Curing with Sound

Latest Episodes:

Ep16: Treating Advanced Breast Cancer with Noninvasive Focused Ultrasound and Radiation: A Conversation with Dr. Gregory Czarnota Oct 24, 2024

In recognition of Breast Cancer Awareness Month, Dr. Greg Czarnota, a senior scientist and radiation oncologist at Sunnybrook Research Institute in Toronto, discusses his innovative research using focused ultrasound in breast cancer treatment. Dr. Czarnota shares promising results from his phase I clinical trial using focused ultrasound-stimulated microbubbles to enhance radiotherapy in patients with advanced breast cancers.
Key points from the conversation include:

The origins of Dr. Czarnota's interest in focused ultrasound and its application in enhancing radiotherapy.
He shares details of the upcoming phase II clinical trials that will be enrolling patients with inoperable breast cancer.
Technical advances with the Arrayus focused ultrasound device could treat larger and more complex tumors.

Dr. Czarnota has also developed ultrasound imaging methods to detect cell death.
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Ep15: Disrupting Media and Medicine: A Conversation with Jane Metcalfe on Focused Ultrasound and the Neobiological Revolution Oct 10, 2024

In this episode of Curing with Sound, Jane Metcalfe, entrepreneur, editor, and co-founder of Wired magazine, shares her insights on the intersection of technology, biology, and healthcare. She explains her role as co-chair of the Focused Ultrasound Foundation’s Council and her passion for advancing this groundbreaking noninvasive technology.
Metcalfe emphasizes the potential of focused ultrasound to revolutionize medical treatments for various conditions and speaks to the importance of raising awareness among patients and medical professionals. She discusses the challenges facing the adoption of focused ultrasound, including lack of awareness, economic barriers, and the need for changes in medical education.
Key points from the conversation include:

The unique approach Wired magazine took in covering technology, focusing on its societal impact rather than just technical specifications.
The concept of the "neobiological revolution" and its potential to transform our understanding of human health and medical treatments.
Metcalfe's introduction to focused ultrasound technology and her role in advocating for its adoption as co-chair of the Focused Ultrasound Foundation’s Council.
Metcalfe's views on the accelerating progress in focused ultrasound research and the potential for disrupting traditional healthcare models.

SHOW TRANSCRIPT
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QUESTIONS?
Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances.

Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation.

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Ep14: Bobby Krause: From Early Onset Parkinson's Patient to Focused Ultrasound Advocate Sep 26, 2024

In this episode, we meet Bobby Krause, a former college athlete and sales executive who was diagnosed with early-onset Parkinson's disease at age 42. Bobby candidly discusses his struggle with debilitating tremors that impacted his ability to engage with his family and perform at work. After experiencing severe side effects from medications, Bobby turned to focused ultrasound treatment for help. Bobby provides a vivid account of the focused ultrasound procedure, describing the immediate and profound results he experienced. Within hours, his tremors disappeared and muscle rigidity eased, allowing him to hike with his sons the very same day. Bobby remains tremor-free and has returned to coaching basketball and other activities he previously enjoyed. Now a passionate advocate for focused ultrasound technology, Bobby has spoken to U.S. policymakers about his experience and founded the Be Still Foundation. The foundation aims to provide financial assistance for those seeking focused ultrasound treatment and raise awareness about this innovative technology.

The patient story shared above is a personal account of an individual’s experience with focused ultrasound treatment. Please be aware that each patient’s situation is unique, and outcomes may vary. The information provided in this story should not be considered as medical advice or a guarantee of specific results. It is important to consult with a qualified healthcare provider to discuss your condition and determine the best treatment options for you. The Focused Ultrasound Foundation does not endorse any specific treatment or medical procedure and encourages all patients to seek professional medical guidance tailored to their individual needs.

Be Still Foundation

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QUESTIONS?
Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances.

Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation.

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Ep13: Champions of Hope: Spotlighting Advocates for Childhood Cancer Awareness Month Sep 12, 2024

In this episode, we speak with Gavin and Wendy Lindberg, founders of The EVAN Foundation, and Dena Sherwood, founder of Arms Wide Open Childhood Cancer Foundation. These passionate advocates, each profoundly impacted by childhood cancer, share their personal stories and discuss how their organizations support families, fund crucial research including innovative treatments like focused ultrasound, and raise awareness for pediatric cancers.
The guests share heartfelt stories about their foundations' programs, including The EVAN Foundation's Treats and Treasures Carts and scholarship initiatives, and Arms Wide Open's family support services and research funding efforts. They emphasize the urgent need for increased funding for childhood cancer research and explore the potential of focused ultrasound technology in treating childhood cancers, highlighting its promise for reducing treatment toxicity and improving quality of life for survivors.
Listeners will gain insight into the challenges faced by children with cancer and their families, the long-term effects of current treatments, and the critical importance of supporting childhood cancer research.
The EVAN Foundation
Arms Wide Open Childhood Cancer Foundation
CureFestUSA.org

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QUESTIONS?
Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances.

Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation.

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Ep12: From Anesthesiology to Focused Ultrasound: A Conversation with Dr. Lauren Powlovich Aug 22, 2024

In this episode, Dr. Lauren Powlovich shares her journey from anesthesiology to her current role as Associate Director of Research and Education at the Focused Ultrasound Foundation. From her early exposure to healthcare through her family of nurses to her own unique career path in the medical field, Dr. Powlovich reveals her passion for helping others and her excitement about the revolutionary use of focused ultrasound to treat pediatric brain tumors and neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Throughout the conversation, Dr. Powlovich highlights the importance of collaboration and accessibility in advancing the field of focused ultrasound. She discusses the challenges of making focused ultrasound devices more widely available, particularly in smaller hospitals and remote areas, and the need for more affordable and convenient technology. As a woman in a male-dominated field, Dr. Powlovich reflects on the challenges of balancing motherhood with a demanding occupation and emphasizes the value of having inspiring female role models and mentors throughout her career.

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QUESTIONS?
Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances.

Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation.

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Ep11: Advancing Cancer Immunotherapy with Focused Ultrasound: A Conversation with Dr. Jill O'Donnell-Tormey Aug 08, 2024

In this episode, Dr. Jill O'Donnell-Tormey, CEO and Director of Scientific Affairs at the Cancer Research Institute (CRI), discusses the fascinating history of cancer immunotherapy, recent breakthroughs, and the potential role of focused ultrasound in enhancing immunotherapy treatments.
The conversation explores current challenges and opportunities in cancer immunotherapy, including the need for personalized treatment approaches and the promising potential of combining immunotherapy with other modalities like focused ultrasound. Dr. O'Donnell-Tormey explains key concepts such as checkpoint inhibitors and CAR T-cell therapy, making complex ideas accessible to listeners.
Listeners will gain valuable insights into the collaborative efforts between CRI and the Focused Ultrasound Foundation, learning how this partnership is driving innovation in cancer treatment. Dr. O'Donnell-Tormey also reflects on her career achievements and the evolving landscape of cancer research.
This episode offers a unique opportunity to learn from a leading expert in the field, providing a deeper understanding of the latest advancements in cancer immunotherapy and the potential for innovative technologies like focused ultrasound to improve treatment outcomes for cancer patients.
For more information about CRI visit cancerresearch.org

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QUESTIONS?
Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances.

Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation.

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Ep10: From Tremors to Triumph: Beverly McGowan's Focused Ultrasound Journey Jul 25, 2024

Join us for a compelling conversation with Beverly McGowan, a nurse practitioner whose life was dramatically impacted by essential tremor. Beverly takes us through her journey, from the first signs of tremor affecting her work to the debilitating effects on her personal life and hobbies. She describes the challenges of traditional treatments and her discovery of focused ultrasound as a potential solution.
Beverly provides a vivid, firsthand account of the focused ultrasound procedure, detailing the process step-by-step and sharing her immediate, transformative results. Learn about her rapid recovery, the short-term side effects, and her triumphant return to both her career and beloved hobbies like photography.
Now a dedicated advocate for focused ultrasound technology, Beverly discusses her experiences sharing her story with legislators and offers valuable insights for others considering this treatment. As she steps into her new role as a patient advocate with the Focused Ultrasound Foundation, Beverly's story serves as a beacon of hope for those struggling with essential tremor and showcases the promising future of this groundbreaking medical technology.

SHOW TRANSCRIPT

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QUESTIONS?
Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances.

Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation.

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Ep9: Dr. Clifford Cho | Revolutionizing Cancer Treatment with Histotripsy and Immunotherapy Jul 11, 2024

Dr. Clifford Cho, a renowned surgical oncologist from the University of Michigan, joins us to discuss the revolutionary intersection of histotripsy and cancer immunotherapy. Histotripsy, a noninvasive focused ultrasound mechanism, is changing the landscape of cancer treatment by not only destroying tumors but also potentially boosting the body's immune response against cancer.
Dr. Cho provides an in-depth look at the successful #HOPE4LIVER clinical trial, which demonstrated histotripsy's safety and efficacy in treating liver tumors. He explains how this technology works without heat or radiation, offering a precision treatment option for patients with limited alternatives. The conversation explores the unexpected benefits of histotripsy, including its ability to alter tumor blood vessel architecture and oxygen levels, potentially making cancers more vulnerable to treatment.
The episode also covers the exciting future of focused ultrasound in cancer treatment. Dr. Cho shares his lab's ongoing research, including efforts to make traditionally immunotherapy-resistant cancers, like pancreatic cancer, more responsive to treatment. He discusses the expansion of histotripsy applications to other organs and the development of a new clinical-translational program, promising broader access to this innovative treatment and further advancements in cancer research.

