GI Pearls Podcast

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**GI Pearls Podcast**

Gastroenterology Literature Review

Latest Episodes:

GI Pearls Gastroenterology Podcast Episode 53 - February 2022 Feb 22, 2022

Show notes

Show Notes for Episode 53

Lyophilised oral fecal microbiota transplantation for ulcerative colitis (LOTUS): a randomised, double-blind, placebo-controlled trial. – Lancet Gastro
Effect of prophylactic endoscopic clip placement on clinically significant post-endoscopic mucosal resection bleeding in the right colon: a single centre, randomized controlled trial – Lancet Gastro
Feasibility and diagnostic yield of small-bowel capsule endoscopy in patients with surgically altered gastric anatomy: the SAGA study – GIE
Utility of Serum Biomarker Indices for staging of Hepatic Fibrosis before and after venesection in patients with Hemochromatosis caused by Variants in HFE – CGH
Barrett’s esophagus with low-grade dysplasia: high rate of upstaging at Barrett’s esophagus referral units suggests progression rates may be overestimated. – GIE
ACG Clinical Guideline for the diagnosis and management of GERD – Am J Gastro
Diagnosis and Management of Acute Left-Sided Colonic Diverticulitis: A Clinical Guideline From the American College of Physicians – ACP – Annals of IM

GI Pearls Gastroenterology Podcast Episode 52 - November 2021 Nov 20, 2021

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Episode 52 Show notes

Immediate versus Postponed Intervention for Infected Necrotizing Pancreatitis – NEJM
Benchmarking Adenoma Detection Rates for Colonoscopy: Results From a US-Based Registry – Am J Gastro
Colonoscopy-related Mortality in a Fecal-Immunochemical Test-based Colorectal Cancer Screening Program – CGH
AGA Clinical Practice Update on Endoscopic Surveillance and Management of Colorectal Dysplasia in IBD – expert review – Gastro
Should Treatment Indications for Chronic Hepatitis B be Expanded? – CGH
Urinary Cannabis Metabolite Concentrations in Cannabis Hyperemesis Syndrome – JPGN
A randomized, Controled Trial of the Pan-PPAR Agonist Nanifibranor in NASH – NEJM
Prospective study of Outcomes in Adults with Nonalcoholic Fatty Liver Disease – NEJM
Recommendation Reversals in Gastroenterology Clinical Practice Guidelines – J of Canadian A of Gastro

GI Pearls Gastroenterology Podcast Episode 50 - September 2021 Sep 30, 2021

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Show notes for Episode 51

Role of routine second-look endoscopy in patients with acute peptic ulcer bleeding: meta-analysis of randomized controlled trials- GIE
A Randomized Trial Comparing the Specific Carbohydrate Diet to a Mediterranean Diet in Adults with Crohn’s Disease – Gastroenterology
Comparative effectiveness and harms of antibiotics for outpatient diverticulitis. – Annals of IM
Colonoscopy Versus Fecal Immunochemical Test for Reducing Colorectal Cancer Risk: A Population-Based Case–Control Study – CTG
Combination therapy does not improve rate of clinical or endoscpic remission in patients with IBD treated with vedolizumab or ustekinumab. – CGH
World Gastroenterology Organisation Global Guidelines – Helicobacter Pylori May 2021
Gene-Specific Variation in Colorectal Cancer Surveillance Strategies for Lynch Syndrome
Association between time to colonoscopy after positive fecal testing and colorectal cancer outcomes: Review – CGH
Intestinal Failure: What all gastroenterolgists should know- CGH
ACG Clinical Guidelines: Prevention, Diagnosis and TReatment of Clostridioides difficile Infections – Am J Gastro

