Evidence Based Hair

Latest Episodes:

Season 2, Episode 9 (Isotretinoin and Finasteride for FFA, Eyelash Loss in FFA, Male FFA, LPP Incidence and Prevalence, CCCA Quality of Life) Jul 20, 2022

Show notes

FRONTAL FIBROSING ALOPECIA :

ISOTRETINOIN VS FINASTERIDE

Rakowska A, et al (starts at 9:15). Efficacy of Isotretinoin and Acitretin in Treatment of Frontal Fibrosing Alopecia: Retrospective Analysis of 54 Cases. J Drugs Dermatol. 2017.

Rokni GR et al (starts at 10:43). Evaluating the combined efficacy of oral isotretinoin and topical tacrolimus versus oral finasteride and topical tacrolimus in frontal fibrosing alopecia - A randomized controlled trial. J Cosmet Dermatol. 2022 Jul 11.

FRONTAL FIBROSING ALOPECIA : EYELASH INVOLVEMENT

Salas-Callo C et al (starts at 16:14). Eyelash involvement in frontal fibrosing alopecia: A prospective study. J Am Acad Dermatol 2022 Jul;87(1):232-234.

FRONTAL FIBROSING ALOPECIA : QUALITY OF LIFE

David Saceda-Corralo et al (starts at 22:52). Health-Related Quality of Life in Patients With Frontal Fibrosing Alopecia. JAMA Dermatol. 2018 Apr 1;154(4):479-480.

Varghae A et al (starts at 24:43). Assessment of health-related quality of life in patients with frontal fibrosing alopecia. J Cosmet Dermatol. 2022 Jun 27.

FRONTAL FIBROSING ALOPECIA : MALE FFA STUDIES OF ORAL MINOXIDIL AND FINASTERIDE/DUTASTERIDE

Moussa A et al (starts at 30:00). Clinical features and treatment outcomes of frontal fibrosing alopecia in men. Int J Dermatol. 2022 Jun 21

LPP PREVALENCE STUDIES

Trager MH et al (starts at 40:50). Prevalence estimates for lichen planopilaris and frontal fibrosing alopecia in a New York City health care system. J Am Acad Dermatol 2021 Apr;84(4):1166-1169

Lavian J et al (starts at 41:37). Incidence estimates for lichen planopilaris and frontal fibrosing alopecia in a New York City health care system.Dermatol Online J. 2021 Aug 15;27(8).

Lim S H et al (starts at 42:29). Rapidly increasing incidence and prevalence of lichen planopilaris in an Asian population: A Korean nationwide population-based study. J Dermatol. 2022 Jun 21.

Joshi TP et al (starts at 49:10). Prevalence of lichen planopilaris in the United States: A cross-sectional study of the All of Us research program. JAAD Int. 2022 Jun 13;8:69-70

CENTRAL CENTRIFUGAL CICATRICIAL ALOPECIA: QUALITY OF LIFE

Akintilo et al (starts at 54:48). Health care barriers and quality of life in central centrifugal cicatricial alopecia patients. Cutis. 2018 Dec;102(6):427-432.

Maranga et al (starts at 56:49). Quality of life in patients with central centrifugal cicatricial alopecia: a preliminary study. Br J Dermatol. 2022 Jun 15.

CONCLUSION AND SUMMARY - starts at 58:46

Season 2, Episode 8 (COVID shedding, Trichotillomania, Traction Alopecia, Tinea Capitis Carrier State) Jul 11, 2022

Show notes

STUDIES REFERENCED

COVID RELATED SHEDDING

Mazeto IFS et al (starts at 6:09). Ultrastructural evidence for anagen hair follicle infection with SARS-CoV-2 in early-onset COVID-19 effluvium. J Eur Acad Dermatol Venereol. 2022 Jun 20.

Czech T et al (starts at 14:30). Characteristics of Hair Loss after COVID-19: Systematic Scoping Review. J Cosmet Dermatol. 2022 Jul 8.

TRICTHOTILLOMANIA

Thomson H et al (starts at 24:58). Prevalence and gender distribution of trichotillomania: A systematic review and meta-analysis. J Psychiatr Res. 2022 Jul 1;153:73-81.