SHOW TRANSCRIPT

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QUESTIONS?
Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances.

Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation.

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Ep8: Dr. Stavros Zanos | The Promising Future of Focused Ultrasound Neuromodulation Jun 20, 2024

In this episode, Dr. Stavros Zanos, a renowned researcher at the Feinstein Institutes for Medical Research, discusses the potential of focused ultrasound neuromodulation in treating a wide range of cardiovascular and inflammatory diseases. Dr. Zanos explains how ultrasound activates neurons through mechanosensitive channels and shares the promising results of recent studies using neuromodulation to treat pulmonary arterial hypertension, reduce inflammatory markers, and potentially manage type 2 diabetes.
Learn about the importance of precision in ultrasound neuromodulation to ensure accurate targeting of specific areas in the abdomen. This episode offers a fascinating glimpse into the future of medicine, where focused ultrasound neuromodulation could significantly impact the treatment of millions of patients worldwide.

Show Transcript
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QUESTIONS?
Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances.

Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation.

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Ep7: Dr. Daniel Jeanmonod | Pioneering Breakthroughs in Functional Neurosurgery with Focused Ultrasound Jun 06, 2024

Dr. Daniel Jeanmonod, a renowned functional neurosurgeon, joins us upon his retirement to reflect on his pioneering career. Since 1989, Dr. Jeanmonod has been at the forefront of focused ultrasound research and treatment for neuropathic pain, Parkinson's disease, and essential tremor. He recounts his groundbreaking achievement in using noninvasive focused ultrasound to treat patients at the University Children's Hospital of Zurich. He also discusses the establishment of the SoniModul Center of Ultrasound Functional Neurosurgery in Zurich and the center's impressive track record over its 14-year history.
Dr. Jeanmonod shares fascinating patient stories that highlight the profound impact of focused ultrasound treatments on individuals suffering from chronic, therapy-resistant neuropathic pain. He also emphasizes the importance of considering the psycho-emotional aspects of pain management and the role of psychotherapy in optimizing treatment outcomes.
Throughout the conversation, Dr. Jeanmonod offers valuable advice for young neurosurgeons interested in using focused ultrasound in functional neurosurgery. He stresses the significance of understanding the underlying mechanisms of brain disorders.

Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation.

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Ep6: Special Webinar | Transforming Women’s Health with Focused Ultrasound May 23, 2024

This episode features an insightful discussion on the potential of focused ultrasound in revolutionizing women's health care. The conversation, moderated by Dr. Jessica Foley, Chief Scientific Officer at the Focused Ultrasound Foundation, includes expert panelists Dr. Suzanne LeBlang, neuroradiologist and Director of Clinical Relationships at the Focused Ultrasound Foundation, Dr. Lynn Dengel, surgical oncologist at UVA Health, and Dr. Elisa Konofagou, professor of biomedical engineering and radiology at Columbia University.
The discussion highlights the versatility of focused ultrasound in treating a wide range of conditions that disproportionately affect women, such as uterine fibroids, breast tumors, Alzheimer's disease, chronic pain, depression, and anxiety. The panelists share their experiences and research in using focused ultrasound for various applications, including ablation, immunotherapy, neuromodulation, and opening the blood-brain barrier for drug delivery.
The experts also address the challenges faced in advancing focused ultrasound for women's health, including the need for more clinical trials with female participants, raising awareness among clinicians and patients, and securing insurance coverage. They emphasize the importance of collaboration among researchers, clinicians, and regulatory bodies to accelerate the translation of focused ultrasound technologies from bench to bedside.
This engaging discussion offers valuable insights into the current state and future potential of focused ultrasound in improving the lives of women affected by a variety of health conditions. The episode also highlights the Focused Ultrasound Foundation's efforts in supporting research, fostering collaboration, and advocating for focused ultrasound as a transformative tool in women's health care.

Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation.

