Gladden Longevity Podcast

Latest Episodes:

The Metabolic Approach to Psychiatry - Episode 357 Sep 17, 2026

Show notes

In this episode, Dr. Jeffrey Gladden and psychiatrist Dr. Matt Bernstein discuss the evolving landscape of mental health treatment. Bernstein shares his extensive experience in psychiatry, particularly with serious mental health conditions, and highlights the limitations of traditional medication approaches. He advocates for a more holistic view that considers metabolic health and mitochondrial function as critical components in understanding and treating mental health issues. The conversation also delves into the benefits of the ketogenic diet, cognitive flexibility, and the complexities of medication management in psychiatric care. In this conversation, Dr. Gladden and Matt Bernstein explore the intricate relationship between mental health, metabolism, exercise, and the role of psychedelics in therapy. They discuss the negative metabolic impacts of psychotropic medications, the significant benefits of exercise for mental health, and the importance of understanding individual genetics in managing depression. The conversation also delves into the role of lactate in brain health, mitochondrial function, and the potential of psychedelic therapies for personal transformation. Ultimately, they emphasize the need for a holistic approach to health that encompasses physical, mental, and spiritual well-being.

For Audience

Join the other 20,000+ high-performers getting weekly insights on biological reversal, exponential strategies, and Life Energy optimization→ https://start.gladdenlongevity.com/subscribe If you're ready to measure your 60+ biological ages and build a personalized reversal plan, apply for a discovery call here → https://start.gladdenlongevity.com/apply-now Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/!

Takeaways

· Matt Bernstein has 26 years of experience in psychiatry.

· He works with serious mental health conditions like bipolar disorder and schizophrenia.

· Traditional psychiatric medications often lead to metabolic and neurological side effects.

· Anhedonia is a significant issue in mental health, meaning a lack of pleasure.

· There is a need for a fresh perspective on mental health rooted in metabolism.

· Mitochondrial dysfunction is linked to serious mental illnesses.

· The ketogenic diet can be an effective intervention for mental health.

· Cognitive flexibility is crucial for managing mental health conditions.

· Medication management is complex and requires careful consideration.

· Not all patients can or should stop their medications completely. Psychotropic medications can negatively impact metabolic health.

· Exercise has a greater effect on depression than antidepressants.

· Intense exercise is crucial for mental health benefits.

· Genetics play a significant role in individual responses to depression.

· Lactate production during exercise is beneficial for brain health.

· Mitochondrial health is essential for longevity and mental well-being.

· Stress affects both neurological and hormonal health.

· Psychedelic therapies can provide transformative experiences for some individuals.

· Social connectedness and purpose are vital for longevity.

· Holistic approaches to health should integrate physical, mental, and spiritual aspects.

Chapters

00:00 Introduction to Mental Health Perspectives

02:58 The Limitations of Traditional Psychiatry

05:54 Exploring Root Causes in Mental Health

09:05 The Role of Metabolism and Mitochondrial Function

11:54 The Ketogenic Diet as a Therapeutic Approach

14:59 Cognitive Flexibility and Mental Health

17:56 Medication Management in Psychiatric Care

23:24 Impact of Psychotropics on Metabolism

24:49 The Role of Exercise in Mental Health

27:53 Genetics and Personal Insights on Depression

29:32 Lactate Production and Brain Health

32:46 Mitochondrial Health and Longevity

36:30 Mind-Body Connection and Stress Management

39:08 Psychedelic-Assisted Therapies

45:07 Optimizing Longevity and Health Span To learn more about Dr. Matt Bernstein:Website: www.accordmh.com LinkedIn: www.linkedin.com/in/mattbernsteinmd

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Dr. Jeffrey Gladden's Daily Longevity Routine: How He Trains for Strength, Mobility, and Energy - Episode 356 Sep 10, 2026

Show notes

Dr. Jeffrey Gladden shares the full routine he uses to support longevity day to day, from his first hour in the morning to his weekly, monthly, and yearly training priorities. The episode is useful if you want a practical look at how he combines recovery, movement, therapy, and mindset to stay active and sharp.

