Healthcare Unfiltered

Latest Episodes:

Episode 99: CLL and the Patient Perspective Sep 13, 2022

Show notes

Chadi convenes yet another expert roundtable to discuss CLL with a few returning guests as well as a physician-patient: Liz Brem, MD, assistant clinical professor of hematology, UC Irvine, Alan Skarbnik, MD, director of the lymphoma and CLL program, Novant Health (Charlotte, NC), and Brian Koffman, MDCM, FCFP, DABFM, MS Ed, executive vice president and chief medical officer, CLL Society. The group begins by stating that patients have little-to-no participation in treatment guidelines for CLL, positing whether treatment is necessary for early-stage disease at all, debating what testing procedures should be done after diagnosis, and concluding with what place MRD has in the treatment paradigm. Dr. Koffman shares his personal story of waiting as long as possible to begin his unconventional treatment course (including first remission allogeneic transplant) and the group discusses whether the limited evidence base for this course matters or not. Dissecting the intricacies of treating CLL, especially from the patient perspective, is no easy task and these experts do a very thorough job of detailing the discussion points that matter most.View more information on the CLL Society.https://cllsociety.org/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Episode 98: Evidence-Based Medicine in a COVID World Sep 11, 2022

Show notes

Adam Cifu, MD, general internist and professor of medicine at the University of Chicago, is fresh off his rounds and ready to talk about the advantages and pitfalls of evidence-based medicine in today’s medical world. Dr. Cifu offers his thoughts on the level of evidence needed for vaccinations in children as well as the number of vaccinations and boosters needed for adults, what the evidence tells us about long COVID, whether mask wearing on planes and various other locations still carries any weight, and a general commentary on how evidence factors (or doesn’t) into Twitter discussions surrounding medicine.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Episode 97: Naturopathic and Complementary Medicine: What is it? Aug 30, 2022

Show notes

To explain and dissect the world of naturopathic medicine, Chadi hosts Nasha Winters, ND, FABNO, a renowned speaker and author on the topic. Dr. Winters shares her background of a devastating, terminal ovarian cancer diagnosis 30 years ago, the nontraditional care she received that put her on the road to recovery, and how that set things in motion for her career. Then, Dr. Winters expands on a system she has developed to understand the tumor “terrain” rather than the tumor itself, patient cases she’s dealt with and how integrative treatment approaches have been very powerful, the type of training she received to become qualified to consult and treat patients, and the ins-and-out of the curriculum for this training, among other things.View Dr. Winters’ website.https://www.drnasha.com/Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Episode 96: Practicing Oncology in Low and Middle Income Countries Aug 23, 2022

Show notes

Nikita Mehra, medical oncologist in India, and Guilherme Perini, hematologist in Brazil, join the show to give a first-hand perspective on what it’s like to practice oncology in low and middle income countries. They begin by explaining variation in income levels and cancer care access within their own cities, expound on screening programs and ability to travel for care among their populations, share the testing and diagnostics procedures and availability, describe the market and supply of treatments in India and Brazil vs the US, comment on how their country’s regulatory bodies approve and set the course for reimbursement of new therapies, and a whole lot more.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Episode 95: Radiopharmaceuticals: Resolving an Enigma Aug 16, 2022

Show notes

Hosted by Ralph Weichselbaum, MD, Chair of the Department of Radiation and Cellular Oncology, University of Chicago, this episode tackles the burgeoning world of radiopharmaceuticals and features two radiation oncologists: Jeff Michalski, MD, MBA, Washington University in St. Louis and president of ASTRO, and Freddy Escorcia, MD, PhD, National Cancer Institute and National Institutes of Health. They kick it off by giving background context on isotope therapy and the current data for these therapies in different malignancies, including an update into peptides and SBRT; provide commentary on how randomized controlled trials account for the complexities of radiopharmaceuticals in their design (especially pertaining to selection criteria and dosage); and share how a radiation department is structured and staffed to account for all patient needs, including a push for a novel patient-centered approach that involves the nuclear medicine department.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Episode 94: Careers in Medicine, Mentorship, and Medical Meetings Aug 09, 2022

