IMA (Formerly FLCCC Alliance)

Latest Episodes:

DrBeen#54 Berberine Treats Atherosclerosis via a Vitamin Like Effect Jul 05, 2023

Show notes

DrBeen#54 Berberine Treats Atherosclerosis via a Vitamin Like Effect

Berberine Treats Atherosclerosis in Humans (Small Study)

In this amazing study the researchers demonstrate how berberine was able to reduce atherosclerotic plaque when administered for 4 months. Let's review.

DrBeen: Medical Education Online
https://www.drbeen.com/

FLCCC | Front Line COVID-19 Critical Care Alliance
https://covid19criticalcare.com/

References (April 20, 2023):
Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota | Signal Transduction and Targeted Therapy
https://www.nature.com/articles/s41392-022-01027-6#ethics

Shimadzu (China) Co., Ltd. Exhibited at the China International Import Expo | SHIMADZU TODAY | SHIMADZU CORPORATION
https://www.shimadzu.com/today/20211220-1.html

Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

DrBeen#53 Hyperinsulinemia - Cause or Consequence Jul 05, 2023

Show notes

DrBeen#53 Hyperinsulinemia - Cause or Consequence

In this amazing lecture Dr. Barbara E. Corkey presents the paradigm of hyperinsulenemia leading to insulin resistance, which in turn contributes to diabetes mellitus and obesity. Let's review this Banting awarded lecture.

Banting Lecture 2011 | Diabetes | American Diabetes Association
https://diabetesjournals.org/diabetes/article/61/1/4/15978/Banting-Lecture-2011Hyperinsulinemia-Cause-or

Dr. Been: www.drbeen.com
FLCCC: www.flccc.net

URL list Monday, Apr. 10, 2023

Frederick Banting - Wikipedia
https://en.wikipedia.org/wiki/Frederick_Banting

Barbara Corkey | Chobanian & Avedisian School of Medicine
https://www.bumc.bu.edu/busm/profile/barbara-corkey/

Banting Lecture 2011 | Diabetes | American Diabetes Association
https://diabetesjournals.org/diabetes/article/61/1/4/15978/Banting-Lecture-2011Hyperinsulinemia-Cause-or

Insulin Resistance & Prediabetes - NIDDK
https://www.niddk.nih.gov/health-information/diabetes/overview/what-is-diabetes/prediabetes-insulin-resistance

Banting Lecture 2011 | Diabetes | American Diabetes Association
https://diabetesjournals.org/diabetes/article/61/1/4/15978/Banting-Lecture-2011Hyperinsulinemia-Cause-or

Bariatric Surgery for Type 2 Diabetes Reversal: The Risks | Diabetes Care | American Diabetes Association
https://diabetesjournals.org/care/article/34/Supplement_2/S361/28238/Bariatric-Surgery-for-Type-2-Diabetes-Reversal-The

Bariatric Surgery to Treat Type 2 Diabetes
https://my.clevelandclinic.org/health/treatments/21153-bariatric-weight-loss-surgery-for-treating-diabetes

Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report | Diabetes Care | American Diabetes Association
https://diabetesjournals.org/care/article/42/5/731/40480/Nutrition-Therapy-for-Adults-With-Diabetes-or

International Experts Outline Diabetes Remission Diagnosis Criteria | ADA
https://diabetes.org/newsroom/press-releases/2021/international-experts-outline-diabetes-remission-diagnosis-criteria

Nutritional basis of type 2 diabetes remission | The BMJ
https://www.bmj.com/content/374/bmj.n1449

Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin - PubMed
https://pubmed.ncbi.nlm.nih.gov/30301822/

Case Report: Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194375/

Insights from a general practice service evaluation supporting a lower carbohydrate diet in patients with type 2 diabetes mellitus and prediabetes: a secondary analysis of routine clinic data including HbA1c, weight and prescribing over 6 years - PubMed
https://pubmed.ncbi.nlm.nih.gov/33521540/

HbA1c Calculator - HbA1c
https://www.hba1cnet.com/hba1c-calculator/

Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial - PubMed
https://pubmed.ncbi.nlm.nih.gov/29221645/

Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial - CORE Reader
https://core.ac.uk/reader/196576423

(19) Reversing Type 2 Diabetes | Jason Fung - YouTube
https://www.youtube.com/watch?v=6KS7M0s2fJM

DrBeen#52 Epstein Barr Virus (EBV) Reactivation in Long COVID Jul 05, 2023

Show notes

DrBeen#52 Epstein Barr Virus (EBV) Reactivation in Long COVID

Your long COVID symptoms may be due to the latent virus reactivation, especially Epstein Barr Virus (EBV) reactivation. Let's review some studies.