TINEA CAPITIS

Lecerf P et al (starts at 30:10). Asymptomatic Scalp Carriage among Household Contacts of Children Affected by Tinea Capitis: A Prospective Study in the Metropolitan Area of Brussels, Belgium. Skin Appendage Disord. 2022 May;8(3):200-205.

TRACTION ALOPECIA

Lucia GS et al (starts at 42:30). Traction alopecia: Neglected in women and children of color. J Am Acad Dermatol. 2022 May 28;

FINAL COMMENTS AND SUMMARY - starts at 49:03

Season 2, Episode 7 (AGA and Smoking, Alopecia Areata and Eye Diseases, MTX for Pediatric AA, Upadacitinib for AA) Jul 04, 2022

Show notes

Kavadya T and Mysore V (starts at 5:24). Role of Smoking in Androgenetic Alopecia: A Systematic Review. Int J Trichology. 2022 Mar-Apr; 14(2): 41–48.

Mosley JG and Gibbs AC (starts at 6;30). Premature grey hair and hair loss among smokers: a new opportunity for heatlh education? British Medical Journal 1996; 313: 1616.

Su LH and Chen T H-H (starts at 7:38) Association of Androgenetic Alopecia with Smoking and Its Prevalence Among Asian Men. Archives of Dermatology 2007 143; 1401-1406.

Calvao J et al (starts at 9:16). Finasteride and Floppy Iris Syndrome: What Role Can the Dermatologist Play? Int J Trichology. May-Jun 2022;14(3):115-116.

Ting H-C et al (starts at 14:04). Association between alopecia areata and retinal diseases: A nationwide population-based cohort study. J Am Acad Dermatol . 2021 Nov 1;S0190-9622(21)02735-3.

Thatiparthi A et al (starts at 15:56). Inflammatory ocular comorbidities in alopecia areata: a retrospective cohort study of a single academic center. J Am Acad Dermatol. 2022 Jun 16;S0190-9622(22)01009-X

Albela H et al (starts at 19:32). Efficacy and Tolerability of Methotrexate in the Treatment of Severe Paediatric Alopecia Areata. Skin Appendage Disord. 2022 May;8(3):206-210.

Barton V et al (starts at 24:20). Treatment of pediatric alopecia areata: A systematic review. J Am Acad Dermatol. 2022 Jun;86(6):1318-1334.

Gambardella A, et al (starts at 29:18). Dual Efficacy of Upadacitinib in 2 Patients With Concomitant Severe Atopic Dermatitis and Alopecia Areata. Dermatitis 2021; 32: e85–e86.

Cantelli M et al (starts at 31:35). Upadacitinib improved alopecia areata in a patient with atopic dermatitis: a case report. Dermatol Ther. 2022; 1: e15346

Asfour et al (starts at 32:35). Concurrent chronic alopecia areata and severe atopic dermatitis successfully treated with upadacitinib. Int J Dermatol. 2022 Jun 20.

Gori N et al (starts at 33:53). Assessment of alopecia areata universalis successfully treated with upadacitinib. Int J Dermatol. 2022 Jul 2.

Conclusions and Summary (starts at 37:24)

Season 2, Episode 6 (JAK Inhibitors & Skin Cancer, Isotretinoin Labs, Triangular Alopecia, Hydroxychloroquine Retinopathy) Jun 27, 2022

Show notes

JAK KINASE INHIBITORS AND SKIN CANCER

Jalles et al (starts at 5:29). Skin cancers under Janus kinase inhibitors: A World Health Organization drug safety database analysis. Therapie. 2022 May 7;S0040-5957(22)00092-0.

ISOTRETINOIN LAB MONITORING

Xia E et al (starts at 13:36). Isotretinoin Laboratory Monitoring in Acne Treatment: A Delphi Consensus Study. JAMA Dermatol. 2022 Jun 15.

ISOTRETINOIN & SURGERY

Davis and Perkins (starts at 18:28). Oral isotretinoin (Roaccutane) use during incisional surgery: safe or risky? Case Reports Plast Surg Hand Surg. 2022 May 13;9(1):131-134.