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Ep5: Chuck Walker | A Couple’s Journey with Parkinson’s and Focused Ultrasound May 09, 2024

Chuck Walker, an adventurer and business owner, began experiencing symptoms of Parkinson’s disease in 2013. In this episode, Chuck and his wife, Dr. Maureen Whelihan, share their inspiring journey with focused ultrasound treatment. Chuck shares how his Parkinson’s-related tremor affected his daily life, from running and riding motorcycles to giving presentations at work, and how medications fell short in managing his condition.
Chuck and Maureen discuss their journey in learning about and deciding to participate in a clinical trial for bilateral focused ultrasound treatment. The couple walks us through the treatment process, the remarkable results, and the immediate improvements in Chuck's symptoms. They also touch on the emotional impact of the treatment, with Chuck regaining his dignity and confidence in both his personal and professional life. They emphasize the importance of clinical trials in advancing treatments like focused ultrasound therapy and express gratitude for the organizations and donors making these innovations possible.
This inspiring episode showcases the power of focused ultrasound therapy in improving the lives of those living with Parkinson's disease, offering hope and encouragement to others who may qualify for this innovative treatment option for their symptoms.
The patient story shared above is a personal account of an individual’s experience with focused ultrasound treatment. Please be aware that each patient’s situation is unique, and outcomes may vary. The information provided in this story should not be considered as medical advice or a guarantee of specific results. It is important to consult with a qualified healthcare provider to discuss your condition and determine the best treatment options for you. The Focused Ultrasound Foundation does not endorse any specific treatment or medical procedure and encourages all patients to seek professional medical guidance tailored to their individual needs.

Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation.

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Ep4: Jessica Foley, PhD | Advancing Focused Ultrasound through Science, Policy, and Advocacy Apr 25, 2024

In this episode of Curing with Sound, Dr. Jessica Foley, the Chief Scientific Officer and a Managing Director at the Focused Ultrasound Foundation, discusses her journey in the biomedical field, from her early interest in math and science to the groundbreaking work in focused ultrasound. Dr. Foley holds a Bachelor of Science in Biomedical Engineering from Duke University and a PhD in Bioengineering from the University of Washington, with an emphasis on focused ultrasound.
Throughout the conversation, Dr. Foley shares her unique experience as a fellow for the American Association for the Advancement of Science and how it has shaped her career in science policy and advocacy. She reflects on the highlights of her career, including being present for the first essential tremor patients treated with focused ultrasound, a pivotal moment that has since led to over 10,000 patients receiving treatment worldwide.

Dr. Foley expresses her excitement about the future of focused ultrasound and its versatile applications, from enhancing drug delivery and inducing anti-cancer immune responses to neuromodulation for treating depression, anxiety, and substance use disorders. As the Chief Scientific Officer at the Focused Ultrasound Foundation, she plays a multifaceted role in advancing the field through research funding, advocacy, and government affairs.
She emphasizes the importance of raising awareness about focused ultrasound, increasing its availability, and addressing the challenges of insurance coverage to ensure equitable access for patients. Dr. Foley also touches on her experience as a woman in the biotech field and offers advice for the next generation of women in science and engineering.
Dr. Foley encourages listeners who are passionate about focused ultrasound to reach out and collaborate with the Foundation in breaking down barriers and moving the field forward.

Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation.

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Ep3: Nir Lipsman, MD, PhD | Pioneering Focused Ultrasound Applications for the Brain Apr 11, 2024

In this episode of Curing with Sound, Dr. Neal Kassell, founder and chairman of the Focused Ultrasound Foundation, is joined by Dr. Nir Lipsman, a neurosurgeon and senior scientist at Sunnybrook Research Institute in Toronto, Canada. Dr. Kassell considers Dr. Lipsman to be one of the most influential clinicians in the development and adoption of focused ultrasound, having pioneered several world-first clinical trials for various brain disorders.  
Throughout the conversation, Dr. Lipsman discusses the evolution of his focused ultrasound program at Sunnybrook, which has grown exponentially over the past decade. His team has treated over 500 patients across a wide range of indications, including essential tremor, Parkinson's disease, obsessive-compulsive disorder, major depression, and various types of brain tumors.  One of the most exciting aspects of Dr. Lipsman's work is the use of focused ultrasound for opening the blood-brain barrier to enhance drug delivery.
He shares the groundbreaking results of a trial in which they were able to visually confirm the passage of a large molecule, trastuzumab, directly into the brain to target metastatic breast cancer tumors. This achievement holds immense promise for the treatment of numerous brain disorders, particularly in the neurodegenerative space, where focused ultrasound could potentially change the natural history of diseases like Parkinson's and Alzheimer's.  
Dr. Lipsman emphasizes the importance of collaboration and parallel progress in advancing the field of focused ultrasound. He highlights the critical role of the Focused Ultrasound Foundation in supporting and fostering the growth of his program and the global focused ultrasound community.  
Looking to the future, Dr. Lipsman envisions focused ultrasound becoming a routine, well-tolerated outpatient procedure that can not only treat but also prevent and diagnose brain disorders. He remains committed to building a strong, multidisciplinary team at Sunnybrook and working with the global community to bring the transformative potential of focused ultrasound to patients worldwide.
Harquail Centre for Neuromodulation  

Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation.