For Audience

Takeaways

In this episode, Dr. Gladden explains why he never wakes up to an alarm and instead lets his body set his sleep schedule.
He starts his day with thyroid medication, then uses the first 30 minutes for journaling, gratitude, daily goals, and affirmations.
He describes music as part of his routine, including picking up the guitar each morning to write, doodle, and release emotional energy.
He rotates his exercise instead of repeating the same workout daily, using mountain biking, running, elliptical work, and an elevation training mask to build lung capacity.
He emphasizes getting outside as often as possible and treating movement as a daily non-negotiable.
He stacks cardio with sauna when possible, often doing both before starting work.
He does not begin his workday until 10 a.m., using the morning to train, recover, and mentally prepare for clients and emails.
He trains mobility as seriously as cardio and resistance work, including floor work, crawling, burpees, and deep squat practice.
He mentions monthly therapies such as plasmapheresis, Eboo, red light, and ozone sauna as part of his longer-cycle routine.
He frames longevity as a yearly performance target: stronger, faster, fitter, sharper, and more mobile than the year before.
He stresses treating injuries immediately and using regenerative therapies and peptides to reduce downtime and slow the acceleration of aging.
He believes many people stop short in training and need to lean into hard effort rather than backing off too early.

Chapters

00:00 - Dr. Jeffrey Gladden's longevity philosophy and "100 is the new 30" 00:34 - Waking without an alarm and starting with thyroid medication 01:04 - Journaling, gratitude, goals, and affirmations to center the day 01:32 - Guitar, songwriting, and creative release as part of the morning 01:58 - Rotating cardio: mountain biking, running, elliptico, and lung capacity work 02:21 - Stacking sauna with cardio and why he delays the workday until 10 a.m. 02:57 - Why self-care comes before work performance 03:25 - Weekly training: resistance work, balance, crawling, burpees, and deep squats 03:54 - Building mobility through floor-based movement and outdoor activity 04:18 - Monthly therapies: plasmapheresis, Eboo, red light, and ozone sauna 04:54 - The yearly goal: outperform last year and treat injuries immediately 05:24 - Why aging requires different training strategies, including peptides 05:49 - Leaning into difficult workouts instead of backing off too early 06:19 - VO2 max testing, progress tracking, and listener call to action

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Navigating the World of 503A and 503B Pharmacies - Episode 355 Sep 03, 2026

Show notes

In this episode of the Gladden Longevity Podcast, Dr. Gladden hosts Joshua Fritzler, President of Olympia Pharmaceuticals, and Nicole Snow to discuss the intricacies of compounding pharmacies, focusing on the differences between 503A and 503B pharmacies, the role of compounding in personalized medicine, and the current landscape of peptides and FDA oversight. The conversation highlights the importance of safety, regulation, and quality assurance in compounded medications, providing listeners with a comprehensive understanding of how these pharmacies operate and their significance in modern healthcare.

For Audience

Takeaways

· Compounding pharmacies create personalized medications not commercially available.

· 503A pharmacies serve individual patients with specific prescriptions.

· 503B pharmacies produce larger batches for clinics and have stricter regulations.

· Compounded medications can be tailored to avoid allergens or intolerances.

· FDA does not approve compounded medications, but regulates the pharmacies.

· Safety profiles of compounded medications are generally high when produced correctly.

· Patients can request specific formulations that are not available commercially.

· Compounding pharmacies must comply with state and federal regulations.

· Quality assurance is critical in compounding, including testing for potency.

· Understanding the differences between compounding pharmacies is essential for patients.