DrBeen: Medical Education Online
https://www.drbeen.com/

FLCCC | Front Line COVID-19 Critical Care Alliance
https://covid19criticalcare.com/

URL list from Thursday, Apr. 6 2023

Stress-Induced Epstein-Barr Virus Reactivation - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470332/#:~:text=Overview%20of%20EBV%20Reactivation%20and%20the%20Lytic%20Cycle,%2C%20and%20late%20%5B56%5D.

The prevalence and long-term health effects of Long Covid among hospitalised and non-hospitalised populations: a systematic review and meta-analysis - eClinicalMedicine
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(22)00491-6/fulltext

Investigation of Long COVID Prevalence and Its Relationship to Epstein-Barr Virus Reactivation - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233978/

Positive Epstein–Barr virus detection in coronavirus disease 2019 (COVID-19) patients | Scientific Reports
https://www.nature.com/articles/s41598-021-90351-y

Frontiers | Saliva antibody-fingerprint of reactivated latent viruses after mild/asymptomatic COVID-19 is unique in patients with myalgic-encephalomyelitis/chronic fatigue syndrome
https://www.frontiersin.org/articles/10.3389/fimmu.2022.949787/full

JCI - Chronic viral coinfections differentially affect the likelihood of developing long COVID
https://www.jci.org/articles/view/163669

COVID isn't just infecting you—it could be reactivating viruses that have been dormant in your body for years | Fortune Well
https://fortune.com/well/2022/12/26/is-long-covid-chronic-fatigue-syndrome-myalgic-encephalomyelitis/

SARS-CoV-2 infection triggers reactivation of latent viruses in people with chronic fatigue syndrome
https://www.news-medical.net/news/20221116/SARS-CoV-2-infection-triggers-reactivation-of-latent-viruses-in-people-with-chronic-fatigue-syndrome.aspx

Impact of Pre-Existing Chronic Viral Infection and Reactivation on the Development of Long COVID - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9327632/

Long COVID: major findings, mechanisms and recommendations | Nature Reviews Microbiology
https://www.nature.com/articles/s41579-022-00846-2

Impact of Pre-Existing Chronic Viral Infection and Reactivation on the Development of Long COVID | medRxiv
https://www.medrxiv.org/content/10.1101/2022.06.21.22276660v2

What Have We Learned about Long COVID? | Columbia University Irving Medical Center
https://www.cuimc.columbia.edu/news/what-have-we-learned-about-long-covid

Donate to the Front Line Covid-19 Critical Care Alliance, Inc.
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DrBeen# 51 Alcohol, Chronic Stress, and Brain Health Jul 05, 2023

Show notes

DrBeen# 51 Alcohol, Chronic Stress, and Brain Health

Chronic stress and a high amount of alcohol consumption can cause disruption of the glymphatic system of the brain. This disruption can in turn lead to progression of Alzheimer's Disease and deterioration of other executive functions of the brain. Let's review the last instalment of this series.

DrBeen: Medical Education Online
https://www.drbeen.com/

FLCCC | Front Line COVID-19 Critical Care Alliance
https://covid19criticalcare.com/

URL list from Monday, Mar. 23 2023

The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698404/

Donate to the Front Line Covid-19 Critical Care Alliance, Inc.
To educate medical professionals and the public in safe and effective ways to prevent and treat COVID-19. Click here to make a donation:
https://frontlinecovid-19criticalcarealliance.salsalabs.org/donate/index.html

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https://supportflccc.store/

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alcohol brain health dr been flccc long story short

DrBeen#50 Omega-3 and Exercise for Brain Health Jul 05, 2023

Show notes

DrBeen#50 Omega-3 and Exercise for Brain Health Continuing with our series about brain health and lifestyle choices, today we will discuss omega-3 fish oil and exercise. Omega-3 fish oil or omega-3 polyunsaturated fatty acids (n3-PUFA) have a rich presence in our brain tissue. n3-PUFA helps keep astrocyte from becoming activated. Hence, it reduces inflammation in the brain and also keeps aquaporin 4 (AQP4) channels polarized and on the foot processes of the astrocytes. The result is a better glymphatic flow, which washes away more beta amyloids and helps protect or stall the progress of dementia.