Spring L et al (starts at 20:17). Isotretinoin and Timing of Procedural Interventions: A Systematic Review With Consensus Recommendations. JAMA Dermatol. 2017 Aug 1;153(8):802-809.

Mysore V et al. Standard Guidelines of Care: Performing Procedures in Patients on or Recently Administered with Isotretinoin J Cutan Aesthet Surg. 2017 Oct-Dec; 10(4): 186–194.

CONGENITAL TRIANGULAR ALOPECIA

Shimrada K et al (starts at 23:57). Atypical Localization of Congenital Triangular Alopecia Associated with Down's Syndrome. Indian J Dermatol. 2022 Jan-Feb; 67(1): 94

Starace M et al (starts at 25:40). Atypical Presentation of Congenital Triangular Alopecia: A Case Series in Italy. Dermatol Pract Concept Oct 2020.

HYDROXYCHLOROQUINE DOSING

Chen R et al (ssarts at 30:00). Impact of an Electronic Decision Support Tool to Improve Ophthalmic Safety in Hydroxychloroquine Prescribing Practices Ophthalmic Surg Lasers Imaging Retina. 2022 Jun;53(6):310-316.

Melles & Marmor (starts at 31:24). The Risk of Toxic Retinopathy in Patients on Long-term Hydroxychloroquine Therapy. JAMA Ophthalmol. 2014;132(12):1453–1460.

Season 2, Episode 5 (NAC for LPP, Hydroxychloroquine Melanosis, Linear Scleroderma, Dissecting Cellulitis in Women) Jun 21, 2022

Show notes

The third Monday of the month is dedicated to studies in scarring alopecia.

LICHEN PLANOPILARIS

Kahjoogh et al (starts at 5:34). Efficacy, safety, tolerability and satisfaction of N-acetylcysteine and pentoxifylline in lichen planopilaris patients under treatment with topical clobetasol: a triple arm blinded randomized controlled trial. Dermatol Ther. 2022 Jun 15

HYDROXYCHLOROQUINE

Beatriz Samões et al (starts at 24:05). Hydroxychloroquine induced melanosis. Reumatol Clin (Engl Ed). Jun-Jul 2022;18(6):377-378.

LINEAR SCLERODERMA

de Marsillac P et al (starts at 27:53). Clinical, epidemiological, trichoscopic and histopathological features of linear morphea on the scalp. J Eur Acad Dermatol Venereol. 2022 Jun 13. doi: 10.1111/jdv.18323. Online ahead of print

Ulc E et al (starts at 40:40). Therapeutic and Reconstructive Management Options in Scleroderma (Morphea) en Coup de Sabre in Children and Adults. A Systematic Literature Review. J Clin Med.

DISSECTING CELLULITIS

Melo DF et al (starts at 42:41). Dissecting cellulitis in women: a retrospective multicenter study with 17 patients. Int J Dermatol. 2022 May 15. doi: 10.1111/ijd.16271. Online ahead of print. May;86(5):e207-e208.

Ward N et al (starts at 48:03). Dissecting cellulitis of the scalp associated with peripheral and axial spondyloarthritis: report of a case and review of the literature. Clin Rheumatol 2022 Apr 23.

Season 2, Episode 4 (SSRI’s, COVID 19, iron, traction, trichotillomania) Jun 13, 2022

Show notes

DYSTROPHIC ANAGEN EFFLUVIUM IN COVID 19 SHEDDING

Shanshal M (start 7:52). COVID-19 related anagen effluvium. J Dermatolog Treat. 2022 Mar;33(2):1114-1115.

Anna Carolina Miola et al (starts 9:45). Early-onset effluvium secondary to COVID-19: Clinical and histologic characterization. J Am Acad Dermatol. 2022

ALTERNATE DAY IRON DOSING

Lale Aydın Kaynar et al (starts 12:57). Comparison of daily oral iron replacement therapy with every other day treatment in female reproductive age patients with iron-deficiency anemia. Ann Hematol. 2022 Apr 23.