Chapters

00:00 Introduction to Compounding Pharmacies

02:55 Understanding 503A and 503B Pharmacies

05:56 The Role of Compounding in Personalized Medicine

08:52 Safety and Regulation of Compounded Medications

11:54 Differences Between 503A and 503B Pharmacies

14:52 Navigating Prescription and State Regulations

17:50 The Current Landscape of Peptides and FDA Oversight

24:03 Quality Assurance in Compounding Pharmacies

27:55 Conclusion and Future Directions

55:52 A Call for a Manhattan Project in Chronic Disease Research

To learn more about Joshua: Email: olympia@moburst.com Website: http://olympiapharmacy.com LinkedIn: https://www.linkedin.com/in/joshuafritzler/

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Preventing Heart Disease: A New Paradigm - Episode 354 Aug 27, 2026

Show notes

In this conversation, Dr. Jeffrey Gladden and Dr. Philip Ovadia discuss the critical intersection of cardiology and longevity, emphasizing the need for a shift from treating heart disease to preventing it. They explore personal transformations, the role of diet, particularly low-carb and carnivore diets, and the importance of understanding insulin resistance in relation to heart health. The discussion also highlights advancements in cardiovascular diagnostics and the necessity for early detection and patient education to combat heart disease effectively.

For Audience

Takeaways

· The focus on longevity in cardiology is essential.

· Preventing heart disease is more effective than treating it.

· Personal health transformations can lead to professional insights.

· Dietary changes can significantly impact heart health.

· Insulin resistance is a major factor in heart disease.

· Understanding the role of cholesterol is crucial.

· Early detection of insulin resistance can prevent heart disease.

· Patient education is vital for long-term health outcomes.

· Innovative diagnostics can revolutionize heart disease management.

· A holistic approach to rehabilitation is necessary for recovery.

Chapters

00:00 Introduction to Longevity in Cardiology

02:50 The Shift from Treatment to Prevention

05:59 Personal Transformation and Dietary Changes

08:58 Understanding Insulin Resistance and Heart Disease

12:02 The Role of Diet in Cardiovascular Health

15:07 Innovations in Cardiovascular Diagnostics

18:02 The Importance of Early Detection

20:56 Rehabilitation and Patient Education

24:07 The Future of Cardiology and Preventative Care

To learn more about Dr. Philip Ovadia: Facebook: https://www.facebook.com/ovadiahearthealth Instagram: https://www.instagram.com/ifixhearts/ Twitter: https://twitter.com/ifixhearts X URL: https://x.com/ifixhearts YouTube: https://www.youtube.com/@IFixHearts LinkedIn: Linkedin.com/in/philip-ovadia-heart-health/ Book: https://www.amazon.com/Stay-off-Operating-Table-Metabolic/dp/1737818205/

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Gladden Longevity Podcast Disclosures

Production & Independence

The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas.

Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements.

Medical Disclaimer

The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content.

The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options.

Use of information from this podcast and any linked materials is at the listener's own risk.

Podcast Guest Disclosures

Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team.

Sponsorships & Affiliate Disclosures

To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes.

We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented.

Additional Note on Content Integrity

All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.

Unraveling Alzheimer's: The Pathobiome Connection - Episode 353 Aug 20, 2026

Show notes

Dr. Gladden and Nikki Schultek explore the intricate links between Alzheimer's disease, infections, and the pathobiome. Nikki shares her personal journey through chronic illness and how it led her to advocate for a better understanding of the role of infections in autoimmune and neurodegenerative diseases. They discuss the importance of a systems biology approach to healthcare, emphasizing the need for collaboration among specialists to address complex health issues. The conversation highlights the interplay between genetics, infections, and chronic diseases, and the potential for future research to uncover new treatment avenues. In this conversation, Dr. Gladden and Nikki Schultek discuss the integration of systems biology in health optimization, emphasizing the importance of collaboration in research and the role of AI in uncovering health insights. They explore the microbiome's impact on neurodegenerative diseases, hormonal influences on aging, and the necessity of a strong therapeutic connection in patient care. The discussion also touches on economic incentives in healthcare and the urgent need for a comprehensive approach to chronic disease research, likening it to a Manhattan Project.

For Audience

Takeaways

· Nikki's journey into the world of Alzheimer's began with her own health struggles.

· Infections can drive autoimmune states and neurodegenerative diseases.