DrBeen: Medical Education Online
https://www.drbeen.com/

FLCCC | Front Line COVID-19 Critical Care Alliance
https://covid19criticalcare.com/

URL list from Monday, Mar. 23 2023

The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698404/

Sleep well — and reduce your risk of dementia and death - Harvard Health
https://www.health.harvard.edu/blog/sleep-well-and-reduce-your-risk-of-dementia-and-death-2021050322508

APOE ε4, Alzheimer’s disease neuropathology and sleep disturbance, in individuals with and without dementia | Alzheimer's Research & Therapy | Full Text
https://alzres.biomedcentral.com/articles/10.1186/s13195-022-00992-y

N3 Phase of Sleep.
https://chat.openai.com/chat

Understanding Delta Brain Waves And Sleep
https://www.sixstepstosleep.com/understanding-delta-brain-waves/

N3: Slow Wave Sleep | Sleepopolis
https://sleepopolis.com/education/n3-slow-wave-sleep/

Stage N3 of sleep. Delta waves on EEG recordings are observed. | Download Scientific Diagram
https://www.researchgate.net/figure/Stage-N3-of-sleep-Delta-waves-on-EEG-recordings-are-observed_fig4_280558638

A 30-second Epoch consisting of the parameters of staging sleep... | Download Scientific Diagram
https://www.researchgate.net/figure/4-A-30-second-Epoch-consisting-of-the-parameters-of-staging-sleep-electroencephalogram_fig4_282014972

Hallmark of Stage N3 (slow-wave sleep or Stages 3 and 4 sleep: delta... | Download Scientific Diagram
https://www.researchgate.net/figure/Hallmark-of-Stage-N3-slow-wave-sleep-or-Stages-3-and-4-sleep-delta-waves_fig1_5812861

Frontiers | Perivascular Spaces, Glymphatic System and MR
https://www.frontiersin.org/articles/10.3389/fneur.2022.844938/full

Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology | SpringerLink
https://link.springer.com/article/10.1007/s00234-021-02718-7

Frontiers | Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous System
https://www.frontiersin.org/articles/10.3389/fnana.2020.00017/full

Neuroglia Lab : Glymphatics and virchow-robin space
http://visnu528.blogspot.com/2014/09/glymphatics-and-virchow-robin-space.html

Physiology and Clinical Relevance of Enlarged Perivascular Spaces in the Aging Brain | Neurology
https://n.neurology.org/content/98/3/107

Aquaporin-4 - Wikipedia
https://en.wikipedia.org/wiki/Aquaporin-4

Astrocyte - Wikipedia
https://en.wikipedia.org/wiki/Astrocyte

Neurocytology-Astrocytes
https://neuropathology-web.org/chapter1/chapter1bAstrocytes.html#:~:text=Astrocytic%20foot%20processes%20surround%20brain,maintains%20homeostasis%20in%20the%20CNS.

Blood-brain barrier | RIT
https://www.rit.edu/spotlights/blood-brain-barrier

The Blood-Brain Barrier | Morphology of Nervous System
https://sisu.ut.ee/histology/blood-brain-barrier

Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier | Fluids and Barriers of the CNS | Full Text
https://fluidsbarrierscns.biomedcentral.com/articles/10.1186/s12987-018-0113-6

Disclaimer:
As previous

DrBeen#49 Norepinephrine, Glymphatic System, and Brain Health Jul 04, 2023

Show notes

DrBeen#49 Norepinephrine, Glymphatic System, and Brain Health

During the wakeful hours, the production of norepinephrine increases. This increase helps with alertness, but also causes vasoconstriction. The outcome is a reduction in the interstitial fluid levels and reduction in the clearance of waste products. During sleep, NE levels reduce, reversing the above mentioned mechanisms, leading to more interstitial fluid movement and more glymphatic clearance of the waste products and better brain health.

DrBeen: Medical Education Online
https://www.drbeen.com/

FLCCC | Front Line COVID-19 Critical Care Alliance
https://covid19criticalcare.com/

URL list from Monday, Feb. 20 2023

The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698404/

Norepinephrine: What It Is, Function, Deficiency & Side Effects
https://my.clevelandclinic.org/health/articles/22610-norepinephrine-noradrenaline#:~:text=What%20does%20norepinephrine%20do%20in,pressure%20in%20times%20of%20stress.

