Healthcare Unfiltered

Latest Episodes:

Episode 68: Criticism and Credence to Medical Writing with Marielle Fares and Tom Lang Feb 01, 2022

Show notes

Chadi welcomes two experienced medical writers, Marielle Fares and Tom Lang, to explain what “medical writing” entails and who the intended audience is, the difference between regulatory and medical education writing as well as patient education and scientific publications, how medical projects come in and what types of instructions and materials medical writers are given, the ins-and-outs of the revision process, what it means when medical writers are listed in the acknowledgments of published clinical research, and many more points of interest.View Tom Lang’s instructive publications on medical writing.https://www.amazon.com/dp/1934465143/ref=cm_sw_r_em_api_glc_i_C5VAJPX36K9384Z844CYhttps://www.amazon.com/dp/1930513690/ref=cm_sw_r_em_api_glc_i_7ZKVGTQ9G44AJ9KV2RA1Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Episode 67: Studying and Managing Rare Diseases with Naveen Pemmaraju Jan 25, 2022

Show notes

Naveen Pemmaraju (@doctorpemm), MD, department of leukemia, University of Texas MD Anderson Center, joins the show to discuss how researchers approach the investigation of rare diseases. Chadi and Dr. Pemmaraju break down the latter’s distinguished work in blastic plasmacytoid dendritic cell neoplasm (BPDCN)—a rare, aggressive hematologic cancer—as well as other rare and orphan diseases. Context for the rare and orphan disease drug development pathway, granular classification for malignancies (particularly in hematology), and so much more is provided in this thorough, fascinating dialogue.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Episode 66: FDA Accelerated Approvals and COI Phenomenons With Bishal Gyawali Jan 18, 2022

Show notes

Chadi welcomes back Bishal Gyawali (@oncology_bg), MD, PhD, Queen’s University Cancer Research Institute (Canada), to the show to discuss the history of the FDA’s accelerated approval regulatory pathway, how it is sometimes abused, how low-level surrogate endpoints are being used for approval, what happens (and what should happen) when confirmatory trials do not confirm clinical benefit for drugs approved through this pathway, how conflicts of interest may impact some regulatory decisions, and so much more. Dr. Gyawali raises some thought-provoking questions and critical points in this deep, nuanced discussion.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Episode 65: Is CAR-T Therapy Superior to ASCT for Relapsed/Refractory DLBCL? Jan 11, 2022

Show notes

Continuing his ASH Annual Meeting coverage, Chadi invites Matt Maurer (@MaurerStats), MS, principal biostatistician, Mayo Clinic, and Alan Skarbnik (@ASkarbnik), MD, director of the lymphoma and CLL program, Novant Health (Charlotte, NC), to review the three prominent CAR-T studies in relapsed/refractory DLBCL presented at the meeting. Why were the results divergent and what does this mean for CAR-T’s utility in this setting? The trio break down the ins-and-outs of the trials – both from a statistician and practitioner point of view.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Episode 64: Will POLARIX Finally Spell Doom for R-CHOP? Jan 04, 2022

Show notes

Chadi invites a trio of lymphoma experts to weigh the importance of the POLARIX trial – which was presented at the ASH Annual Meeting and looked at frontline therapy for patients with DLBCL. Matthew Matasar, MD, Memorial Sloan Kettering Cancer Center, co-authored publication of the POLARIX study “Polatuzumab Vedotin in Previously Untreated Diffuse Large B-Cell Lymphoma” in the New England Journal of Medicine and defends the its results with guests Liz Brem, MD, UC Irvine, and Daniel Landsburg, MD, University of Pennsylvania. Can polatuzumab vedotin supplant conventional R-CHOP as the standard of care for previously untreated DLBCL? As they work through the details of the study, the experts share whether they believe the data supports an immediate standard-of-care change or if more research is needed.Read the study published in NEJMhttps://www.nejm.org/doi/full/10.1056/NEJMoa2115304Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Episode 63: Masking Children in School: Debunking the Science Dec 28, 2021

