Huberman Lab

David: https://davidprotein.com/huberman

Timestamps

00:00:00 Matthew Johnson; Psychedelics

00:01:44 Different Classes of Psychedelics

00:04:33 Psychedelics & Altering Models

00:06:18 Sponsor: David

00:07:33 LSD, Psylocibin & Serotonin

00:09:55 Psychedelic Clinical Trials

00:13:40 Therapy, Trust, Psychedelics

00:16:47 Letting Go & Psychedelic Experience, Self-Representation, Lasting Changes

00:22:31 Sponsors: AG1 & BetterHelp

00:25:26 MDMA, Dopamine & Serotonin; Bad Trips & Transcendental Experience

00:28:49 Dangers of Psychedelics

00:31:11 Microdosing Psychedelics, Antidepressant

00:35:27 Head Injuries, Psychedelics, Depression

00:38:29 Acknowledgements

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Health Effects & Risks of Kratom, Opioids & Other Natural Occurring Medicines | Dr. Chris McCurdy Jul 21, 2025

Show notes

My guest is Dr. Chris McCurdy, PhD, FAAPS, professor of medicinal chemistry at the University of Florida and a world expert on the pharmacology of kratom and other plant-derived medicinal compounds. We discuss kratom’s wide-ranging effects, including its use for boosting energy, enhancing mood, managing pain and as a potential opioid substitute, while also explaining its critical safety concerns and addictive potential, especially for kratom-derived/isolate products. We also discuss plant-based compounds more generally for their potential benefits and risks. Dr. McCurdy offers a balanced perspective on kratom and other plant-based and naturally occurring medicinal compounds, highlighting and contrasting their promise for human health with potential serious risks.

Read the episode show notes at hubermanlab.com.

Thank you to our sponsors

David Protein: https://davidprotein.com/huberman

Eight Sleep: https://eightsleep.com/huberman

ROKA: https://roka.com/huberman

Timestamps

00:00:00 Chris McCurdy

00:02:51 Kratom (Mitragyna speciosa), Origin, Effects, Low vs High Doses

00:07:19 Sponsors: David Protein & Eight Sleep

00:10:07 Kratom, Traditional Use vs Commercial Kratom Products, Absorption

00:17:00 Kratom Products, Serving Size, Kids; Semi-Synthetics; Tool: Understand Kratom Product Labels

00:23:16 Kratom Products & Various Desired Effects; Physical Dependence

00:32:53 Different Kratom Usage Patterns, Opioid Dependence

00:36:59 Alkaloid Compounds, Nitrogen, Nicotine; Animals & Self-Experimentation

00:47:47 Sponsors: AG1 & ROKA

00:51:05 Medicine Development, Disconnection from Nature, Product Concentrations

00:59:00 Alkaloids & Natural Products, Opium Poppy, Coca Leaf, Tool: Kratom Leaf vs Extracts (Kratom-Derived/Kratom Isolates)

01:09:06 Is It Safe for Kids to Consume Kratom Products?

01:12:19 Kratom, Energy, Mood & Pain Management, Dose; Caffeine

01:16:56 Respiratory Depression & Kratom Products

01:20:16 Sponsor: Function

01:22:04 Kratom Leaf vs Derivatives, FDA Regulations, Usage Guidelines

01:26:59 Kratom, Alcohol Consumption, Respiratory Failure?

01:29:09 Kratom Alkaloids, Mood & Stimulant Effects, Multiple Pathways for Pain Relief

01:38:17 Plant Alkaloids & Chemical Defense, Kratom & Antifungal Alkaloids; Geckos

01:44:35 White, Red & Brown Vein Kratom, Leaf Processing; Terpenes

01:51:08 Kratom as an Anti-Depressant?; Discontinuing Kratom Use, Opioid Use

01:58:03 Kratom, Drug Interactions & Seizure, Opioids

02:01:51 Cacao Beans, Chocolate

02:09:34 Coca-Cola, Coca Plant & Cocaine, History of Soft Drinks

02:19:49 Career Journey, Pharmacy, Chemistry & Education, Lobelia

02:28:44 Nicotine; Natural Products & Career Journey, Salvia divinorum, Kratom

02:40:22 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter

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Essentials: Healthy Eating & Eating Disorders - Anorexia, Bulimia, Binging Jul 17, 2025

Show notes

In this Huberman Lab Essentials episode, I discuss both healthy eating and clinically recognized eating disorders, including anorexia, bulimia and binge eating disorder.