Frontiers | Locus Coeruleus Norepinephrine in Learned Behavior: Anatomical Modularity and Spatiotemporal Integration in Targets
https://www.frontiersin.org/articles/10.3389/fncir.2021.638007/full#:~:text=The%20locus%20coeruleus%20(LC)%2C,%2C%20cerebellum%2C%20and%20spinal%20cord.

fncir-15-638007-g001.jpg (1700×984)
https://www.frontiersin.org/files/Articles/638007/fncir-15-638007-HTML/image_m/fncir-15-638007-g001.jpg

Sleep well — and reduce your risk of dementia and death - Harvard Health
https://www.health.harvard.edu/blog/sleep-well-and-reduce-your-risk-of-dementia-and-death-2021050322508

N3 Phase of Sleep.
https://chat.openai.com/chat

Understanding Delta Brain Waves And Sleep
https://www.sixstepstosleep.com/understanding-delta-brain-waves/

N3: Slow Wave Sleep | Sleepopolis
https://sleepopolis.com/education/n3-slow-wave-sleep/

Frontiers | Perivascular Spaces, Glymphatic System and MR
https://www.frontiersin.org/articles/10.3389/fneur.2022.844938/full

Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology | SpringerLink
https://link.springer.com/article/10.1007/s00234-021-02718-7

Frontiers | Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous System
https://www.frontiersin.org/articles/10.3389/fnana.2020.00017/full

Neuroglia Lab : Glymphatics and virchow-robin space
http://visnu528.blogspot.com/2014/09/glymphatics-and-virchow-robin-space.html

Physiology and Clinical Relevance of Enlarged Perivascular Spaces in the Aging Brain | Neurology
https://n.neurology.org/content/98/3/107

Aquaporin-4 - Wikipedia
https://en.wikipedia.org/wiki/Aquaporin-4

Astrocyte - Wikipedia
https://en.wikipedia.org/wiki/Astrocyte

Neurocytology-Astrocytes
https://neuropathology-web.org/chapter1/chapter1bAstrocytes.html#:~:text=Astrocytic%20foot%20processes%20surround%20brain,maintains%20homeostasis%20in%20the%20CNS.

Disclaimer

As per previous episodes

DrBeen#48 Alzheimer's, Sleep Disturbance, and Brain Health Jul 04, 2023

Show notes

DrBeen#48 Alzheimer's, Sleep Disturbance, and Brain Health

Studies present an association between APOE4 and sleep disturbance. Additionally APOE4 is linked to sleep disturbance before the onset of Alzheimer's symptoms. In ‘The Sleeping Brain’ article (see below) the authors suggest that sleep disturbance causes reduced removal of the waste products from the brain, leading to the accumulation of beta amyloids - which in turn is observed in Alzheimer's disease. Additionally, it is thought that APOE directly leads to beta amyloid metabolism disturbance. And, finally, it is thought that stress-related proteolytic cleavage of APOE4 leads to accumulation of tau proteins. Let's review the evidence.

DrBeen: Medical Education Online
https://www.drbeen.com/

FLCCC | Front Line COVID-19 Critical Care Alliance
https://covid19criticalcare.com/

URL list from Monday, Feb. 20 2023

The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698404/

Sleep well — and reduce your risk of dementia and death - Harvard Health
https://www.health.harvard.edu/blog/sleep-well-and-reduce-your-risk-of-dementia-and-death-2021050322508

N3 Phase of Sleep.
https://chat.openai.com/chat

Understanding Delta Brain Waves And Sleep
https://www.sixstepstosleep.com/understanding-delta-brain-waves/

N3: Slow Wave Sleep | Sleepopolis
https://sleepopolis.com/education/n3-slow-wave-sleep/

Frontiers | Perivascular Spaces, Glymphatic System and MR
https://www.frontiersin.org/articles/10.3389/fneur.2022.844938/full

Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology | SpringerLink
https://link.springer.com/article/10.1007/s00234-021-02718-7

Frontiers | Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous System
https://www.frontiersin.org/articles/10.3389/fnana.2020.00017/full