· The medical system often operates in silos, complicating patient care.

· Chronic infections may be overlooked in patients with complex symptoms.

· A systems biology approach is essential for understanding chronic diseases.

· Genetics and the pathobiome are interconnected in disease development.

· Certain infections are linked to both heart disease and Alzheimer's.

· Advocacy and collaboration are crucial for advancing research.

· Lifestyle factors play a significant role in chronic disease prevention.

· Future research should focus on the interplay between infections and chronic diseases. A systems biology approach can optimize health outcomes.

· Collaboration in research is essential for progress.

· AI can provide insights into complex health issues.

· The microbiome plays a crucial role in neurodegenerative diseases.

· Hormonal changes significantly affect aging and health.

· Therapeutic connections between patients and providers are vital.

· Economic incentives often misalign with health outcomes.

· A comprehensive approach to chronic disease is necessary.

· Existing solutions can be leveraged for better health.

· Innovation in healthcare is accelerating rapidly.

Chapters

00:00 Introduction to Alzheimer's and Pathobiome

04:59 Personal Journey: From Illness to Advocacy

10:04 The Role of Infections in Chronic Diseases

15:00 Exploring the Connection Between Heart Disease and Alzheimer's

20:03 Genetics and the Pathobiome: A Complex Relationship

25:03 The Importance of a Systems Biology Approach

30:08 Future Directions in Research and Treatment

30:38 Integrating Systems Biology in Health Optimization

32:25 Collaborative Research and Team Science

34:34 Leveraging AI for Health Insights

36:20 The Role of the Microbiome in Neurodegenerative Diseases

38:21 Hormonal Influences on Aging and Neurodegeneration

40:44 The Therapeutic Connection in Patient Care

42:49 Economic Incentives in Healthcare and Innovation

55:52 A Call for a Manhattan Project in Chronic Disease Research

To learn more about Nikki Schultek: Website: https://www.alzpi.org/ and https://www.intracellresearchgroup.com/ Instagram: https://www.instagram.com/nikki_schultek/ LinkedIn: https://www.linkedin.com/in/nikki-schultek-03634887/

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Gladden Longevity Podcast Disclosures

Production & Independence

Medical Disclaimer

Use of information from this podcast and any linked materials is at the listener's own risk.

Podcast Guest Disclosures

Sponsorships & Affiliate Disclosures

Additional Note on Content Integrity

From Reactive Care to Preventive Longevity - Episode 352 Aug 13, 2026

Show notes

In this episode, Dr. Gladden speaks with Dr. Hany Demian about the shift from reactive medicine to prevention, personalization, and longevity-focused care. Dr. Hany shares how his journey through breast surgery, emergency medicine, and chronic pain management led him to a more systems-based approach to health, aging, and healing. They discuss why aging may be better understood as a condition, how patient empowerment changes outcomes, and why nervous system regulation, stress reduction, and individualized care matter as much as diagnostics and therapies.

For Audience

Takeaways

· Dr. Hany says many chronic conditions are the result of biology drifting over time, not just isolated bad luck

· He emphasizes that healthy patients are rarely rewarded in the current billing system

· His approach is to assess where a patient's biology is now and how far it has diverged from a healthier baseline

· Lifestyle foundations like sleep, nutrition, exercise, and supplements are treated as the first levers

· Dr. Hany believes aging should be classified as a diagnosable, measurable condition

· He points to hallmarks of aging, mitochondrial dysfunction, and epigenetic disruption as actionable signals

· The conversation frames aging as something that can potentially be slowed, prevented, or reversed

· Dr. Gladden discusses the limits of siloed, specialty-based care and linear thinking in medicine

· Both speakers favor a systems biology model that looks at the whole person

· The idea is to find not just the root cause, but the root cause of the root cause

· Dr. Hany says the longevity field can become overly commercialized and supplement-heavy

· He prefers a science-based, selective approach rather than flooding patients with interventions

