CGA-IGC Podcast Series

Latest Episodes:

S.3 Ep. 4 Highlights from the 2020 ASCO Annual Meeting Sep 14, 2020

Show notes

This episode is hosted by Dr. Leah Biller and features Dr. Zsofia Stadler, a medical oncologist at Memorial Sloan Kettering Cancer Center and CGA council member, and Dr. Michael Hall, a medical oncologist at Fox Chase Cancer Center and CGA past president. They discuss data from Abstract 1500 (https://meetinglibrary.asco.org/record/185963/abstract), which reports on targeted therapy based on germline analysis of tumor-normal sequencing in a pan-cancer population, as well as data from the plenary presentation about the clinical trial KEYNOTE-177 (https://meetinglibrary.asco.org/record/186928/abstract), a study of pembrolizumab versus standard therapy for treatment of MSI-H metastatic colorectal cancer.
This episode was recorded on August 28, 2020 and reflects expert opinion at the time of the recording.

S.3 Ep.3: Updates in the Evaluation and Management of Serrated Polyposis Syndrome (SPS) Jul 13, 2020

Show notes

The third episode, hosted by CGA-IGC Council Member Dr. Swati Patel, features Dr. Arne Bleijenberg, who is a research fellow at Amsterdam University Medical Center, and Dr. Evelien Dekker, who is a professor in the Department of Gastroenterology & Hepatology and Gastrointestinal Oncology and the head of the Hereditary Cancer Center at the Amsterdam University Medical Center. They discuss the recently updated World Health Organization Guidelines on diagnosis of Serrated Polyposis Syndrome (SPS) (summarized here https://pubmed.ncbi.nlm.nih.gov/31982410/). Dr. Bleijenberg and Dr. Dekker also discuss their recent publications that shed light on a personalized approach to surveillance in SPS (https://pubmed.ncbi.nlm.nih.gov/30981990/) and long-term outcomes and natural disease course in those with SPS undergoing colonoscopic surveillance (https://pubmed.ncbi.nlm.nih.gov/32360902/). This episode was recorded on July 9, 2020 and reflects expert opinion at the time of the recording.

S.3 Ep.2: A Multi-Institutional Cohort of Therapy-Associated Polyposis in Childhood and Young Adulthood Cancer Survivors May 18, 2020

Show notes

The second episode features Dr. Leah Biller, CGA education committee member, who is interviewed by fellow CGA education committee member TJ Slavin. They discuss "A Multi-Institutional Cohort of Therapy-Associated Polyposis in Childhood and Young Adulthood Cancer Survivors", recently published online in Cancer Prevention Research. You can find the article here: https://www.ncbi.nlm.nih.gov/pubmed/32051178
This episode was recorded May 5, 2020 and reflects expert opinion at the time of the recording.

S3. Ep.1: Collaborative Group of the Americas on Inherited Gastrointestinal Cancer Position statement on multigene panel testing for patients with colorectal cancer and/or polyposis Apr 13, 2020

Show notes

Each episode of the 2020 season of the CGA-IGC podcast series will be a short journal club featuring a recently published article of interest to our membership.
The first episode features Brandie Heald Leach, former CGA president, who is interviewed by CGA education committee member TJ Slavin. They discuss the CGA-IGC position statement on multi-gene panel testing for hereditary colorectal cancer and polyposis, published online in Familial Cancer on March 14, 2020.
You can find the article here: https://www.ncbi.nlm.nih.gov/pubmed/32172433
This episode was recorded April 8, 2020 and reflects expert opinion at the time of the recording.

S2 Ep.6: Transitioning from Pediatric to Adult Care for Patients with FAP Dec 19, 2019

Show notes

The 2019 season of the CGA-IGC podcast series, Expert Approach to Hereditary Gastrointestinal Cancers, will focus on the management of extra-colonic features of Familial Adenomatous Polyposis, or FAP. FAP is an inherited condition that is primarily characterized by the development of many colon polyps and an increased risk for colon cancer, but there are other aspects of FAP that are also important to be aware of and manage appropriately.
The sixth and final episode features Kristin Zajo, a genetic counselor at Nationwide Children’s Hospital in Columbus Ohio. In this episode, we focus on children and young adults with FAP and special considerations regarding management and transitioning from pediatric to adult care.
Note: This episode was recorded on April 23, 2019, and reflects expert opinion at the time of recording. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