Neuroglia Lab : Glymphatics and virchow-robin space
http://visnu528.blogspot.com/2014/09/glymphatics-and-virchow-robin-space.html

Physiology and Clinical Relevance of Enlarged Perivascular Spaces in the Aging Brain | Neurology
https://n.neurology.org/content/98/3/107

Aquaporin-4 - Wikipedia
https://en.wikipedia.org/wiki/Aquaporin-4

Astrocyte - Wikipedia
https://en.wikipedia.org/wiki/Astrocyte

Neurocytology-Astrocytes
https://neuropathology-web.org/chapter1/chapter1bAstrocytes.html#:~:text=Astrocytic%20foot%20processes%20surround%20brain,maintains%20homeostasis%20in%20the%20CNS.

Donate to the Front Line Covid-19 Critical Care Alliance, Inc.
https://frontlinecovid-19criticalcarealliance.salsalabs.org/donate/index.html

Subscribe to our mailing list on our website:
http://flccc.net/signup

Disclaimer:
As per others

DrBeen#47 Role of The Glymphatic System in Sleep and Brain Health Jul 04, 2023

Show notes

DrBeen#47 Role of The Glymphatic System in Sleep and Brain Health

N3 Sleep, Glymphatic System, and Brain Health

N3 phase of the sleep is characterised by delta waves, also called slow wave sleep (SWS). This is the most restorative phase of the sleep. An important part of this phase is the increase in the glymphatic convection in the brain leading to clearance of the waste products. Let's review.

DrBeen: Medical Education Online
https://www.drbeen.com/

FLCCC | Front Line COVID-19 Critical Care Alliance
https://covid19criticalcare.com/

URL list from Monday, Feb. 20 2023

The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698404/

N3 Phase of Sleep.
https://chat.openai.com/chat

Understanding Delta Brain Waves And Sleep
https://www.sixstepstosleep.com/understanding-delta-brain-waves/

N3: Slow Wave Sleep | Sleepopolis
https://sleepopolis.com/education/n3-slow-wave-sleep/

Frontiers | Perivascular Spaces, Glymphatic System and MR
https://www.frontiersin.org/articles/10.3389/fneur.2022.844938/full

Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology | SpringerLink
https://link.springer.com/article/10.1007/s00234-021-02718-7

Frontiers | Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous System
https://www.frontiersin.org/articles/10.3389/fnana.2020.00017/full

Neuroglia Lab : Glymphatics and virchow-robin space
http://visnu528.blogspot.com/2014/09/glymphatics-and-virchow-robin-space.html

Physiology and Clinical Relevance of Enlarged Perivascular Spaces in the Aging Brain | Neurology
https://n.neurology.org/content/98/3/107

Aquaporin-4 - Wikipedia
https://en.wikipedia.org/wiki/Aquaporin-4

Astrocyte - Wikipedia
https://en.wikipedia.org/wiki/Astrocyte

Neurocytology-Astrocytes
https://neuropathology-web.org/chapter1/chapter1bAstrocytes.html#:~:text=Astrocytic%20foot%20processes%20surround%20brain,maintains%20homeostasis%20in%20the%20CNS.

Blood-brain barrier | RIT
https://www.rit.edu/spotlights/blood-brain-barrier

The Blood-Brain Barrier | Morphology of Nervous System
https://sisu.ut.ee/histology/blood-brain-barrier

The glymphatic systems in the brain and the eye export fluid and... | Download Scientific Diagram
https://www.researchgate.net/figure/The-glymphatic-systems-in-the-brain-and-the-eye-export-fluid-and-solutes-from_fig1_353240231

External Carotid Artery: Anatomy & Branches | Study.com
https://study.com/academy/lesson/external-carotid-artery-anatomy-branches.html

Cervical Node Mets fron Occult Primary
http://www.aboutcancer.com/cervical_node_occult_utd_907.htmep 46

Buy FLCCC gear:
https://supportflccc.store/

Subscribe to our mailing list on our website:
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Disclaimer:
As per others

DrBeen#46 Intermittent Fasting and Brain Health Jul 04, 2023

Show notes

DrBeen#46 Intermittent Fasting and Brain Health

Intermittent fasting causes production of beta hydroxybutarate, which in turn helps improve the glymphatic flow of fluids in the brain. This in turn leads to a better clearance of waste products from the brain, helping to improve the cognitive state, memory, and potentially stall the progress of dementia.