· The goal is to help the body restore itself with the right support

· He describes building AI tools that track patients through wearables 24/7

· His team combines genetic testing, ongoing data collection, and clinical interpretation

· The aim is to predict future health trajectories and intervene earlier

· Dr. Hany explains that not everyone is a fit for a longevity program

· Patients must qualify, understand the plan, and commit to the process

· He sees the best outcomes when patients become active partners in their care

· Dr. Gladden emphasizes that the nervous system shapes aging, inflammation, cognition, and resilience

· The episode explores parasympathetic versus sympathetic states and the value of flow over chronic stress

· Both speakers agree that unresolved trauma and emotional strain affect physical health

· Dr. Gladden shares how forgiveness can reduce psychic strain and support healing

· Dr. Hany reflects on the difference between being successful and feeling fulfilled

· They both highlight service, courage, and purpose as central to a meaningful life

Chapters

00:00 - Welcome and the shift from reactive to preventive medicine 01:11 - Breast cancer, family motivation, and the limits of surgery 03:56 - Why personalized medicine starts with biology, not billing 05:24 - Sleep, nutrition, exercise, and supplements as prevention tools 06:33 - Aging hallmarks and why aging may be a condition 08:40 - Reductionist medicine versus systems biology 11:23 - Why the longevity field needs standards and science 14:56 - Patient selection, trust, and individualized care plans 16:25 - Patients as partners, not passive recipients 19:54 - Longevity as adding life to years, not just years to life 20:22 - Stem cells, MSCs, peptides, exosomes, and plasma exchange 21:50 - Brain health, heart health, and musculoskeletal care 22:48 - AI, wearables, and real-time patient monitoring 25:20 - Predicting health five, ten, and fifteen years ahead 26:53 - The nervous system, stress, and psycho-spiritual health 30:25 - Teaching people to live from parasympathetic flow 33:24 - Forgiveness, psychic barriers, and emotional healing 35:42 - Why psychological health improves regenerative outcomes 36:22 - Finding purpose after success 39:15 - Success versus fulfillment 41:17 - Small daily acts of generosity as a path to joy To learn more about Dr. Hany Demian:Website: https://drdemian.com/ Instagram: https://www.instagram.com/drhanydemian/ LinkedIn: https://www.linkedin.com/in/hany-demian-md-5b79b659/ YouTube: https://www.youtube.com/@drhanydemain TikTok: https://www.tiktok.com/@dochanydemian

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Gladden Longevity Podcast Disclosures

Production & Independence

Medical Disclaimer

Use of information from this podcast and any linked materials is at the listener's own risk.

Podcast Guest Disclosures

Sponsorships & Affiliate Disclosures

Additional Note on Content Integrity

The Exponential Curve of Aging - Episode 351 Aug 06, 2026

Show notes

Michael Clinton and Dr. Gladden explore the concept of longevity and the evolving perception of aging. They discuss the importance of viewing the second half of life as an opportunity for growth and adventure rather than a decline. The discussion covers the significance of role models, the idea of life layering to build identities beyond work, the necessity of movement and engagement, and the architectural approach to health through five circles. They also touch on the generational transfer of health and the importance of community and connection in combating loneliness and mental health issues. In this conversation, Michael Clinton and Dr. Gladden explore the interconnected themes of community support, generational trauma, the impact of aging, and the power of creativity. They discuss how understanding one's family history can help in addressing mental health issues and the importance of embracing aging positively. The dialogue emphasizes the significance of co-creation and friendships across generations, highlighting how these relationships can enhance joy and fulfillment in life.

For Audience

Takeaways

· We're living 21st century lives in 20th century constructs.

· Aging is an exponential decline, not a linear decline.

· If you're 65 and healthy, you're gonna live to 95.

· Life layering is building another identity beyond profession.

· The number one natural medicine is movement.

· You can start life layering at any age.

· Generational transfer of health is crucial for longevity.

· Community ensures that the elderly have daily human contact.

· Loneliness and depression are closely linked.

· Living life in flow can reduce stress and loneliness. We need to look out for each other regarding mental health.