Stoffel NU et al (starts 17:23). Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trials. Lancet Haematol. 2017 Nov;4(11):e524-e533.

Mehta S et al (starts 19:03). A Prospective, Randomized, Interventional Study of Oral Iron Supplementation Comparing Daily Dose with Alternate Day Regimen Using Hepcidin as a Biomarker in Iron Deficiency Anemia. J Assoc Physicians India. 2020 May;68(5):39-41.

INTRAVENOUS IRON

Aratsu et al (starts 22:57). Analysis of Adverse Events and Intravenous Iron Infusion Formulations in Adults With and Without Prior Infusion Reactions. JAMA Netw Open. 2022 Mar; 5(3): e224488.

SSRI AND HAIR LOSS

Etiman M et al (starts 29:44). Risk of hair loss with different antidepressants: a comparative retrospective cohort study. Int Clin Psychopharmacol 2018 Jan;33(1):44-48.

Pejcic and Paudel (starts 31:17). Alopecia associated with the use of selective serotonin reuptake inhibitors: Systematic review. Psychiatry Res. 2022 May 10;313:114620. ;86(5):e207-e208.

TRACTION ALOPECIA

Beach RA (starts 35:56). Case series of oral minoxidil for androgenetic and traction alopecia: Tolerability & the five C's of oral therapy. Dermatol Ther. 2018 Nov;31(6):e12707.

Kim and Craiglow (starts 36:38). Treatment of traction alopecia with oral minoxidil. JAAD Case Rep. 2022 Apr 1;23:112-113.

N ACETYL CYSTEINE IN TRICHOTILLOMANIA

Grant JE et al (starts 44:20). Arch Gen Psychiatry 2009

Bloch MH et al (starts 46:05) N-Acetylcysteine in the treatment of pediatric trichotillomania: a randomized, double-blind, placebo-controlled add-on trial. J Am Acad Child Adolesc Psychiatry. 2013 Mar;52(3):231-40.

Popova L and Mancuso J (starts 48:09). Dramatic Improvement of Trichotillomania with 6 Months of Treatment With N-Acetylcysteine. Glob Pediatr Health. 2022 Mar 14;9:2333794X221086576.

Season 2, Episode 3 (Oral minoxidil in males, dutasteride microneedling, sleep disturbances in AGA, endothelial dysfunction in alopecia areata, pediatric alopecia areata) Jun 06, 2022

Show notes

ANDROGENETIC ALOPECIA STUDIES

Sanabria et al (starts at 4:40). Prospective cardiovascular evaluation with 24-h Holter and 24-h ambulatory blood pressure monitoring in men using 5 mg oral minoxidil for androgenetic alopecia. J Am Acad Dermatol. 2022 May 18;

Klein E et al (starts at 13:40). Comparing combination low-dose oral minoxidil and topical minoxidil with oral minoxidil alone for the treatment of non-scarring alopecia; a retrospective chart review. J Cosmet Dermatol. 2022 Jun 1.

Cao L et al (starts at 21:19). Nailfold capillaroscopy alterations in androgenetic alopecia: A cross-sectional study. Indian J Dermatol Venereol Leprol. 2022 Feb 28;1-7. doi: 10.25259/IJDVL_714_2021.

Emmanuel Sánchez-Meza et al (starts at 28:17). Microneedling plus topical dutasteride solution for androgenetic alopecia: a randomized placebo-controlled study. J Eur Acad Dermatol Venereol. 2022 Jun 1. doi: 10.1111/jdv.18285.

David Saceda-Corralo et al. Mesotherapy with Dutasteride in the Treatment of Androgenetic Alopecia. Int J Trichology. 2017 Jul-Sep; 9(3): 143–145.

Liamsombut S et al (starts at 34:45). Sleep quality in men with androgenetic alopecia. Sleep and Breathing. 2022 Apr 25.

ALOPECIA AREATA STUDIES

Anna Waśkiel-Burnat et al (starts at 41:33). Patients with alopecia areata are at risk of endothelial dysfunction: results of a case-control study. Clin Exp Dermatol. 2022 Mar 31.