DrBeen: Medical Education Online
https://www.drbeen.com/

FLCCC | Front Line COVID-19 Critical Care Alliance
https://covid19criticalcare.com/

URL list from Friday, Feb. 17 2023 19:11 PM

The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698404/

Frontiers | Perivascular Spaces, Glymphatic System and MR
https://www.frontiersin.org/articles/10.3389/fneur.2022.844938/full

Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology | SpringerLink
https://link.springer.com/article/10.1007/s00234-021-02718-7

Frontiers | Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous System
https://www.frontiersin.org/articles/10.3389/fnana.2020.00017/full

Neuroglia Lab : Glymphatics and virchow-robin space
http://visnu528.blogspot.com/2014/09/glymphatics-and-virchow-robin-space.html

Physiology and Clinical Relevance of Enlarged Perivascular Spaces in the Aging Brain | Neurology
https://n.neurology.org/content/98/3/107

Aquaporin-4 - Wikipedia
https://en.wikipedia.org/wiki/Aquaporin-4

Astrocyte - Wikipedia
https://en.wikipedia.org/wiki/Astrocyte

Neurocytology-Astrocytes
https://neuropathology-web.org/chapter1/chapter1bAstrocytes.html#:~:text=Astrocytic%20foot%20processes%20surround%20brain,maintains%20homeostasis%20in%20the%20CNS.

Blood-brain barrier | RIT
https://www.rit.edu/spotlights/blood-brain-barrier

The Blood-Brain Barrier | Morphology of Nervous System
https://sisu.ut.ee/histology/blood-brain-barrier

External Carotid Artery: Anatomy & Branches | Study.com
https://study.com/academy/lesson/external-carotid-artery-anatomy-branches.html

Cervical Node Mets fron Occult Primary
http://www.aboutcancer.com/cervical_node_occult_utd_907.htm

Donate to the Front Line Covid-19 Critical Care Alliance, Inc.  To educate medical professionals and the public in safe and effective ways to prevent and treat COVID-19. Click here to make a donation:
https://frontlinecovid-19criticalcarealliance.salsalabs.org/donate/index.html

Buy FLCCC gear:
https://supportflccc.store/

Subscribe to our mailing list on our website:
http://flccc.net/signup

DrBeen#45 Berberine and Pancreatic Beta Cells Jul 04, 2023

Show notes

DrBeen#45 Berberine and Pancreatic Beta Cells

Berberine has many important mechanisms. In the current series of talks we are presenting the mechanisms related to the management of Type 2 diabetes mellitus. In the current talk we look at the high level mechanism of how Berberine helps increase the insulin secretion.

Note: cell's depolarization process is intentionally skipped to keep the focus on the potassium channels.

DrBeen: Medical Education Online
https://www.drbeen.com/

FLCCC | Front Line COVID-19 Critical Care Alliance
https://covid19criticalcare.com/

URL list from Sunday, Feb. 13, 2023

Berberine is an insulin secretagogue targeting the KCNH6 potassium channel | Nature Communications
https://www.nature.com/articles/s41467-021-25952-2

AMP-activated protein kinase - Wikipedia
https://en.wikipedia.org/wiki/AMP-activated_protein_kinase

Frontiers | Cerebral Gluconeogenesis and Diseases
https://www.frontiersin.org/articles/10.3389/fphar.2016.00521/full

Phosphoenolpyruvate carboxykinase - Wikipedia
https://en.wikipedia.org/wiki/Phosphoenolpyruvate_carboxykinase

Gluconeogenesis - Wikipedia
https://en.wikipedia.org/wiki/Gluconeogenesis

Metformin - Wikipedia
https://en.wikipedia.org/wiki/Metformin

Sterol regulatory element-binding protein 1 - Wikipedia
https://en.wikipedia.org/wiki/Sterol_regulatory_element-binding_protein_1

The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707648/

mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis | PNAS
https://www.pnas.org/doi/10.1073/pnas.1000323107

Insulin Signaling Pathway | Antibodies.com
https://www.antibodies.com/insulin-signaling-pathway

Regulation of SREBP by insulin signaling pathway | Download Scientific Diagram
https://www.researchgate.net/figure/Regulation-of-SREBP-by-insulin-signaling-pathway_fig3_258503248

The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976015/

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