· Understanding genetics can help us support individuals better.

· Generational trauma can affect our mental health and well-being.

· Knowing your family history is crucial for personal growth.

· Trauma can imprint on our nervous systems and affect our lives.

· Aging should be embraced, not feared or stigmatized.

· Creativity can enhance longevity and well-being.

· Co-creation with others brings joy and satisfaction.

· Friendships across generations enrich our lives.

· The narrative around aging is changing, and we must adapt.

Chapters

00:00 Roaring into the Second Half of Life

02:50 The Exponential Curve of Aging and Opportunities

05:48 Role Models for Future Generations

09:01 Life Layering: Building Identities Beyond Work

12:06 The Importance of Movement and Engagement

15:09 Architecting Longevity: Five Circles of Health

18:05 Generational Health Transfer and Future Longevity

21:14 Community, Connection, and Loneliness

24:01 The Intersection of Loneliness and Mental Health

25:08 Understanding Generational Trauma

26:27 The Impact of Trauma on Health

28:40 Embracing Aging and Wisdom

30:34 Redefining Aging in Society

32:02 The Power of Creativity for Longevity

36:41 The Joy of Co-Creation and Friendship

To learn more about Michael Clinton:Email: mclinton@hearst.com

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Gladden Longevity Podcast Disclosures

Production & Independence

Medical Disclaimer

Use of information from this podcast and any linked materials is at the listener's own risk.

Podcast Guest Disclosures

Sponsorships & Affiliate Disclosures

Additional Note on Content Integrity

Unlocking the Secrets of Nutrigenomics - Episode 350 Jul 30, 2026

Show notes

In this conversation, Dr. Gladden and Annelie Smith explore the intersection of genetics and nutrition, emphasizing the importance of personalized approaches to health. They discuss the evolution of nutrigenomics, the role of AI in developing tailored health plans, and the complexities of hormonal balance as influenced by genetics. Annelie shares insights from her clinical experience, highlighting the need for a systems biology approach to understand the intricate relationships between genes, hormones, and overall health. The discussion also touches on future directions in genetic testing and the potential for more accessible and actionable insights for individuals. In this conversation, Dr. Gladden and Annelie Smith delve into the complexities of hormone replacement therapy, emphasizing the importance of understanding hormonal pathways and the role of genetics. They discuss how stress impacts hormonal balance and the significance of reprogramming the nervous system for better health outcomes. The conversation also highlights the relevance of nutrigenomics in personalized nutrition and the powerful benefits of sulforaphane. Finally, they explore the value of genetic testing for optimizing health and wellness.

For Audience

Use the code GLADDEN20 for $20 off at https://3x4genetics.com/pages/gladden !

Takeaways

· Nutrigenomics provides insights into personalized nutrition.

· Understanding genetics can enhance dietary recommendations.

· AI is transforming the landscape of personalized medicine.

· Systems biology offers a holistic view of health.

· Patient engagement is key to successful health interventions.

· Genetic testing can reveal vulnerabilities in health.

· Hormonal balance is influenced by genetic factors.

· Personalized health plans can improve patient outcomes.

· The future of genetics holds promise for broader applications.

· Access to genetic information can empower individuals. Hormone replacement therapy is complex and requires a systems approach.

· Understanding genetic pathways is crucial for effective hormone management.

· Stress significantly impacts hormonal balance and overall health.

· Reprogramming the nervous system can alleviate stress and improve health.

· Nutrigenomics plays a vital role in personalized nutrition.

· Sulforaphane is a powerful compound with numerous health benefits.

· Diet should be tailored to the individual, not a one-size-fits-all approach.

· Genetic testing provides valuable insights for health optimization.

· Managing stress involves rebuilding mental constructs that generate it.

· Investing in genetic testing is a one-time opportunity with lasting benefits.