GI Pearls Gastroenterology Podcast Episode 50 - May 2021 May 25, 2021

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Histologic Changes caused by Injection of a novel submucosal lifting agent for endoscopic resection in GI lesions. – GIE
Prevalence of Barrett’s Esophagus and performance of societal screening guidelines in an unreferred Primary care Population of US veterans. – GIE
The usefulness of olive oil enema in children with severe chronic constipation – J Ped Surg
Rates of Postoperative Recurrence of Crohn’s Disease and Effects of Immunosuppresive and Biologic Therapies – CGH
Histopathologic features and fragmentation of polyps with cold snare defect protrusions. – GIE
AGA Clinical Practice Update on Diagnosis and Management of Immune Checkpoint Inhibitor Colitis – Gastro
Management and outcomes of bleeding within 30 days of colonic polypectomy in a Large, Real-Life, Multicenter Cohort study. – CGH
Hypothermic Machine Perfusion in Liver Transplantation – NEJM
EUS-guided gallbladder drainage vs laparoscopic cholecystectomy for acute cholecystitis: a propensity score analysis with 1-year follow up data. – GIE
The prevalence of small-bowel polyps on video capsule endoscopy in patients with sporadic duodenal or ampullary adenomas. – GIE
Adverse events and residual lesions rate after cold endoscopic mucosal resection of serrated lesions >10mm.
Colorectal EMR outcomes in octogenarians versus younger patients referred for removal of large (>20mm) non-pedunculated polyps. – GIE

GI Pearls Gastroenterology Podcast Episode 49 - April 2021 Apr 14, 2021

Show notes

Show notes for Episode 49 for April 2021

Effectiveness of Oral Vancomycin for Prevention of Healtchare Facility-onset C.diff infection in Targeted Patients during Systemic antibiotic Exposure – Clinical ID
The Detrimental Effects of oral Vancomycin – Letter to Editor – Clinical ID
Linked color imaging focused on Neoplasm detection in the Upper GI tract – randomised trial – Annals of Internal Medicine
AGA clinical Practice Update on Medical Management of Colonic Diverticulitis: Expert Review
Comparative effectiveness and harms of antibiotics for outpatient diverticulitis: Two nationwide cohort studies. Ann Intern Med
Effects of Tenofovir vs Entecavir on Risk of HCC in patients with chronic HBV infection: A SRMA – CGH
Factors that affect adequacy of Colon cleansing for colonoscopy in Hospitalized Patients – CGH
https://app.calculoid.com/#/calculator/69490
ACG Clinical Guidelines: Colorectal Cancer Screening 2021

GI Pearls Gastroenterology Podcast Episode 48 - March 2021 Feb 28, 2021

Show notes

Show notes for Episode 48 March 2021

Younger physicians and longer withdwaral times are associated with detection of advanced neoplasia in a large community practice. – CGH
It’s All The RAVE: Time to Give up on “Chronic Radiation Proctitis” Misnomer – Gastroenterology
Local immune response to food antigens drives meal-induced abdominal pain – Nature
Prevalence of a First-Degree Relative with Colorectal Cancer and Uptake of screening among persons 40-54 years old. – CGH
Prevalence of IBS-type symptoms in patients with IBD in remission: SRMA – Lancet:Gastro and Hep
Impact of 9-Minute Withdrawal Time on the Adenoma Detection Rate: A Multicenter Randomized Controlled Trial – CGH
Use of proton pump inhibitors to treat persistent throat symptoms: multicentre, double blind, randomised, placebo controlled trial – BMJ
Effects of Colesevelam on Bowel Symptoms, Biomarkers, and Colonic Mucosal gene Expression in Patients with Bile Acid Diarrhea in a Randomized Trial. – CGH
Possible tumour cell reimplantation during curative endoscopic therapy of superficial Barrett’s carcinoma – GUT
Pneumatic dilation for persistent dysphagia after antireflux surgery, a multicentre single-blind randomized sham-controlled clinical trial. – GUT
Efficacy of Therapy for EOE in Real-World Practice – CGH
ACG Clinical Guideline: Management of Irritable Bowel Syndrome – ACG

FYI – if you need me to send you the article, please e-mail me, and I will.

GI Pearls Gastroenterology Podcast Episode 47 - January 2021 Jan 02, 2021

Show notes

Show notes for Episode 47, January 2021

Endoscopic Recognition and management strategies for Malignant Colorectal Polyps: Recommendation of the US Multi-Society Task force on Colorectal Cancer – GIE
Polyp morphology: an interobserver evaluation for the Paris classification among international experts – AmJ Gastro
Outcomes in lower GI bleeding comparing weekend with weekday admission. – GIE
Efficacy and Safety of Ornithine Phenylacetate for Treating Overt Hepatic Encephalopathy in a Randomized Trial – CGH
A Trial of Ornithine Phenylacetate and the Arc of Ammonia’s History for Overt Hepatic Encephalopathy – CGH
Are Gastrointestinal Symptoms Specific for Coronavirus 2019 Infection? A Prospective Case-Control Study from the United States – Gastro
A randomized trial comparing antibiotics with appendectomy for appendicitis. – NEJM
FIT test after negative colonoscopy may reduce the risk of incident colorectal cancer in a population-based screening programme – GUT
The efficacy and safety of Vitamin C for Iron Supplementation in Adult Patients with Iron Deficiency Anemia – Jama Open
Randomised comparison of postpolypectomy surveillance intervals following a two-round baseline colonoscopy. – GUT
Disease Progression and Outcomes of Pregnancies in Women With Eosinophilic Esophagitis – CGH
Comparing Laparoscopic Elective Sigmoid Resection with Conservative Treatment in improving QoL of Patients with Diverticulitis. – JAMA Surgery