I explain how brain circuits, hormones such as leptin and reward systems interact to regulate appetite, satiety and overall eating behaviors. I also discuss the serious health risks associated with anorexia, explain how disrupted eating habits contribute to its development and highlight evidence-based treatments for anorexia. Finally, I explore binge eating and bulimia, discussing the underlying causes and the pharmacological treatments commonly used to support recovery.

Read the episode show notes at hubermanlab.com.

Thank you to our sponsors

Timestamps

00:00:00 Eating Disorders

00:01:05 Fasting, Intermittent Fasting, Healthy Eating

00:06:10 Self-Diagnosis Caution

00:07:20 Sponsor: LMNT

00:08:52 Eating Disorders, Anorexia Nervosa

00:12:39 Hunger & Satiety; Appetite, Body Fat & Brain

00:17:20 Homeostasis & Reward Systems, Eating Disorders

00:21:12 Sponsor: AG1

00:22:49 Anorexia, Puberty, Hyperacuity & Food

00:25:55 Decision-Making vs Reflexes/Habits, Anorexia

00:29:29 Anorexia & Breaking Habits, Therapies & Family-Based Models

00:32:08 Distorted Self-Image & Anorexia

00:35:03 Sponsor: Function

00:36:43 Bulimia & Binge-Eating Disorder, Impulsivity & Prescription Treatments

00:40:28 Recap & Key Takeaways

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How Nature & Other Physical Environments Impact Your Focus, Cognition & Health | Dr. Marc Berman Jul 14, 2025

Show notes

My guest is Dr. Marc Berman, PhD, a professor of psychology at the University of Chicago whose research explores how different physical environments—particularly nature and patterns found in nature—can positively impact our ability to focus, our cognitive performance and our mental and physical health. We discuss how our physical environment influences our attention, stress levels and brain and heart health. He explains how even brief periods in nature and exposure to natural images and sounds can restore and improve attentional capacity, reduce mental fatigue and help combat rumination and depression. Whether you live in a city, suburb or rural area, this episode offers simple science-backed strategies for incorporating nature and natural elements into your daily life to positively transform your cognitive ability and mental and physical health.

Read the episode show notes at hubermanlab.com.

Thank you to our sponsors

Helix Sleep: https://helixsleep.com/huberman

Our Place: https://fromourplace.com/huberman

Timestamps

00:00:00 Marc Berman

00:02:14 Direct vs Involuntary Attention, Mental Fatigue, Attention Restoration Theory

00:06:59 Attention Fatigue, Focus & Vision, Tool: Restoring Attention in Nature

00:11:26 Sponsors: Helix Sleep & BetterHelp

00:13:50 Focused Work, Tool: Pre-Work Nature Breaks to Enhance Focus

00:15:54 Nature Walks & Cognitive Benefits, Comparing Nature vs Urban Environments

00:21:31 Nature, “Softly Fascinating Stimulation”, Fractals

00:27:12 Nature Images & Sounds, Cognitive Benefits

00:30:03 Urban vs Nature Images, Complexity & Image Compression; Semantics

00:40:44 Time Perception & Nature; Art Galleries

00:45:32 Tools: Resetting Attention & Nature Break; Features of a Restorative Nature Environments vs Focused Workspace; Length of Time in Nature

00:52:47 Sponsors: AG1 & Our Place

00:55:59 Nature, Time & Widening Attention; Fractals & Nature

01:02:21 Nature vs Urban Environments & Brain, Social Media & Attention

01:09:44 Depression & Rumination, Mental Well-Being, Attention & Nature

01:14:56 Sleep vs Wakefulness; Protecting Attention, Social Media

01:24:44 Sponsor: LMNT

01:26:19 Impulsivity, Texting & Attention, Meditation vs Nature Restoration

01:33:10 Passive Restorative vs Passive Depleting Activities, “Mental Obesity”, Shrinking Attention Span

01:37:31 Kids, Phones, Tool: Nature Free Play; Social Happy Hour, Tool: Solitary Nature Breaks

01:45:30 Physical Health Benefits of Nature, Trees & Indoor Greenery; Aquariums

01:53:26 Thoughts, Feelings & Physical Spaces, Biophilic Design, Bringing Nature Indoors

02:01:03 Nature Breaks, Incorporating Nature into Schools, Work, Home & Cities; Forest Bathing

02:09:18 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter

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Essentials: Science of Stress, Testosterone, Aggression & Motivation | Dr. Robert Sapolsky Jul 10, 2025

Show notes

In this Huberman Lab Essentials episode my guest is Dr. Robert Sapolsky, PhD, a professor of biology, neurology and neurological sciences at Stanford University.

