CGA-IGC Podcast Series

Latest Episodes:

Episode 4: Episode 4: S.6 Ep.4 Fight CRC Advocate Danielle Ripley-Burgess: "Life After Total Proctocolectomy in Lynch Syndrome” Nov 06, 2023

Show notes

This episode is hosted by Thomas Slavin, MD, FACMG, DABMD, a Chief Scientific Officer, and Emma Keel, MS, CGC, a genetic counselor, who have the privilege of speaking with Danielle Ripley-Burgess as she shares her story and experience on "Life After Total Proctocolectomy in Lynch Syndrome.”
We're incredibly grateful that she took the time to share her story with us, and we hope it will give our members and the broader #HereditaryGICancer community greater insight into the patient's perspective.

Episode 3: Episode 3: S.6 Ep.3 Clinical characteristics of pancreatic and biliary tract cancers in Lynch syndrome: A retrospective analysis from the Finnish National Lynch Syndrome Research Registry Oct 13, 2023

Show notes

This episode is hosted by Julie Yang, MD, a gastroenterologist at the Icann School of Medicine at Mount Sinai, New York, USA and features Toni T. Seppälä, M.D., PhD, a GI surgeon and Professor of Cancer Research at Tampere University, Helsinki, Finland.
They discuss the results from a retrospective analysis published this year, “Clinical characteristics of pancreatic and biliary tract cancers in Lynch syndrome: A retrospective analysis from the Finnish National Lynch Syndrome Research Registry," which can be found here.
Read our blog post "Insights gained from the largest cohort of patients with pancreaticobiliary cancer and Lynch Syndrome"here

Episode 2: Episode 2: S.6 Ep.2 Considerations for individuals with Hereditary Diffuse Gastric Cancer Syndrome when considering a prophylactic gastrectomy Jun 20, 2023

Show notes

This episode is hosted by Josie Baker, MS, CGC, a genetic counselor at The Ohio State University, and features Rachael Lopez, MPH, RD, CSO, a clinical research dietitian at the National Institutes of Health.
Together they discuss the considerations for individuals with Hereditary Diffuse Gastric Cancer Syndrome when considering a prophylactic gastrectomy. This episode highlights the professional experience when working with these individuals before and after surgery, as well as the challenges individuals may face during this process.

Episode 1: Previous CGA-IGC Grant recipients - Dr. Allison Burton-Chase May 31, 2023

Show notes

The CGA-IGC Research Committee will host a new podcast series highlighting the work of the CGA-IGC Research Grant recipients. The first episode will feature the 2014 grant recipient, Dr. Allison Burton-Chase, and explore her research into Lynch syndrome patient-provider relationships, communication, and transition.
The papers in the order they were referenced:

Hennig K, DeCoster B, Chu R, Parker W, Campo-Engelstein L, Burton-Chase AM. Patients educating health care providers on Lynch syndrome. Patient Experience Journal. 2018; 5(3):91-96. doi: 10.35680/ 2372-0247.1319. https://pxjournal.org/cgi/viewcontent.cgi?article=1319&context=journal
Burton-Chase AM, Parker WM, Hennig K, Sisson F, Bruzzone LL. The Use of Social Media to Recruit Participants With Rare Conditions: Lynch Syndrome as an Example. JMIR Res Protoc. 2017 Jan 23;6(1):e12. doi: 10.2196/resprot.6066. PMID: 28115298; PMCID: PMC5294367. https://pubmed.ncbi.nlm.nih.gov/28115298/

Episode 1: Episode 1: S.6 Ep.1 Cancer Prevention with Resistant Starch in Lynch (CAPP2 Trial) Mar 22, 2023

Show notes

This episode is hosted by Swati G. Patel, M.D., MS and features Sir John Burn, M.D., MBBS, BMedSci, a professor of Clinical Genetics at Newcastle University and senior leader in England's National Health Service.
Together they discuss the 10 year follow-up results of the seminal Cancer Prevention Programme (CAPP2) trial described in the Cancer Prevention Research article titled “Cancer Prevention with Resistant Starch in Lynch Syndrome Patients in the CAPP2-Randomized Placebo-Controlled Trial: Planned 10-Year Follow-up” which can be found here.
Read our blog post Does starch prevent cancer in patients with lynch syndrome by a mechanism that might be applicable to the general population here.

Episode 8: S.5 Ep.8 PD-1 Blockade in Mismatch Repair-Deficient, Locally Advanced Rectal Cancer Nov 29, 2022

Show notes

This episode is hosted by Matt Yurgelun, M.D, a GI medical oncologist at the Dana-Farber Cancer Institute in Boston, MA, and features a discussion between Zsofia Stadler, M.D, a GI medical oncologist at the Memorial Sloan Kettering Cancer Center, New York, NY and Andrea Cercek, M.D, a GI medical oncologist also at the Memorial Sloan Kettering Cancer Center, New York, NY.