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GI pearls December 2020 Dec 05, 2020

Show notes

Show notes for Episode 46 for December 2020

Sequential endoscopist-driven phone calls improve capture rate of adverse events after ERCP: a prospective study – GIE
Regular use of proton pump inhibitors and risk of type 2 diabetes: results from three prospective cohort studies – GUT
Long-Term Consequences of Undiagnosed Celiac seropositivity – Am J Gastro
Hyperbaric oxygen therapy is effective in the treatment of inflammatory and fistulizing pouch complications. – CGH
Evaluating the optimum number of biopsies to assess histological inflammation in ulcerative colitis: a retrospective cohort study – Alimentary Pharmacology&Ther
Neutrophil-to-lymphocyte ratio and risk of neoplastic progression in patients with Barrett’s esophagus – Endoscopy
Empirical Treatment With Carbapenem vs Third-generation Cephalosporin for Treatment of Spontaneous Bacterial Peritonitis
Combination Therapy of Adalimumab With an Immunomodulator Is Not More Effective Than Adalimumab Monotherapy in Children With Crohn’s Disease: A Post Hoc Analysis of the PAILOT Randomized Controlled Trial – IBD journal
Treatment of Gut Fermentation Syndrome with FMT – Annals of IM
A Prospective evaluation of POCUS diagnosis of diverticulitis in the emergency Department – Ann Emerg Med 2020
The long-term outcomes and natural disease course of serrated polyposis syndrome: over 10 years of prospective follow-up in a specialized center – GIE

GI Pearls - November 2020 Nov 01, 2020

Show notes

Show notes for Episode 45 for November 2020

Evaluation of Acute Mountain Sickness by Unsedated Transnasal Esophagogastroduodenoscopy at High Altitude – CGH
Early Colonoscopy Does Not Improve Outcomes of Patients With Lower Gastrointestinal Bleeding: SRM – CGH
Adverse Events After Inpatient Colonoscopy in Octogenarians – J of Clinical Gastro
Comparative Efficacy of Drugs for the Treatment of Chronic Constipation – J of Clinical Gastro
Two vs one forward view examination of right colon on adenoma detection: an international multicenter randomized trial – CGH
Effects of Time-Restricted Eating on Weight Loss and Other Metabolic Parameters in Women and Men With Overweight and Obesity – Jama Internal Medicine
Anti–Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis – NEJM
Coexistent faecal incontinence and constipation: A cross-sectional study of 4027 adults undergoing specialist assessment – EClinical Medicine
Meta-analysis of Virtual-based Chromoendoscopy Compared With Dye-spraying Chromoendoscopy Standard and High-definition White Light Endoscopy in Patients With Inflammatory Bowel Disease at Increased Risk of Colon Cancer – IBD journal

GI Pearls - October 2020 Oct 05, 2020

Show notes

Show Notes for October 2020 – Episode 44

A Quarter of Participants With Advanced Neoplasia Have Discordant Results From 2-Sample Fecal Immunochemical Tests for Colorectal Cancer Screening – CGH
Assessment of Clinical Conditions Associated with Splenic Infarction in Adult Patients – JAMA Internal Medicine
Unsedated colonoscopy – impact on quality indicators – Dig Dis Sci
The effect of green kiwifruit on gas transit and tolerance in healthy humans – Neurogastroenterology & Motility
Second international Guidelines for the Diagnosis and Management of HHT – Annals of IM
AGA Clinical Practice Guidelines on the Gastrointestinal Evaluation of Iron Deficiency Anemia – GASTRO
AGA Clinical Practice Guidelines on the Role of Probiotics in the Management of Gastrointestinal Disorders – Gastro
Interview with Jonathan Tsoni Peled, MD/PhD from Memorial Sloan Kettering in NYC. Twitter: @tsonipeled

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