Show notes

David Zweig (@davidzweig), published author and science journalist based in New York, joins the show to tackle one specific topic pertaining to the COVID-19 pandemic: mask mandates for children in schools. David’s article “The CDC’s Flawed Case for Wearing Masks in School” was published in The Atlantic early this month and spotlights the “very shaky science” propped up by the CDC that has compelled many schools throughout the US to institute mask mandates for their students. Chadi and David analyze the data—fleshing out all of the details and scenarios—of mask wearing in schools in this fiery, no-holds-barred discussion that will surely ruffle some feathers.Read David’s article in The Atlantichttps://www.theatlantic.com/science/archive/2021/12/mask-guidelines-cdc-walensky/621035/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Episode 62: Omicron, Boosters, Vaccines, Myocarditis, and More With Emily Landon Dec 21, 2021

Show notes

Emily Landon, MD, Executive Medical Director, Infection Prevention and Control, University of Chicago, makes her long-awaited return to the show to provide an update on the status of COVID-19 in the US. Chadi and Dr. Landon discuss the proportion of people in America that have gotten their vaccine and booster, how Omicron has come along so quickly as an “escape” variant, how effective the vaccines are against contracting and fighting Omicron, whether vaccine mandates for healthcare workers are justifiable, why Omicron is likely to be worse in the US than in South Africa, when and where people should wear masks now, weighing the risk (ie, myocarditis) and benefits of vaccines for children, and so much more.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Episode 61: Training, Immigration, and Illness With Samer Al Hadidi Dec 14, 2021

Show notes

Samer Al Hadidi (@HadidiSamer), MD, assistant professor in the multiple myeloma program, University of Arkansas, shares his own human experience of receiving an unfortunate diagnosis as an immigrant going through residency and through fellowship, all while dealing with the loss of a close relative. Dr. Al Hadidi recounts the dilemma he had as an immigrant in the US on a visa and deciding whether to prioritize his health or his medical training, the way things escalated while progressing through his fellowship, how the pandemic further complicated travel opportunities for immigrant trainees and HCPs, and many more unfortunate details in his story to date. There is much to be learned and lessons to be taken from Dr. Al Hadidi’s story, and at the very least, it’s an emotional interview that reminds us to count our blessings during this holiday season.Read Dr. Al Hadidi’s published commentary in ASCO Connection https://connection.asco.org/blogs/vacationCheck out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Episode 60: Real-World Evidence vs Clinical Trials Dec 07, 2021

Show notes

To debate the utility and appropriateness of real-world evidence against clinical trials for treating patients with hematologic malignancies, Chadi welcomes back Aaron Goodman (@AaronGoodman33), MD, hematologist, University of California San Diego, and Alan Skarbnik (@ASkarbnik), MD, director of the lymphoma and CLL program, Novant Health (Charlotte, NC), as well as invites first-time guest Liz Brem (@DrLizBrem), MD, assistant clinical professor of hematology, UC Irvine. Can RCT designers ever escape inherent bias? Will we ever enroll a more diverse, higher volume patient population in clinical trials? Who has the right to criticize a clinical trial design? The group uses a phase I study published in Lancet Hematology to frame their arguments in this riveting, hotly contested discussion.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Episode 59: All Things Hodgkin Lymphoma With Graham Collins Nov 30, 2021

Show notes

Chadi hosts Graham Collins (@graham74GC), MBBS, MA, MRCP, FRCPath, DPhil, hematology consultant in the UK, for a broad discussion aimed to simplify an often complicated disease: Hodgkin lymphoma. The duo talk about early-stage disease categorizing, treatment considerations for each stage, reasonable clinical trial endpoints of practice-changing potential, adverse effects resulting from intensive treatments, notable clinical trials and novel treatment approaches, and programs for young adult survivors. This episode is a perfect refresher to get you in the spirit for the ASH Annual Meeting – just a few weeks away!Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

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