Show notes

Drs. Ross Levine, David Steensma, and a surprise recurring guest form a roundtable on today’s show to discuss making the career choice of a non-PhD lab-based scientist and what that entails on a day-to-day basis, how mentoring individuals in other labs is a rewarding and continuous process, what makes a good mentor, managing and securing grant funding for lab research (including the secrets of writing effective grants), making the transition from the clinic to industry and the day-to-day expectations in this environment, and misconceptions of the intentions and cultures of pharmaceutical companies. They wrap up the discussion with a commentary on the overabundance of medical meetings and how they are managing their conference travel schedules against their COVID wariness.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Episode 93: Advances and Controversies in Thoracic Oncology Aug 02, 2022

Show notes

Jarushka Naidoo, MBBCH, MD, Chair of the Thoracic Oncology Division, Beaumont RCSI Cancer Centre (Dublin, Ireland), and Stephen Liu, MD, Director of Thoracic Oncology and Director of Developmental Therapeutics, Lombardi Comprehensive Cancer Center of Georgetown University, join the show to preview all of the important and exciting advancements in thoracic oncology leading up to the IASLC 2022 World Conference on Lung Cancer. The trio cover early-stage lung cancer, pathologic response as a surrogate endpoint for new clinical trials, promising new agents in development and testing, sequencing with immunotherapy, updates in data and targeted therapy for EGFR mutations, and a round-up of other studies highlighting different disease histologies.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Episode 92: Can Urologists Spearhead Medical Oncology Research? Jul 26, 2022

Show notes

Chadi hosts Dr. Neal Shore, a urologic oncologist who became heavily involved in GU oncology research – including trials that incorporate systemic chemotherapy. Dr. Shore has a unique practice where he and his staff deliver chemotherapy when appropriate. Chadi was intrigued by this setting as medical oncologists are the ones customarily delivering chemotherapy, and invited him to the show to share how this all started, its pros and cons, and the impact on patients.Dr. Shore explains how the field has seen drastic changes since the early 1990’s, why he decided to spearhead bringing clinical research into his community clinic, and how his clinic is staffed and structured to support a functioning and successful research hub. Then, the discussion pivots to his recently published clinical trial, ENACT, and the controversy surrounding use of enzalutamide monotherapy in low- or intermediate-risk prostate cancer. There’s been so much controversy and backlash about the ENACT trial that Chadi had to ask him about it and his reaction to what happened when the article was published.View Dr. Shore’s recently published ENACT study in JAMA Oncology. https://jamanetwork.com/journals/jamaoncology/fullarticle/2793567Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Episode 91: Nuances of the Newest Leukemia Classification Jul 19, 2022

Show notes

Returning guests Sanam Loghavi, MD, hematopathologist and molecular pathologist, University of Texas MD Anderson Center, and Aaron Goodman, MD, hematologist, University of California San Diego, break down the latest classification system updates in leukemia. They begin by explaining what triggers a new classification and why it is needed, how soon clinicians should adopt it, and the relationship as well as differences between the ICC and WHO classification systems. Then, the experts go into the details of the changes that have been made to AML and MDS diagnoses and how these are likely to impact clinical trials, among other important points.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Episode 90: Complexities of Designing Clinical Trials Jul 12, 2022

Show notes

On this special episode, Chadi hosts three phenomenal physicians to help us better understand the complexity of designing and executing clinical trials. Hira Mian, MD, faculty of health sciences, McMaster University (Canada), and Murali Janakiram, MD, MS, assistant professor, City of Hope, both faced and continue to face challenges in bringing their clinical trial ideas to light. Saad Usmani, MD, MBA, FACP, chief of myeloma service, Memorial Sloan Kettering Cancer Center, joins as a senior investigator to shed light on the journey and to advise both junior faculty on what can be done next. The group reacts to trial ideas they’ve each had and continue to funding roadblocks. They consider how long down the road researchers should look when formulating a clinical trial design, how limited funding availability figures to be a lasting barrier for many important study ideas, how junior faculty members are vying for such funding to get published research under their belt and earn promotions, and so many more intricacies involved in the clinical trial landscape. This is a perfect episode for anyone interested in clinical trials and wanting to understand the role of a clinician investigator.Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/Watch all Healthcare Unfiltered episodes on Youtube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

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