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Ep2: Ken Dychtwald, PhD & Katsuto Shinohara, MD | Navigating a Prostate Cancer Diagnosis with Focused Ultrasound Mar 28, 2024

In this episode of Curing with Sound, we speak with Dr. Ken Dychtwald, renowned gerontologist, best-selling author, and Founder of Age Wave, and Dr. Katsuto Shinohara, a leading urologic oncologist at UCSF.

Dr. Dychtwald, who has dedicated his life to studying gerontology and the aging population, shares his initial shock upon being diagnosed with prostate cancer. He emphasizes the importance of men openly discussing prostate health issues, as many of his friends had experienced similar diagnoses.

When presented with treatment options, Dr. Dychtwald was intrigued by the potential of high-intensity focused ultrasound (HIFU), a minimally invasive procedure he had previously advocated for in his work. Under the care of Dr. Shinohara at UCSF, Dr. Dychtwald underwent HIFU treatment, which precisely targets cancerous tissue while preserving surrounding healthy tissue.

The procedure itself was swift, lasting less than 15 minutes, and Dr. Dychtwald was able to return to work the same day. He expresses his gratitude for the availability of this advanced technology and encourages others to inquire about focused ultrasound as a potential treatment option.

Both Dr. Dychtwald and Dr. Shinohara express optimism about the advancements in medical technology and the potential for focused ultrasound to revolutionize the treatment of various cancers and other conditions, ultimately contributing to improved quality of life and longevity.

Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation.

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Ep1: Neal Kassell, MD | A Remarkable Journey from Unconventional Student to World-Renowned Neurosurgeon Mar 13, 2024

In the premiere episode of "Curing with Sound," we spotlight Dr. Neal Kassell, the Founder and Chairman of the Focused Ultrasound Foundation. Despite being blind in one eye and not completing his undergraduate degree, Dr. Kassell's unwavering commitment to making a significant impact on the world propelled him to become a leading neurosurgeon and a pioneer for focused ultrasound therapy.
From a young age, Dr. Kassell was drawn to neurosurgery, gaining experience in a research lab at the age of 16 and later performing life-saving surgeries that would impact the lives of prominent figures and everyday individuals alike. His quest for better treatment options led him to focused ultrasound, a revolutionary noninvasive technology with the potential to transform treatment for a wide range of medical disorders, from neurodegenerative diseases like Alzheimer’s and Parkinson’s to cancer.
Dr. Kassell is now spearheading the global adoption of this cutting-edge therapy through the Focused Ultrasound Foundation, which he established in 2006, with the mission of redefining patient care and improving millions of lives worldwide. His dedication to advancing medical innovation is not just about a breakthrough technology; it's about the power of determination and the passion to help others, even in the face of personal challenges.
Tune in to hear Dr. Kassell’s inspiring story, learn about the future of medical treatment with focused ultrasound, and discover how his vision is bringing hope and healing to countless individuals around the world.
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QUESTIONS?
Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances.

Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation.

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Ep0: Introduction to Curing with Sound Mar 07, 2024

Welcome to Curing with Sound, a podcast presented by the Focused Ultrasound Foundation. In each episode, we'll explore the revolutionary therapy of focused ultrasound and how it's transforming the treatment of serious diseases and medical conditions such as Alzheimer's, Parkinson's, cancer, and more.
Join host Allison Preston-Smith as she engages in thought-provoking discussions with leading researchers, medical experts, influential advocates, and the patients who have experienced the life-changing benefits of focused ultrasound firsthand.
We'll also highlight the Foundation's steadfast commitment to advancing this technology and making it accessible to patients worldwide. You'll learn the latest advancements, clinical trials, and success stories, and gain a deeper understanding of how focused ultrasound works, its current applications, and its potential to alter the future of healthcare.
Whether you're a doctor seeking cutting-edge treatment options, someone facing a health challenge, or simply fascinated with the future of science and medicine, Curing with Sound is your gateway to the extraordinary world of focused ultrasound and how its poised to reshape the medical landscape.

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QUESTIONS?
Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances.

Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation.

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