Chapters

00:00 Introduction to Nutrigenomics and Personalization

02:49 The Role of Genetics in Nutrition

06:01 Systems Biology Approach to Health

08:55 AI in Nutrigenomics and Personalized Medicine

11:51 Case Study: Hormonal Balance and Genetics

14:59 Future Directions in Genetics and Health

23:35 Understanding Hormone Replacement Therapy

26:16 The Complexity of Hormonal Pathways

28:26 The Role of Stress in Hormonal Balance

30:22 Reprogramming the Nervous System

32:37 Nutrigenomics and Personalized Nutrition

36:27 The Power of Sulforaphane

39:04 Exploring Genetic Testing for Health Optimization

To learn more about Annelie Smith:Email: annelie@3X4.io Website: www.3X4Genetics.com

Reach out to us at:

Gladden Longevity Podcast Disclosures

Production & Independence

Medical Disclaimer

Use of information from this podcast and any linked materials is at the listener's own risk.

Podcast Guest Disclosures

Sponsorships & Affiliate Disclosures

Additional Note on Content Integrity

The Microbial Connection to Autoimmunity - Episode 349 Jul 23, 2026

Show notes

In this episode of the Gladden Longevity Podcast, Dr. Gladden interviews Dr. Bill Rawls, who shares his transformative journey from conventional medicine to holistic healing. Bill discusses his struggles with chronic illness, particularly Lyme disease, and how he discovered the importance of cellular health and autophagy in recovery. He emphasizes the role of herbal therapies and adaptogens in promoting wellness and protecting cellular function, ultimately leading to a deeper understanding of chronic illness and aging. In this conversation, they explore the intricate connections between autoimmunity, chronic illness, and the role of microbial influences. They discuss the implications of long COVID, the benefits of adaptogenic herbs, and the importance of nervous system regulation in healing. The conversation emphasizes the need for a holistic approach to health, focusing on creating a supportive environment for healing and the potential of herbal medicine in managing chronic conditions.

For Audience

Takeaways

· Dr. Bill Rawls transitioned from conventional medicine to holistic healing due to personal health struggles.

· Chronic Lyme disease was a pivotal point in Dr. Bill's journey, leading him to explore alternative therapies.

· Understanding cellular health is crucial for addressing chronic illnesses.

· Autophagy is a key process for cellular rejuvenation and health.

· Herbal therapies can effectively support the body's healing processes.

· Adaptogens help the body adapt to stress and promote resilience.

· Impaired autophagy is linked to many chronic illnesses.

· Dr. Bill emphasizes the importance of diet, sleep, and lifestyle in maintaining health.

· Herbs can protect cells from stress and inflammation.

· The journey of healing is often non-linear and requires exploration of various therapies. Autoimmunity may be driven by microbial invasion and immune response.

· Long COVID symptoms could be linked to reactivation of dormant pathogens.

· Adaptogenic herbs can support cellular health and stress management.

· Nervous system regulation is crucial for effective healing.

· Herbal preparations can be more effective than traditional medications.

· Creating a healthy environment is essential for chronic illness management.

· The body's stress response can exacerbate chronic health issues.

· Herbs can provide a broad spectrum of benefits beyond just antimicrobial effects.

· Education and environment play key roles in health improvement.

· Chronic illness management requires a shift in healthcare focus.

Chapters

00:00 Dr. Bill Rawls' Journey from Conventional Medicine to Holistic Healing

05:12 Understanding Lyme Disease and Chronic Illness

10:46 The Role of Autophagy in Health and Disease

16:36 Herbal Therapies and Adaptogens in Healing

25:20 Protecting Cellular Health and Mitochondrial Function

26:20 Understanding Autoimmunity and Microbial Influence

28:02 Long COVID and Chronic Illness Connections

30:14 The Role of Adaptogenic Herbs in Healing

32:07 Nervous System Regulation and Healing

33:55 Herbal Preparations and Their Efficacy

37:54 The Broad Spectrum of Herbal Medicine

40:59 Creating a Healthy Environment for Healing

49:03 The Future of Health and Chronic Illness Management

To learn more about Dr. Bill Rawls:Facebook: https://www.facebook.com/rawlsmd/ Website: rawlsmd.com Instagram: https://www.instagram.com/rawlsmd/

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Gladden Longevity Podcast Disclosures

Production & Independence

Medical Disclaimer

Use of information from this podcast and any linked materials is at the listener's own risk.