We discuss different types of stress and how our perception of stress as harmful or beneficial largely depends on context. He also explains how testosterone amplifies pre-existing behaviors and tendencies, and he highlights the crucial role of estrogen in supporting brain and body health. We also discuss daily cognitive practices for stress mitigation and how modern life, influenced by social media and complex social hierarchies, shapes our responses to stress.

Read the episode show notes at hubermanlab.com.

Thank you to our sponsors

David: https://davidprotein.com/huberman

Timestamps

00:00:00 Robert Sapolsky

00:00:23 Positive & Negative Stress; Excitement, Amygdala

00:02:47 Testosterone & Brain, Aggression, Hierarchy

00:06:27 Sponsors: Function & LMNT

00:09:18 Testosterone, Motivation, Challenge & Confidence

00:13:52 Dopamine, Testosterone & Motivation

00:16:20 Estrogen, Brain & Health, Replacement Therapies

00:18:12 Stress Mitigation

00:22:09 Sponsors: AG1 & David

00:24:59 Cognitive Practices for Stress Mitigation, Individual Variability, Consistency

00:27:18 Stress, Perception & Individual Differences

00:29:39 Context, Stress & Brain

00:32:47 Social Media, Context, Multiple Hierarchies

00:35:57 Acknowledgments

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How to Lose Fat & Gain Muscle With Nutrition | Alan Aragon Jul 07, 2025

Show notes

My guest is Alan Aragon, a renowned nutrition and fitness expert and researcher known for sharing the strongest evidence-based approaches to fat loss, muscle gain and overall health and fitness. We discuss how to optimize your protein intake, including how much to consume per meal and when, and the facts and myths about the “30-gram rule” and the “anabolic window” following exercise. We also discuss controversial topics such as seed oils, artificial sweeteners, animal vs. plant proteins, training fasted for fat loss and collagen supplementation. Alan Aragon clarifies the most important topics in nutrition and offers valuable time-saving yet extra-effective ways to exercise. He is a true expert in providing data-supported actionable exercise and nutrition protocols for anyone seeking to improve their body composition and health.

Read the episode show notes at hubermanlab.com.

Thank you to our sponsors

Carbon: https://joincarbon.com/huberman

Wealthfront**: https://wealthfront.com/huberman

David: https://davidprotein.com/huberman

**This experience may not be representative of the experience of other clients of Wealthfront, and there is no guarantee that all clients will have similar experiences. Cash Account is offered by Wealthfront Brokerage LLC, Member FINRA/SIPC. The Annual Percentage Yield (“APY”) on cash deposits as of December 27,‬ 2024, is representative, subject to change, and requires no minimum. Funds in the Cash Account are swept to partner banks where they earn the variable‭ APY. Promo terms and FDIC coverage conditions apply. Same-day withdrawal or instant payment transfers may be limited by destination institutions, daily transaction caps, and by participating entities such as Wells Fargo, the RTP® Network, and FedNow® Service. New Cash Account deposits are subject to a 2-4 day holding period before becoming available for transfer.

Timestamps

00:00:00 Alan Aragon

00:02:17 Dietary Protein & Protein Synthesis Limits?, Tool: Post-Resistance Training & Protein Intake (30-50g)

00:09:16 Training Fasted, Post-Exercise Anabolic Window, Tool: Total Daily Protein

00:15:53 Daily Protein Intake, Timing & Exercise, Muscle Strength/Size

00:23:00 Sponsors: Carbon & Wealthfront

00:26:46 Does Fasted Training Increase Body Fat Loss?, Cardio, Individual Flexibility

00:36:53 Dietary Protein & Body Composition

00:38:58 Animal vs Plant Proteins (Whey, Soy, Pea, Quorn), Muscle Size & Strength

00:51:24 Sponsors: AG1 & David

00:54:14 Body Re-Composition, Gain Muscle While Losing Fat?, Tool: Protein Intake & Exercise

01:02:55 Fiber; Starchy Carbohydrates & Fat Loss, Ketogenic Diet

01:10:36 Inflammation, Fat & Macronutrients, Hyper-Palatability; Fish Oil Supplementation

01:16:52 Added Dietary Sugars, Sugar Cravings, Tool: Protein Intake

01:24:03 Artificial Sweeteners (Aspartame, Sucralose, Saccharine, Stevia), Diet Soda, Weight Loss

01:30:16 Sponsor: Function

01:32:04 Caffeine, Exercise & Fat Loss

01:34:53 Alcohol, Red Wine, Sleep, Lifestyle; Quitting Drinking & Stress Resilience

01:44:43 Seed Oils vs Animal Fats, Canola Oil, Olive Oil, Oil Production, Tool: Improve Diet Quality

01:55:50 Butter & Cardiovascular Risk, Saturated Fat, Mediterranean Keto Diet, Testosterone

02:00:43 Menstrual Cycle, Tool: Diet Breaks; Menopause Transition & Body Composition

02:07:04 Collagen Supplementation, Skin Appearance

02:12:44 Supplements: Multivitamins, Vitamin D3, Fish Oil, Creatine, Vitamin C

02:20:03 Resistance & Cardio Training, Tool: Cluster Sets & Super Sets

02:31:35 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter

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Essentials: Understanding & Conquering Depression Jul 03, 2025

Show notes

In this Huberman Lab Essentials episode, I explore major depression, including its underlying biology and discuss science-based approaches to alleviate symptoms and improve mood.