Conic et al. Prevalence of cardiac and metabolic diseases among patients with alopecia areata.J Eur Acad Dermatol Venereol . 2021 Feb;35(2):e128-e129.

Youssef S et al (starts at 48:28). Tofacitinib Therapy for Alopecia Areata is not Associated with Adverse Events during COVID-19 Infection. J Am Acad Dermatol. 2022 May 9;S0190-9622(22)00795-2.

McKenzie P et al (starts at 53:32). Evaluation of the Prevalence and Incidence of Pediatric Alopecia Areata Using Electronic Health Record Data. JAMA Dermatol. 2022 May 1;158(5):547-551.

Season 2, Episode 2 (Oral Minoxidil, Sarcoidosis, JAK inhibitor safety and Trichomegaly) May 23, 2022

Show notes

Recording of the Evidence Based Hair Podcast for the May 23, 2022 issue.

ORAL MINOXIDIL USE IN PEDIATRIC PATIENTS

Nicolas-Ruanes et al (starts at 4:00). Low-dose oral minoxidil for treatment of androgenetic alopecia and telogen effluvium in a pediatric population: A descriptive study. J Am Acad Dermatol. 2022 Apr 26;

Jerjen R et al. Low-dose oral minoxidil improves global hair density and length in children with loose anagen hair syndrome. Br J Dermatol. 2021;184(5):977-978.

ORAL MINOXIDIL COMPOUNDING ERRORS

Moreno-Arrones OM et al (starts at 9:06). Serious Adverse effects From Compounding Errors With Low-Dose Oral Minoxidil for Alopecia Treatment. Actas Dermosifiliogr. 2022 May 12;S0001-7310(22)00414-8.

DOXYCYCLINE SKIN PIGMENTATION

Afrin et al (starts at 17:15). Doxycycline-Associated Hyperpigmentation: A Case Report and Literature Review. Cureus. 2022 Apr 2;14(4):e23754.

SCALP SARCOIDOSIS

Kim JC and Lee ES (starts at 22:06). Unusual Case of Scalp Sarcoidosis with Alopecia: An Only Manifestation of Cutaneous Sarcoidosis without Systemic Involvement. Ann Dermatol. 2022 Apr;34(2):154-156.

Long T et al. Severe scalp sarcoidosis in an unlikely patient. JAAD Case Rep. 2020 Apr 24;6(11):1165-1166.

House NS et al. Sarcoidosis-induced alopecia.Dermatol Online J 2012 Aug 15;18(8):4.

Ghosh A et al. Single lesion of sarcoidosis presenting as cicatricial alopecia: a rare report from India. Int J Trichology . 2014 Apr;6(2):63-6.

Prohaska J et al. Scalp Sarcoidosis Presenting as Cicatricial Alopecia. J Am Osteopath Assoc. 2018 Dec 1;118(12):824-826.

Conde K et al. Lupus Pernio in Chronic Sarcoidosis. Cureus 2021 Sep; 13(9): e18331.

Hubail et al. Lupus pernio (Besnier-Tenneson syndrome): A rare form of sarcoidosis. Dermatol Reports 2018 Oct 1; 10(2): 7696.

Gopikrishnan Anjaneyan and Rita Vora Lupus pernio without systemic involvement. Indian Dermatol Online J. 2013 Oct-Dec; 4(4): 314–317.

JAK INHIBITOR SAFETY

Hoisnard L et al (starts at 37:53). Adverse events associated with JAK inhibitors in 126,815 reports from the WHO pharmacovigilance database. Sci Rep. 2022 May 3;12(1):7140

EYELASH TRICHOMEGALY WITH EGFR INHIBITORS

Inamadar S and Kumar NSP (starts at 59:03). Lady with Long Eyelashes… Int J Trichology. Mar-Apr 2022;14(2):71-72.

Season 2, Episode 1 (Frontal fibrosing alopecia, Lichen planopilaris, Dissecting cellulitis) May 16, 2022

Show notes

Evidence Based Hair Podcast for the May 16, 2022 issue.