Podcast Guest Disclosures

Sponsorships & Affiliate Disclosures

Additional Note on Content Integrity

The Cost-Effectiveness of Compounding Pharmacies - Episode 348 Jul 16, 2026

Show notes

In this episode of the Gladden Longevity podcast, Dr. Gladden interviews Shaun Noorian from Empower Pharmacy, discussing the growth and mission of the pharmacy, the cost-effectiveness of compounding medications, quality standards in compounding, regulatory oversight, and the ongoing controversy surrounding peptides and FDA decisions. The conversation highlights the importance of personalized medicine and the challenges faced by compounding pharmacies in providing affordable and effective treatments for patients. In this conversation, Dr. Gladden and Shaun Noorian discuss the evolving landscape of compounding pharmacies and personalized medicine. They explore the regulatory challenges faced by compounding pharmacies, the promise of new medications like retatrutide, and the role of GLP-1s in health management. The discussion highlights the importance of muscle preservation in weight loss therapies and the advocacy needed to ensure patient access to compounded medications. They emphasize the renaissance of compounding in healthcare, which is making treatments more accessible and affordable for patients.

For Audience

Takeaways

· Empower Pharmacy has been operational for 17 years and focuses on personalized medicine.

· Compounding pharmacies are becoming more popular due to their cost-effectiveness compared to commercial options.

· Quality standards in compounding are well-established and continuously updated.

· Compounding pharmacies are subject to rigorous regulatory oversight and inspections.

· The FDA is currently reviewing the status of several peptides for compounding.

· Recent changes in the FDA advisory committee may impact the approval of new compounds.

· The conversation emphasizes the need for evidence-based decisions in healthcare.

· Dr. Gladden highlights the discrepancies in drug approvals and their implications for patient care.

· The black market for peptides poses significant risks to patient safety.

· The discussion underscores the importance of maintaining high-quality standards in compounding pharmacies. The FDA's decisions will significantly impact compounding pharmacies.

· Compounding pharmacies ensure medication integrity and safety.

· Personalized medicine is expanding into various health areas.

· Regulatory challenges hinder the compounding of certain medications.

· Retatrutide is expected to revolutionize weight loss therapies.

· GLP-1s have multiple health benefits beyond weight loss.

· Weight loss therapies can lead to muscle loss, complicating health outcomes.

· Innovative alternatives to GLP-1s are emerging in the market.

· Compounding pharmacies play a crucial role in patient access to medications.

· Advocacy against pharmaceutical monopolies is essential for patient care.

Chapters

00:00 Empower Pharmacy's Growth and Mission

03:01 Cost-Effectiveness of Compounding Pharmacies

06:00 Quality Standards in Compounding

08:54 Regulatory Oversight and Compliance

12:01 The Peptide Controversy

15:03 The Impact of FDA Decisions on Patient Care

18:21 The Future of Compounding Pharmacies

20:09 Expanding Areas of Personalized Medicine

21:11 Regulatory Challenges in Compounding

22:04 The Promise of Retatrutid

23:39 The Role of GLP-1s in Health

25:02 The Impact of Weight Loss Therapies

26:07 Innovative Alternatives to GLP-1s

27:10 The Importance of Muscle Preservation

28:31 The Role of Compounding Pharmacies in Patient Access

30:16 Advocacy Against Pharmaceutical Monopolies

32:20 Navigating Regulatory Landscapes

34:14 The Renaissance of Compounding in Healthcare

To learn more about Shaun Noorian:Email: media@Empowerpharmacy.com Website: https://www.empowerpharmacy.com/ Instagram: https://www.instagram.com/empowerpharmacy

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Gladden Longevity Podcast Disclosures

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Use of information from this podcast and any linked materials is at the listener's own risk.

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