I describe the wide-ranging symptoms of depression and explain how key neurotransmitters, hormones, stress, genetics and inflammation contribute to its development and persistence. I also cover treatment options, from traditional classes of antidepressant medications to emerging therapies such as ketamine and psilocybin. Finally, I highlight lifestyle-based tools, including exercise, supplementation and dietary strategies that can help manage depressive symptoms and promote mental well-being.

Read the episode show notes at hubermanlab.com.

Thank you to our sponsors

Our Place: https://fromourplace.com/huberman

Timestamps

00:00:00 Major Depression

00:01:10 Depression Symptoms

00:06:14 Sponsor: BetterHelp

00:07:33 Pharmaceuticals for Depression, SSRIs; Norepinephrine, Dopamine & Serotonin

00:14:33 Thyroid Hormone, Cortisol, Stress & Depression, Menstrual Cycle, Genetics

00:17:43 Sponsor: AG1

00:19:20 Increase Norepinephrine, Tools: Deliberate Cold Exposure & Exercise

00:21:40 Chronic Inflammation & Depression, Tools: Omega-3s (EPA) & Exercise

00:26:49 Sponsor: Our Place

00:28:41 Tool: Creatine Monohydrate Supplementation & Improving Depression

00:30:20 Novel Depression Therapies, Ketamine, Psilocybin

00:35:29 Ketogenic Diet & Refractory Depression, GABA

00:37:57 Recap & Key Takeaways

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The Chemistry of Food & Taste | Dr. Harold McGee Jun 30, 2025

Show notes

Dr. Harold McGee, PhD, is a renowned author on the topics of food chemistry and culinary science. He explains how cooking methods, types of cookware and temperature can be used to transform food and drink flavors and presents simple but powerful ways to improve nutrient availability. We also discuss how our individual biology, genetic and cultural backgrounds shape our taste preferences. Whether you’re a seasoned cook or someone who simply loves to eat, our conversation will change how you think about food and cooking, give you actionable tools to try and deepen your appreciation of the experience of eating and drinking.

Read the episode show notes at hubermanlab.com.

Thank you to our sponsors

Eight Sleep: https://eightsleep.com/huberman

Our Place: https://fromourplace.com/huberman

Mateina: https://drinkmateina.com/huberman

Timestamps

00:00:00 Harold McGee

00:02:21 Food Chemistry, Using Copper, Modern vs Traditional Techniques

00:09:59 Sponsors: Eight Sleep & Our Place

00:13:33 Cooking, Food & Heat, Taste & Smell

00:22:10 Umami, Savory Tastes, Braising & Meat

00:29:56 Chemistry of Cooking & Eating, Sugars & Conjugates; Slowly Enjoying Food

00:36:14 Savory Meal & Dessert; Food Course Order; Palate Cleansers

00:43:56 Salt, Baseline & Shifting Taste Preferences

00:47:18 Sponsors: AG1 & Mateina

00:50:07 Whole vs Processed Foods, Taste & Enjoyment

00:53:37 Brewing Coffee, Water Temperature, Grind Size

01:00:33 Tea & Tannins, Growing Tea Plants; Tea & Meals, Polyphenols

01:08:16 Food Combinations, Individual Tolerance; Is there an Optimal Diet?

01:11:34 Onions & Garlic, Histamines, Tool: Reduce Crying when Cutting Onions

01:13:55 Gut Sensitivities & Food, Capsaicin & Spicy Foods

01:17:21 Supertasters & Taste Buds, Bitter Taste, Chefs

01:21:57 Sponsor: Function

01:23:45 Salt & Bitter, Salting Fruit, Beer or Coffee, Warming Beer

01:26:11 Human History of Alcohol & Chocolate

01:29:25 Wine Expense vs Taste, Wine Knowledge

01:35:49 Cheese Making, Aged Cheese & Crystals, Tyrosine; Smoke Flavors, Distilling