STUDIES REFERENCED FRONTAL FIBROSING ALOPECIA STUDIES Arasu et al (starts at 3:40). Vitamin D status in patients with frontal fibrosing alopecia: A retrospective study. JAAD Int. 2022 Apr 18;7:129-130. Sun et al (starts at 11:30). Extensive facial scarring after ablative laser resurfacing in a patient with frontal fibrosing alopecia. JAAD Case Rep. 2022 Mar 26;23:123-127 Lobato-Berezo et al (starts at 18:32). Pustular frontal fibrosing alopecia: a new variant within the folliculitis decalvans and lichen planopilaris phenotypic spectrum? Br J Dermatol. 2022 May;186(5):905-907. Rocha VB et al (starts at 22:50). Uncommon subtypes of frontal fibrosing alopecia: retrospective analysis of clinical characteristics and prognosis. Anais Brasileiros de Dermatologia An Bras Dermatol. Mar-Apr 2022;97(2):260-262. LICHEN PLANOPILARIS STUDIES Diab R et al (starts at 30:17). Lichen planus and lichen planopilaris flare after COVID-19 vaccination. Dermatol Ther. 2022 Mar;35(3):e15283. DISSECTING CELLULITIS STUDIES Babalola et al (starts at 35:27). Refractory Dissecting Cellulitis of the Scalp Treated With Risankizumab. J Drugs Dermatol. 2022 Mar 1;21(3):313-314. Awad A and Sinclair R (starts at 42:45). Treatment of dissecting cellulitis of the scalp with Tildrakizumab. Australas J Dermatol 2022 May 4

Season 1, Episode 12 (Season 1 Finale; Scalp Allergic Contact Dermatitis, PDL laser induced hair loss, Plaquenil Oral Pigmentation, Persistent Chemotherapy Induced Alopecia) Apr 26, 2022

Show notes

Recording of the Evidence Based Hair Podcast for the April 25, 2022 issue.

STUDIES REFERENCED

ALLERGIC CONTACT DERMATITIS STUDIES

Feryel A et al (starts at 3:51). Unusual clinical presentation of allergic contact dermatitis to topical minoxidil. Contact Dermatitis. 2022 Mar 28

Pham et al (starts at 12:18). Allergic Contact Dermatitis of the Scalp Associated With Scalp Applied Products: A Systematic Review of Topical Allergens. Dermatitis. 2022 Mar 22.

PULSED DYE LASER AND HAIR LOSS IN INFANTILE HEMANGIOMAS

Yang et al (starts at 19:56). Risk factors of long-term alopecia after pulsed-dye laser treatment for infantile scalp hemangiomas: A retrospective study. J Dermatol. 2022 Apr 5.

Feldstein S et al. Can long-term alopecia occur after appropriate pulsed-dye laser therapy in hair-bearing sites? Pediatric dermatologists weigh in. Dermatol Surg. 2015 Mar;41(3):348-51.

ORAL PIGMENTATION FROM HYDROXYCHLOROQUINE

Silva PUJ et al (starts at 31:26). Oral pigmentation as an adverse effect of chloroquine and hydroxychloroquine use: A scoping review. Medicine (Baltimore). 2022 Mar 18;101(11):e29044.

PERMANENT CHEMOTHERAPY INDUCED ALOPECIA

Lyakhovitsky A et al (starts at 37:38). Permanent chemotherapy-induced alopecia after hematopoietic stem cell transplantation treated with low-dose oral minoxidil. JAAD Case Rep. 2022 Feb 17;22:64-67.

Vano-Galvan S et al. Safety of low dose oral minoxidil for hair loss: A multicenter study of 1404 patients. JAAD 2021; 84: 1644-51.

Sanabria B et al. Adverse effects of low dose oral minoxidil for androgenetic alopecia in 435 patients. JAAD 2021; 84: 1175-78.

Kolla et al (starts at 54:24). Permanent chemotherapy-induced alopecia presenting with erosive pustular dermatosis-like retention hyperkeratosis. JAAD Case Rep. 2022 Jan 6;21:77-79.

Yin et al (starts at 58:25). Dermatologist Awareness of Scalp Cooling for Chemotherapy-induced Alopecia. J Am Acad Dermatol. 2022 Mar 9;S0190-9622(22)00386-3

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