S2. Ep.5: Thyroid disease in FAP Oct 22, 2019

Show notes

The 2019 season of the CGA-IGC podcast series, Expert Approach to Hereditary Gastrointestinal Cancers, will focus on the management of extra-colonic features of Familial Adenomatous Polyposis, or FAP. FAP is an inherited condition that is primarily characterized by the development of many colon polyps and an increased risk for colon cancer, but there are other aspects of FAP that are also important to be aware of and manage appropriately.
The fifth episode features Dr. Jennifer Sipos, an endocrinologist at the Ohio State University. In this episode, she reviews the epidemiology, surveillance, and management of thyroid disease in FAP.
Note: This episode was recorded on April 26, 2019, and reflects expert opinion at the time of recording. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
Episodes to come in Season 2:
- "Transition from Pediatric to Adult Care" with Kristin Zajo, MS, CGC

S2 Ep.4: Desmoid disease in FAP Sep 09, 2019

Show notes

The 2019 season of the CGA-IGC podcast series, Expert Approach to Hereditary Gastrointestinal Cancers, will focus on the management of extra-colonic features of Familial Adenomatous Polyposis, or FAP. FAP is an inherited condition that is primarily characterized by the development of many colon polyps and an increased risk for colon cancer, but there are other aspects of FAP that are also important to be aware of and manage appropriately.
The fourth episode features Dr. James Church, colorectal surgeon, and Dr. Dale Shepard, medical oncologist, both of the Cleveland Clinic. In this episode, they discuss the biology, medical and surgical management of desmoid disease in FAP.
Note: This episode was recorded on August 15, 2019, and reflects expert opinion at the time of recording. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
Episodes to come in Season 2:
- "Thyroid Lesion Management" with Jennifer Sipos, MD
- "Transition from Pediatric to Adult Care" with Kristin Zajo, MS, CGC

S2 Ep.3: Management of Duodenal Neoplasia in FAP Aug 06, 2019

Show notes

The 2019 season of the CGA-IGC podcast series, Expert Approach to Hereditary Gastrointestinal Cancers, will focus on the management of extra-colonic features of Familial Adenomatous Polyposis, or FAP. FAP is an inherited condition that is primarily characterized by the development of many colon polyps and an increased risk for colon cancer, but there are other aspects of FAP that are also important to be aware of and manage appropriately.
The third episode features Dr. Jewel Samadder, gastroenterologist and advanced endoscopist at the Mayo Clinic in Phoenix, Arizona. Dr. Samadder has a specific focus on hereditary cancer conditions, with distinct expertise in familial adenomatous polyposis. In this episode, Dr. Samadder discusses the necessary screening, endoscopic and surgical approaches, and chemoprevention options for duodenal neoplasia in FAP.
Note: This episode was recorded on July 16th, 2019 and reflects expert opinion at the time of recording. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
Episodes to come in Season 2:
- "Desmoids" with Dr. James Church and Dr. Dale Shepard
- "Thyroid Lesion Management" with Dr. Jennifer Sipos
- "Transition from Pediatric to Adult Care" with Kristin Zajo, MS, CGC

S2 Ep.2: Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS) May 28, 2019

Show notes

The 2019 season of the CGA-IGC podcast series, Expert Approach to Hereditary Gastrointestinal Cancers, will focus on the management of extra-colonic features of APC-Associated conditions.
In the second episode, Dr. Daniel Worthley, an expert in hereditary cancer syndromes from the South Australian Health and Medical Research Institute, tells the tale of how Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS) was first recognized and characterized. GAPPS is caused by a mutation in the promotor region of the APC gene and is inherited in an autosomal dominant fashion. This condition is associated with a significantly increased risk of gastric cancer, but unlike FAP, GAPPS is not associated with tumors in the colon or small bowel. Dr. Worthley reviews the characteristics of this rare condition and current approach to management.
Note: This episode was recorded on April 23, 2019, and reflects expert opinion at the time of recording. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

S2 Ep.1: Gastric Polyps and Cancer in FAP Apr 29, 2019

Show notes

The 2019 season of the CGA-IGC podcast series, Expert Approach to Hereditary Gastrointestinal Cancers, will focus on the management of extra-colonic features of Familial Adenomatous Polyposis, or FAP. FAP is an inherited condition that is primarily characterized by the development of many colon polyps and an increased risk for colon cancer, but there are other aspects of FAP that are also important to be aware of and manage appropriately.
In the first episode, Dr. Dennis Ahnen interviews Drs. Carol Burke and Gautam Mankaney, who are both gastroenterologists in the Cleveland Clinic Hereditary Cancer Clinic. They discuss the types of polyps that may develop in the stomach of individuals with FAP, as well as the risk for gastric cancer in FAP.
Note: This episode was recorded on April 4, 2019, and reflects expert opinion at the time of recording. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

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