (17 MB .mp3, 29 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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Links for this episode

Neuroinvasive West Nile infection in solid organ transplant recipients (TID)
Clinical markers of post-Chikungunya chronic inflammatory joint disease (PLOSNTD)
Cholera outbreak in Haiti (CDC)
Legionella bononiensis isolated from a hotel water in Nothern Italy (MS)
Contemporary pharmacotherapies for nontuberculosis mycobacterial infections (IDT)
Defining the optimal duration of therapy for hospitalized patients with UTIs and Bacteremia (CID)
Fidaxomicin to prevent recurrent Clostridioides difficile (JAC)
Evaluating predictive value of resected proximal bone margins in Diabetic Foot Osteomyelitis(OFID)
Postoperative inflammation and fever after elective aortic valve and aortic root replacement (OFID)
Fungal nomenclature: managing change is the name of the game (OFID)
Clinical microbiology laboratories should use nomenclature based on current taxonomy (JCM)
Race and ethnicity: risk factors for fungal infections (PLOS)
Mosquito net use in early childhood and survival to adulthood in Tanzania (NEJM)
Probiotic for pathogen-specific Staphylococcus aureus decolonisation in Thailand (The Lancet)

Music is by Ronald Jenkees

Infectious Disease Puscast #19 Jan 10, 2023

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On episode #19 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 12/22/22 – 1/3/23.

Hosts: Daniel Griffin and Sara Dong

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Links for this episode

Burden of postinfectious symptoms after Acute Dengue (EID)
Maribavir for CMV treatment in the real world (OFID)
24-Week all-oral regimen for Rifampin-Resistant Tuberculosis (NEJM)
Beta lactam allergy association with surgical site infections (JPIDS)
Effect of Macrolides on mortality in Bacteremic Pneumonia (CID)
Association of repeated blood cultures with mortality in adult patients with Gram-Negative Bacilli Bacteremia (OFID)
Evaluating predictive value of surgical resected proximal bone margins in Diabetic foot Osteomyelitis with clinical outcomes (OFID)
Burden of serious Fungal Infections in India (OFID)
Bartonella quintana transmitted by head lice (CID)
Balamuthia mandrillaris Granulomatous Amoebic Encephalitis (JPIDS)
Detecting Leishmania in dogs (PLOS NTD)
Primer on home infusion administration methods (OFID)
Biomarkers of infection or sepsis at the bedside (ICM)
Implementation roadmap for establishing remote infectious disease specialist support in resource-limited settings (OFID)
Perceptions and reality of antimicrobial prescribing during the transition to comfort measures (OFID)
Can the future of ID escape the inertial dogma of its past? (OFID

Music is by Ronald Jenkees

Infectious Disease Puscast #18 Dec 27, 2022

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On episode #18 of the Infectious Disease Puscast, Daniel and Sara review the infectious disease literature for the previous two weeks, 12/9/22 – 12/21/22.

Hosts: Daniel Griffin and Sara Dong

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Links for this episode

Human Rabies in Texas, 2021 (CDC)
Human rabies despite post-exposure prophylaxis (The Lancet)
The Qatar FIFA World Cup 2022 and camel pageant championships increase risk of MERS-CoV transmission and global spread (The Lancet)
An update on eukaryotic viruses revived from ancient permafrost (bioRx)
Colistin monotherapy vs combination therapy for carbapenem-resistant organisms (NEJM)
Outcomes of Ceftriaxone vs antistaphylococcal Penicillins or Cefazolin for definitive therapy of Methicillin-susceptible Staphylococcus aureus bacteremia (OFID)
Salmonella enteritidis cardiovascular implantable electronic device infection (OFID)
Evaluation of serotonin syndrome with Linezolid and serotonergic agents at an academic medical center (OFID)
Preemptive antifungal therapy for the prevention of invasive candidiasis following gastrointestinal surgery for Intra-abdominal infections (CID)
Risk factors and outcomes of invasive aspergillosis in kidney transplant recipients (CID)
Predictive performance of gram staining of catheter tips for Candida catheter-related bloodstream infections (OFID)
Integrative genetic manipulation of Plasmodium cynomolgireveals multidrug resistance-(JID)
Clinical characteristics of patients with calcified parenchymal neurocysticercosis and perilesional edema (OFID)
Impact of sequestration on artemisinin-induced parasite clearance in Plasmodium falciparum malaria in Africa (CID)
Factors contributing to delayed academic advancement of women in infectious diseases (OFID)
Characterization of problematic alcohol use among physicians (JAMA)
Alpha-gal syndrome in the ID clinic (OFID)
Efficacy and safety of Azithromycin vs placebo to treat lower respiratory tract infections associated with low procalcitonin (The Lancet)

Music is by Ronald Jenkees

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