Together they discuss "PD-1 Blockade in Mismatch Repair-Deficient, Locally Advanced Rectal Cancer" which was published in the New England Journal of Medicine and found here https://pubmed.ncbi.nlm.nih.gov/35660797/
This study showed a remarkable response to immune checkpoint inhibitors in Lynch syndrome-associated rectal cancers. This exciting work is reviewed and includes insightful discussion of the design, outcomes, side effects, and future questions raised by researchers.

This episode was recorded on October 25th, 2022 and reflects expert opinion at the time of the recording.
If you enjoyed this podcast, you can listen to more high quality scientific podcasts here

Episode 7: S.5 Ep.7 Evidence for Gastric Cancer Surveillance in Lynch Syndrome Oct 20, 2022

Show notes

This episode is hosted by Pooja Dharwadkar, M.D, assistant professor at the University of California San Francisco, and features a discussion between Carol Burke, M.D, codirector of the Hereditary Cancer Clinic at the Cleveland Clinic; Robert Hüneburg, M.D, gastroenterologist at the National Center for Hereditary Tumor Syndromes at University Hospital Bonn in Bonn, Germany; and Bryson Katona, M.D, director of the GI Cancer Genetics and Cancer Risk Evaluation programs at the Hospital of the University of Pennsylvania in Philadelphia, PA. They discuss the benefits of upper GI cancer surveillance in Lynch syndrome – specifically as it applies to gastric cancer – and the studies that have contributed to recent updates in the National Comprehensive Cancer Network screening and surveillance guidelines for individuals with Lynch syndrome.

This episode references the following articles:

“Upper endoscopic surveillance in Lynch syndrome detects gastric and duodenal adenocarcinomas,” found here: https://pubmed.ncbi.nlm.nih.gov/32859614/
“Value of upper gastrointestinal endoscopy for gastric cancer surveillance in patients with Lynch syndrome,” found here: https://pubmed.ncbi.nlm.nih.gov/32930401/

“Clinically actionable findings on surveillance EGD in asymptomatic patients with Lynch syndrome,” found here: https://pubmed.ncbi.nlm.nih.gov/34252420/

This episode was recorded on July 9th, 2022 and reflects expert opinion at the time of the recording.

Episode 6: S.5 Ep.6 Is it Time for Universal Germline Genetic Testing for All GI Cancers? A podcast debate! Sep 28, 2022

Show notes

On the occasion of the 2022 #PrevivorDay and #HereditaryCancerWeek, we're delighted to bring you a podcast debate as part of the CGA-IGC 2022 Podcast Series - Episode 6.

This episode is hosted by Michael J. Hall, MD, MS, Fox Chase Cancer Centre and features Heather Hampel, MS, CGC, City of Hope and Matthew B. Yurgelun, MD, Dana-Farber Cancer Institute.

The debate features Professor Heather Hampel and Dr Matthew Yurgelun going head to head over "Is it Time for Universal Germline Genetic Testing for All GI Cancers?", which was published in the Journal of Clinical Oncology can be found here https://pubmed.ncbi.nlm.nih.gov/35649230/

This episode was recorded on September 19th, 2022 and reflects expert opinion at the time of the recording.

Episode 5: S.5 Ep.5 The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival Aug 16, 2022

Show notes

This episode is hosted by Beth Dudley, MS, MPH, CGC, University of Pittsburgh Medical Center and features Michael G. Goggins, M.B.B.CH., M.D., The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions.

Together they discuss “The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival” which was published in the Journal of Clinical Oncology and found here: https://pubmed.ncbi.nlm.nih.gov/35704792/

This episode was recorded on June 21st, 2022 and reflects expert opinion at the time of the recording.

Episode 4: S.5 Ep.4 Evaluation of Urinalysis-Based Screening for Urothelial Carcinoma in Patients With Lynch Syndrome Jul 18, 2022

Show notes

This episode is hosted by Joshua Sommovilla, M.D, The Sanford R. Weiss, MD Center for Hereditary Colorectal Neoplasia at the Cleveland Clinic and features Matthew Kalady, M.D, The Ohio State University Wexner Medical Center and Mohammad Abbas, M.D., MPH, Northwestern University.

Together they discuss “Evaluation of Urinalysis-Based Screening for Urothelial Carcinoma in Patients With Lynch Syndrome” which was published in the Journal of Dis Colon Rectum. and found here: https://pubmed.ncbi.nlm.nih.gov/34882627/

This episode was recorded on April 25th, 2022 and reflects expert opinion at the time of the recording.

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