01:44:30 Fermentation, “Stink Fish”, Caviar, Traditional & New Foods

01:50:42 Personal Journey, Astronomy, Poetry & Food

01:54:55 Beans & Gas, Tool: Soaking Beans

01:57:23 Gut Microbiome, Fermented Foods; Kids & Food Aversions

02:00:47 Cilantro & Divergent Tastes; Microwave Popcorn, Parmesan Cheese

02:04:46 John Keats Poetry, To Autumn; Acknowledgements

02:10:48 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter

Learn more about your ad choices. Visit megaphone.fm/adchoices

Essentials: Understanding & Treating Addiction | Dr. Anna Lembke Jun 26, 2025

Show notes

In this Huberman Lab Essentials episode, my guest is Dr. Anna Lembke, MD, Chief of the Stanford Addiction Medicine Dual Diagnosis Clinic at Stanford University School of Medicine.

We discuss how dopamine drives reward, motivation and addictive behaviors. Dr. Lembke explains the concept of the pleasure-pain balance of dopamine and how this cycle plays a key role in the development and persistence of addiction. We also discuss some of the challenges of addiction recovery, including withdrawal, relapses and the potential benefits of psychedelic-assisted therapy.

Read the episode show notes at hubermanlab.com.

Thank you to our sponsors

Wealthfront**: https://wealthfront.com/huberman

Timestamps

00:00:00 Anna Lembke

00:00:15 Dopamine, Reward & Movement

00:01:54 Baseline Dopamine; Genetics, Temperament & Addiction

00:05:24 Addiction, Modern Life & Boredom

00:07:18 Sponsor: AG1

00:08:55 Pleasure-Pain Balance, Dopamine, Addiction

00:14:17 Resetting Dopamine, Substance or Behavior Recovery, Tool: 30-Day Abstinence

00:16:04 Relapse, Addiction, Reflexive Behavior, Empathy

00:20:17 Triggers, Relapse, Dopamine

00:23:15 Sponsor: Wealthfront & BetterHelp

00:26:04 Shame, Truth Telling & Recovery

00:28:26 Addiction, Psychedelic-Assisted Therapy, Psilocybin, MDMA

00:33:29 Social Media & Addiction, Tool: Intentionality

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Control Your Vagus Nerve to Improve Mood, Alertness & Neuroplasticity Jun 23, 2025

Show notes

In this episode I explain how your vagus nerve—an extensive neural pathway linking your brain and body in both directions—powerfully regulates your mood, digestion, alertness and even certain food cravings, and I explain how you can activate certain vagus nerve pathways to improve your heart rate variability (HRV), a key marker of health and longevity. I also explain how to control vagal pathways to enhance your focus and alertness to improve learning and neuroplasticity. And I explain how your vagus nerve controls levels of serotonin in both your gut and brain, impacting your mood and emotional resilience and how to keep that pathway robust.

Read the episode show notes at hubermanlab.com.

Thank you to our sponsors

Joovv: https://joovv.com/huberman

ROKA: https://roka.com/huberman

Timestamps

00:00:00 Vagus Nerve

00:02:43 Sponsors: LMNT & Joovv

00:05:41 Cranial Nerves, Inputs (Afferents) & Outputs (Efferents), Sensory & Motor

00:12:40 Vagus Nerve & Sensory Pathways, Body & Brain

00:18:30 Sensory Information, Chemical & Mechanical Information

00:23:49 Sympathetic & Parasympathetic Nervous Systems, Vagus Nerve, Tool: Calming & Auricular (Ear) Sensation

00:30:19 Sponsors: AG1 & ROKA

00:33:38 Vagus Nerve Motor Outputs

00:36:00 Autoregulation, Improving Heart Rate Variability (HRV) Tools: HR Deceleration

00:49:46 Aging, Declining HRV, Health, Activity, Tool

00:52:31 Tool: Exercise, Increase Alertness for Cognitive & Physical Activity, Motivation

01:04:26 Sponsor: Function

01:06:14 Adult Neuroplasticity & Learning, Acetylcholine, Alpha GPC Nicotine

01:11:48 Tools: High-Intensity Exercise, Increase Alertness, Focus & Learning; Sleep

01:18:14 Serotonin, Gut, Brain & Mood, Depression & SSRIs

01:21:34 Serotonin, Improve Mood & Gut Health, Irritable Bowel Syndrome (IBS), Tools: Low-Sugar Fermented Foods, Tryptophan

01:28:49 Mood, Depression, Gut Health & Vagal Signaling, Probiotics

01:32:12 Calming Down via Vagus Nerve, Tool: Neck Peri-Arterial Vagus Stretch

01:42:00 Tools: Calming Down, Humming, Extended Exhales

01:46:38 Recap

01:48:46 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter